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1,25(OH)2D3

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https://www.readbyqxmd.com/read/27902586/neurological-psychological-and-cognitive-disorders-in-patients-with-chronic-kidney-disease-on-conservative-and-replacement-therapy
#1
Silvia Lai, Oriano Mecarelli, Patrizia Pulitano, Roberto Romanello, Leonardo Davi, Alessia Zarabla, Amalia Mariotti, Maria Carta, Giorgia Tasso, Luca Poli, Anna Paola Mitterhofer, Massimo Testorio, Nicla Frassetti, Paola Aceto, Alessandro Galani, Carlo Lai
Chronic kidney disease (CKD) is a highly prevalent condition in the world. Neurological, psychological, and cognitive disorders, related to CKD, could contribute to the morbidity, mortality, and poor quality of life of these patients. The aim of this study was to assess the neurological, psychological, and cognitive imbalance in patients with CKD on conservative and replacement therapy.Seventy-four clinically stable patients affected by CKD on conservative therapy, replacement therapy (hemodialysis (HD), peritoneal dialysis (PD)), or with kidney transplantation (KT) and 25 healthy controls (HC), matched for age and sex were enrolled...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27896775/uplc-ms-ms-determination-of-deuterated-25-hydroxyvitamin-d-d3-25ohd3-and-other-vitamin-d-metabolites-for-the-measurement-of-25ohd-half-life
#2
Shima Assar, Inez Schoenmakers, Albert Koulman, Ann Prentice, Kerry S Jones
Plasma 25-hydroxyvitamin D (25OHD) half-life (25OHDt 1/2) is a dynamic marker of vitamin D metabolism that can be used to assess vitamin D expenditure and help inform vitamin D requirements. Our group recently established an approach to determine the 25OHDt 1/2 as an alternative biomarker of 25OHD expenditure in humans. The approach uses a small oral dose of stable isotope labeled 25OHD3 [3-(2)H-25OHD(3) (6,19,19-d3)] (d3-25OHD3) (tracer), which is distinguishable from endogenous 25OHD by liquid chromatography tandem-mass spectrometry (LC-MS/MS)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27893751/25-hydroxy-and-1%C3%AE-25-dihydroxycholecalciferol-have-greater-potencies-than-25-hydroxy-and-1%C3%AE-25-dihydroxyergocalciferol-in-modulating-cultured-human-and-mouse-osteoblast-activities
#3
Allahdad Zarei, Philippa A Hulley, Afsie Sabokbar, M Kassim Javaid, Alireza Morovat
Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and their 1α-hydroxylated forms (1,25(OH)2D3 and 1,25(OH)2D2) on cellular activity of vitamin D-responsive cells have hardly been compared. We studied differences in the effects of these metabolites on cell number, gene transcription, protein expression and mineralisation of cultured human bone marrow-derived stromal cells (hBMSC) and rapidly mineralising mouse 2T3 osteoblasts...
2016: PloS One
https://www.readbyqxmd.com/read/27884393/1-25-dihydroxyvitamin-d3-targeting-vegf-pathway-alleviates-house-dust-mite-hdm-induced-airway-epithelial-barrier-dysfunction
#4
Ruhui Zhang, Hangming Dong, Haijin Zhao, Liqin Zhou, Fei Zou, Shaoxi Cai
BACKGROUND: In our previous studies, we have indentified that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) can alleviate toluene diisocyanate-induced airway epithelial barrier disruption and we also found that vascular endothelial growth factor (VEGF) derived from airway epithelials cells could disrupt epithelial barrier. OBJECTIVE: The study aimed to investigate whether 1,25(OH)2D3 can inhibit house dust mite (HDM) induced airway epithelial barrier dysfunction by regulating the VEGF pathway...
November 16, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27883226/the-circadian-gene-clock-regulates-bone-formation-via-pdia3
#5
Gongsheng Yuan, Bingxuan Hua, Yang Yang, Lirong Xu, Tingting Cai, Ning Sun, Zuoqin Yan, Chao Lu, Ruizhe Qian
The expression patterns of clock-controlled genes (ccgs) are regulated by circadian rhythm, which is a major regulatory and physiological mechanism tied to the solar day. Disruptions in circadian rhythm contribute to the development of cardiovascular diseases, cancer, metabolic syndromes and aging. It has been reported that bone remodeling is also regulated by circadian rhythm. However, the molecular mechanism by which the circadian gene Clock regulates bone remodeling has yet to be elucidated. Here, we show that Clock mutant mice exhibit a significant reduction in bone density as well as increased apoptosis...
November 24, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27883024/lower-vitamin-d-metabolites-levels-were-associated-with-increased-coronary-artery-diseases-in-type-2-diabetes-patients-in-india
#6
Ramu Adela, Roshan M Borkar, Murali Mohan Bhandi, Gayatri Vishwakarma, P Naveen Chander Reddy, R Srinivas, Sanjay K Banerjee
The purpose of the present study was to measure six vitamin D metabolites and to find the association between vitamin D deficiency and coronary artery diseases in diabetes (T2DM_CAD). Four groups [control (n = 50), type 2 diabetes (T2DM, n = 71), coronary artery diseases (CAD, n = 28), T2DM_CAD (n = 38)] of total 187 subjects were included in the study. Six vitamin D metabolites (D2, D3, 25(OH)D2, 25(OH)D3, 1,25(OH)2D2, 1,25(OH)2D3), total 25(OH)D and total 1,25(OH)2D were measured by UPLC/APCI/HRMS method in these subjects...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876536/the-protective-effect-of-1alpha-25-dihydroxyvitamin-d3-and-metformin-on-liver-in-type-2-diabetic-rats
#7
REVIEW
Samah Elattar, Suzanne Estaphan, Enas A Mohamed, Ahmed Elzainy, Mary Naguib
There is an accumulating evidence suggesting an immunomodulatory role of 1α,25(OH)2D3. Altered 1α,25(OH)2D3 level may play a role in the development of T2DM and contribute to the pathogenesis of liver diseases. Our study was designed to study and compare the effect of metformin and 1α,25(OH)2D3 supplementation on liver injury in type 2 diabetic rat. Sixty male Albino rats were divided into 5 groups; group 1: control rats. the remaining rats were fed high fat diet for 2 weeks and injected with streptozotocin (35mg/kg BW, i...
November 19, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27871077/impact-of-annexin-a-7-deficiency-on-fgf23-plasma-concentrations
#8
Anja T Umbach, Omar El-Attar, Dong Luo, Hajar Fakhri, Rosi Bissinger, Florian Lang
BACKGROUND/AIMS: The release of fibroblast growth factor FGF23, a powerful regulator of 1,25(OH)2D3 formation and mineral metabolism, is stimulated by store-operated Ca2+ entry (SOCE), which is accomplished by the pore forming Ca2+ release activated channel protein Orai1. Regulators of Orai1 and thus FGF23 release include serum & glucocorticoid inducible kinase SGK1, a kinase up-regulated by glucocorticosteroids. Some effects of glucocorticoids require the presence of annexin A7, such as suppression of prostaglandin E2 in gastric glands...
November 21, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27856242/1-25-oh-2d3-induced-interaction-of-vitamin-d-receptor-with-p50-subunit-of-nf-%C3%AE%C2%BAb-suppresses-the-interaction-between-klf5-and-p50-contributing-to-inhibition-of-lps-induced-macrophage-proliferation
#9
Dong Ma, Ruo-Nan Zhang, Ya Wen, Wei-Na Yin, Disi Bai, Guo-Ying Zheng, Jin-Shui Li, Bin Zheng, Jin-Kun Wen
KLF5 and nuclear factor κB (NF-κB) regulate cell proliferation and inflammation. Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. However, an actual relationship between KLF5, NF-κB and VDR in the inflammation and proliferation of macrophages is still unclear. Here, we showed that LPS and proinflammatory cytokines stimulate KLF5 gene expression in macrophages, and that 1, 25(OH)2D3 suppresses LPS-induced KLF5 expression and cell proliferation via upregulation of VDR expression...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27852823/phosphorylation-of-human-retinoid-x-receptor-%C3%AE-at-serine-260-impairs-its-subcellular-localization-receptor-interaction-nuclear-mobility-and-1%C3%AE-25dihydroxyvitamin-d3-dependent-dna-binding-in-ras-transformed-keratinocytes
#10
Sylvester Jusu, John F Presley, Richard Kremer
Human retinoid X receptor alpha (hRXRα) plays a critical role in DNA binding and transcriptional activity through heterodimeric association with several members of the nuclear receptor superfamily including the human vitamin D receptor (hVDR). We previously showed that hRXRα phosphorylation at serine 260 through the Ras-Raf-Mitogen activated protein kinase extra-cellular signal regulated kinases 1 and 2 (MAP kinase ERK1/2) activation is responsible for resistance to the growth inhibitory effects of 1α, 25dihydroxyvitamin D3 (1α,25(OH)2D3), the biologically active metabolite of vitamin D3 To further investigate the mechanism of this resistance we studied intranuclear dynamics of hVDR and hRXRα tagged constructs in living cells together with endogenous and tagged protein in fixed cells...
November 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27830022/transplantation-of-bone-marrow-derived-mesenchymal-stem-cells-rescues-partially-rachitic-phenotypes-induced-by-1-25-dihydroxyvitamin-d-deficiency-in-mice
#11
Zengli Zhang, Shaomeng Yin, Xian Xue, Ji Ji, Jian Tong, David Goltzman, Dengshun Miao
To determine whether the transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) can improve the 1,25(OH)2D deficiency-induced rachitic phenotype, 2×10(6) BM-MSCs from wild-type mice or vehicle were transplanted by tail vein injection into mice deficient in 1,25(OH)2D due to targeted deletion of 1α(OH)ase (1α(OH)ase(-/-)). Our results show that 1α(OH)ase mRNA was expressed in the BM-MSCs derived from wild-type mice, and was detected in long bone, kidney and intestine from BM-MSC-transplanted 1α(OH)ase(-/-) recipients...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27806875/immune-regulatory-effects-of-high-dose-vitamin-d3-supplementation-in-a-randomized-controlled-trial-in-relapsing-remitting-multiple-sclerosis-patients-receiving-ifn%C3%AE-the-solarium-study
#12
Anne-Hilde Muris, Joost Smolders, Linda Rolf, Marielle Thewissen, Raymond Hupperts, Jan Damoiseaux
Multiple sclerosis (MS) is characterized by a disturbed immune homeostasis and low serum vitamin D levels are associated with an increased disease activity. While vitamin D has been hypothesized to promote the maintenance of immune homeostasis, vitamin D supplementation could be of benefit to patients with MS. The SOLAR study investigated the effects of high dose vitamin D3 supplementation on clinical outcomes in a randomized controlled trial. Here we present the immune regulatory effects, investigated in the SOLARIUM sub-study...
November 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27795667/chronic-ethanol-exposure-effects-on-vitamin-d-levels-among-subjects-with-alcohol-use-disorder
#13
Olalekan Ogunsakin, Tete Hottor, Ashish Mehta, Maureen Lichtveld, Michael McCaskill
Vitamin D has been previously recognized to play important roles in human immune system and function. In the pulmonary system, vitamin D regulates the function of antimicrobial peptides, especially cathelicidin/LL-37. Human cathelicidin/LL-37 is a bactericidal, bacteriostatic, and antiviral endogenous peptide with protective immune functions. Chronic exposure to excessive alcohol has the potential to reduce levels of vitamin D (inactive vitamin D [25(OH)D3] and active vitamin D [1, 25(OH)2D3]) and leads to downregulation of cathelicidin/LL-37...
2016: Environmental Health Insights
https://www.readbyqxmd.com/read/27790378/vitamin-d-calcium-homeostasis-and-aging
#14
REVIEW
Vaishali Veldurthy, Ran Wei, Leyla Oz, Puneet Dhawan, Yong Heui Jeon, Sylvia Christakos
Osteoporosis is characterized by low bone mass and microarchitecture deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. Evidence is accumulating for an important role of calcium deficiency as the process of aging is associated with disturbed calcium balance. Vitamin D is the principal factor that maintains calcium homeostasis. Increasing evidence indicates that the reason for disturbed calcium balance with age is inadequate vitamin D levels in the elderly...
2016: Bone Research
https://www.readbyqxmd.com/read/27785371/vitamin-d-receptor-expression-in-human-bone-tissue-and-dose-dependent-activation-in-resorbing-osteoclasts
#15
Allahdad Zarei, Alireza Morovat, Kassim Javaid, Cameron P Brown
The effects of vitamin D on osteoblast mineralization are well documented. Reports of the effects of vitamin D on osteoclasts, however, are conflicting, showing both inhibition and stimulation. Finding that resorbing osteoclasts in human bone express vitamin D receptor (VDR), we examined their response to different concentrations of 25-hydroxy vitamin D3 [25(OH)D3] (100 or 500 nmol·L(-1)) and 1,25-dihydroxy vitamin D3 [1,25(OH)2D3] (0.1 or 0.5 nmol·L(-1)) metabolites in cell cultures. Specifically, CD14+ monocytes were cultured in charcoal-stripped serum in the presence of receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor (M-CSF)...
2016: Bone Research
https://www.readbyqxmd.com/read/27779898/reflections-about-inflammatory-bowel-disease-and-vitamins-a-and-d
#16
Sandra Maria Barbalho, Marcelo Dib Bechara, Ricardo de Alvares Goulart, Karina Quesada, Rodrigo Galhardi Gasparini, Antonely de Cássio Alves de Carvalho, Adriana Maria Ragassi Fiorini
Ulcerative colitis and Crohn's disease are two major forms of the inflammatory bowel diseases (IBDs). Vitamin A (VA) and vitamin D (VD) may be associated with reduction in inflammation in these disorders. The aim of this review was to show the current evidence that may associate VA and VD with IBDs. Data linking VA, VD, and IBDs were studied. Both VA and VD may be related to the immune system in different manners. The active form of VA, retinoic acid, may be related to the growth factor-β and release of interleukin-10 (IL-10), thus involved with the resolution of the inflammation...
October 25, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27755569/1-25-oh-2d3-and-vdr-signaling-pathways-regulate-the-inhibition-of-dectin-1-caused-by-cyclosporine-a-in-response-to-aspergillus-fumigatus-in-human-corneal-epithelial-cells
#17
Yiping Xia, Guiqiu Zhao, Jing Lin, Cui Li, Lin Cong, Nan Jiang, Qiang Xu, Qian Wang
BACKGROUND: The objective of this study is to observe whether cyclosporine A (CsA) inhibits the expression of dectin-1 in human corneal epithelial cells infected with Aspergillus fumigatus (A. fumigatus) and to investigate the molecular mechanisms of the inhibition. METHODS: Immortalized human corneal epithelial cells (HCECs) were pretreated with 1,25(OH)2D3 and VDR inhibitor for 1 h, and then they were pretreated with CsA for 12h. After these pretreatments, the HCECs were stimulated with A...
2016: PloS One
https://www.readbyqxmd.com/read/27741217/efficacy-of-high-dose-vitamin-d-supplements-for-elite-athletes
#18
Daniel J Owens, Jonathan C Y Tang, Warren J Bradley, S Andy Sparks, William D Fraser, James P Morton, Graeme L Close
PURPOSE: Supplementation with dietary forms of vitamin D is commonplace in clinical medicine, elite athletic cohorts and the general population, yet the response of all major vitamin D metabolites to high doses of vitamin D is poorly characterized. We aimed to identify the responses of all major vitamin D metabolites to moderate and high dose supplemental vitamin D3. METHODS: A repeated measures design was implemented in which 46 elite professional European athletes were block randomized based on their basal 25[OH]D concentration into two treatment groups...
October 13, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27734704/-vitamin-d-and-autoimmune-thyroid-diseases
#19
Karel Vondra
From the recent literature data it may be concluded that vitamin D deficiency is associated with increased risk of thyroid autoimmunity development and thus should be considered as an additional important risk factor for both chronic autoimmune thyroiditis (postpartum thyroiditis including) and Graves´ disease. A higher risk of Graves´ disease development is also associated with several polymorphisms in the gene encoding for vitamin D binding protein and for the specific receptor of active form of vitamin D - 1,25-(OH)2D3 in the respective target cells...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27721584/the-three-sisters-of-fate-in-multiple-sclerosis-klotho-clotho-fibroblast-growth-factor-23-lachesis-and-vitamin-d-atropos
#20
Hamit Yasar Ellidag, Necat Yilmaz, Fatma Kurtulus, Ozgur Aydin, Esin Eren, Ayca Inci, Suleyman Dolu, Fatma Demet Arslan Ince, Özlem Giray, Aylin Yaman
BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). PURPOSE: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. METHODS: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38...
September 2016: Annals of Neurosciences
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