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"Cognitive activity" aging

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https://www.readbyqxmd.com/read/28803853/developmental-suppression-of-forebrain-trka-receptors-and-attentional-capacities-in-aging-rats-a-longitudinal-study
#1
Brittney Yegla, Vinay Parikh
Basal forebrain (BF) cholinergic neurons innervating the cortex regulate cognitive, specifically attentional, processes. Cholinergic atrophy and cognitive decline occur at an accelerated pace in age-related neurodegenerative disorders such as Alzheimer's disease; however, the mechanism responsible for this phenomenon remains unknown. Here we hypothesized that developmental suppression of nerve growth factor signaling, mediated via tropomyosin-related kinase A (trkA) receptors, would escalate age-related attentional vulnerability...
August 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28758705/coping-with-changes-and-uncertainty-a-qualitative-study-of-young-adult-cancer-patients-challenges-and-coping-strategies-during-treatment
#2
Nataskja-Elena Kersting Lie, Torill Marie Bogsnes Larsen, May Aasebø Hauken
Young adult cancer patients (YACPs), aged 18-35 years when diagnosed with cancer, are in a vulnerable transitioning period from adolescence to adulthood, where cancer adds a tremendous burden. However, YACPs' challenges and coping strategies are under-researched. The objective of this study was to explore what challenges YACP experience during their treatment, and what coping strategies they applied to them. We conducted a qualitative study with a phenomenological-hermeneutic design, including retrospective, semi-structured interviews of 16 YACPs who had undergone cancer treatment...
July 31, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28743599/cognitive-behavioral-therapy-cbt-for-preventing-alzheimer-s-disease
#3
REVIEW
Larry D Reid, Faith E Avens, Alicia A Walf
This review provides the rationale for implementing cognitive behavioral therapy (CBT) for the prevention of Alzheimer's disease (AD). There are known risk factors associated with the development of AD, some of which may be ameliorated with CBT. We posit that treating the risk factors of inactivity, poor diet, hyposmia and anosmia, sleep disorders and lack of regularly engaged challenging cognitive activity will modify the physiology of the brain sufficiently to avoid the accumulation of excess proteins, including amyloid beta, causal events in the development of AD...
July 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28707959/interactions-of-the-salience-network-and-its-subsystems-with-the-default-mode-and-the-central-executive-networks-in-normal-aging-and-mild-cognitive-impairment
#4
Ganesh B Chand, Junjie Wu, Ihab Hajjar, Deqiang Qiu
Previous functional magnetic resonance imaging (fMRI) investigations suggest that the intrinsically organized large-scale networks and the interaction between them might be crucial for cognitive activities. A triple network model, which consists of the default-mode network, salience network, and central-executive network, has been recently used to understand the connectivity patterns of the cognitively normal brains versus the brains with disorders. This model suggests that the salience network dynamically controls the default-mode and central-executive networks in healthy young individuals...
August 10, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28701360/multicentre-randomised-clinical-trial-of-paediatric-concussion-assessment-of-rest-and-exertion-pedcare-a-study-to-determine-when-to-resume-physical-activities-following-concussion-in-children
#5
Andrée-Anne Ledoux, Nicholas J Barrowman, Kathy Boutis, Adrienne Davis, Sarah Reid, Gurinder Sangha, Ken J Farion, Kevin Belanger, Mark S Tremblay, Keith Owen Yeates, Carol DeMatteo, Nick Reed, Roger Zemek
INTRODUCTION: Rest until symptom-free, followed by a progressive stepwise return to activities, is often prescribed in the management of paediatric concussions. Recent evidence suggests prolonged rest may hinder recovery, and early resumption of physical activity may be associated with more rapid recovery postconcussion. The primary objective is to determine whether the early reintroduction of non-contact physical activity beginning 72 hours postinjury reduces postconcussive symptoms at 2 weeks in children following an acute concussion as compared with a rest until asymptomatic protocol...
July 12, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28539130/the-relation-of-education-occupation-and-cognitive-activity-to-cognitive-status-in-old-age-the-role-of-physical-frailty
#6
Andreas Ihle, Élvio R Gouveia, Bruna R Gouveia, Duarte L Freitas, Jefferson Jurema, Angenay P Odim, Matthias Kliegel
BACKGROUND: It remains unclear so far whether the role of cognitive reserve may differ between physically frail compared to less frail individuals. Therefore, the present study set out to investigate the relation of key markers of cognitive reserve to cognitive status in old age and its interplay with physical frailty in a large sample of older adults. METHODS: We assessed Mini-Mental State Examination (MMSE) in 701 older adults. We measured grip strength as indicator of physical frailty and interviewed individuals on their education, past occupation, and cognitive leisure activity...
May 25, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28455361/what-is-the-difference-in-concussion-management-in-children-as-compared-with-adults-a-systematic-review
#7
REVIEW
Gavin A Davis, Vicki Anderson, Franz E Babl, Gerard A Gioia, Christopher C Giza, William Meehan, Rosemarie Scolaro Moser, Laura Purcell, Philip Schatz, Kathryn J Schneider, Michael Takagi, Keith Owen Yeates, Roger Zemek
AIM: To evaluate the evidence regarding the management of sport-related concussion (SRC) in children and adolescents. The eight subquestions included the effects of age on symptoms and outcome, normal and prolonged duration, the role of computerised neuropsychological tests (CNTs), the role of rest, and strategies for return to school and return to sport (RTSp). DESIGN: Systematic review. DATA SOURCES: MEDLINE (OVID), Embase (OVID) and PsycInfo (OVID)...
June 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28423745/reasoning-and-data-representation-in-a-health-and-lifestyle-support-system
#8
Sten Hanke, Karl Kreiner, Johannes Kropf, Marc Scase, Christian Gossy
Case-based reasoning and data interpretation is an artificial intelligence approach that capitalizes on past experience to solve current problems and this can be used as a method for practical intelligent systems. Case-based data reasoning is able to provide decision support for experts and clinicians in health systems as well as lifestyle systems. In this project we were focusing on developing a solution for healthy ageing considering daily activities, nutrition as well as cognitive activities. The data analysis of the reasoner followed state of the art guidelines from clinical practice...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28400244/the-interconnection-of-mental-fatigue-and-aging-an-eeg-study
#9
Stefan Arnau, Tina Möckel, Gerhard Rinkenauer, Edmund Wascher
Mental fatigue, a state of reduced alertness and decreased overall performance due to prolonged cognitive activity, is a major cause for a large number of accidents in traffic and industry. Against the background of an aging workforce, the investigation of the interconnection of mental fatigue and aging is of great practical relevance. In the present study, a group of younger and a group of older adults performed a cognitive task for 3h. The experimental design also comprised breaks with various durations. Beside behavioral data, the spectral properties of the ongoing EEG with respect to time on task and breaks were analyzed...
April 8, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28373835/no-evidence-that-short-term-cognitive-or-physical-training-programs-or-lifestyles-are-related-to-changes-in-white-matter-integrity-in-older-adults-at-risk-of-dementia
#10
Patrick Fissler, Hans-Peter Müller, Olivia C Küster, Daria Laptinskaya, Franka Thurm, Alexander Woll, Thomas Elbert, Jan Kassubek, Christine A F von Arnim, Iris-Tatjana Kolassa
Cognitive and physical activities can benefit cognition. However, knowledge about the neurobiological mechanisms underlying these activity-induced cognitive benefits is still limited, especially with regard to the role of white matter integrity (WMI), which is affected in cognitive aging and Alzheimer's disease. To address this knowledge gap, we investigated the immediate and long-term effects of cognitive or physical training on WMI, as well as the association between cognitive and physical lifestyles and changes in WMI over a 6-month period...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28369164/the-time-trends-of-cognitive-impairment-incidence-among-older-chinese-people-in-the-community-based-on-the-clhls-cohorts-from-1998-to-2014
#11
Mingyue Gao, Weihong Kuang, Peiyuan Qiu, Huali Wang, Xiaozhen Lv, Min Yang
Objective: to examine a 16-year trend in cognitive impairment (CI) incidence and associated factors among older Chinese people. Subjects: aged 60 and above whose cognitive function were normal at their first test. Methods: a secondary analysis that identified subjects from the database of Chinese Longitudinal Healthy Longevity Survey (CLHLS). The database contained mixed longitudinal cohorts of older Chinese people surveyed in 1998, 2000, 2002, 2005, 2008-09, 2011-12 and 2014...
March 21, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28363508/risk-factors-associated-with-the-onset-and-progression-of-alzheimer-s-disease-a-systematic-review-of-the-evidence
#12
Mona Hersi, Brittany Irvine, Pallavi Gupta, James Gomes, Nicholas Birkett, Daniel Krewski
A systematic review was conducted to identify risk factors associated with the onset and progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews were eligible for inclusion. Primary studies reporting on non-genetic risk factors associated with neuropathologically or clinically confirmed AD were considered. Eighty one systematic reviews reporting on AD onset and 12 reporting on progression satisfied the eligibility criteria. Four hundred and thirty-two relevant primary studies reporting on onset were identified; however, only those published between 2010 and 2012 (n=65) were included in the qualitative synthesis...
March 29, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28322422/use-it-or-lose-it-cognitive-activity-as-a-protec-tive-factor-for-cognitive-decline-associated-with-alzheimer-s-disease
#13
Panagiota Mistridis, Jutta Mata, Stefan Neuner-Jehle, Jean-Marie Annoni, Andreas Biedermann, Irene Bopp-Kistler, Dominique Brand, Andrea Brioschi Guevara, Hedi Decrey-Wick, Jean-François Démonet, Ulrich Hemmeter, Reto W Kressig, Brian Martin, Luca Rampa, Egemen Savaskan, Andreas Stuck, Philipp Tschopp, Dina Zekry, Andreas Monsch
Because of the worldwide aging of populations, Alzheimer's disease and other dementias constitute a devastating experience for patients and families as well as a major social and economic burden for both healthcare systems and society. Multiple potentially modifiable cardiovascular and lifestyle risk factors have been associated with this disease. Thus, modifying these risk factors and identifying protective factors represent important strategies to prevent and delay disease onset and to decrease the social burden...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28282912/predictors-of-nightly-subjective-objective-sleep-discrepancy-in-poor-sleepers-over-a-seven-day-period
#14
Vanessa Herbert, Daniel Pratt, Richard Emsley, Simon D Kyle
This study sought to examine predictors of subjective/objective sleep discrepancy in poor sleepers. Forty-two individuals with insomnia symptoms (mean age = 36.2 years, 81% female) were recruited to take part in a prospective study which combined seven days of actigraphy with daily assessment of sleep perceptions, self-reported arousal, sleep effort, and mood upon awakening. A high level of intra-individual variability in measures of sleep discrepancy was observed. Multilevel modelling revealed that higher levels of pre-sleep cognitive activity and lower mood upon awakening were significantly and independently predictive of the underestimation of total sleep time...
March 9, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28282326/effects-of-mental-fatigue-on-endurance-performance-in-the-heat
#15
Jeroen VAN Cutsem, Kevin DE Pauw, Luk Buyse, Samuele Marcora, Romain Meeusen, Bart Roelands
PURPOSE: Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity and has been observed to decrease time trial (TT) endurance performance by ∼3.5% in normal ambient temperatures. Recently, it has been suggested that heat may augment the negative effect of mental fatigue on cognitive performance, raising the question whether it may also amplify the effect of mental fatigue on TT performance. METHODS: In 30°C and 30% relative humidity, 10 endurance-trained male athletes (mean ± SD; age = 22 ± 3 yr, Wmax = 332 ± 41 W) completed two experimental conditions: intervention (I; 45-min Stroop task) and control (C; 45-min documentary)...
August 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28263928/the-spatiotemporal-substrates-of-autobiographical-recollection-using-event-related-ica-to-study-cognitive-networks-in-action
#16
Chris Tailby, Genevieve Rayner, Sarah Wilson, Graeme Jackson
Higher cognitive functions depend upon dynamically unfolding brain network interactions. Autobiographical recollection - the autonoetic re-experiencing of context rich, emotionally laden, personally experienced episodes - is an excellent example of such a process. Autobiographical recollection unfolds over time, with different cognitive processes engaged at different times throughout. In this paper we apply a recently developed analysis technique - event related independent components analysis (eICA) - to study the spatiotemporal dynamics of neural activity supporting autobiographical recollection...
March 2, 2017: NeuroImage
https://www.readbyqxmd.com/read/28151002/lack-of-associations-between-modifiable-risk-factors-and-dementia-in-the-very-old-findings-from-the-cambridge-city-over-75s-cohort-study
#17
Kay Deckers, Sebastian Köhler, Martin van Boxtel, Frans Verhey, Carol Brayne, Jane Fleming
OBJECTIVES: To investigate the association between modifiable risk and protective factors and severe cognitive impairment and dementia in the very old. Additionally, the present study tests the predictive validity of the 'LIfestyle for BRAin health' (LIBRA) score, an index developed to assess an individual's dementia prevention potential. METHOD: Two hundred seventy-eight individuals aged 85 years or older from the Cambridge City over-75s cohort study were followed-up until death...
February 2, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28131014/executive-function-performance-and-change-in-aging-is-predicted-by-apolipoprotein-e-intensified-by-catechol-o-methyltransferase-and-brain-derived-neurotrophic-factor-and-moderated-by-age-and-lifestyle
#18
Shraddha Sapkota, Lars Bäckman, Roger A Dixon
Recent studies have reported several genetic, health, and aging interaction effects in predicting cognitive performance and change. We used an accelerated longitudinal design to examine interactions among genetic, lifestyle, and aging for executive function (EF) in non-demented older adults (n = 634; age range = 53-95 years). The polymorphisms were apolipoprotein E (APOE), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF). We tested (1) independent and additive effects of APOE, COMT, and BDNF and (2) APOE effect modification for COMT + BDNF, on EF performance and 9-year change as separated by age and lifestyle activities...
April 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28067190/leisure-activities-education-and-cognitive-impairment-in-chinese-older-adults-a-population-based-longitudinal-study
#19
Xinyi Zhu, Chengxuan Qiu, Yi Zeng, Juan Li
BACKGROUND: We examine the association between leisure-time activities and the risk of developing cognitive impairment among Chinese older people, and further investigate whether the association varies by educational level. METHODS: This follow-up study included 6,586 participants (aged 79.5 ± 9.8 years, range 65-105 years, 51.7% female) of the Chinese Longitudinal Healthy Longevity Survey who were aged ≥65 years and were free of cognitive impairment in 2002...
May 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28025282/memory-resilience-to-alzheimer-s-genetic-risk-sex-effects-in-predictor-profiles
#20
Kirstie L McDermott, G Peggy McFall, Shea J Andrews, Kaarin J Anstey, Roger A Dixon
OBJECTIVES: Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer's disease (AD) and episodic memory (EM) decline. Memory resilience occurs when genetically at-risk adults perform at high and sustained levels. We investigated whether (a) memory resilience to AD genetic risk is predicted by biological and other risk markers and (b) the prediction profiles vary by sex and AD risk variant. METHOD: Using a longitudinal sample of nondemented adults (n = 642, aged 53-95) we focused on memory resilience (over 9 years) to 2 AD risk variants (APOE, CLU)...
December 26, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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