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Diabetic retinopathy epidemiology

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https://www.readbyqxmd.com/read/27908354/a-test-in-context-hemoglobin-a1c-and-cardiovascular-disease
#1
REVIEW
M Odette Gore, Darren K McGuire
Measurement of glycated hemoglobin (HbA1c), the most widely accepted indicator of long-term glycemic exposure, is central for the diagnosis and management of diabetes mellitus. Levels of HbA1c track epidemiologically with diabetic complications, and glycemic control, as reflected by HbA1c reduction, results in decreased risk of microvascular complications, including diabetic kidney disease, neuropathy, and retinopathy. The relationship between HbA1c reduction and cardiovascular disease prevention in patients with diabetes is more complex, with data from large randomized trials published over the past decade providing clear evidence that lowering of HbA1c per se is an inadequate marker for a therapeutic regimen's impact on cardiovascular outcomes and patient survival...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27903086/the-association-of-smokeless-tobacco-use-and-pack-years-of-smokeless-tobacco-with-age-related-macular-degeneration-in-indian-population
#2
Sangeetha Srinvasan, Gayathri Swaminathan, Vaitheeswaran Kulothungan, Tarun Sharma, Rajiv Raman
PURPOSE: To explore the association of use and the influence of pack-year use of smokeless tobacco versus no use with that of early and late age-related macular degeneration (AMD) in rural and urban south Indian population. We hypothesized that the use and pack-years of use would be significantly associated with both early and late AMD. We therefore sought to examine subjects who gave a history of using smokeless tobacco and we quantified the usage as pack-years, to examine the association with that of early and late AMD...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27858934/contrast-sensitivity-and-its-determinants-in-people-with-diabetes-sn-dreams-ii-report-no-6
#3
L Gella, R Raman, S S Pal, S Ganesan, T Sharma
PurposeTo assess contrast sensitivity (CS) and to elucidate the factors associated with CS among subjects with type 2 diabetes in a cross-sectional population-based study.Patients and MethodsSubjects were recruited from a follow-up cohort, Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular genetics Study (SN-DREAMS II). Of 958 subjects who were followed up in SN-DREAMS II, a subset of 653 subjects was included in the analysis. All subjects underwent a comprehensive eye examination, which included CS assessment using the Pelli-Robson chart...
November 18, 2016: Eye
https://www.readbyqxmd.com/read/27784886/diabetic-peripheral-neuropathy-and-prevalence-of-erectile-dysfunction-in-japanese-patients-aged-65-years-with-type-2-diabetes-mellitus-the-dogo-study
#4
S Furukawa, T Sakai, T Niiya, H Miyaoka, T Miyake, S Yamamoto, K Maruyama, T Ueda, H Senba, Y Todo, M Torisu, H Minami, M Onji, T Tanigawa, B Matsuura, Y Hiasa, Y Miyake
Only limited epidemiological evidence exists regarding the relationship between diabetic neuropathy and erectile dysfunction (ED) among Japanese patients with type 2 diabetes mellitus. To investigate the relationship between diabetic neuropathy and ED among Japanese patients with type 2 diabetes mellitus, a multicenter cross-sectional study was conducted in 287 male Japanese patients with type 2 diabetes mellitus, age (19-65 years). Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, decreased or disappeared Achilles tendon reflex and/or abnormal vibration perception...
October 27, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27766584/presence-and-risk-factors-for-glaucoma-in-patients-with-diabetes
#5
Brian J Song, Lloyd Paul Aiello, Louis R Pasquale
Diabetes mellitus represents a growing international public health issue with a near quadrupling in its worldwide prevalence since 1980. Though it has many known microvascular complications, vision loss from diabetic retinopathy is one of the most devastating for affected individuals. In addition, there is increasing evidence to suggest that diabetic patients have a greater risk for glaucoma as well. Though the pathophysiology of glaucoma is not completely understood, both diabetes and glaucoma appear to share some common risk factors and pathophysiologic similarities with studies also reporting that the presence of diabetes and elevated fasting glucose levels are associated with elevated intraocular pressure-the primary risk factor for glaucomatous optic neuropathy...
December 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27766550/predictors-of-electrocardiographic-abnormalities-in-type-1-diabetes-the-wisconsin-epidemiologic-study-of-diabetic-retinopathy
#6
Wesley T O'Neal, Kristine E Lee, Elsayed Z Soliman, Ronald Klein, Barbara E K Klein
PURPOSE: To determine the incidence and determinants of developing abnormalities on the 12-lead electrocardiogram (ECG) in persons with type 1 diabetes. METHODS: We evaluated the distribution of ECG abnormalities and risk factors for developing new abnormalities in 266 (mean age = 44 years ± 9.0; 50 % female) people with type 1 diabetes from the Wisconsin Epidemiologic Study of Diabetic Retinopathy. This analysis included participants with complete ECG data from study visit 5 (2000-2001) and follow-up ECGs from study visit 7 (2012-2014)...
October 20, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27711179/prevalence-risk-factors-and-complications-of-diabetes-in-the-kilimanjaro-region-a-population-based-study-from-tanzania
#7
John W Stanifer, Charles R Cleland, Gerald Jamberi Makuka, Joseph R Egger, Venance Maro, Honest Maro, Francis Karia, Uptal D Patel, Matthew J Burton, Heiko Philippin
BACKGROUND: In sub-Saharan Africa, diabetes is a growing burden, yet little is known about its prevalence, risk factors, and complications. To address these gaps and help inform public health efforts aimed at prevention and treatment, we conducted a community-based study assessing diabetes epidemiology. METHODS AND FINDINGS: We conducted a stratified, cluster-designed, serial cross-sectional household study from 2014-2015 in the Kilimanjaro Region, Tanzania. We used a three-stage cluster probability sampling method to randomly select individuals...
2016: PloS One
https://www.readbyqxmd.com/read/27601058/associations-between-recent-severe-hypoglycemia-retinal-vessel-diameters-and-cognition-in-adults-with-type-1-diabetes
#8
Christopher M Ryan, Barbara E K Klein, Kristine E Lee, Karen J Cruickshanks, Ronald Klein
AIMS: Mild cognitive dysfunction has been identified in children and adults with type 1 diabetes, but most studies have failed to find a relationship between severe hypoglycemia and cognition, despite reports of such associations in older adults with type 2 diabetes. Focusing on older adults with type 1 diabetes, we examined the associations between cognitive performance and recent episodes of severe hypoglycemia, retinal vessel diameters and the presence of micro- and macrovascular complications...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27585063/global-epidemiology-of-diabetic-foot-ulceration-a-systematic-review-and-meta-analysis
#9
Pengzi Zhang, Jing Lu, Yali Jing, Sunyinyan Tang, Dalong Zhu, Yan Bi
Diabetic foot is a severe public health issue, yet rare studies investigated its global epidemiology. Here we performed a systematic review and meta-analysis through searching PubMed, EMBASE, ISI Web of science and Cochrane database. We found that that global diabetic foot ulcer prevalence was 6.3% (95%CI: 5.4%-7.3%), which was higher in males (4.5%, 95%CI: 3.7%-5.2%) than in females (3.5%, 95%CI: 2.8%-4.2%), and higher in type 2 diabetic patients (6.4%, 95%CI: 4.6%-8.1%) than in type 1 diabetics (5.5%, 95%CI: 3...
September 1, 2016: Annals of Medicine
https://www.readbyqxmd.com/read/27539884/haptoglobin-2-2-genotype-and-the-risk-of-coronary-artery-disease-in-the-diabetes-control-and-complications-trial-epidemiology-of-diabetes-interventions-and-complications-study-dcct-edic
#10
Trevor J Orchard, Jye-Yu C Backlund, Tina Costacou, Patricia Cleary, Maria Lopes-Virella, Andrew P Levy, John M Lachin
AIMS/HYPOTHESIS: Haptoglobin(Hp) 2-2 genotype has been shown to increase coronary artery disease (CAD) risk in numerous type 2 diabetes studies but in only one type 1 diabetes cohort. We assessed the association of Hp2-2 with incident CAD over 26years of follow-up in 1303 Caucasian participants of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. METHODS: DCCT randomized volunteers with type 1 diabetes to intensive versus conventional therapy within two cohorts: 'primary prevention' with 1-5years diabetes duration and 'secondary intervention' with 1-15years diabetes duration and early retinopathy, with or without albuminuria, but no advanced complications...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27525681/fenofibrate-and-diabetic-retinopathy
#11
REVIEW
Jared E Knickelbein, Akshar B Abbott, Emily Y Chew
Diabetic retinopathy, a common and sight-threatening microvascular complication of diabetes mellitus, is a leading cause of blindness among working-aged adults. Medical therapies including intensive control of hyperglycemia and hypertension have been shown to reduce the incidence and progression of diabetic retinopathy. The association of dyslipidemia and treatment with statins with diabetic retinopathy is inconsistent in epidemiologic studies. However, two recent randomized clinical trials have demonstrated beneficial effects of systemic fenofibrate therapy in reducing the progression of diabetic retinopathy independently of serum lipid levels...
October 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27497477/breakdown-of-the-cerebrovasculature-and-blood-brain-barrier-a-mechanistic-link-between-diabetes-mellitus-and-alzheimer-s-disease
#12
Eric L Goldwaser, Nimish K Acharya, Abhirup Sarkar, George Godsey, Robert G Nagele
Alzheimer's disease (AD) and diabetes mellitus (DM) are among the most pervasive and devastating disorders that afflict people throughout the world. Although typically associated with older demographics, recent epidemiologic studies have reported parallel trends in decreasing age of onset and increasing incidence of these conditions. Promising research continues to implicate the cerebrovasculature and blood-brain barrier (BBB) as playing key roles in AD pathoetiology. Similarly, complications accompanying DM, such as diabetic nephropathy/retinopathy, cardiovascular disease, and stroke, have been rooted in vascular compromise...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27496796/diabetic-macular-oedema
#13
Gavin S Tan, Ning Cheung, Rafael Simó, Gemmy C M Cheung, Tien Yin Wong
Diabetic macular oedema, characterised by exudative fluid accumulation in the macula, is the most common form of sight-threatening retinopathy in people with diabetes. It affects one in 15 people with diabetes resulting in more than 20 million cases worldwide. Few epidemiological studies have been done to specifically investigate risk factors for diabetic macular oedema, although poor glycaemic and blood pressure control are associated with the presence and development of the disorder. The pathophysiological processes begin with chronic hyperglycaemia, and interplay between vascular endothelial growth factor (VEGF) and inflammatory mediators...
August 2, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27488152/failure-to-initiate-early-insulin-therapy-a-risk-factor-for-diabetic-retinopathy-in-insulin-users-with-type-2-diabetes-mellitus-sankara-nethralaya-diabetic-retinopathy-epidemiology-and-molecular-genetics-study-sn-dreams-report-number-35
#14
Aditi Gupta, Kushal S Delhiwala, Rajiv P G Raman, Tarun Sharma, Sangeetha Srinivasan, Vaitheeswaran Kulothungan
CONTEXT: Insulin users have been reported to have a higher incidence of diabetic retinopathy (DR). AIM: The aim was to elucidate the factors associated with DR among insulin users, especially association between duration, prior to initiating insulin for Type 2 diabetes mellitus (DM) and developing DR. MATERIALS AND METHODS: Retrospective cross-sectional observational study included 1414 subjects having Type 2 DM. Insulin users were defined as subjects using insulin for glycemic control, and insulin nonusers as those either not using any antidiabetic treatment or using diet control or oral medications...
June 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27449710/prevalence-and-comorbidities-of-double-diabetes
#15
S R Merger, W Kerner, M Stadler, A Zeyfang, P Jehle, M Müller-Korbsch, R W Holl
BACKGROUND: A growing number of people with type 1 diabetes (T1DM) are identified with features of metabolic syndrome (MS) known as "double diabetes", but epidemiologic data on the prevalence of MS in T1DM and its comorbidities are still lacking. Aim of this cross sectional study is to better estimate the prevalence of MS in T1DM, and to assess its association with comorbidities. METHODS: Data of 31,119 persons with autoimmune diabetes mellitus were analysed for signs of MS and presence of late complications...
September 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27449153/assessment-of-the-prevalence-and-risk-factors-of-ophthalmoplegia-among-diabetic-patients-in-a-large-national-diabetes-registry-cohort
#16
Eman S Al Kahtani, Rajiv Khandekar, Khalid Al-Rubeaan, Amira M Youssef, Heba M Ibrahim, Ahmed H Al-Sharqawi
BACKGROUND: There are limited data on the epidemiology and risk factors of ophthalmoplegia among diabetic patients. This study aims to determine the prevalence and important risk factors related to ophthalmoplegia among diabetic patients. METHODS: This is an observational registry-based study using the Saudi National Diabetes Registry (SNDR) database to select diabetic patients regardless of their diabetes type. A total of 64,351 Saudi diabetic patients aged more than 18 years and registered in SNDR between January 2000 and December 2010 were analyzed to identify ophthalmoplegic cases...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27380941/depression-in-diabetic-retinopathy-a-review-and-recommendation-for-psychiatric-management
#17
REVIEW
Xiaohong Chen, Lin Lu
BACKGROUND: Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the main causes of irreversible vision impairment in the working-age population. Multiple studies have demonstrated the significantly high prevalence of depression in patients with DR in recent years. The progression of DR could lead to depression, whereas depressive symptoms often worsen the condition of DR. Therefore, DR is one of the causes of psychosomatic diseases, the treatment for which should combine traditional DR therapy with depression interventions...
September 2016: Psychosomatics
https://www.readbyqxmd.com/read/27362756/localising-microaneurysms-in-fundus-images-through-singular-spectrum-analysis
#18
Su Wang, Hongying Lilian Tang, Lutfiah Ismail Al Turk, Yin Hu, Saeid Sanei, George Michael Saleh, Tunde Peto
: Reliable recognition of microaneurysms is an essential task when developing an automated analysis system for diabetic retinopathy detection. In this work, we propose an integrated approach for automated microaneurysm detection with high accuracy. METHODS: Candidate objects are first located by applying a dark object filtering process. Their cross-section profiles along multiple directions are processed through singular spectrum analysis. The correlation coefficient between each processed profile and a typical microaneurysm profile is measured and used as a scale factor to adjust the shape of the candidate profile...
June 27, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27355693/ten-emerging-trends-in-the-epidemiology-of-diabetic-retinopathy
#19
Charumathi Sabanayagam, WanFen Yip, Daniel S W Ting, Gavin Tan, Tien Y Wong
PURPOSE: Diabetes is a major public health problem affecting 415 million people worldwide. With the increasing prevalence of diabetes, diabetic retinopathy (DR) is emerging as the leading cause of avoidable blindness worldwide. METHODS: We reviewed previous and recent literature to provide an overview of emerging trends on the burden, epidemiology, risk factors, and prevention of DR. RESULTS: First, there is clear evidence of a global increase in the prevalence of diabetes...
August 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/27352282/-national-guidelines-for-treatment-of-diabetic-retinopathy-second-edition-of-the-national-guidelines-for-treatment-of-diabetic-retinopathy
#20
F Ziemssen, K Lemmen, B Bertram, H P Hammes, H Agostini
The updated German clinical practice guidelines (second edition) describe the consensus recommendations for prevention and treatment of retinal complications secondary to diabetes. According to the updated numbers on epidemiology a further increase of persons affected is expected. The prevalence of diabetic retinopathy is estimated to be 9-16 % in type 2 diabetes and 24-27 % in type 1 diabetes. A prolongation of the screening interval from 1 to 2 years is recommended for those patients with a lower risk of progression, when retinopathy has not already occurred and no increased systemic risk factors are present...
July 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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