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Diabetic retinopathy epidemiology

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https://www.readbyqxmd.com/read/28427059/the-burden-of-diabetes-emerging-data
#1
Paola Maffi, Antonio Secchi
In recent times, the global prevalence of diabetes has increased substantially, reaching 8.3% in 2014, which corresponds to 387 million patients. Studies in Europe and USA have shown increased incidence of type 1 Diabetes (T1D) over time at a rate of 3-5% per year. Another most worrying feature of the rapid increase of diabetes is the emergence of type 2 Diabetes (T2D) in children, adolescents, and young adults. The well-known behavioral risks factors and epigenetic mechanisms recently observed require an integrated approach to prevent T2D...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28423305/frequency-of-evidence-based-screening-for-retinopathy-in-type-1-diabetes
#2
(no author information available yet)
Background In patients who have had type 1 diabetes for 5 years, current recommendations regarding screening for diabetic retinopathy include annual dilated retinal examinations to detect proliferative retinopathy or clinically significant macular edema, both of which require timely intervention to preserve vision. During 30 years of the Diabetes Control and Complications Trial (DCCT) and its longitudinal follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) study, retinal photography was performed at intervals of 6 months to 4 years...
April 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28396744/diabetic-nephropathy-as-the-cause-of-end-stage-kidney-disease-reported-on-the-medical-evidence-form-cms2728-at-a-single-center
#3
Christina M Yuan, Robert Nee, Kevin A Ceckowski, Kendral R Knight, Kevin C Abbott
Background: End-stage renal disease (ESRD) incidence due to Type 2 diabetic nephropathy (DN) is 35-50%, according to the United States Renal Data System. Methods: A single-center, retrospective cohort study to determine incidence and diagnostic accuracy for Type 2 DN as the primary cause of ESRD (Code 250.40) on the Center for Medicare & Medicaid (CMS) Medical Evidence Report form (CMS2728) submitted at renal replacement therapy initiation. All patients  ≥18 years of age with a CMS2728 submitted between 1 March 2006 and 31 March 2015 at a single academic military medical center (ESRD Network 5) were included...
April 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28393040/vitreous-haemorrhage-a-population-based-study-of-the-incidence-and-risk-factors-in-taiwan
#4
Ching-Yu Wang, Wai-Man Cheang, De-Kuang Hwang, Ching-Heng Lin
AIM: To report the epidemiology and incidence of vitreous hemorrhage and to evaluate risk factors for patients with vitreous hemorrhage (VH) in Taiwan. METHODS: A retrospective population-based study. Analyzing a sample of one million subjects from all enrollees of the Taiwan Health Insurance programme. All data were obtained from the Taiwan Health Insurance Research Database, which contained patient sex, date of birth, all records of clinical visits and hospitalizations, and diagnosis codes as included in the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28387762/age-related-macular-degeneration-in-a-south-indian-population-with-and-without-diabetes
#5
S Srinivasan, G Swaminathan, V Kulothungan, S Ganesan, T Sharma, R Raman
PurposeTo elucidate the prevalence and risk factors of age-related macular degeneration (AMD) in people with diabetes.MethodsOf the 5495 subjects ≥60 years of age recruited in the population-based study in south India, 4791 subjects with gradable images on 30° three-field retinal photographs were analyzed. AMD and diabetic retinopathy (DR) were graded based on the International ARM Epidemiological Study Group classification and International Clinical Diabetic Retinopathy Disease Severity Scale, respectively...
April 7, 2017: Eye
https://www.readbyqxmd.com/read/28362881/the-period-effect-in-the-prevalence-of-proliferative-diabetic-retinopathy-gross-proteinuria-and-peripheral-neuropathy-in-type-1-diabetes-a-longitudinal-cohort-study
#6
Christine A Kiire, Kayla Horak, Kristine E Lee, Barbara E K Klein, Ronald Klein
AIMS: To investigate whether, for a specific duration of type 1 diabetes, there is a significant change in the prevalence of proliferative diabetic retinopathy, gross proteinuria and peripheral neuropathy in those more recently diagnosed with diabetes (a period effect), in the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Where present, to determine how common risk factors for diabetic complications might be associated with it, and what might be driving it. MATERIALS AND METHODS: Longitudinal cohort study with seven examination phases between 1980 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28332894/incidence-and-progression-of-diabetic-retinopathy-in-urban-india-sankara-nethralaya-diabetic-retinopathy-epidemiology-and-molecular-genetics-study-sn-dreams-ii-report-1
#7
Rajiv Raman, Suganeswari Ganesan, Swakshyar Saumya Pal, Laxmi Gella, Vaitheeswaran Kulothungan, Tarun Sharma
PURPOSE: To evaluate the 4-year incidence and progression of and risk factors for diabetic retinopathy (DR) in an Indian population. METHODS: From a cross-sectional study of 1425 subjects with diabetes, 911 (63.9%) returned for 4-year follow-up. After excluding 21 with ungradable retinal images, data from 890 subjects were analyzed. Participants underwent examinations based on a standard protocol, which included grading of retinal photographs. RESULTS: The incidences of DR, diabetic macular edema (DME), and sight-threatening diabetic retinopathy (STDR) were 9...
March 23, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28321416/oxidative-stress-epigenetics-environment-and-epidemiology-of-diabetic-retinopathy
#8
EDITORIAL
Goran Petrovski, Kai Kaarniranta, Daniel Petrovič
No abstract text is available yet for this article.
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28296786/association-between-macular-degeneration-and-mild-to-moderate-chronic-kidney-disease-a-nationwide-population-based-study
#9
Chun-Yu Chen, Ciou-Sia Dai, Chin-Chan Lee, Yu-Chiau Shyu, Ting-Shuo Huang, Ling Yeung, Chi-Chin Sun, Huang-Yu Yang, I-Wen Wu
Chronic kidney disease (CKD) and macular degeneration (MD) are 2 grave diseases leading to significant disability secondary to renal failure and blindness. The 2 diseases share not only common risk factors but also similar pathogenic mechanisms to renal and retinal injuries. Previous epidemiological studies indicated association between these 2 diseases. However, this concept is challenged by recent investigations. Patients with mild to moderate CKD (n = 30,696) between January 1, 1995 and December 31, 2005 were selected from the Taiwan National Health Insurance Database...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28287861/association-of-skin-intrinsic-fluorescence-with-retinal-microvascular-complications-of-long-term-type-1-diabetes-in-the-wisconsin-epidemiologic-study-of-diabetic-retinopathy
#10
Barbara E K Klein, Kayla L Horak, John D Maynard, Kristine E Lee, Ronald Klein
OBJECTIVE: To determine the association between skin intrinsic fluorescence (SIF), a noninvasive measure of advanced glycation endproducts and oxidative stress in skin, and retinal microvascular complications of long duration type 1 diabetes, proliferative diabetic retinopathy (PDR) and macular edema. METHODS: A cross-sectional cohort study of persons with type 1 diabetes in the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) who participated in a 32-year follow-up examination in 2012-2014...
March 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28270484/differences-in-incidence-of-diabetic-retinopathy-between-type-1-and-2-diabetes-mellitus-a-nine-year-follow-up-study
#11
Pedro Romero-Aroca, Raul Navarro-Gil, Aida Valls-Mateu, Ramon Sagarra-Alamo, Antonio Moreno-Ribas, Nuria Soler
BACKGROUND/AIMS: To determine the incidence of any diabetic retinopathy (any-DR), sight-threatening diabetic retinopathy (STDR) and diabetic macular oedema (DMO) and their risk factors in type 1 diabetes mellitus (T1DM) over a screening programme. METHODS: Nine-year follow-up, prospective population-based study of 366 patients with T1DM and 15 030 with T2DM. Epidemiological risk factors were as follows: current age, age at DM diagnosis, sex, type of DM, duration of DM, arterial hypertension, levels of glycosylated haemoglobin (HbA1c), triglycerides, cholesterol fractions, serum creatinine, estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR)...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28183874/novel-insights-into-dna-methylation-and-its-critical-implications-in-diabetic-vascular-complications
#12
REVIEW
Jia Zheng, Jing Cheng, Qian Zhang, Xinhua Xiao
Recent epidemiological and clinical studies have shown that type 2 diabetic patients can develop diabetic vascular complications even after intensive glycaemic control. It has been suggested that this phenomenon could be explained by the hypothesis of 'metabolic memory'. The underlying mechanisms between these enduring effects and the prior hyperglycaemic state are still not well understood. Preliminary studies demonstrate that hyperglycaemia can regulate gene expression by epigenetic modifications, such as DNA methylation, which can persistently exist even after glucose normalization...
April 30, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28134328/effect-of-bilirubin-concentration-on-the-risk-of-diabetic-complications-a-meta-analysis-of-epidemiologic-studies
#13
Bo Zhu, Xiaomei Wu, Yifei Bi, Yang Yang
Diabetes can affect many parts of the body and is associated with serious complications. Oxidative stress is a major contributor in the pathogenesis of diabetic complications and bilirubin has been shown to have antioxidant effects. The number of studies on the effect of bilirubin on the risk of diabetic complications has increased, but the results are inconsistent. Thus, we performed a meta-analysis to determine the relationship between bilirubin concentration and the risk of diabetic complications, and to investigate if there was a dose-response relationship...
January 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28099347/prediction-of-risk-of-diabetic-retinopathy-for-all-cause-mortality-stroke-and-heart-failure-evidence-from-epidemiological-observational-studies
#14
Xiao-Rong Zhu, Yong-Peng Zhang, Lu Bai, Xue-Lian Zhang, Jian-Bo Zhou, Jin-Kui Yang
To examine and quantify the potential relation between diabetic retinopathy (DR) and risk of all-cause mortality, stroke and heart failure (HF).The resources of meta-analysis of epidemiological observational studies were from Pub-med, EMBASE, CINAHL, Cochrane Library, conference, and proceedings.Random/fixed effects models were used to calculate pooled subgroup analysis stratified by different grades of DR was performed to explore the potential source of heterogeneity. Statistical manipulations were undertaken using program STATA...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069622/prevalence-of-diabetic-retinopathy-among-13473-patients-with-diabetes-mellitus-in-china-a-cross-sectional-epidemiological-survey-in-six-provinces
#15
Yan Liu, Yifan Song, Liyuan Tao, Weiqiang Qiu, Huibin Lv, Xiaodan Jiang, Mingzhou Zhang, Xuemin Li
OBJECTIVE: To describe the prevalence and severity of diabetic retinopathy (DR) and sight-threatening DR (STDR) among Chinese adults with diabetes. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional epidemiological survey across Mainland China (N=13 473). Participants were diagnosed with diabetes mellitus by physicians and transferred to our screening clinics (1/3 from hospital patients, 1/3 from city residents, the other 1/3 from rural residents). 2 fundus photographs were taken of each eye with a colourful, non-mydriatic and non-stereoscopic camera and were graded according to the UK guidelines...
January 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28038984/type-2-diabetes-genetic-variants-and-risk-of-diabetic-retinopathy
#16
Yong He Chong, Qiao Fan, Yih Chung Tham, Alfred Gan, Shu Pei Tan, Gavin Tan, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu Cheng
PURPOSE: Genetic association studies to date have not identified any robust risk loci for diabetic retinopathy (DR). We hypothesized that individuals with more diabetes genetic risk alleles have a higher risk of developing DR. DESIGN: Case-control genetic association study. PARTICIPANTS: We evaluated the aggregate effects of multiple type 2 diabetes-associated genetic variants on the risk of DR among 1528 participants with diabetes from the Singapore Epidemiology of Eye Diseases Study, of whom 547 (35...
December 27, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28032809/rationale-and-methodology-for-a-community-based-study-of-diabetic-retinopathy-in-an-indonesian-population-with-type-2-diabetes-mellitus-the-jogjakarta-eye-diabetic-study-in-the-community
#17
Muhammad B Sasongko, Angela N Agni, Firman S Wardhana, Satya P Kotha, Prateek Gupta, Tri W Widayanti, Supanji, Felicia Widyaputri, Rifa Widyaningrum, Tien Y Wong, Ryo Kawasaki, Jie Jin Wang, Suhardjo Pawiroranu
PURPOSE: There are no available data about diabetic retinopathy (DR) in the Indonesian population. This report summarizes the rationale and study design of the Jogjakarta Eye Diabetic Study in the Community (JOGED.COM), a community-based study to estimate the prevalence and risk factors of DR in persons with type 2 diabetes in Jogjakarta, Indonesia. METHODS: The JOGED.COM aimed to examine a cross-sectional sample of 1200 persons with type 2 diabetes aged 30 years and older residing in the study area...
February 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28009969/the-role-of-connexin43-in-diabetic-microvascular-complications
#18
Hui Li, Fang Wang
Diabetes mellitus is one of the largest global healthcare problems. People with diabetes have high risk of developing any of the microvascularcomplications, including retinopathy, nephropathy, and neuropathy, which can bring much more serious psychological and economic burden for the diabetic patients. As a consequence of its microvascular complications, diabetes has become the leading cause of blindness, end-stage renal disease, and a variety of debilitating neuropathies. Although the mechanisms involved in the development and progression of these three diabetic microvascular complications are different and have not been completely elucidated, some common histopathological features like increased vascular permeability and apoptosis of specific vascular cells are shared in retinopathy and nephropathy...
November 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27990441/diabetic-retinopathy-in-italy-epidemiology-data-and-telemedicine-screening-programs
#19
REVIEW
Stela Vujosevic, Edoardo Midena
In Italy, the number of people living with diabetes is about 3.5 million (5.5% of the population), with an increase by about 60% in the last 20 years and with 1 person out of 3 older than 65 years. The Italian Health Service system estimates that 10 billion euros is spent annually on caring for patients with diabetes, a figure that increases yearly. No national data on prevalence and incidence of legal blindness in patients with diabetes and no national registry of patients with diabetic retinopathy (DR) are currently available...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27935651/epidemiology-of-diabetic-kidney-disease-in-adult-patients-with-type-1-diabetes-in-italy-the-amd-annals-initiative
#20
Antonio Pacilli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
BACKGROUND: Patients with type 1 diabetes mellitus are at increased risk of death. This risk appears to be modulated by kidney dysfunction. The aim of this study was to evaluate the prevalence of diabetic kidney disease (DKD), its traits, and clinical correlates in a large sample of patients with type 1 diabetes. METHODS: Clinical data of 20 464 patients with type 1 diabetes were extracted from electronic medical records. Estimated glomerular filtration rate (eGFR) and increased urinary albumin excretion were considered...
December 9, 2016: Diabetes/metabolism Research and Reviews
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