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Diabetic retinopathy epidemiology

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https://www.readbyqxmd.com/read/29649538/identification-of-factors-to-increase-efficacy-of-telemedicine-screening-for-diabetic-retinopathy-in-endocrinology-practices-using-the-intelligent-retinal-imaging-system-iris-platform
#1
Sapna Naik, Charles C Wykoff, William C Ou, Jonathan Stevenson, Sunil Gupta, Ankoor R Shah
AIMS: Diabetic retinopathy (DR) and diabetic macular edema (DME) can be evaluated using telemedicine systems, such as the Intelligent Retinal Imaging Systems (IRIS), in patients with Diabetes Mellitus (DM). In an endocrinology-based population utilizing IRIS we determine prevalence rates of DR and DME, and identify associated epidemiologic correlations. METHODS: This is a multicenter, retrospective chart review using screening data from IRIS. Centers for Disease Control and Prevention (CDC) data on epidemiologic variables (by county) namely, prevalence of DM, incidence of DM, obesity, and time of physical inactivity, were compared against prevalence rates of DR found at screening...
April 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29561508/invasive-fungal-infections-in-neonates-in-canada-epidemiology-and-outcomes
#2
Joseph Ting, Ashley Roberts, Anne Synnes, Roderick Canning, Jaya Bodani, Luis Monterossa, Prakesh S Shah
BACKGROUND: Neonatal fungaemia is associated with adverse neonatal outcomes and higher overall healthcare expenditure. Our objective is to review the epidemiology of invasive fungal infections (IFIs) in neonates in Canada. METHODS: A retrospective cohort study using data collected by the Canadian Neonatal Network (CNN) was conducted. Using a nested matched cohort study design, risk factors and outcomes of neonates born <33 weeks gestation (n=39,305) during 2003-2013 were compared between neonates diagnosed with an IFI during their stay to infection-free controls...
March 15, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29551993/gonadal-hormones-and-retinal-disorders-a-review
#3
REVIEW
Raffaele Nuzzi, Simona Scalabrin, Alice Becco, Giancarlo Panzica
Aim: Gonadal hormones are essential for reproductive function, but can act on neural and other organ systems, and are probably the cause of the large majority of known sex differences in function and disease. The aim of this review is to provide evidence for this hypothesis in relation to eye disorders and to retinopathies in particular. Methods: Epidemiological studies and research articles were reviewed. Results: Analysis of the biological basis for a relationship between eye diseases and hormones showed that estrogen, androgen, and progesterone receptors are present throughout the eye and that these steroids are locally produced in ocular tissues...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29523638/complement-c3-and-risk-of-diabetic-microvascular-disease-a-cohort-study-of-95202-individuals-from-the-general-population
#4
Katrine Laura Rasmussen, Børge Grønne Nordestgaard, Sune Fallgaard Nielsen
BACKGROUND: Whether the complement system is involved in the development of diabetic microvascular disease is unknown. We tested the hypothesis that high concentrations of complement C3 are associated with increased risk of diabetic retinopathy, nephropathy, and neuropathy in individuals from the general population. METHODS: We studied 95202 individuals from the general population with baseline measurements of complement C3, genotyped for rs1065489, rs429608, and rs448260 determining concentrations of complement C3, and enrolled in the Copenhagen General Population Study from 2003 through 2013, following them until April 10, 2013...
March 9, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29502187/epidemiology-and-correlates-of-osteoporotic-fractures-among-type-2-diabetic-patients
#5
Inbal Goldshtein, Allison Martin Nguyen, Anne E dePapp, Sofia Ish-Shalom, Julie M Chandler, Gabriel Chodick, Varda Shalev
This study analyzed data on 87,224 osteoporotic patients with up to 18 years of computerized medical history. Patients with osteoporosis and type 2 diabetes had higher bone density yet more fractures than non-diabetic osteoporotic patients. Fracture incidence among the diabetic patients was associated with retinopathy and cardiovascular disease, but not with diabetes duration. PURPOSE: Little is known about the association between type 2 diabetes mellitus (T2DM) and fragility fractures or the mechanism(s) involved...
March 3, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29493707/projection-of-eye-disease-burden-in-singapore
#6
John P Ansah, Victoria Koh, Dirk F de Korne, Steffen Bayer, Chong Pan, Jayabaskar Thiyagarajan, David B Matchar, Ecosse Lamoureux, Desmond Quek
INTRODUCTION: Singapore's ageing population is likely to see an increase in chronic eye conditions in the future. This study aimed to estimate the burden of eye diseases among resident Singaporeans stratified for age and ethnicity by 2040. MATERIALS AND METHODS: Prevalence data on myopia, epiretinal membrane (ERM), retinal vein occlusion (RVO), age macular degeneration (AMD), diabetic retinopathy (DR), cataract, glaucoma and refractive error (RE) by age cohorts and educational attainment from the Singapore Epidemiology of Eye Diseases (SEED) study were applied to population estimates from the Singapore population model...
January 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29488397/long-term-changes-in-retinal-vascular-diameter-and-cognitive-impairment-in-type-1-diabetes
#7
Karen A Nunley, Andrea L Metti, Ronald Klein, Barbara E Klein, Judith A Saxton, Trevor J Orchard, Tina Costacou, Howard J Aizenstein, Caterina Rosano
OBJECTIVE: To assess associations between cognitive impairment and longitudinal changes in retinal microvasculature, over 18 years, in adults with type 1 diabetes. RESEARCH DESIGN AND METHODS: Participants of the Pittsburgh Epidemiology of Diabetes Complications Study received ≥3 fundus photographs between baseline (1986-1988) and time of cognitive assessment (2010-2015: N = 119; 52% male; mean age and type 1 diabetes duration 43 and 34 years, respectively). Central retinal arteriolar equivalent and central retinal venular equivalent were estimated via computer-based methods; overall magnitude and speed of narrowing were quantified as cumulative average and slope, respectively...
February 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29460410/lessons-learned-from-the-1-hour-post-load-glucose-level-during-the-ogtt-current-screening-recommendations-for-dysglycemia-should-be-revised
#8
Michael Bergman, Ram Jagannathan, Martin Buysschaert, Manan Pareek, Michael H Olsen, Peter M Nilsson, José Luis Medina, Jesse Roth, Angela Chetrit, Leif Groop, Rachel Dankner
This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycemia and proposes that the 1-hour post-load glucose level during the 75 gram OGTT may serve as a novel biomarker to detect dysglycemia earlier than currently recommended screening criteria for glucose disorders. Considerable evidence suggests that a 1-hour post-load plasma glucose value >155 mg/dl (8.6 mmol/l) may identify individuals with reduced β-cell function prior to progressing to prediabetes and diabetes and is highly predictive of those likely to progress to diabetes more than the HbA1c or 2-hour post-load glucose values...
February 19, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29451661/association-between-the-rage-receptor-for-advanced-glycation-end-products-374t-a-gene-polymorphism-and-diabetic-retinopathy-in-t2dm
#9
Dan Tao, Xuancheng Mai, Tiesong Zhang, Yan Mei
OBJECTIVE: Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological studies on the association between RAGE gene -374T/A polymorphism and diabetic retinopathy (DR) risk were inconsistent. Thus, we conducted this meta-analysis to summarize the possible association between RAGE -374T/A polymorphism and DR risk...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29382329/the-economic-impact-of-sight-loss-and-blindness-in-the-uk-adult-population
#10
Lynne Pezzullo, Jared Streatfeild, Philippa Simkiss, Darren Shickle
BACKGROUND: To quantify the economic impact of sight loss and blindness in the United Kingdom (UK) population, including direct and indirect costs, and its burden on health. METHODS: Prevalence data on sight loss and blindness by condition, Census demographic data, data on indirect costs, and healthcare cost databases were used. Blindness was defined as best corrected visual acuity (BCVA) of < 6/60, and sight loss as BCVA < 6/12 to 6/60, in the better-seeing eye...
January 30, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29290461/oculomotor-palsy-in-diabetics
#11
H Lajmi, W Hmaied, W Ben Jalel, Z Chelly, A Ben Yakhlef, F Ben Zineb, L El Fekih
INTRODUCTION: Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications of diabetic patients. It generates less interest in the literature than the other ocular manifestations. Our goal was to study the clinical, epidemiological, therapeutic and prognostic characteristics of oculomotor palsy in the diabetic. METHODS: This is a retrospective study of 24 diabetic patients with oculomotor palsy. The ophthalmological examination emphasized ocular motility...
January 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29217148/ethnic-differences-in-the-prevalence-and-risk-factors-of-diabetic-retinopathy-the-singapore-epidemiology-of-eye-diseases-study
#12
Gavin S Tan, Alfred Gan, Charumathi Sabanayagam, Yih Chung Tham, Kumari Neelam, Paul Mitchell, Jie Jin Wang, Ecosse L Lamoureux, Ching-Yu Cheng, Tien Y Wong
PURPOSE: To evaluate the prevalence and risk factors for diabetic retinopathy (DR) in the Singapore Epidemiology of Eye Diseases (SEED) Study. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons of Malay, Indian, and Chinese ethnicity aged 40+ years, living in Singapore. METHODS: Diabetes was defined as nonfasting plasma glucose ≥200 mg/dl (11.1 mmol/l), glycated hemoglobin A1c (HbA1c) >6.5%, self-reported physician-diagnosed diabetes, or the use of glucose-lowering medication...
April 2018: Ophthalmology
https://www.readbyqxmd.com/read/29210634/preventive-and-therapeutic-potentials-of-anthocyanins-in-diabetes-and-associated-complications
#13
Swathi Putta, Nagendra Sastry Yarla, Eswar K Kumar, Dhananjaya Bhadrapura Lakkappa, Mohammad A Kamal, Luciana Scotti, Marcus T Scotti, Ghulam Md Ashraf, George E Barreto, B Sasi Bhusana Rao, D Sarala Kumari, Gorla V Reddy, Vadim V Tarasov, Sarat Babu Imandi, Gjumrakch Aliev
Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, it is to be considering the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29210010/management-of-diabetic-macular-edema-in-japan-a-review-and-expert-opinion
#14
REVIEW
Hiroko Terasaki, Yuichiro Ogura, Shigehiko Kitano, Taiji Sakamoto, Toshinori Murata, Akito Hirakata, Tatsuro Ishibashi
Diabetic retinopathy is a frequent cause of visual impairment in working-age adults (≥ 30 years) and in Japan is most commonly observed in those aged 50-69 years. Diabetic macular edema (DME) is one of the main causes of vision disturbance in diabetic retinopathy, which is a clinically significant microvascular complication of diabetes. Anti-vascular endothelial growth factor (VEGF) therapy is becoming the mainstay of treatment for DME. However, to achieve sustained long-term improvement in visual acuity, conventional laser photocoagulation, vitrectomy and steroid therapy are also expected to play a role in the treatment of DME...
January 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29188902/inadequate-glycaemic-control-and-therapeutic-management-of-adults-over-65-years-old-with-type-2-diabetes-mellitus-in-spain
#15
F Formiga, J Franch-Nadal, L Rodriguez, L Ávila, E Fuster
OBJECTIVES: The glycaemic goals for older patients with type 2 diabetes mellitus (DM) are recommended to avoid an HbA1c levels <7%. The purpose of this study was to analyse the glycaemic control and therapeutic management of older adults (≥65 years) with type 2 DM. DESIGN: Pooled analysis of patients enrolled in three Spanish cross-sectional epidemiological studies. SETTING: The study was conducted between 2009 and 2011 by primary care or specialist physicians...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29175970/macular-thickness-profile-and-diabetic-retinopathy-the-singapore-epidemiology-of-eye-diseases-study
#16
Wei Dai, Yih Chung Tham, Ning Cheung, Masayuki Yasuda, Nicholas Y Q Tan, Carol Y Cheung, Jie Jin Wang, Paul Mitchell, Charumathi Sabanayagam, Tien-Yin Wong, Ching-Yu Cheng
BACKGROUND: To evaluate retinal thickness profiles in eyes with and without diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT) among individuals with diabetes. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians aged 40 years or older residing in Singapore. All participants underwent standardised systemic and ophthalmic examinations...
November 24, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29145583/association-between-the-severity-of-diabetic-retinopathy-and-falls-in-an-asian-population-with-diabetes-the-singapore-epidemiology-of-eye-diseases-study
#17
Preeti Gupta, Amudha Aravindhan, Alfred T L Gand, Ryan E K Man, Eva K Fenwick, Paul Mitchell, Nicholas Tan, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse L Lamoureux
Importance: The presence and severity of diabetic retinopathy (DR) may contribute to the risk of falling in persons with diabetes, but evidence is currently equivocal. Objective: To investigate the associations of diabetes and DR severity with the likelihood of falls in a multiethnic Asian population. Design, Setting, and Participants: Cross-sectional post hoc analysis of the Singapore Epidemiology of Eye Diseases study, a population-based study of participants from 3 ethnic groups (3280 Malay, 3400 Indian, and 3353 Chinese individuals) conducted from 2004 to 2011...
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29134229/decursin-and-decursinol-angelate-molecular-mechanism-and-therapeutic-potential-in-inflammatory-diseases
#18
REVIEW
Adeeb Shehzad, Sajida Parveen, Munibah Qureshi, Fazli Subhan, Young Sup Lee
Epidemiological studies have shown that inflammation plays a critical role in the development and progression of various chronic diseases, including cancers, neurological diseases, hepatic fibrosis, diabetic retinopathy, and vascular diseases. Decursin and decursinol angelate (DA) are pyranocoumarin compounds obtained from the roots of Angelica gigas. Several studies have described the anti-inflammatory effects of decursin and DA. Decursin and DA have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated B cells, cellular enzymes including matrix metalloproteinases cyclooxygenase, and protein kinases such as extracellular receptor kinase, phosphatidylinositol-3-kinase, and protein kinase C...
November 13, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29098840/-distribution-of-traditional-chinese-medicine-syndromes-of-diabetic-retinopathy-and-correlation-between-symptoms
#19
Yan-Qing Zhao, Qing-Song Li, Min-Hong Xiang, Wei Zhang, Xing-Ru Zhang
To investigate the distribution of traditional Chinese medicine (TCM) Syndromes of diabetic retinopathy and explore the correlation between various symptoms. Based on the literature in databases of China Journal Full-text Database (CNKI), Wanfang database, VIP network, China biomedical literature database (CBM) and PubMed, SPSS 20.0 and IBM SPSS Modeler 14.1 software were used to analyze the location of disease, symptoms, tongue and pulse, and syndrome type distribution through frequency statistics. In addition, association rule algorithm was used to explore the basic rules for underlying symptoms combinations of diabetic retinopathy...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29044066/color-vision-abnormalities-in-type-ii-diabetes-sankara-nethralaya-diabetic-retinopathy-epidemiology-and-molecular-genetics-study-ii-report-no-2
#20
Laxmi Gella, Rajiv Raman, Vaitheeswaran Kulothungan, Swakshyar Saumya Pal, Suganeswari Ganesan, Sangeetha Srinivasan, Tarun Sharma
PURPOSE: The purpose of this study is to assess color vision abnormalities in a cohort of subjects with type II diabetes and elucidate associated risk factors. METHODS: Subjects were recruited from follow-up cohort of Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study I. Six hundred and seventy-three eyes of 343 subjects were included from this population-based study. All subjects underwent detailed ophthalmic evaluation, including the Farnsworth-Munsell 100 hue test...
October 2017: Indian Journal of Ophthalmology
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