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Obesity, diabetes, bariatrics, bariatric surgery, metabolic surgery, diet, gastric surgery, metabolic syndrome, weight, surgery, gastric bypass

Vlad V Simianu, Jonathan G Sham, Andrew S Wright, Skye D Stewart, Mouhamad Alloosh, Michael Sturek, David E Cummings, David R Flum
BACKGROUND: The impact of Roux-en-Y gastric bypass (RYGB) on type 2 diabetes mellitus is thought to result from upper and/or lower gut hormone alterations. Evidence supporting these mechanisms is incomplete, in part because of limitations in relevant bariatric-surgery animal models, specifically the lack of naturally insulin-resistant large animals. With overfeeding, Ossabaw swine develop a robust metabolic syndrome, and may be suitable for studying post-surgical physiology. Whether bariatric surgery is feasible in these animals with acceptable survival is unknown...
August 2015: Surgical Science
Ines Valenta, Vasken Dilsizian, Alessandra Quercioli, Freimut D Jüngling, Giuseppe Ambrosio, Richard Wahl, Thomas H Schindler
Increases in intra-abdominal visceral adipose tissue have been widely appreciated as a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance, and type 2 diabetes, whereas this is not the case for peripheral or subcutaneous obesity. While the underlying mechanisms that contribute to these differences in adipose tissue activity remain uncertain, increases in visceral fat commonly induce metabolic dysregulation, in part because of increased venous effluent of fatty acids and/or adipokines/cytokines to the liver...
January 2014: Current Cardiology Reports
Rajendra Raghow
The worldwide epidemic of obesity and its medical complications are being dealt with a combination of life style changes (e.g., healthier diet and exercise), medications and a variety of surgical interventions. The Roux-en Y gastric bypass (RYGB) and laparoscopic adjustable gastric banding (LAGB) are two of the most common weight loss surgeries for morbid obesity-associated metabolic syndrome and insulin resistance. A vast majority of patients that undergo RYGB and LAGB are known to experience marked weight loss and attenuation of diabetes...
June 15, 2013: World Journal of Diabetes
M García-Caballero, M Valle, J M Martínez-Moreno, F Miralles, J A Toval, J M Mata, D Osorio, A Mínguez
INTRODUCTION: Diabetes mellitus type 2 (DMT2) is a major cause of death in the world. The medical therapy for this disease has had enormous progress, but it still leaves many patients exposed to the complications developed from the disease. It is well known the beneficial effects of bariatric surgery in obese diabetic patients, however it is important to investigate if the same principles of bariatric surgery that improve diabetes in obese patients, could be applied to non obese normal weight diabetics...
March 2012: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Froukje J Verdam, Paulien R Liedorp, Noëlle Geubbels, Ruben Schouten, Ignace M C Janssen, Ger H Koek, Jan Willem Greve
The prevalence of obesity is increasing worldwide. Its primary treatment consists of lifestyle changes. In severely obese (BMI > 40 kg/m2 or ≥ 35 kg/m2 with comorbidity) patients though, bariatric surgery has been found to be the only way to achieve permanent weight loss. Operations such as the placement of a gastric band or a gastric bypass can, however, lead to complications and necessitate secondary interventions. In search of less invasive treatments, placement of the EndoBarrier duodenal jejunal bypass liner appears to be a promising, safe and effective method for facilitating weight loss...
2012: Nederlands Tijdschrift Voor Geneeskunde
Bryan J Sandler, Roberto Rumbaut, C Paul Swain, Gustavo Torres, Luis Morales, Lizcelly Gonzales, Sarah Schultz, Mark Talamini, Santiago Horgan
BACKGROUND: This report describes the authors' experience with a unique endoluminal, endoscopically delivered and retrieved gastroduodenojejunal bypass sleeve, including short-term weight loss and changes in comorbidities. METHODS: A prospective, single-center trial was designed. The patients were morbidly obese individuals who met the National Institutes of Health criteria for bariatric surgery. The device used was a unique gastroduodenojejunal bypass sleeve secured at the esophagogastric junction with endoscopic and laparoscopic techniques and designed to create an endoluminal gastroduodenojejunal bypass...
September 2011: Surgical Endoscopy
Kazunori Kasama, Nobumi Tagaya, Eiji Kanahira, Akiko Umezawa, Tetsuya Kurosaki, Takashi Oshiro, Makoto Ishikawa, Yuka Negishi, Yoshimochi Kurokawa, Norio Suzuki, Yasuharu Kakihara, Shoujirou Taketsuka, Kenji Horie, Tetsuya Nakazato, Eri Kikkawa, Sayuri Kabasawa, Yuko Fukuda, Kazuko Sonoda
BACKGROUND: Obesity is steadily increasing in Asia due to factors such as a lack of exercise, adoption of a more Western diet, changing lifestyles, environments, or stresses. Even in Japan, this tendency is notable, and metabolic syndrome has become widely recognized. However, bariatric surgery is still uncommon in Japan. There are no adequate data regarding the experience and outcome of bariatric surgery in Asia. Here, we report on the current status of morbid obesity and the outcomes of bariatric surgery by a single surgeon in Japan...
November 2008: Obesity Surgery
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