keyword
https://read.qxmd.com/read/38537213/occult-smarca4-deficient-undifferentiated-carcinoma-unmasked-by-68ga-fapi-46-pet-ct
#1
JOURNAL ARTICLE
Weizhi Xu, Long Zhao, Jiayu Cai, Haojun Chen
SMARCA4-deficient undifferentiated tumors (SMARCA4-dUT) are rare and aggressive neoplasms commonly found in male smokers and portend a poor prognosis. In this case, we reported 18F-FDG and 68Ga-FAPI-46 PET/CT findings in an occult SMARCA4-dUT located in the left pulmonary hilum along with mediastinal lymph node metastases. 68Ga-FAPI-46 PET/CT showed superiority over 18F-FDG for detecting SMARCA4-dUT lesions. This case highlighted that 68Ga-FAPI-46 PET/CT may be a promising imaging modality in the evaluation of SMARCA4-dUT, particularly for detecting the occult SMARCA4-dUT arising in uncommon sites...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537208/68ga-fapi-pet-ct-in-an-interesting-case-of-metastatic-pulmonary-meningioma
#2
JOURNAL ARTICLE
Priyavrat Purohit, Bhagwant Rai Mittal, Rajender Kumar, Harmandeep Singh, Jaya Shukla, Amanjit Bal, Navneet Singh
Meningiomas are one of the major primary CNS tumors. Most meningiomas are benign, but rarely, these metastasize to distant organs, the lungs being the commonest site of metastasis. 18F-FDG PET/CT has been used to evaluate metastatic pulmonary meningioma. However, 68Ga-FAPI PET/CT has not yet been evaluated. The present case highlights the 68Ga-FAPI uptake in metastatic pulmonary meningioma in a postoperated case of left tentorial meningioma presenting with lung masses. Image-guided biopsy from the lung mass was consistent with metastatic meningioma...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38536644/hereditary-ttp-upshaw-schulman-syndrome-the-ductus-arteriosus-controls-newborn-survival
#3
REVIEW
Yoshihiro Fujimura
Hereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment. In utero, fetal blood flowing from the pulmonary artery through the ductus arteriosus (DA) to the aorta is under low-shear-force...
March 27, 2024: International Journal of Hematology
https://read.qxmd.com/read/38535582/brucellar-endocarditis-of-the-tricuspid-valve-a-case-report-and-review-of-the-literature
#4
Evangelo Boumis, Pierangelo Chinello, Vincenzo Galati, Simone Topino, Francesca Gavaruzzi, Stefania Cicalini
Brucellar endocarditis is a rare entity commonly described as a severe disease associated with high mortality and generally requiring valve surgery for cure. Right-sided endocarditis, a very uncommon presentation of brucellosis, may be associated with a better prognosis. We describe the case of a 72-year-old woman admitted to our institution with a persistent fever and multiple pulmonary infiltrates. Transthoracic echocardiography and serologic tests led to the diagnosis of brucellar tricuspid endocarditis...
March 8, 2024: Pathogens
https://read.qxmd.com/read/38535514/pediatric-lemierre-s-syndrome-a-comprehensive-literature-review
#5
REVIEW
Salvatore Lavalle, Edoardo Masiello, Salvatore Cocuzza, Piero Pavone, Alessandra Di Nora, Christian Calvo-Henriquez, Jerome Rene Lechien, Miguel Mayo Yanez, Andrea Praticò, Manuela Ceccarelli, Giannicola Iannella, Annalisa Pace, Federica Maria Parisi, Giuseppe Magliulo, Antonino Maniaci
BACKGROUND: Lemierre syndrome is a rare, potentially fatal complication of oropharyngeal infections characterized by septic thrombophlebitis of the internal jugular vein. It primarily affects healthy adolescents and young adults. Its incidence declined after the antibiotic era, but it may have resurged in recent decades, likely due to judicious antibiotic use and increasing bacterial resistance. Prompt diagnosis and treatment are imperative to prevent significant morbidity and mortality...
March 18, 2024: Pediatric Reports
https://read.qxmd.com/read/38534129/pulmonary-thromboemboli-due-to-leiomyoma
#6
JOURNAL ARTICLE
Julita Gongolli, Anna Vanderschaegen, Shannon Renfrow, Kimberly D Collins, Joseph A Prahlow
Uterine leiomyomas are the most common pelvic tumor in women and the most frequent indication for hysterectomy. Although benign lesions, leiomyomas can cause dysfunctional uterine bleeding, pelvic pain or discomfort, infertility, and spontaneous abortion. Despite the fact that uterine leiomyomas can result in a significant amount of morbidity, it is relatively rare for these common tumors to lead to death. Here we present a case of fatal pulmonary thromboembolism that occurred due to pelvic vein thrombosis in the setting of leiomyomas...
March 27, 2024: American Journal of Forensic Medicine and Pathology
https://read.qxmd.com/read/38532938/real-world-data-on-treatment-patterns-and-bleeding-in-cancer-associated-thrombosis-data-from-the-troll-registry
#7
JOURNAL ARTICLE
Zygimantas Zaboras, Camilla Tøvik Jørgensen, Andreas Stensvold, Heidi Hassel Pettersen, Aleksandra Galovic Grdinic, Sigrid Kufaas Brækkan, Waleed Ghanima, Mazdak Tavoly
Background  International guidelines are increasingly recommending direct oral anticoagulants (DOACs) as the first-line treatment for cancer-associated thrombosis (CAT). However, data regarding treatment patterns and adherence to guidelines in patients with CAT are scarce. Objectives  This study aimed to explore anticoagulant treatment patterns in patients with CAT and to calculate the incidence rates of bleeding events. Methods  Patients ≥18 years with active cancer and a first-time venous thromboembolism between 2005 and 2020 were identified through the Venous T hrombosis R egistry in Østf OL d Hospita L ...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38532909/aluminosis-pneumoconiosis-presenting-as-hyperdense-lung-nodules
#8
Sara E Mantz, Matthew J DeVries
We present the case of a 66-year-old man who presented with new incidentally found hyperdense pulmonary nodules. Further workup with a PET/CT revealed that the nodules were FDG-avid and that there was associated hypermetabolic lymphadenopathy. Due to his history of aluminum toxicity from welding, aluminosis pneumoconiosis was suspected. Biopsy of one of the nodules was done which reinforced this diagnosis. Aluminosis pneumoconiosis is a rare occupational lung disease mostly associated with industrial workers with prolonged unprotected exposure to fine aluminum dust...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38532763/isolated-laryngeal-tuberculosis-complex-infection-expect-the-unexpected
#9
Giulia C D'Aleo Canova, Chiara Zeroli, Federico Barberi, Armela Gorica, Maurizio Bignami, Augusto Cattaneo
Laryngeal tuberculosis (LT), a rare but possible manifestation of extrapulmonary tuberculosis (TBC) and the most frequent granulomatous disease of the larynx, is slowly resurfacing due to the worldwide recrudescence of TBC. We present the case of a 59 y-o Caucasian woman, non-smoker, with no history of recent travels in endemic areas, affected by pulmonary sarcoidosis, that presented with a symptomatic vegetating lesion involving the left free margin of the epiglottic and a small, ulcerated lesion over the right arytenoid mucosa...
March 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38531384/a-rare-but-fatal-beh%C3%A3-et-variant-the-hughes-stovin-syndrome-successful-case-report-and-new-evidence-from-literature-review
#10
JOURNAL ARTICLE
Andrea Ascoli Marchetti, Lorella Belvivere, Renato Argirò, Barbara Kroegler, Fabio M Oddi, Federico Pennetta, Alice de Giorgi, Stefano Fazzini, Daniele Morosetti, Paola Triggianese, Elisabetta Greco, Arianna D'Antonio, Ilaria Coccia, Manfredi Tesauro, Federica Sangiuolo, Arnaldo Ippoliti
Hughes-Stovin syndrome (HSS) is a rare potentially fatal vasculitis supposedly belonging to the spectrum of Behçet disease without ocular involvement. HSS tends to play by a temporal pattern, starting with thrombosis and followed by formation of pulmonary aneurysms. Since its mortality can reach 25% of cases, early recognition and appropriate therapy represent the major clinical challenges. We describe a rare case of HSS successfully treated via multidisciplinary management by an endovascular approach and immunosuppressive therapy...
March 26, 2024: Aorta (Stamford, Conn.)
https://read.qxmd.com/read/38531037/daptomycin-induced-eosinophilic-pneumonia
#11
JOURNAL ARTICLE
Michael R Hassett
Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare complication of daptomycin use. Manifestations most commonly include fever, hypoxia, dyspnea, cough, eosinophilia, and lung changes on radiographs and CT. Patients typically have had recent daptomycin exposure and develop fever, dyspnea, infiltrates on chest radiograph, more than 25% eosinophils on bronchoalveolar lavage, and improvement of symptoms after withdrawal of daptomycin. Treatment includes discontinuation of daptomycin, corticosteroids, and supportive measures such as supplemental oxygen...
April 1, 2024: JAAPA: Official Journal of the American Academy of Physician Assistants
https://read.qxmd.com/read/38530625/acute-high-output-heart-failure-with-pulmonary-hypertension-and-severe-liver-injury-caused-by-amlodipine-poisoning-a-case-report
#12
JOURNAL ARTICLE
Chenlong Wang, Qingcheng Zhu, Dingyu Tan, Joseph Walline, Yachao Wang
Acute high-output heart failure (HOHF) with pulmonary hypertension and liver injury caused by amlodipine poisoning is very rare. We report a 52-year-old woman who suffered from severe shock after an overdose of amlodipine. Hemodynamic monitoring showed that while her left ventricular systolic function and cardiac output were elevated, her systemic vascular resistance decreased significantly. At the same time, the size of her right heart, her central venous pressure, and the oxygen saturation of her central venous circulation all increased abnormally...
March 26, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38529681/radiological-and-clinical-features-of-large-consolidative-type-pulmonary-invasive-mucinous-adenocarcinoma
#13
JOURNAL ARTICLE
Jiaqi Chen, Linlin Qi, Jianwei Wang, Liyan Xue, Qi Xue, Jia Jia, Guochao Zhang, Jianing Liu, Fenglan Li, Shulei Cui
BACKGROUND: This study aimed to investigate the radiological, pathological, and prognostic characteristics of large consolidative-type pulmonary invasive mucinous adenocarcinomas (IMA). METHODS: We retrospectively reviewed 738 patients who confirmed IMA between January 2010 and August 2022, and two radiologists reviewed imaging data to determine subtypes. We included 41 patients with pathologically large consolidative-type IMA. We analyzed their radiological, pathological, and prognostic characteristics...
March 2024: Clinical Respiratory Journal
https://read.qxmd.com/read/38529652/diagnostic-strategy-for-suspected-unilateral-absence-of-the-pulmonary-artery
#14
JOURNAL ARTICLE
Van Luong Hoang, Viet Anh Lam, Thanh Nguyen Pham
UNLABELLED: <p>Background: Unilateral absence of the pulmonary artery (UAPA) is a very rare congenital anomaly. OBJECTIVE: To analyze the diagnostic strategy applied to seven patients with UAPA who were examined and subsequently treated at the National Lung Hospital, Hanoi, Vietnam. METHODS: All seven patients, including three pediatric cases (1, 2, and 14 years old) and four adult cases (21, 26, 44, and 53 years old), had a history of recurrent pneumonia, and the clinical symptoms on admission included cough, progressive dyspnea, chest pain, and fatigue...
March 19, 2024: Current medical imaging
https://read.qxmd.com/read/38529577/comparative-analysis-of-ct-findings-and-clinical-outcomes-in-adult-patients-with-disseminated-and-localized-pulmonary-nocardiosis
#15
JOURNAL ARTICLE
Han Na Lee, Kyung-Hyun Do, Eun Young Kim, Jooae Choe, Heungsup Sung, Sang-Ho Choi, Hwa Jung Kim
BACKGROUND: Pulmonary nocardiosis is a rare opportunistic infection with occasional systemic dissemination. This study aimed to investigate the computed tomography (CT) findings and prognosis of pulmonary nocardiosis associated with dissemination. METHODS: We conducted a retrospective analysis of patients diagnosed with pulmonary nocardiosis between March 2001 and September 2023. We reviewed the chest CT findings and categorized them based on the dominant CT findings as consolidation, nodules and/or masses, consolidation with multiple nodules, and nodular bronchiectasis...
March 25, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38529351/ers-international-congress-2023-highlights-from-the-interstitial-lung-diseases-assembly
#16
JOURNAL ARTICLE
Laura Fabbri, Julien Guiot, Marie Vermant, Ewa Miądlikowska, Deborah Estrella, Marlies S Wijsenbeek, Wim Wuyts, Elena Bargagli, Antoine Froidure, Paolo Spagnolo, Marcel Veltkamp, Maria Molina-Molina, Cormac McCarthy, Katerina Antoniou, Michael Kreuter, Catharina C Moor
This article summarises a selection of scientific highlights in the field of interstitial lung diseases (ILDs) presented at the International Congress of the European Respiratory Society in 2023. Translational and clinical studies focused on the whole spectrum of ILDs, from (ultra)rare ILDs to sarcoidosis, ILDs associated with connective tissue disease and idiopathic pulmonary fibrosis. The main topics of the 2023 Congress presentations were improving the diagnostic process of ILDs, better prediction of disease course and investigation of novel treatment options...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38526363/-a-case-of-right-heart-failure-when-it-is-not-pulmonary-embolism
#17
JOURNAL ARTICLE
Enrico Tadiello, Emma Zimelli, Giulia Urbani, Tommaso Hinna Danesi, Daniela Reghellin, Claudio Bilato
A 66-year-old patient with recent instrumental findings (echocardiogram, cardiac magnetic resonance imaging) of right ventricular failure was hospitalized due to worsening signs and symptoms of right heart failure, while waiting for diagnostic definition. Pulmonary computed tomography angiography revealed findings compatible with bilateral pulmonary thromboembolism involving the main pulmonary artery. Anticoagulant therapy was initiated with initial benefit, partial relief of symptoms, and moderate improvement in right ventricular function...
April 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38525763/pulmonary-involvement-in-recurrent-respiratory-papillomatosis-a-systematic-review
#18
REVIEW
Illari Sechi, Narcisa Muresu, Biagio Di Lorenzo, Laura Saderi, Mariangela Puci, Stefano Aliberti, Ivana Maida, Michele Mondoni, Andrea Piana, Giovanni Sotgiu
Recurrent respiratory papillomatosis (RRP) is a non-malignant disease, characterized by the production of wart-like growths in the respiratory tract, affecting both young people and adults (juvenile-onset recurrent respiratory papillomatosis, JORRP, and adult-onset recurrent respiratory papillomatosis, AORRP, respectively). Infection caused by human papillomavirus (HPV) is known as the main factor involved in RRP development. Complications of RRP may rarely occur, including lung involvement and malignant transformation...
February 28, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38525523/numerous-multinucleated-giant-cells-in-cutaneous-epithelioid-angiosarcoma-and-pulmonary-metastasis-a-unique-observation-with-potential-diagnostic-pitfalls
#19
Yushi Kanatani, Yasuhiro Mitsui, Kohei Ogawa, Maiko Takeda, Fumi Miyagawa, Satoru Shinkuma, Takeshi Kawaguchi, Takaya Fukumoto, Hideo Asada
The histopathologic diagnosis of poorly differentiated cutaneous angiosarcoma can be challenging. We report a case of cutaneous epithelioid angiosarcoma with numerous multinucleated giant cells (MGCs) developing pulmonary metastasis. A 79-year-old man presented with a red-purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2-40, and ERG...
March 25, 2024: Journal of Cutaneous Pathology
https://read.qxmd.com/read/38525427/case-report-metastatic-choriocarcinoma-in-the-second-trimester-of-a-viable-pregnancy-with-successful-delivery-and-outcome-after-chemotherapy
#20
Yalin Tian, Jiayi Yu, Xin Dan, Tanglin Chen, Yalin He
Metastatic choriocarcinoma during viable pregnancy is rare worldwide, and neonate survival following pregnancy termination in the second trimester is uncommon. Here, we report the successful delivery of a pregnancy by a patient with metastatic choriocarcinoma, who received three courses of etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA-CO) chemotherapy in the second trimester. After multidisciplinary discussions, she was administered paclitaxel and carboplatin (TC) chemotherapy...
2024: Frontiers in Oncology
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