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https://www.readbyqxmd.com/read/29076214/thinking-small-progress-on-microscale-neurostimulation-technology
#1
REVIEW
Joseph J Pancrazio, Felix Deku, Atefeh Ghazavi, Allison M Stiller, Rashed Rihani, Christopher L Frewin, Victor D Varner, Timothy J Gardner, Stuart F Cogan
OBJECTIVES: Neural stimulation is well-accepted as an effective therapy for a wide range of neurological disorders. While the scale of clinical devices is relatively large, translational, and pilot clinical applications are underway for microelectrode-based systems. Microelectrodes have the advantage of stimulating a relatively small tissue volume which may improve selectivity of therapeutic stimuli. Current microelectrode technology is associated with chronic tissue response which limits utility of these devices for neural recording and stimulation...
October 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28978747/optimal-dynamic-soaring-consists-of-successive-shallow-arcs
#2
Gabriel D Bousquet, Michael S Triantafyllou, Jean-Jacques E Slotine
Albatrosses can travel a thousand kilometres daily over the oceans. They extract their propulsive energy from horizontal wind shears with a flight strategy called dynamic soaring. While thermal soaring, exploited by birds of prey and sports gliders, consists of simply remaining in updrafts, extracting energy from horizontal winds necessitates redistributing momentum across the wind shear layer, by means of an intricate and dynamic flight manoeuvre. Dynamic soaring has been described as a sequence of half-turns connecting upwind climbs and downwind dives through the surface shear layer...
October 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28940348/empty-spaces
#3
Adira Hulkower
"I'm Jewish, you know, and my mother said, 'Always trust the rabbis.'" I never heard Mr. Weisman's refrain from his own lips. I never heard him say any words all. By the time I met him he was in a vegetative state, a man on the precipice of invisibility-white hair, thin pale limbs, melting into sheets of the same color. When I think about Mr. Weisman, I see empty spaces-the absence of his voice, the too-large bed for his shrinking frame, the always-empty chair by his bedside, and most of all, the myriad gaps in his life story...
September 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28860674/assessing-the-resilience-of-norway-spruce-forests-through-a-model-based-reanalysis-of-thinning-trials
#4
Rupert Seidl, Friedrich Vigl, Günter Rössler, Markus Neumann, Werner Rammer
As a result of a rapidly changing climate the resilience of forests is an increasingly important property for ecosystem management. Recent efforts have improved the theoretical understanding of resilience, yet its operational quantification remains challenging. Furthermore, there is growing awareness that resilience is not only a means to addressing the consequences of climate change but is also affected by it, necessitating a better understanding of the climate sensitivity of resilience. Quantifying current and future resilience is thus an important step towards mainstreaming resilience thinking into ecosystem management...
March 15, 2017: Forest Ecology and Management
https://www.readbyqxmd.com/read/28781996/opinion-hazards-faced-by-macromolecules-when-confined-to-thin-aqueous-films
#5
REVIEW
Robert M Glaeser, Bong-Gyoon Han
Samples prepared for single-particle electron cryo-microscopy (cryo-EM) necessarily have a very high surface-to-volume ratio during the short period of time between thinning and vitrification. During this time, there is an obvious risk that macromolecules of interest may adsorb to the air-water interface with a preferred orientation, or that they may even become partially or fully unfolded at the interface. In addition, adsorption of macromolecules to an air-water interface may occur even before thinning. This paper addresses the question whether currently used methods of sample preparation might be improved if one could avoid such interfacial interactions...
2017: Biophysics Reports
https://www.readbyqxmd.com/read/28725425/letter-to-the-editor-health-professionals-attitudes-toward-individuals-with-eating-disorders-who-do-we-think-they-are
#6
Deborah Lynn Reas, Kjersti Solhaug Gulliksen, Johanna Levallius, Rasmus Isomaa
Health professionals are not immune to stigmatizing attitudes and stereotypes found in society-at-large. Along with patients and their loved ones, treatment providers are important stakeholders - and gatekeepers - in the successful delivery of mental healthcare. Prevailing attitudes among professionals can facilitate timely recognition, enable access to care and uptake of evidence-based practices, or undermine help-seeking and therapeutic engagement. At an interactive activity at the 2016 Nordic Eating Disorders Society (NEDS) meeting, we asked health professionals to describe individuals with eating disorders...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28476174/a-patient-with-a-history-of-breast-cancer-and-multiple-bone-lesions-a-case-report
#7
Marie-Angela Schnyder, Paul Stolzmann, Gerhard Frank Huber, Christoph Schmid
BACKGROUND: Long-term severe hyperparathyroidism leads to thinning of cortical bone and cystic bone defects referred to as osteitis fibrosa cystica. Cysts filled with hemosiderin deposits may appear colored as "brown tumors." Osteitis fibrosa cystica and brown tumors are occasionally visualized as multiple, potentially corticalis-disrupting bone lesions mimicking metastases by bone scintigraphy or (18)F-fluorodeoxyglucose positron emission tomography. CASE PRESENTATION: We report a case of a 72-year-old white woman who presented with malaise, weight loss, and hypercalcemia...
May 6, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28370105/understanding-patient-and-physician-perceptions-of-male-androgenetic-alopecia-treatments-in-asia-pacific-and-latin-america
#8
Zrinka Lulic, Shigeki Inui, Woo-Young Sim, Hoon Kang, Gwang Seong Choi, Woosung Hong, Toshiki Hatanaka, Timothy Wilson, Michael Manyak
This survey aimed to explore patient and physician attitudes towards male androgenetic alopecia (AGA), satisfaction with currently available male AGA treatments and investigate the factors affecting treatment choice. The survey was carried out in five countries (Japan, South Korea, Taiwan, Mexico and Brazil) between November and December 2015 using a standard market research methodology. Questionnaires were completed by patients with male AGA or hair loss/thinning and practicing physicians who were responsible for prescribing AGA treatment...
August 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28290624/thick-melanoma-in-tuscany
#9
Alessandra Chiarugi, Paolo Nardini, Lorenzo Borgognoni, Paola Brandani, Gianni Gerlini, Pietro Rubegni, Arianna Lamberti, Camilla Salvini, Giovanni Lo Scocco, Roberto Cecchi, Riccardo Sirna, Stefano Lorenzi, Riccardo Gattai, Silvio Battistini, Emanuele Crocetti
BACKGROUND: The epidemiologic trends of cutaneous melanoma are similar in several countries with a Western-type life style, where there is a progressive increasing incidence and a low but not decreasing mor- tality, or somewhere an increase too, especially in the older age groups. Also in Tuscany there is a steady rise in incidence with prevalence of in situ and invasive thin melanomas, with also an increase of thick melanomas. It is necessary to reduce the frequency of thick melanomas to reduce specific mortality...
March 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27981359/evaluation-of-the-ossification-of-the-medial-clavicle-according-to-the-kellinghaus-substage-system-in-identifying-the-18-year-old-age-limit-in-the-estimation-of-forensic-age-is-it-necessary
#10
Murat Serdar Gurses, Nursel Turkmen Inanir, Esra Soylu, Gokhan Gokalp, Elif Kir, Recep Fedakar
The evaluation of the ossification of the medial clavicular epiphysis being part of an assigned expert approach according to standard plays an important role within civil and criminal proceedings in assessing whether a person has reached her/his 19th or 22nd year of age. Evaluation of the medial clavicular epiphysis with thin-section CT is one of the methods recommended by the Study Group on Forensic Age Diagnostics of the German Association of Forensic Medicine. In this retrospective study, we evaluated the thin-section CT (section thickness of 0...
March 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27864082/individual-variation-in-intentionality-in-the-mind-wandering-state-is-reflected-in-the-integration-of-the-default-mode-fronto-parietal-and-limbic-networks
#11
Johannes Golchert, Jonathan Smallwood, Elizabeth Jefferies, Paul Seli, Julia M Huntenburg, Franziskus Liem, Mark E Lauckner, Sabine Oligschläger, Boris C Bernhardt, Arno Villringer, Daniel S Margulies
Mind-wandering has a controversial relationship with cognitive control. Existing psychological evidence supports the hypothesis that episodes of mind-wandering reflect a failure to constrain thinking to task-relevant material, as well the apparently alternative view that control can facilitate the expression of self-generated mental content. We assessed whether this apparent contradiction arises because of a failure to consider differences in the types of thoughts that occur during mind-wandering, and in particular, the associated level of intentionality...
February 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/27797888/use-of-oral-anticoagulation-in-the-management-of-atrial-fibrillation-in-patients-with-esrd-pro
#12
Peter A McCullough, Timothy Ball, Katy Mathews Cox, Manish D Assar
Warfarin has had a thin margin of benefit over risk for the prevention of stroke and systemic embolism in patients with ESRD because of higher bleeding risks and complications of therapy. The successful use of warfarin has been dependent on the selection of patients with nonvalvular atrial fibrillation at relatively high risk of stroke and systemic embolism and lower risks of bleeding over the course of therapy. Without such selection strategies, broad use of warfarin has not proven to be beneficial to the broad population of patients with ESRD and nonvalvular atrial fibrillation...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27770392/evaluation-of-retinal-nerve-fiber-layer-ganglion-cell-layer-and-macular-changes-in-patients-with-migraine
#13
Abdulkadir Tunç, Belma Doğan Güngen, Ferhat Evliyaoğlu, Yeşim Güzey Aras, Aysel Kaya Tekeşin
The aim of this study was to investigate retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) thickness, macular changes (central subfield thickness (CST), cube average thickness (CAT), cube volume (CV) in patients with migraine using spectral-domain optical coherence tomography (OCT) and to assess if there was any correlation with white matter lesions (WML). In this prospective case-control study, RNFL, GCL thickness and macular changes of 19 migraine patients with aura (MA), 41 migraine without aura (MO) and 60 age- and gender-matched healthy subjects were measured using OCT device...
March 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27639949/-progressive-paralysis-of-the-diaphragm-following-intra-abdominal-chemotherapy
#14
S Guinard, A Olland, M Ohana, P-E Falcoz, R Kessler, G Massard
INTRODUCTION: In patients presenting with intra-abdominal tumor and peritoneal carcinomatosis, cytoreductive surgery associated with hyperthermic chemotherapy may offer improved survival. We describe a case of diaphragmatic paralysis following that kind of procedure. CASE REPORT: A 60-year-old woman presented with respiratory insufficiency following cytoreductive surgery and intra-abdominal hyperthermic chemotherapy performed for pseudomyxoma intraperitonei. Pulmonary function assessment demonstrated a restrictive pattern...
March 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/27526950/examination-of-parental-dieting-and-comments-as-risk-factors-for-increased-drive-for-thinness-in-men-and-women-at-20-year-follow-up
#15
Kelly M Klein, Tiffany A Brown, Grace A Kennedy, Pamela K Keel
OBJECTIVE: Popular beliefs suggest that parents influence children's eating disorder risk through modeling pathological behaviors and attitudes, and this history may contribute to disordered eating in adulthood. However, the empirical basis for this popular thinking is limited by a reliance on cross-sectional designs that do not distinguish between maternal and paternal influences and use primarily child and adolescent samples. To address these limitations, the present study examined the impact of maternal and paternal dieting and comments about weight and eating, as reported by late adolescents, on the eating pathology of those late adolescents at 20-year follow-up...
May 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/27491068/effects-of-emotional-acceptance-and-rumination-on-media-induced-body-dissatisfaction-in-anorexia-and-bulimia-nervosa
#16
Eva Naumann, Brunna Tuschen-Caffier, Ulrich Voderholzer, Johanna Schäfer, Jennifer Svaldi
INTRODUCTION: Body dissatisfaction is an important risk and maintaining factor for eating disorders. The aim of the present study was to experimentally test the effects of two emotion regulation strategies - acceptance and rumination - on media-induced body dissatisfaction in eating disorders. METHOD: After watching pictures of thin models, women with anorexia nervosa (AN; n = 39) and bulimia nervosa (BN; n = 39) were encouraged to either use emotional acceptance or rumination to cope with their feelings...
November 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27476278/investigation-of-a-mixture-containing-alprazolam-codeine-and-paracetamol-using-thin-layer-and-high-performance-liquid-chromatography-methods
#17
Paulius Ciegis, Andrejus Zevzikovas, Augusta Zevzikoviene, Palma Nenortiene, Daiva Kazlauskiene
The increasing drug consumption in Lithuania and all over the world makes us think about the negative consequences - the risk of toxicity. Fast and accurate identification of material that caused the poisoning reduces the probability in death cases and makes easier to determine the main cause of death. The results have shown that the most appropriate systems of solvents for qualitative analysis by TLC method of the mixture consisting of alprazolam, codeine and paracetanol are: system "D" (trichloromethane : acetone : conc...
May 2016: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26894425/think-yourself-thin-concern-for-appropriateness-mediates-the-link-between-hypnotizability-and-disordered-eating
#18
Rachel Bachner-Melman, Lilac Lev-Ari, Raz Levin, Pesach Lichtenberg
There has been no research examining why people with disordered eating tend to be highly hypnotizable. The authors examine the hypothesis that concern for appropriateness mediates the association between hypnotizability and disordered eating. Fifty participants aged 15 to 30 completed the Eating Attitudes Test-26 (EAT-26) and the Concern for Appropriateness Scale (CAS) and were administered the Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C). EAT-26 scores predicted CAS scores (β = 0.24, p < ...
2016: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/26880285/does-media-literacy-mitigate-risk-for-reduced-body-satisfaction-following-exposure-to-thin-ideal-media
#19
Siân A McLean, Susan J Paxton, Eleanor H Wertheim
Exposure to thin-ideal media can contribute to increased body dissatisfaction in adolescent girls. Understanding the factors that may prevent or exacerbate the negative effects of media exposure on body dissatisfaction is important to facilitate prevention of these problems. This study evaluated the effects of exposure to thin-ideal media images on body image in three instructional set experimental conditions: appearance comparison, peer norms, and control. An important aim was to examine baseline levels of media literacy as a protective factor and trait thin-ideal internalization and trait upward appearance comparison as risk factors...
August 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/26866314/minimum-5-year-results-with-duracon-press-fit-metal-backed-patellae
#20
Anthony K Hedley
Negative outcomes of earlier metal-backed patella designs have overshadowed reports of positive outcomes achieved with careful attention paid to component design, patellar tracking, and surgical technique. Much as reported elsewhere, we found earlier component failures were caused by poor locking mechanisms, thin polyethylene, poor tracking, and minimal femur contact. Over the past decade, however, our outcomes with Duracon metal-backed patellae have been encouraging. We think these positive outcomes, seen over a minimum 5-year follow-up, are largely attributable to the thicker polyethylene and improved articular conformity of this component relative to earlier designs...
February 2016: American Journal of Orthopedics
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