keyword
https://read.qxmd.com/read/38533320/displacement-of-abdominal-organs-into-the-thoracic-cavity-a-rare-case-of-adult-bochdalek-hernia
#21
Sien Hu, Xiaohui Yang, Yulian Wu
Congenital diaphragmatic hernias are primarily found in infants and have a high mortality rate due to neonatal respiratory distress. The most common type of congenital diaphragmatic hernia is Bochdalek hernia, which occurs in the posterolateral diaphragm, with the left side being the most commonly affected. However, congenital diaphragmatic hernias are extremely rare in adults and are often misdiagnosed due to their subtle symptoms. Therefore, we suggest that a contrast-enhanced CT scan should be used for early screening and diagnosis in all patients with sudden severe pain or recurrent ambiguous symptoms in the chest and abdomen...
March 2024: Curēus
https://read.qxmd.com/read/38533276/primary-hyperparathyroidism-in-young-and-adolescents-alike-or-unlike-adult-hyperparathyroidism-a-series-from-south-india
#22
JOURNAL ARTICLE
Dhalapathy Sadacharan, Smitha S Rao, Shriraam Mahadevan, G Shanmugasundar, S Murthy, Shruti Chandrashekaran, Vijay Bhaskar Reddy, Bharath Ramji
BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrine condition but rare in the pediatric and adolescent populations. The presentations can be unique, accounting for significant morbidity in the case of untimely detection. AIM: To study surgically treated pediatric PHPT retrospectively. METHODS: Surgically treated children of PHPT up to 20 years of age between 2010 to 2022 were analyzed. All of them were operated on by an endocrine surgeon and team...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532991/effective-doses-of-low-dose-naltrexone-for-chronic-pain-an-observational-study
#23
JOURNAL ARTICLE
Norman J Marcus, Lexi Robbins, Aya Araki, Edward J Gracely, Theoharis C Theoharides
PURPOSE: Despite the availability of a wide variety of analgesics, many patients with chronic pain often experience suboptimal pain relief in part related to the absence of any medication to address the nociplastic component of common pain syndromes. Low-dose naltrexone has been used for the treatment of chronic pain, typically at 4.5 mg per day, even though it is also noted that effective doses of naltrexone for chronic pain presentations range from 0.1 to 4.5 mg per day. We performed an observational analysis to determine the range of effective naltrexone daily dosing in 41 patients with chronic musculoskeletal pain...
2024: Journal of Pain Research
https://read.qxmd.com/read/38532873/case-report-neurological-adverse-events-in-subject-with-myasthenia-gravis-after-pcsk9-inhibitor-administration
#24
Věra Adámková, Martina Vitásková, Jaroslav A Hubáček
BACKGROUND: Myasthenia gravis is a rare chronic autoimmune neuromuscular disorder mainly caused by autoantibodies to the nicotinic acetylcholine receptor. Cholesterol is an essential molecule that affects the distribution and proper functioning of this receptor. Several reports have described the potential worsening of myasthenia gravis in patients treated with statins. CASE PRESENTATION: The patient was an obese 72 years old man, past smoker, diagnosed with ischaemic heart disease, type 2 diabetes mellitus and lipid metabolism disorder...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38532867/osteochondritis-dissecans-of-the-hip-in-legg-calv%C3%A3-perthes-disease-case-report-and-review
#25
Luiz Renato Agrizzi de Angeli, Bárbara Lívia Corrêa Serafim, Felippi Guizardi Cordeiro, Felipe Spinelli Bessa, Daniel Augusto Carvalho Maranho
INTRODUCTION: Legg-Calvé-Perthes disease (LCPD) is the idiopathic osteonecrosis of the capital femoral epiphysis in children. It is a self-healing condition, and the morphology of the hip may vary according to the severity of the disease, among several other factors. The treatment focuses on attempts to prevent femoral head collapse, obtain functional hip motion recovery, and reduce pain. Osteochondritis Dissecans (OCD) of the femoral head has been reported in 2% to 7% of patients diagnosed with healed LCPD...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532698/examining-the-impact-of-far-infrared-technology-on-quality-of-life-in-older-adults
#26
JOURNAL ARTICLE
Melanie Homan, Shavonnye U L Rath, Virginia L S Green, Jennifer Hutson, Marcie J Myers, Joshua D Guggenheimer
The purpose of this study was to examine the effects of far-infrared (FIR) heat on quality of life (QOL) in older adults. Participants were assigned to either a convective heat group (CON) or a convective and FIR group. Participants received six, 30-min heat sessions over the course of three weeks. Pre- and post-assessments included physical measures such as range of motion, gait speed, Timed Up and Go, and hand grip strength. Standardized questionnaires were used to determine pain severity and its interference with daily life, and the impact pain had on overall QOL...
March 27, 2024: International Journal of Aging & Human Development
https://read.qxmd.com/read/38532646/the-current-state-of-knowledge-on-care-for-co-occurring-chronic-pain-and-opioid-use-disorder-a-scoping-review
#27
REVIEW
Léonie Archambault, Karine Bertrand, Marc O Martel, Mélanie Bérubé, Salima Belhouari, Michel Perreault
BACKGROUND AND AIMS: Opioid use disorder often co-occurs with chronic pain but assessment and treatment of these co-occurring disorders is complex. This review aims to identify current treatments and delivery models for co-occurring chronic pain and opioid use disorder (OUD) documented in the scientific literature. DESIGN: Scoping review. METHODS: The review was conducted in six databases in June 2022 (no time limit): CINAHL, PsycINFO, Web of Science, Cochrane, PubMed and Embase...
March 26, 2024: Journal of Clinical Nursing
https://read.qxmd.com/read/38532639/automating-sedation-state-assessments-using-natural-language-processing
#28
JOURNAL ARTICLE
Aaron Conway, Jack Li, Mohammad Goudarzi Rad, Sebastian Mafeld, Babak Taati
INTRODUCTION: Common goals for procedural sedation are to control pain and ensure the patient is not moving to an extent that is impeding safe progress or completion of the procedure. Clinicians perform regular assessments of the adequacy of procedural sedation in accordance with these goals to inform their decision-making around sedation titration and also for documentation of the care provided. Natural language processing could be applied to real-time transcriptions of audio recordings made during procedures in order to classify sedation states that involve movement and pain, which could then be integrated into clinical documentation systems...
March 26, 2024: Journal of Nursing Scholarship
https://read.qxmd.com/read/38532474/an-investigation-into-how-accurately-uk-rabbit-owners-identify-pain-in-their-pet-rabbits
#29
JOURNAL ARTICLE
Charlotte Forder, Livia Benato, Nicola J Rooney
BACKGROUND: Rabbits are popular family pets. They are prey species and so have evolved to hide signs of illness and pain. Recent research has developed robust pain scales for use in a clinical setting, but to date none has examined rabbit owners' ability to recognise pain in their animals. This study investigated how owners identify pain in their pet rabbits and their ability to correctly identify different levels of pain, in order to determine any need for owner education in this area...
March 27, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38532425/symptoms-and-quality-of-life-among-men-starting-treatment-for-metastatic-castration-resistant-prostate-cancer-a-prospective-multicenter-study
#30
JOURNAL ARTICLE
Ulrika Rönningås, Maja Holm, Per Fransson, Lars Beckman, Agneta Wennman-Larsen
BACKGROUND: Men with metastatic castration-resistant prostate cancer (mCRPC) have an incurable disease. Along with prolonging life, symptom management is one of the main goals with treatment. This is also important from a palliative care perspective where the life prolonging outcomes should be balanced with quality of life (QoL) in this late phase. It is also essential in symptom management to view different dimensions of symptoms, for example how severe or distressing symptoms are, to support best QoL...
March 27, 2024: BMC Palliative Care
https://read.qxmd.com/read/38532253/heterotopic-ossification-of-the-abdomen-a-rare-sequela-following-trauma-and-damage-control-laparotomy
#31
JOURNAL ARTICLE
Patrick Cherfan, Michael D Cobler-Lichter, Joshua P Kronenfeld, Zoe Weiss, Patricia M Byers
Heterotopic ossification (HO) of the abdomen is a rare yet highly morbid complication following blunt and penetrating trauma requiring damage control laparotomy. We present the case of a 22-year-old man, 20 months after life-threatening motor vehicle crash with major vascular injury requiring multiple abdominal surgeries. The patient was initially treated at a community hospital and subsequently developed a chronic left lower quadrant enterocutaneous fistula, accompanied by a gradually worsening diffuse abdominal pain...
March 26, 2024: American Surgeon
https://read.qxmd.com/read/38532121/symptom-burden-and-relief-in-palliative-care-units-of-german-comprehensive-cancer-center-and-other-hospitals
#32
JOURNAL ARTICLE
Julia Berendt, Sarah Brunner, Maria Heckel, Mitra Tewes, Christoph Ostgathe, Susanne Gahr
PURPOSE: The National Hospice and Palliative Registry contains patient data from German hospice and palliative care facilities about symptoms. The aim of the study at hand is to differentiate symptom burden of patients in palliative care units between Comprehensive Cancer Center (CCC) and other hospitals regarding symptom burden and relief of patients in palliative care units. METHODS: The registry analysis provided data of patients in palliative care units (2014-2018)...
March 27, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38531788/rare-but-still-there-a-scoping-review-on-endometriosis-associated-ovarian-cancer
#33
JOURNAL ARTICLE
Karl Livori, Jean Calleja-Agius
Endometriosis is a medical condition affecting at least up to 10% of women of reproductive age. This condition occurs when ectopic endometrial glands and stroma implant outside the uterus and there are several theories regarding the underlying origins of the disease. Endometriosis is one of the major causes of severe dysmenorrhoea, chronic pelvic pain and infertility. While endometriosis is generally a non-malignant condition, it rarely may transform into an invasive cancer, and increase the risk for epithelial ovarian cancer, notably endometrioid or clear cell ovarian cancer...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531621/guselkumab-provides-durable-improvement-across-psoriatic-arthritis-disease-domains-post-hoc-analysis-of-a-phase-3-randomised-double-blind-placebo-controlled-study
#34
JOURNAL ARTICLE
Laura C Coates, Laure Gossec, Miriam Zimmermann, May Shawi, Emmanouil Rampakakis, Natalie J Shiff, Alexa P Kollmeier, Xie L Xu, Peter Nash, Philip J Mease, Philip S Helliwell
OBJECTIVE: Evaluate long-term guselkumab effectiveness across Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-recognised domains/related conditions of psoriatic arthritis (PsA). METHODS: Post hoc analyses used data from DISCOVER-2 (NCT03158285) biologic/Janus-kinase inhibitor-naïve participants with active PsA (≥5 swollen/≥5 tender joints, C-reactive protein ≥0.6 mg/dL), randomised (1:1:1) to guselkumab every 4 or 8 weeks (Q4W/Q8W) or placebo with crossover to guselkumab...
March 26, 2024: RMD Open
https://read.qxmd.com/read/38531612/individual-outcomes-after-tailored-versus-generic-self-management-strategies-for-persistent-fatigue-in-youth-with-a-fatigue-syndrome-or-rheumatic-condition-a-multiple-single-case-study
#35
JOURNAL ARTICLE
Anouk Vroegindeweij, Jan Houtveen, Desiree A Lucassen, Elise M Van De Putte, Nico M Wulffraat, Sanne L Nijhof, Joost F Swart
OBJECTIVE: To examine individual outcomes after tailored lifestyle (PROfeel) or generic dietary advice as self-management intervention for persistent fatigue in adolescents and young adults with a chronic condition, to compare participants who did and did not benefit and to explore changes to factors in the biopsychosocial model of fatigue after PROfeel. METHOD: A multiple single-case AB-phase design was embedded in a randomized crossover trial (N = 45)...
March 26, 2024: British Journal of Health Psychology
https://read.qxmd.com/read/38531539/patient-satisfaction-with-ultrasound-whole-body-ct-and-whole-body-diffusion-weighted-mri-for-pre-operative-ovarian-cancer-staging-a-multicenter-prospective-cross-sectional-survey
#36
JOURNAL ARTICLE
Patrícia Pinto, Lil Valentin, Martina Borčinová, Markéta Wiesnerová, Fruhauf Filip, Andrea Burgetova, Martin Masek, Lukas Lambert, Valentina Chiappa, Dorella Franchi, Antonia Carla Testa, Francesca Moro, Giacomo Avesani, Camilla Panico, Sarah Alessi, Paola Pricolo, Raffaella Vigorito, Giuseppina Calareso, Roman Kocian, Jiri Slama, Anna Fagotti, Ailyn Mariela Vidal Urbinati, Mauro Signorelli, Francesca Bertolina, David Cibula, Daniela Fischerova
BACKGROUND: In addition to the diagnostic accuracy of imaging methods, patient-reported satisfaction with imaging methods is important. OBJECTIVE: To report a secondary outcome of the prospective international multicenter Imaging Study in Advanced ovArian Cancer (ISAAC Study), detailing patients' experience with abdomino-pelvic ultrasound, whole-body contrast-enhanced computed tomography (CT), and whole-body diffusion-weighted magnetic resonance imaging (WB-DWI/MRI) for pre-operative ovarian cancer work-up...
March 26, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38531476/the-impact-of-embedment-of-the-side-arms-of-52-mg-levonorgestrel-intrauterine-device-on-bleeding-and-pain-a-prospective-cohort-study
#37
JOURNAL ARTICLE
P A H H van der Heijden, M Y Bongers, S Veersema, J P Dieleman, P M A J Geomini
PURPOSE: The purpose of this study was to analyse the impact of embedment of side arms of the levonorgestrel 52 mg intrauterine device (LNG-IUD) in the myometrium (assessed by three-dimensional transvaginal ultrasound (3D-TVUS)) on uterine bleeding and pain. MATERIALS AND METHODS: We performed a prospective cohort study in a large Dutch teaching hospital between February 2015 and December 2016. Participants over 18 years of age who selected a LNG-IUD for contraception or because of heavy menstrual bleeding were eligible for inclusion...
March 24, 2024: Journal of Gynecology Obstetrics and Human Reproduction
https://read.qxmd.com/read/38531195/comparison-of-local-versus-intramuscular-steroid-injection-in-patients-with-carpal-tunnel-syndrome-a-prospective-open-label-randomized-clinical-trial
#38
JOURNAL ARTICLE
Mritunjai Kumar, Jagbir Singh, Rajni Singh, Ashutosh Tiwari, Niraj Kumar
AIM: This study compared the efficacy and safety of local corticosteroid injection (LCI) vs intramuscular (IM) corticosteroid injection in mild to moderate carpal tunnel syndrome (CTS). METHODS: This is an open labeled, randomized controlled trial conducted during December 2021 to August 2023. Eighty-six patients with CTS were randomized in 1:1 ratio to receive either single 40 mg methylprednisolone (MP) injection at the wrist (LCI arm), or single 40 mg MP intramuscular injection (IM arm) in the deltoid...
March 25, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38531152/a-literature-review-of-biomechanical-studies-on-physiological-and-pathological-sacroiliac-joints-articular-surface-structure-joint-motion-dysfunction-and-treatments
#39
REVIEW
Ryota Toyohara, Toshiro Ohashi
BACKGROUND: Sacroiliac joints are affected by mechanical environments; the joints are formed under mechanical stimulation, receive impact of walking between the upper and lower parts of the bodies and can be a cause of pain due to non-physiological loads. However, there are so far very few studies that reviewed biomechanics of physiological and pathological sacroiliac joints. This review article aims to describe the current sacroiliac joint biomechanics. METHODS: Previous original papers have been summarized based on three categories: articular surface structure, sacroiliac joint motion and sacroiliac joint dysfunction and treatments...
March 21, 2024: Clinical Biomechanics
https://read.qxmd.com/read/38531121/a-next-generation-peripherally-restricted-cav%C3%AE-2%C3%AE-1-ligand-with-inhibitory-action-on-cav2-2-channels-and-utility-in-neuropathic-pain
#40
JOURNAL ARTICLE
Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris
The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus of human Cavα2δ-1...
March 25, 2024: Biomedicine & Pharmacotherapy
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