keyword
MENU ▼
Read by QxMD icon Read
search

Severe pain

keyword
https://www.readbyqxmd.com/read/29342356/the-dark-side-of-total-synthesis-strategies-and-tactics-in-psychoactive-drug-production
#1
Schuyler A Chambers, Jenna M DeSousa, Eric D Huseman, Steven D Townsend
Humankind has used and abused psychoactive drugs for millennia. Formally, a psychoactive drug is any agent that alters cognition and mood. The term "psychotropic drug" is neutral and describes the entire class of substrates, licit and illicit, of interest to governmental drug policy. While these drugs are prescribed for issues ranging from pain management to anxiety, they are also used recreationally. In fact, the current opioid epidemic is the deadliest drug crisis in American history. While the topic is highly politicized with racial, gender, and socioeconomic elements, there's no denying the toll drug mis- and overuse is taking on this country...
January 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29341240/a-case-report-and-literature-review-of-autism-and-attention-deficit-hyperactivity-disorder-in-paediatric-chronic-pain
#2
Camilla Wiwe Lipsker, Margareta von Heijne, Sven Bölte, Rikard K Wicksell
Psychiatric disorders are common in paediatric patients with chronic pain, but the overall prevalence of comorbid neurodevelopmental disorders is unclear. We report on a case of severe chronic pain in a child with undiagnosed comorbid autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), where significant improvements in pain and function occurred following methylphenidate medication and parental behavioural training. CONCLUSION: The inclusion of behavioural assessment and screening for neurodevelopmental comorbidity may be essential in addressing complex paediatric chronic pain...
January 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29340913/a-randomized-pilot-trial-of-a-novel-behavioral-intervention-for-chronic-pain-tailored-to-individuals-with-hiv
#3
Jessica S Merlin, Andrew O Westfall, Dustin Long, Susan Davies, Michael Saag, William Demonte, Sarah Young, Robert D Kerns, Matthew J Bair, Stefan Kertesz, Janet M Turan, Meredith Kilgore, Olivio J Clay, Joanna Starrels, Dorothy Pekmezi, Mallory O Johnson
Chronic pain is an important and understudied comorbidity in people living with HIV (PLWH). We conducted a pilot trial of Skills TO Manage Pain (STOMP), an innovative social cognitive theory-based pain self-management intervention tailored to PLWH, to assess feasibility, acceptability, and preliminary efficacy. Eligibility criteria included being HIV+, ≥ moderate pain for ≥ 3 months and a score of ≥ 4 on the three-item PEG pain severity and interference scale. Participants were randomized in a 1:1 fashion to STOMP or a usual care comparison...
January 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29340877/brief-report-subjective-social-mobility-and-depressive-symptoms-in-syrian-refugees-to-germany
#4
Frank Euteneuer, Sarina J Schäfer
Previous findings indicate that refugees are at increased risk for mental health problems. In addition to stressful pre-migration experiences, post-migration factors may contribute to poor mental health outcomes. Among immigrants to the United States, downward mobility in subjective social status (SSS) was associated with depression, corroborating the potentially detrimental mental health consequences of a decline in one's perceived social position. The present study examined whether downward mobility in SSS among male refugees from Syria to Germany is associated with depression...
January 16, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29340793/neuroimaging-findings-in-patients-with-medication-overuse-headache
#5
REVIEW
Tzu-Hsien Lai, Shuu-Jiun Wang
Medication overuse headache (MOH) is a secondary headache syndrome defined as the deterioration of the headache associated with the overuse of analgesics. The prevalence of MOH is 1-2% in the general population and even up to 50% in special clinics. Overuse of abortive medications is highly associated with chronic daily headaches and also a known risk factor for headache evolution. Possible mechanisms include neural plasticity changes such as sensitization and defective endogenous pain inhibition. Psychological studies have suggested dependence, even addiction, in patients with MOH...
January 16, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29339984/functional-vs-traditional-analysis-in-biomechanical-gait-data-an-alternative-statistical-approach
#6
Jihong Park, Matthew K Seeley, Devin Francom, C Shane Reese, J Ty Hopkins
In human motion studies, discrete points such as peak or average kinematic values are commonly selected to test hypotheses. The purpose of this study was to describe a functional data analysis and describe the advantages of using functional data analyses when compared with a traditional analysis of variance (ANOVA) approach. Nineteen healthy participants (age: 22 ± 2 yrs, body height: 1.7 ± 0.1 m, body mass: 73 ± 16 kg) walked under two different conditions: control and pain+effusion. Pain+effusion was induced by injection of sterile saline into the joint capsule and hypertonic saline into the infrapatellar fat pad...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339053/upregulation-of-nlrp3-via-stat3-dependent-histone-acetylation-contributes-to-painful-neuropathy-induced-by-bortezomib
#7
Cui-Cui Liu, Zhu-Xi Huang, Xiao Li, Kai-Feng Shen, Meng Liu, Han-Dong Ouyang, Su-Bo Zhang, Yu-Ting Ruan, Xiao-Long Zhang, Shao-Ling Wu, Wen-Jun Xin, Chao Ma
Painful neuropathy, as a severe side effect of chemotherapeutic bortezomib, is the most common reason for treatment discontinuation. However, the mechanism by which administration of bortezomib leads to painful neuropathy remains unclear. In the present study, we found that application of bortezomib significantly increased the expression of NOD-like receptor family pyrin domain containing 3 (NLRP3) and phosphorylated signal transducer and activator of transcription-3 (STAT3) in dorsal root ganglion (DRG). Intrathecal injection of NLRP3 siRNA significantly prevented the mechanical allodynia induced by bortezomib treatment, and intrathecal injection of recombinant adeno-associated virus vector encoding NLRP3 markedly decreased paw withdrawal threshold of naive rats...
January 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29338982/involvement-of-peripheral-alpha2a-adrenoceptor-in-the-acceleration-of-gastrointestinal-transit-and-abdominal-visceral-pain-induced-by-intermittent-deprivation-of-rem-sleep
#8
Fukie Yaoita, Masamichi Muto, Hiroki Murakami, Shiori Endo, Mifuyu Kozawa, Masahiro Tsuchiya, Takeshi Tadano, Koichi Tan-No
Many studies have associated sleep alterations with the severity of irritable bowel syndrome (IBS) symptoms, but the direct pathophysiological relationship has not been clarified. In addition, alterations in noradrenergic signaling have been implicated in the pathophysiology of IBS, and alpha2-adrenoceptors are potential treatment targets. We have previously shown that acceleration of gastrointestinal transit (GIT) elicited by intermittent rapid eye movement (REM) sleep deprivation stress may fulfill the profile of a model of IBS...
January 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29338591/association-between-health-status-and-sociodemographic-clinical-and-treatment-disparities-in-the-patient-centered-outcomes-related-to-treatment-practices-in-peripheral-arterial-disease-investigating-trajectories-portrait-registry
#9
Adam M Noyes, J Dawn Abbott, Kensey Gosch, Kim Smolderen, John A Spertus, Omar Hyder, Peter Soukas, Mehdi H Shishehbor, Herbert D Aronow
Patients with peripheral artery disease (PAD) and intermittent claudication (IC) have impaired functional status and quality of life. However, little is known about which factors are associated with poorer health status at the time of initial presentation for PAD specialty care. Characterization of such features might provide insight into disparities that impact health status in this population. A total of 1258 patients from the United States, the Netherlands and Australia with new or worsened IC were enrolled at their first PAD specialty care visit between June 2011 and December 2015...
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29338493/challenges-of-peroral-endoscopic-myotomy-in-the-treatment-of-distal-esophageal-spasm
#10
Fraukje Anna-Marie Ponds, André J P M Smout, Paul Fockens, Albert J Bredenoord
OBJECTIVE: Distal esophageal spasm (DES) is a rare motility disorder characterized by premature and rapidly propagated contractions of the distal esophagus. Treatment options are limited and often poorly effective. Peroral endoscopic myotomy (POEM) seems an effective and attractive new treatment option for DES. In this case report we describe some of the difficulties that could arise. MATERIALS AND METHODS: A 84-year old man with therapy-refractory DES and complaints of severe dysphagia and chest pain underwent a POEM procedure under general anesthesia...
January 17, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29338288/transcranial-magnetic-stimulation-tms-safety-a-practical-guide-for-psychiatrists
#11
Rohan Taylor, Veronica Galvez, Colleen Loo
OBJECTIVES: Repetitive transcranial magnetic stimulation (rTMS) is increasingly being utilised as a treatment option for depression, and with this comes a need for a practical review of safety issues intended for clinicians. This article provides an overview of the current literature regarding safety issues with rTMS for depression, and provides recommendations for clinical practice. CONCLUSIONS: Overall, rTMS is a well-tolerated treatment with common side effects (such as headache or local pain at the site of stimulation) being mild...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29338144/mortality-and-long-term-quality-of-life-after-percutaneous-tracheotomy-in-intensive-care-unit-a-prospective-observational-study
#12
Maria Vargas, Yuda Sutherasan, Iole Brunetti, Camilla Micalizzi, Angelo Insorsi, Lorenzo Ball, Marta Folentino, Rosanna Sileo, Arduino DE Lucia, Manuela Cerana, Alessandro Accattatis, Domenico DE Lisi, Angelo Gratarola, Francesco Mora, Giorgio Peretti, Giuseppe Servillo, Paolo Pelosi
BACKGROUND: Quality of life and mortality after percutaneous dilatational tracheotomy (PDT) has been poorly investigated. The aims of this study were to evaluate the independent risk factors for Intensive Care Unit (ICU) mortality and investigate quality of life over the first year after PDT in critically ill patients. METHODS: This was a prospective, single-center, cohort study performed in a tertiary care University Hospital, enrolling consecutive ICU patients requiring elective PDT, collecting data during the tracheotomy procedure and the ICU stay...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29337783/s1-sacrectomy-for-re-recurrent-rectal-cancer-our-experience-with-reconstruction-using-an-expandable-vertebral-body-replacement-device
#13
Daniel Jin Keat Lee, Kelvin Yafan Wang, Peter Michael Sagar, Jake Timothy
INTRODUCTION: R0 resection is achieved by high sacrectomy for local recurrence of colorectal cancer, but significant rates of perioperative complications and long-term patient morbidity are associated with this procedure. In this report, we outline our unique experience of using an expandable cage for vertebral body reconstruction following S1 sacrectomy in a 66-year-old patient with re-recurrent rectal cancer. We aim to highlight several key steps, with a view to improving postoperative outcomes...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337598/comparative-study-of-intramedullary-hammertoe-fixation
#14
Caterina Obrador, Marta Losa, Ricardo Becerro, Christina A Kabbash
BACKGROUND: Temporary Kirschner wire fixation (K-wire) is a widely used, low-cost fixation method for the correction of hammertoe deformity. Reported complications associated with K-wires prompted the development of new implants over the past decade. However, there is a lack of literature on comparative studies analyzing functional outcomes using validated questionnaires. The purpose of this study was to analyze functional outcomes in patients who had undergone proximal interphalangeal joint fusion using 2 types of intramedullary implant, the Smart Toe and the TenFuse, and to compare them with the outcomes in patients treated with standard K-wire fixation...
January 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29337405/effects-of-transcutaneous-electrical-nerve-stimulation-on-pain-intensity-during-application-of-carboxytherapy-in-patients-with-cellulite-a-randomized-placebo-controlled-trial
#15
Adria Y Sadala, Aline F P Machado, Richard E Liebano
BACKGROUND: Carboxytherapy may generate local pain that is considered the main limiting factor in clinical practice. Transcutaneous electric nerve stimulation (TENS) is widely used in the control of acute pain; however, the effect of TENS on pain relief during carboxytherapy has not been studied to date. AIMS: To assess the effect of TENS on pain intensity during carboxytherapy in patients with cellulite in the gluteal region. PATIENTS/METHODS: This randomized clinical trial was conducted with 84 patients, 18-44 years of age, who had moderate cellulite in the gluteal region, according to Cellulite Severity Scale, but never received carboxytherapy...
January 16, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29337220/botaf-a-new-buthus-occitanus-tunetanus-scorpion-toxin-produces-potent-analgesia-in-rodents
#16
Riadh Maatoug, Jed Jebali, Régis Guieu, Michel De Waard, Riadh Kharrat
This work reports the purification of new potent scorpion neuropeptide, named BotAF, by an activity-guided screening approach. BotAF is a 64-residue long-chain peptide that shares very high similarity with the original β-like scorpion toxin group, in which several peptides have been characterized to be anti-nociceptive in rodents. BotAF administration to rodents does not produce any toxicity or motor impairment, including at high doses. In all models investigated, BotAF turned out to be an efficient peptide in abolishing acute and inflammatory (both somatic and visceral) pain in rodents...
January 11, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29337179/surgical-treatment-of-recurrent-varicose-veins-in-the-lower-limbs-associated-with-endovascular-treatment-of-iliac-vein-stenosis
#17
Jie Kong, Peng Liu, Jinyong Li, Xueqiang Fan, Jianyan Wen, Jianbin Zhang, Rongwei Xu, Yiyao Cui, Xia Zhen, Zhidong Ye
OBJECTIVE: We present our experience with endovascular surgery for recurrent varicose veins (RVV) of the lower limbs combined with the iliac vein compression syndrome (IVCS). MATERIALS AND METHODS: This study was a retrospective analysis of 6 patients with RVVs combined with IVCS who were admitted to our hospital between January 2007 and December 2014. Transfemoral venography was performed to confirm IVCS. Balloon dilation and stent placement were successful in all 6 patients...
January 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29337163/utility-of-ultra-deep-sequencing-for-detection-of-varicella-zoster-virus-antiviral-resistance-mutations
#18
Mélanie Mercier-Darty, David Boutolleau, Raphaël Lepeule, Christophe Rodriguez, Sonia Burrel
We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus affecting populations worldwide. VZV is commonly acquired in youth whose primary infection usually manifests as benign varicella (chickenpox)...
January 11, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29337026/effect-of-recombinant-human-growth-hormone-on-rotator-cuff-healing-after-arthroscopic-repair-preliminary-result-of-a-multicenter-prospective-randomized-open-label-blinded-end-point-clinical-exploratory-trial
#19
Joo Han Oh, Seok Won Chung, Kyung-Soo Oh, Jae Chul Yoo, Wonhee Jee, Jung-Ah Choi, Yang-Soo Kim, Jin-Young Park
BACKGROUND: This study evaluated the effect of systemic injection of recombinant human growth hormone (rhGH) on outcomes after arthroscopic rotator cuff repair. METHODS: This multicenter, prospective, randomized, comparative trial, randomized patients who underwent arthroscopic repair of large-sized rotator cuff tears into 3 groups: rhGH 4 mg group (n = 26), rhGH 8 mg group (n = 24) , and control group (n = 26). Sustained release rhGH was injected subcutaneously once weekly for 3 months postoperatively...
January 11, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29337024/moderators-of-treatment-outcomes-following-telehealth-self-management-and-education-in-adults-with-multiple-sclerosis-a-secondary-analysis-of-a-randomized-controlled-trial
#20
Dawn M Ehde, Anne Arewasikporn, Kevin N Alschuler, Abbey J Hughes, Aaron P Turner
OBJECTIVE: To examine moderators of treatment effects in a randomized controlled trial comparing a telehealth self-management intervention to a telehealth MS education intervention for fatigue, pain, and mood in adults with multiple sclerosis (MS). DESIGN: Secondary analysis of a single-blind randomized controlled trial. SETTING: community. PARTICIPANTS: Adults with MS and chronic fatigue, chronic pain, and/or moderate depressive symptoms (N=163) recruited from across the United States...
January 11, 2018: Archives of Physical Medicine and Rehabilitation
keyword
keyword
81833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"