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https://www.readbyqxmd.com/read/28329905/-acute-abdominal-pain
#1
Peter Becker, Knut A Böttcher, Dieter Schilling
Acute abdominal pain is a potentially life-threatening condition that requires a concise and quick workup. Patient history, physical examination and laboratory studies help to establish a working diagnosis. If abdominal Ultrasound is not conclusive, contrast-enhanced Computertomography should be performed. Every patient should be treated aggressively for pain control and fluid substitution independent of the diagnostic workflow. In cases of severe disease, initiation of broad spectrum antibiotic therapy should be considered early...
March 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28328884/aggression-in-group-housed-laboratory-mice-why-can-t-we-solve-the-problem
#2
Elin M Weber, Jamie Ahloy Dallaire, Brianna N Gaskill, Kathleen R Pritchett-Corning, Joseph P Garner
Group housing is highly important for social animals. However, it can also give rise to aggression, one of the most serious welfare concerns in laboratory mouse husbandry. Severe fighting can lead to pain, injury and even death. In addition, working with animals that are severely socially stressed, wounded or singly-housed as a result of aggression may compromise scientific validity. Some general recommendations on how to minimize aggression exist, but the problem persists. Thus far, studies attempting to find solutions have mainly focused on social dominance and territorial behavior, but many other aspects of routine housing and husbandry that might influence aggressive behavior have been overlooked...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28328825/prevalence-of-symptomatic-hip-knee-and-spine-osteoarthritis-nationwide-health-survey-analysis-of-an-elderly-korean-population
#3
Jung-Ho Park, Jae-Young Hong, Kyungdo Han, Seung-Woo Suh, Si-Young Park, Jae-Hyuk Yang, Seung-Woo Han
Osteoarthritis is prominent among the elderly, with symptoms originating from multiple parts of the body. A cross-sectional study of a nationwide survey was performed to describe the prevalence of and identify factors related to symptomatic hip, knee, and spine osteoarthritis.This cross-sectional study collected data from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V-5; 2010-2012). After excluding ineligible subjects, there were 8976 subjects in this study (3830 males and 5146 females)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328811/treatment-of-great-auricular-neuralgia-with-real-time-ultrasound-guided-great-auricular-nerve-block-a-case-report-and-review-of-the-literature
#4
Younghoon Jeon, Saeyoung Kim
RATIONALE: The great auricular nerve can be damaged by the neck surgery, tumor, and long-time pressure on the neck. But, great auricular neuralgia is very rare condition. It was managed by several medication and landmark-based great auricular nerve block with poor prognosis. PATIENT CONCERNS: A 25-year-old man presented with a pain in the left lateral neck and auricle. DIAGNOSIS: He was diagnosed with great auricular neuralgia. INTERVENTIONS: His pain was not reduced by medication...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328697/the-fear-avoidance-components-scale-facs-responsiveness-to-functional-restoration-treatment-in-a-chronic-musculoskeletal-pain-disorder-cmpd-population
#5
Randy Neblett, Tom G Mayer, Mark J Williams, Sali Asih, Antonio I Cuesta-Vargas, Meredith M Hartzell, Robert J Gatchel
OBJECTIVES: To assess the clinical validity and factor structure of the Fear-Avoidance Components Scale (FACS), a new fear-avoidance (FA) measure. METHODS: In this study, 426 chronic musculoskeletal pain disorder (CMPD) patients were admitted to a functional restoration program (FRP). They were categorized into five FACS severity levels, from Subclinical to Extreme, at admission, and again at discharge. Associations with objective lifting performance and other patient-reported psychosocial measures were determined at admission and discharge, and objective work outcomes for this predominantly disabled cohort, were assessed one-year later...
March 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28328612/complications-after-treatment-of-head-and-neck-venous-malformations-with-sodium-tetradecyl-sulfate-foam
#6
Giacomo Colletti, Alberto Deganello, Alessandro Bardazzi, Raul Mattassi, Pietro Dalmonte, Luca Gazzabin, Francesco Stillo
PURPOSE: The aim of this study was to evaluate complications in patients with head and neck venous malformations (VMs) treated with foam sclerotherapy using sodium tetradecyl sulfate (STS). METHODS: The authors retrospectively evaluated the complications, pain. and degree of satisfaction in 69 consecutive patients affected by cervicofacial VM managed with STS using the Tessari method in a single institution. RESULTS: The average number of procedures for each patient was 2...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28328595/hemorrhage-and-infarction-of-the-conjunctiva-and-orbit-in-essential-thrombocythemia
#7
Jaehoon Na, Soo Youn Choi, Sehyun Baek, Hwa Lee
An 82-year-old woman who had a history of essential thrombocythemia presented with ocular pain, bleeding, and decreased visual acuity of the left eye. Orbital computed tomography revealed a relatively well-defined homogenous mass-like lesion in the left subconjunctival and intraconal space. Conjunctival biopsy showed acute inflammation with necrosis, vascular ectasia with thrombosis and hemorrhage. After the treatment with hydroxyurea and anagrelide, her symptom and lesion were markedly improved. Hematologic disorders like essential thrombocythemia should be considered in patients with severe spontaneous bleeding around the eye...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28328578/sustained-improvements-in-pain-mood-function-and-opioid-use-post-interdisciplinary-pain-rehabilitation-in-patients-weaned-from-high-and-low-dose-chronic-opioid-therapy
#8
Kelly L Huffman, Taylor E Rush, Youran Fan, Giries W Sweis, Brinder Vij, Edward C Covington, Judith Scheman, Manu Mathews
Increased prescribing of opioids for chronic non cancer pain is associated with significant social costs, including overdose and addiction. In this context, there is interest in interdisciplinary chronic pain rehabilitation programs (ICPRP) focusing on self-management and minimizing opioid use. This study examined outcomes of patients weaned from opioids in an ICPRP from 2007-2012. Participants included 413 patients on high dose (HD) chronic opioid therapy (COT; >100mg), 528 on low dose (LD) COT and 516 not on opioids (NO)...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28328573/activity-rhythms-and-clinical-correlates-in-fibromyalgia
#9
Ariel B Neikrug, Gary Donaldson, Eli Iacob, Sam L Williams, Christopher A Hamilton, Akiko Okifuji
The primary aim of this study was to evaluate activity rhythms in fibromyalgia syndrome (FMS) and their association with FMS-related symptoms. We hypothesized that stronger and more consistent activity rhythms would be associated with reduced symptom severity and presentation in FMS. 292 patients with FMS (Mean age = 45.1±11.1; 272 females) provided a 7-day actigraphy recording and responses to questionnaires addressing degree of pain, fatigue, mood, and physical impairment. Using a simple cosine model, we extracted Amplitude (activity range), Phi (time at maximum), Mesor (mean activity), and their variabilities (across days) from each participant's actigraphy...
March 21, 2017: Pain
https://www.readbyqxmd.com/read/28328011/when-emotional-pain-becomes-physical-adverse-childhood-experiences-pain-and-the-role-of-mood-and-anxiety-disorders
#10
Natalie J Sachs-Ericsson, Julia L Sheffler, Ian H Stanley, Jennifer R Piazza, Kristopher J Preacher
OBJECTIVE: We examined the association between retrospective reports of adverse childhood experiences (ACEs) and painful medical conditions. We also examined the mediating and moderating roles of mood and anxiety disorders in the ACEs-painful medical conditions relationship. METHOD: Ten-year longitudinal data were obtained from the National Comorbidity Surveys (NCS-1, NCS-2; N = 5001). The NCS-1 obtained reports of ACEs, current health conditions, current pain severity, and mood and anxiety disorders...
March 22, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28327442/immune-cells-and-mediators-involved-in-the-inflammatory-responses-induced-by-a-p-i-metalloprotease-and-a-phospholipase-a2-from-bothrops-atrox-venom
#11
Danilo L Menaldo, Carolina P Bernardes, Karina F Zoccal, Anna L Jacob-Ferreira, Tássia R Costa, Maria P F M Del Lama, Rose M Z G Naal, Fabiani G Frantz, Lúcia H Faccioli, Suely V Sampaio
Bothrops envenomations can promote severe inflammatory responses by inducing edema, pain, leukocyte recruitment and release of chemical mediators by local cells. In the present study, two toxins from Bothrops atrox venom (the P-I metalloprotease Batroxase and the acidic phospholipase A2 BatroxPLA2) were evaluated in relation to their inflammatory effects induced in vivo and in vitro, mainly focusing on the participation of different immune cells and inflammatory mediators. Both toxins mainly promoted acute inflammatory responses with significant recruitment of neutrophils in the early hours (1-4h) after administration into the peritoneal cavity of C57BL/6 mice, and increased infiltration of mononuclear cells especially after 24h...
March 16, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28327419/concomitant-unilateral-post-traumatic-leg-and-foot-compartment-syndrome-in-a-5-years-old-child-case-report
#12
Aissam Elmhiregh, Adel El Feghih, Khaled Faraj
BACKGROUND: Compartment syndrome is one of the most serious orthopedic emergencies [4]. It is usually anticipated and looked at in every single orthopedic case. Early recognition and management of those cases are quite important in order to avoid the devastating consequences of such condition. CASE SUMMARY: This is a case report of a 5 years old child with concomitant unilateral leg and foot compartment syndrome after a roll over trauma. The patient was presented with significant leg and foot swelling, severe pain and absent distal pulses...
February 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28327414/posttraumatic-symptom-profiles-among-adult-survivors-of-childhood-sexual-abuse-a-longitudinal-study
#13
Iris M Steine, Dagfinn Winje, Jens Christoffer Skogen, John H Krystal, Anne Marita Milde, Bjørn Bjorvatn, Inger Hilde Nordhus, Janne Grønli, Ståle Pallesen
In the present study, our aim was to examine longitudinal posttraumatic stress symptom (PTSS) trajectories in a Norwegian sample of adults who had experienced sexual abuse during childhood, and to identify predictors of PTSS-trajectory belongingness. The sample consisted of 138 adult survivors of childhood sexual abuse (96.4% women, mean age=42.9years, mean age at the first abuse=5.9 years), recruited from support centers for sexual abuse survivors. The majority (78.3%) reported penetrative abuse, and a large proportion of the sample reported that the perpetrator was a biological parent (38...
March 16, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28327184/catestatin-vasostatin-cortisol-and-pain-assessments-in-dogs-suffering-from-traumatic-bone-fractures
#14
Thanikul Srithunyarat, Ragnvi Hagman, Odd V Höglund, Mats Stridsberg, Ulf Olsson, Jeanette Hanson, Chalermkwan Nonthakotr, Anne-Sofie Lagerstedt, Ann Pettersson
BACKGROUND: Traumatic bone fractures cause moderate to severe pain, which needs to be minimized for optimal recovery and animal welfare, illustrating the need for reliable objective pain biomarkers for use in a clinical setting. The objectives of this study were to investigate catestatin (CST) and vasostatin (VS) concentrations as two new potential biomarkers, and cortisol concentrations, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF), and visual analog scale (VAS) in dogs suffering from traumatic bone fractures before and after morphine administration in comparison with healthy dogs...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28327114/study-protocol-for-a-randomized-controlled-trial-comparing-clinical-and-radiological-results-after-three-different-posterior-decompression-techniques-for-lumbar-spinal-stenosis-the-spinal-stenosis-trial-sst-part-of-the-nordsten-study
#15
Erland Hermansen, Ivar Magne Austevoll, Ulla Kristina Romild, Frode Rekeland, Tore Solberg, Kjersti Storheim, Oliver Grundnes, Jørn Aaen, Jens Ivar Brox, Christian Hellum, Kari Indrekvam
BACKGROUND: There are several posterior decompression techniques for lumbar spinal stenosis (LSS). There is a trend towards performing less invasive surgical procedures, but no multicentre randomized controlled trials have evaluated the relative efficacy of these techniques at short and long-term. METHOD/DESIGN: A multicentre randomized controlled trial [the Spinal Stenosis Trial (SST) (part of the NORDSTEN study)] including 465 patients aged 18-80 years with neurogenic claudication or radiating pain and MRI findings indicating lumbar spinal stenosis without spondylolisthesis is performed to compare three posterior decompression techniques: unilateral laminotomy with crossover, bilateral laminotomy and spinous process osteotomy...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28327082/out-of-hours-care-in-germany-high-utilization-by-adult-patients-with-minor-ailments
#16
R Leutgeb, P Engeser, S Berger, J Szecsenyi, G Laux
BACKGROUND: Family practitioners (FPs) who work in Out-Of-Hours Care (OOHC) - especially in rural areas - complain about high workload related to low urgency and potentially unnecessary patient presentations with minor ailments. The aim of this study was to describe Reasons for Encounter (RFEs) in primary OOHC taken into account the doctor's perspective in the context of high workload without knowing patients' motives for visiting an OOHC-centre. METHODS: Within this descriptive study, OOHC data from 2012 were evaluated from a German statutory health insurance company in the federal state of Baden-Wuerttemberg...
March 21, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28326948/rare-presentation-of-intrathecal-morphine-withdrawal-psychosis
#17
Rohit Aiyer, Vivek Jain, Anurag Bhatia, Boris Mekinulov, Semih Gungor
We report a case of a 57-year-old male patient with intrathecal morphine pump failure who presented with psychosis as part of a clinical presentation of opioid withdrawal. The patient was being treated for chronic back pain with an intrathecal morphine pump for several years. The patient spontaneously started to experience psychotic symptoms which included disorganized thinking, delusional thoughts, paranoia, auditory and visual hallucinations. Upon interrogation of intrathecal pump, it was found not to be functioning, thereby not delivering intrathecal morphine...
February 28, 2017: Pain Management
https://www.readbyqxmd.com/read/28326931/overexpression-of-suppressor-of-cytokine-signaling-3-in-dorsal-root-ganglion-attenuates-cancer-induced-pain-in-rats
#18
Jinrong Wei, Meng Li, Dieyu Wang, Hongyan Zhu, Xiangpeng Kong, Shusheng Wang, You-Lang Zhou, Zhong Ju, Guang-Yin Xu, Guo-Qin Jiang
Background Cancer-induced pain (CIP) is one of the most severe types of chronic pain with which clinical treatment remains challenging and the involved mechanisms are largely unknown. Suppressor of cytokine signaling 3 (SOCS3) is an important intracellular protein and provides a classical negative feedback loop, thus involving in a wide variety of processes including inflammation and nociception. However, the role of SOCS3 pathway in CIP is poorly understood. The present study was designed to investigate the role of SOCS3 in dorsal root ganglion (DRG) in the development of CIP...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326926/potential-protein-biomarkers-for-burning-mouth-syndrome-discovered-by-quantitative-proteomics
#19
Eoon Hye Ji, Cynthia Diep, Tong Liu, Hong Li, Robert Merrill, Diana Messadi, Shen Hu
Burning mouth syndrome (BMS) is a chronic pain disorder characterized by severe burning sensation in normal looking oral mucosa. Diagnosis of BMS remains to be a challenge to oral healthcare professionals because the method for definite diagnosis is still uncertain. In this study, a quantitative saliva proteomic analysis was performed in order to identify target proteins in BMS patients' saliva that may be used as biomarkers for simple, non-invasive detection of the disease. By using isobaric tags for relative and absolute quantitation labeling and liquid chromatography-tandem mass spectrometry to quantify 1130 saliva proteins between BMS patients and healthy control subjects, we found that 50 proteins were significantly changed in the BMS patients when compared to the healthy control subjects ( p ≤ 0...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28326850/multimodal-analgesia-in-moderate-to-severe-pain-a-role-for-a-new-fixed-combination-of-dexketoprofen-and-tramadol
#20
Giustino Varrassi, Magdi Hanna, Giorgos Macheras, Antonio Montero, Antonio Montes Perez, Winfried Meissner, Serge Perrot, Carmelo Scarpignato
Untreated and undertreated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of efficacy and/or safety concerns. Another limitation of single-agent analgesia is that, in general, pain is due to multiple causes. Combining drugs from different classes, with different and complementary mechanism(s) of action, provides a better opportunity for effective analgesia at reduced doses of individual agents...
March 22, 2017: Current Medical Research and Opinion
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