Read by QxMD icon Read


Oneka T Cummings, Jeffrey R Enders, Gregory L McIntire, R Backer, A Poklis
Poklis and Backer published a survey of the concentrations of fentanyl and norfentanyl that could be expected in urine from patients using Duragesic(®), a transdermal fentanyl patch. That study employed a relatively small number of patient data points and analysis by Gas Chromatography/Mass Spectrometry. This work examines a larger population of patient positives for fentanyl and norfentanyl to determine whether more than a decade later the original report remains accurate in predicting the range and median levels of fentanyl and norfentanyl concentrations physicians can expect to see from their patients...
October 2016: Journal of Analytical Toxicology
Anushree Herwadkar, Neha Singh, Carter Anderson, Andrew Korey, William Fowler, Ajay K Banga
PURPOSE: The objective of this work was to identify deactivation agents and develop a disposal system for unused/ residual/ expired medications. METHODS: Deactivation agents screened included oxidizing agent-sodium percarbonate, hydrolysis agent- sodium carbonate and adsorbants- zeolite and activated carbon. Deactivation studies using these agents were performed on four active pharmaceutical agents (APIs) including ketoprofen, dexamethasone sodium phosphate, metformin hydrochloride and amoxicillin trihydrate...
January 2016: Pharmaceutical Research
Cameron K M W Schauer, James A D Shand, Thomas M Reynolds
Fentanyl is a potent opioid analgesic used in the treatment of pain. Transdermal fentanyl patches are now widely utilized as an acceptable and efficacious method of medication delivery. Unfortunately, the potential for their abuse is well recognized. Previous case reports have documented deaths after intravenous (IV) misuse of fentanyl which had been extracted from Duragesic (liquid reservoir type) patches. We present a case of IV fentanyl abuse after the extraction from a Mylan (matrix type) patch. This method of abuse has not previously been described in the literature...
November 2015: Basic & Clinical Pharmacology & Toxicology
Thepakorn Sathitkarnmanee, Sirirat Tribuddharat, Kanlayarat Noiphitak, Sunchai Theerapongpakdee, Sasiwimon Pongjanyakul, Yuwadee Huntula, Maneerat Thananun
PURPOSE: To assess the efficacy of a transdermal fentanyl patch (TFP) (50 μg/hour) applied 10-12 hours before surgery versus placebo for postoperative pain control of total knee arthroplasty (TKA). MATERIALS AND METHODS: We enrolled 40 patients undergoing elective TKA under spinal anesthesia using isobaric or hyperbaric bupivacaine. Subjects were randomized to receive a TFP (Duragesic(®) 50 μg/hour) or placebo patch applied with a self-adhesive to the anterior chest wall 10-12 hours before spinal anesthesia...
2014: Journal of Pain Research
Sudeep R Bista, Michael Lobb, Alison Haywood, Janet Hardy, Angela Tapuni, Ross Norris
Monitoring fentanyl concentration in saliva and plasma may be useful in pharmacokinetic/pharmacodynamic studies. Salivettes(®) have been used widely for collecting saliva samples. However due to its lipophilicity, fentanyl adsorbs to the cotton dental bud (CDB) used in this device. Furthermore, due to dry mouth being a common adverse effect seen in patients treated with opioids, obtaining enough saliva for analysis is often a challenge. Hence, a simple simultaneous method to quantify fentanyl and its metabolite in both human plasma and saliva was developed and validated...
June 1, 2014: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
A V Solenkova, A A Imaev, A A Bondarenko, A Iu Lubnin
The survey studies analgesic effect of postoperative therapy in two groups of patients with spinal disorders. In the first group the standard scheme with NSAID on demand was used. In the second group transdermal therapeutic system Duragesic Matrix was applied. The pain level (by pain level scale) as well as psychological status and IL-6 rate (a reliable indicator of surgical trauma and pain severity) were assessed before and after surgery. Transdermal therapeutic system Duragesic Matrix applied before surgery appeared to be more effective for analgesic therapy than standard scheme with NSAID on demand...
July 2011: Anesteziologiia i Reanimatologiia
Frank LoVecchio, Lee Ramos
No abstract text is available yet for this article.
January 2011: American Journal of Emergency Medicine
Leonardo Kapural, Katarina Sakic, Kaylea Boutwell
OBJECTIVES: Discogenic pain in the thoracic region is a challenging condition characterized by refractoriness to conservative treatments. Unlike lumbar discogenic pain there is a lack of effective surgical options. Reported here is the treatment of thoracic discogenic pain in 3 patients using a new minimally invasive procedure named intradiscal biacuplasty. METHODS: Clinical case series in outpatient clinical setting. The procedure is detailed and step-by-step fluoroscopic imaging is presented...
May 2010: Clinical Journal of Pain
Seyed Mojtaba Taghizadeh, Arezou Soroushnia, Fatemeh Mohamadnia
In this study, some single-layer and double-layer transdermal drug delivery systems (TDDSs) with different functional and non-functional acrylic pressure-sensitive adhesives (PSAs) were prepared. For this purpose, fentanyl as a drug was used. The effects of PSAs type, single-layer and double-layer TDDSs on skin permeation and in vitro drug release from devices were evaluated using a hydrodynamically well-characterized Chien permeation system fitted with excised rat abdominal skin. The adhesion properties of devices such as peel strength and tack values were obtained as well...
March 2010: AAPS PharmSciTech
Suneela Prodduturi, Nakissa Sadrieh, Anna M Wokovich, William H Doub, Benjamin J Westenberger, Lucinda Buhse
The United States Food and Drug Administration (FDA) has received numerous reports of serious adverse events, including death, in patients using fentanyl transdermal systems (FTS). To gain a better understanding of these problems, the current research focuses on the in vitro characterization of fentanyl reservoir (Duragesic) and matrix (Mylan) systems with respect to drug release and skin permeation under conditions of elevated temperature and compromised skin. In addition, different synthetic membrane barriers were evaluated to identify the one that best simulates fentanyl skin transport, and thus may be useful as a model for these systems in future studies...
May 2010: Journal of Pharmaceutical Sciences
Wei Dong Wu, Yi Wang, Yong Ming Fang, Hai Yan Zhou
BACKGROUND: There is much variation in the response of both individuals and different ethnic populations to opioids, with genetic differences being responsible for interindividual variation. The micro-opioid receptor single nucleotide polymorphism (rs number 1799971) at nucleotide position 118 (OPRM1 118A>G) affects the analgesic response to opioids. OBJECTIVE: This study aimed to investigate the association between the OPRM1 118A>G polymorphism and the effects of fentanyl-induced analgesia, respiratory depression, and anesthetic recovery responses in a population of Han Chinese patients...
2009: Molecular Diagnosis & Therapy
Carmen Walter, Lisa Felden, Jörn Lötsch
With the increasing appearance of transdermal fentanyl generics since 2004 when patent protection of the reference Duragesic expired, opportunities to switch between different generics have arisen. Transdermal fentanyl is subject to bioequivalence regulation because only approximately 92% of the dose is absorbed as a result of the need to maintain a diffusion gradient from plaster to skin. Considering the high potency of fentanyl and the potential dangerous adverse effects of full mu opioid receptor agonists, we assessed evidence suggesting a revision of the confidence limits of bioequivalence of 80-125%...
2009: Clinical Pharmacokinetics
(no author information available yet)
Transdermal fentanyl (Duragesic, and others) offers a convenient delivery system for patients with chronic pain but it has some drawbacks. One is that exposing the patch to heat, either from an external source, increased exertion or possibly high fever, could increase release of the drug, which might lead to an overdose and fatal respiratory depression. A recent article in the NY Times about this problem may have aroused the concerns of some patients using the patches.
August 10, 2009: Medical Letter on Drugs and Therapeutics
Olaf J Biedrzycki, David Bevan, Sebastian Lucas
Introduced into clinical practice in the 1960s, the analgesic fentanyl is 100 times more potent than morphine. Various methods of administration exist including the transdermal Duragesic patch system, widely used in chronic pain and palliative care settings. Numerous, often imaginative methods of abuse of fentanyl patches have been reported; the majority of fatal fentanyl overdose cases resulting from deliberate abuse or suicide. We describe the accidental overdose of a young black male with sickle cell/beta-thalassemia who had been using the Duragesic system for almost 2 years...
June 2009: American Journal of Forensic Medicine and Pathology
Vincent Minville, Vincent Lubrano, Vincent Bounes, Antoine Pianezza, Anna Rabinowitz, Claude Gris, Kamran Samii, Olivier Fourcade
STUDY OBJECTIVE: To determine whether a new transdermal fentanyl patch (TFP) is a good choice for the postoperative pain management of patients undergoing primary total hip arthroplasty compared with patient-controlled analgesia (PCA). DESIGN: Randomized, prospective study. SETTING: University hospital. PATIENTS: 30 patients undergoing primary total hip arthroplasty. INTERVENTIONS: Patients received either a TFP (group T; Duragesic 50 microg/h, matrix fentanyl patch, Janssen-Cilag) applied approximately 10 hours before induction of general anesthesia and PCA programmed in the postanesthesia care unit (PACU), or PCA programmed in the PACU (group P)...
June 2008: Journal of Clinical Anesthesia
Anna M Wokovich, Stanley A Brown, Meiyu Shen, William H Doub, Bing Cai, Nakissa Sadrieh, Mei Ling Chen, Stella Machado, Lucinda F Buhse
In a previous study on peel adhesion for medical tapes, it was shown that a stainless steel (SS) substrate better discriminated among medical tapes than a high-density polyethylene (HDPE) substrate. The objective of this study was to determine if a SS substrate would also better distinguish among transdermal drug delivery systems (TDDSs). Five TDDSs (Vivelle Dot, Climara, Catapres-TTS, Duragesic, and Mylan Fentanyl) were evaluated on three different substrates (SS, HDPE, and human cadaver skin). All measurements were made using a dwell time of approximately 3 min, a peel angle of 90 degrees, and a peel speed of 300 mm/min...
January 2009: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Michelle Firestone, Brian Goldman, Benedikt Fischer
Prescription opioids (POs) are playing an increasingly central role in street drug use and related harms in North America. One distinct PO substance of interest is Fentanyl (Duragesic), a potent opioid analgesic designed for transdermal time-release application. Studies from Europe and North America have documented the sizeable overdose and mortality burden associated with the non-medical use of this drug. This study explores practices and risk dynamics associated with Fentanyl abuse, also considering public health implications...
January 2009: International Journal on Drug Policy
Karen L Woodall, Teri L Martin, Barry A McLellan
In order to increase the understanding regarding the oral abuse and potential toxicity of fentanyl patches seven cases were identified over a 3-year period where fentanyl, either alone or in combination with other factors, contributed to death following the oral abuse of Duragesic patches. The decedents comprised three females and four males with ages ranging from 20 to 51 years. Postmortem blood fentanyl concentrations were determined in all cases and ranged from 7 to 97 ng/mL. Two deaths were classified as a fentanyl overdose, three deaths were classified as a fentanyl and ethanol overdose, one death was considered a mixed drug intoxication and the remaining death was determined to be a combination of fentanyl and medical causes...
January 2008: Journal of Forensic Sciences
Habib Bagheri, Ali Es-haghi, Faezeh Khalilian, Mohammad-Reza Rouini
A head-space solid-phase microextraction (HS-SPME) method coupled to GC-MS was developed to extract fentanyl from human plasma. The protein binding was reduced by acidification and, eventually, the sample was deproteinized with trichloroacetic acid. The parameters influencing adsorption (extraction time, temperature, pH and salt addition) and desorption (desorption time and temperature) of the analyte on the fibre were investigated and validated for method development. The developed method proved to be rapid, simple, easy and inexpensive and offers high sensitivity and reproducibility...
April 11, 2007: Journal of Pharmaceutical and Biomedical Analysis
Scott Worrich, Gregg Schuler, Piotr K Janicki
OBJECTIVE: Transdermal fentanyl is a commonly used analgesic for the treatment of severe chronic pain. Recent investigations have shown the presence of mu-opioid receptors in the skin and opioid analgesic efficacy with alternative routes of administration of narcotics. This placebo-controlled, double-blind prospective study assessed whether transdermal fentanyl administration produces local peripheral opioid analgesia at the site of application. DESIGN: Baseline pain threshold and supra-threshold pain intensity assessments were measured using Quantitative Sensory Testing in 12 healthy volunteers...
January 2007: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"