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https://www.readbyqxmd.com/read/29240674/evaluation-of-the-cytotoxicity-and-genotoxicity-of-flavonolignans-in-different-cellular-models
#1
Michal Bijak, Ewelina Synowiec, Przemyslaw Sitarek, Tomasz Sliwiński, Joanna Saluk-Bijak
Flavonolignans are the main components of silymarin, which represents 1.5-3% of the dry fruit weight of Milk thistle (Silybum marianum L. Gaernt.). In ancient Greece and Romania, physicians and herbalists used the Silybum marianum to treat a range of liver diseases. Besides their hepatoprotective action, silymarin flavonolignans have many other healthy properties, such as anti-platelet and anti-inflammatory actions. The aim of this study was to evaluate the toxic effect of flavonolignans on blood platelets, peripheral blood mononuclear cells (PBMCs) and human lung cancer cell line-A549-using different molecular techniques...
December 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29240511/meeting-the-nutritional-needs-of-premature-babies-their-future-is-in-our-hands
#2
Arieh Riskin
The goals of early nutrition in preterm infants are to provide all the necessary vital nutrients, achieve extra-uterine growth rates similar to fetuses of the same gestational age, and support functional neurodevelopmental outcomes that are comparable to those of infants born at term. It is vital to provide nutrition that will maximally support brain growth and development, but over-feeding with accelerated growth, fat accumulation and long-term metabolic consequences should also be avoided. Because the morbidity associated with prematurity increases nutritional and energetic demands, the basic approach is of providing early intensive nutrition...
December 2, 2017: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29239412/screening-natural-libraries-of-human-milk-oligosaccharides-against-lectins-using-car-esi-ms
#3
Amr El-Hawiet, Yajie Chen, Km Shams-Ud-Doha, Elena N Kitova, Pavel I Kitov, Lars Bode, Naim Hage, Franco H Falcone, John S Klassen
Human milk oligosaccharides (HMOs) afford many health benefits to breast-fed infants, such as protection against infection and regulation of the immune system, through the formation of non-covalent interactions with protein receptors. However, the molecular details of these interactions are poorly understood. Here, we describe the application of catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) for screening natural libraries of HMOs against lectins. The HMOs in the libraries were first identified based on molecular weights (MWs), ion mobility separation arrival times (IMS-ATs) and collision-induced dissociation (CID) fingerprints of their deprotonated anions...
December 14, 2017: Analyst
https://www.readbyqxmd.com/read/29238458/bacteriocinogenic-potential-and-virulence-traits-of-enterococcus-faecium-and-e-faecalis-isolated-from-human-milk
#4
Soodabeh Khalkhali, Naheed Mojgani
Background and Objectives: Human milk is a continuous supply of Lactic Acid bacteria (LAB), including enterococci with probiotic potentials. The aim of this study was to analyze two Enterococcus species, isolated from human milk for their probiotic potential, bacteriocin producing ability and virulence traits. Materials and Methods: Enterococcus faecium TA0033 and E. faecalis TA102 were tested for acid and bile tolerance, survival in simulated gastric and intestinal conditions...
August 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29238342/breastfeeding-behaviors-and-the-innate-immune-system-of-human-milk-working-together-to-protect-infants-against-inflammation-hiv-1-and-other-infections
#5
REVIEW
Bethany M Henrick, Xiao-Dan Yao, Laila Nasser, Ava Roozrogousheh, Kenneth L Rosenthal
The majority of infants' breastfeeding from their HIV-infected mothers do not acquire HIV-1 infection despite exposure to cell-free virus and cell-associated virus in HIV-infected breast milk. Paradoxically, exclusive breastfeeding regardless of the HIV status of the mother has led to a significant decrease in mother-to-child transmission (MTCT) compared with non-exclusive breastfeeding. Although it remains unclear how these HIV-exposed infants remain uninfected despite repeated and prolonged exposure to HIV-1, the low rate of transmission is suggestive of a multitude of protective, short-lived bioactive innate immune factors in breast milk...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29235902/storage-of-unfed-and-leftover-mothers-own-milk
#6
April D Fogleman, Ting Meng, Jason Osborne, Maryanne T Perrin, Frances Jones, Jonathan C Allen
OBJECTIVE: The objective was to examine the bacteriological and immunological properties of freshly expressed, previously frozen, and leftover mothers' own milk during storage. MATERIALS AND METHODS: In the first of two pilot studies, 12 mother-infant dyads participated. The milk studied included freshly expressed unfed and freshly expressed leftover milk. Milk samples were stored at 24°C, 4°C, or -20°C. In the second pilot study, 11 mother-infant dyads participated...
December 13, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29233626/icp-ms-measurement-of-toxic-and-essential-elements-in-human-breast-milk-a-comparison-of-alkali-dilution-and-acid-digestion-sample-preparation-methods
#7
Michael Levi, Camilla Hjelm, Florencia Harari, Marie Vahter
No abstract text is available yet for this article.
December 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29232646/determination-of-uv-filters-in-human-breast-milk-using-turbulent-flow-chromatography-and-babies-daily-intake-estimation
#8
Daniel Molins-Delgado, María Del Mar Olmo-Campos, Gemma Valeta-Juan, Vanessa Pleguezuelos-Hernández, Damià Barceló, M Silvia Díaz-Cruz
UV filters (UV-Fs) are a group of hormonally active chemical compounds used to protect against the deleterious effects of UVA and UVB solar radiation, which are currently present in most consumer goods (personal care products, plastics, fabrics, paints, etc). Last years the concern about these emerging contaminants has been on the rise, and increasing efforts are being taken in order to properly asses the hazard that the exposure to these compounds in the early stages of life may pose. In this study, a new method for the analysis of 11 UV-Fs residues in human breast milk samples has been developed...
December 9, 2017: Environmental Research
https://www.readbyqxmd.com/read/29232282/selected-food-herb-drug-interactions-mechanisms-and-clinical-relevance
#9
Cecilia N Amadi, Amaka A Mgbahurike
BACKGROUND: Food/Herb-drug interactions have become a major problem in health care. These interactions can lead to loss of therapeutic efficacy or toxic effects of drugs. AREAS OF UNCERTAINTY: To probe the clinical relevance of such interactions, the impact of food/herb intake on the clinical effects of drug administration has to be evaluated. Failure to identify and efficiently manage food-drug interactions can lead to serious consequences. A comprehensive knowledge of the mechanisms that underpin variability in disposition will help optimize therapy...
November 22, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29230345/new-trends-for-the-evaluation-of-heat-treatments-of-milk
#10
REVIEW
Mena Ritota, Maria Gabriella Di Costanzo, Maria Mattera, Pamela Manzi
Milk is generally very rich in nutrients and this may lead it to be an ideal growth environment for many microorganisms, including pathogens, so effective measurements aiming to ensure total microbiological safety of milk and minimize the risk to human health are needed. Milk heat treatments are the most common practices carried out to inhibit the microbial growth; therefore it is necessary to have analytical procedures that are more and more up-to-date and capable of detecting the effectiveness of the heat treatments...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29225754/methicillin-resistance-and-selective-genetic-determinants-of-staphylococcus-aureus-isolates-with-bovine-mastitis-milk-origin
#11
Zohreh Ahangari, Masoud Ghorbanpoor, Masoud Reza Seifiabad Shapouri, Darioush Gharibi, Kiarash Ghazvini
Background and Objectives: Staphylococcus aureus is one of the major causes of bovine mastitis, which can be transmitted from animals to humans. Methicillin-resistant S. aureus (MRSA) isolates are more attentive and if not treated promptly, they can cause death. The aim of this study was to determine the prevalence of methicillin resistance and frequency of selected virulence factors of S. aureus isolates with bovine mastitis milk origin in Ahvaz, southwest of Iran. Materials and Methods: During a two-year period (2014-2015), 75 S...
June 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29223822/exposure-to-acrylamide-induces-cardiac-developmental-toxicity-in-zebrafish-during-cardiogenesis
#12
Mengmeng Huang, Jingjing Jiao, Jun Wang, Zhidan Xia, Yu Zhang
Acrylamide (AA), an environmental pollutant, has been linked to neurotoxicity, genotoxicity and carcinogenicity. AA is widely used to synthesize polymers for industrial applications, is widely found in Western-style carbohydrate-rich foods and cigarette smoke, and can also be detected in human umbilical cord blood and breast milk. This is the first study that demonstrated the cardiac developmental toxicity of AA in zebrafish embryos. Post-fertilization exposure to AA caused a clearly deficient cardiovascular system with a shrunken heart and abortive morphogenesis and function...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29223775/association-between-prenatal-bisphenol-a-and-phthalate-exposures-and-fetal-metabolic-related-biomarkers-the-hokkaido-study-on-environment-and-children-s-health
#13
Machiko Minatoya, Atsuko Araki, Chihiro Miyashita, Yu Ait Bamai, Sachiko Itoh, Jun Yamamoto, Yu Onoda, Kazuki Ogasawara, Toru Matsumura, Reiko Kishi
Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to bisphenol A and phthalates...
December 7, 2017: Environmental Research
https://www.readbyqxmd.com/read/29222900/comparisons-of-proteomic-profiles-of-whey-protein-between-donor-human-milk-collected-earlier-than-3-months-and-6-months-after-delivery
#14
Won-Ho Hahn, Joon-Hwan Song, Jong-Bok Seo, Jung Eun Lee, Jeong-Sang Lee, Seunghyun Song, Joohyun Lee, Nam Mi Kang
BACKGROUND AND OBJECTIVES: Human milk has nutritional, protective, and developmental advantages for premature infants. However, proteomic information of low abundant protein of donor milk is insufficient. The purpose of this study is to analyze and compare the proteome of low abundant protein of donor milk obtained at different postpartum ages other than the colostrum. METHODS AND STUDY DESIGN: Donor breast milk from 12 healthy mothers was collected 15 days, 2 months and 6 months after delivery and stored by medically approved methods...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222098/longitudinal-study-of-the-occurrence-persistence-and-contamination-routes-of-listeria-monocytogenes-genotypes-on-three-finnish-dairy-cattle-farms
#15
Hanna Castro, Anniina Jaakkonen, Marjaana Hakkinen, Hannu Korkeala, Miia Lindström
The molecular epidemiology of Listeria monocytogenes was investigated in a longitudinal study of three Finnish dairy farms during 2013 -- 2016. Totals of 186 bulk tank milk (BTM) samples, 224 milk filter socks (MFS), and 1702 samples of the barn environment were analyzed and isolates of L. monocytogenes were genotyped using pulsed-field gel electrophoresis. L. monocytogenes occurred throughout the year in all sample types, and the prevalence in MFS increased significantly during the indoor season. L. monocytogenes was more prevalent in MFS (29%) than in BTM samples (13%)...
December 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29221760/substrate-specificity-and-transfucosylation-activity-of-gh29-%C3%AE-l-fucosidases-for-enzymatic-production-of-human-milk-oligosaccharides
#16
Birgitte Zeuner, Jan Muschiol, Jesper Holck, Mateusz Lezyk, Mattias Raae Gedde, Carsten Jers, Jørn Dalgaard Mikkelsen, Anne S Meyer
Human milk oligosaccharides (HMOs) constitute a unique family of bioactive lactose-based molecules present in human breast milk. HMOs are of major importance for infant health and development but also virtually absent from bovine milk used for infant formula. Among the HMOs, the fucosylated species are the most abundant. Transfucosylation catalysed by retaining α-L-fucosidases is a new route for manufacturing biomimetic HMOs. Seven α-L-fucosidases from glycosyl hydrolase family 29 were expressed, characterized in terms of substrate specificity and thermal stability, and shown to be able to catalyse transfucosylation...
December 5, 2017: New Biotechnology
https://www.readbyqxmd.com/read/29221672/cost-and-use-of-pasteurized-donor-human-milk-at-a-children-s-hospital
#17
Diane L Spatz, Abbey C Robinson, Elizabeth B Froh
OBJECTIVE: To determine the cost and use of pasteurized donor human milk (PDHM) at a children's hospital with a strong human milk culture. DESIGN: A retrospective descriptive cohort study. SETTING: A children's hospital in the northeastern region of the United States. PARTICIPANTS: Infants (N = 281) younger than 1 year of age at the time of hospitalization who received PDHM between January 2011 and November 2014. Infants older than 1 year of age at the time of hospitalization were excluded from the study sample...
December 5, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29221571/micrornas-milk-s-epigenetic-regulators
#18
REVIEW
Bodo C Melnik, Gerd Schmitz
Our perception of milk has changed from a "simple food" to a highly sophisticated maternal-neonatal nutrient and communication system orchestrating early programming of the infant. Milk miRNAs delivered by exosomes and milk fat globules derived from mammary gland epithelial cells play a key role in this process. Exosomes resist the harsh intestinal environment, are taken up by intestinal cells via endocytosis, and reach the systemic circulation of the milk recipient. The most abundant miRNA found in exosomes and milk fat globules of human and cow's milk, miRNA-148a, attenuates the expression of DNA methyltransferase 1, which is critically involved in epigenetic regulation...
August 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29221567/iodine-in-dairy-milk-sources-concentrations-and-importance-to-human-health
#19
REVIEW
Olivia L van der Reijden, Michael B Zimmermann, Valeria Galetti
Milk and dairy products are major iodine sources in industrialized countries. However, consumption of milk and dairy, as well as their iodine concentrations, vary widely, making them an unpredictable iodine source. Milk iodine concentrations in industrialized countries range from 33 to 534 μg/L and are influenced by the iodine intake of dairy cows, goitrogen intake, milk yield, season, teat dipping with iodine-containing disinfectants, type of farming and processing. We estimate milk and dairy contribute ≈13-64% of the recommended daily iodine intake based on country-specific food intake data...
August 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29219785/higher-absorption-of-vitamin-c-from-food-than-from-supplements-by-breastfeeding-mothers-at-early-stages-of-lactation
#20
Dorota Martysiak-Żurowska, Maciej Zagierski, Ewa Woś-Wasilewska, Agnieszka Szlagatys-Sidorkiewicz
The aim of the present study was to determine the effect of vitamin C supply in the diet of lactating women on vitamin C concentrations in human milk (n = 97) sampled at different stages of lactation. Vitamin C levels were measured by liquid chromatography. Dietary intake of vitamin C was determined based on 3-day food dairies kept by breastfeeding mothers. Maternal dietary intakes of vitamin C from natural sources on lactation day 90 (n = 18) were significantly higher than on lactation days 15 (n = 42) and 30 (n = 37)...
December 8, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
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