keyword
https://read.qxmd.com/read/38537035/polyphenol-analysis-in-human-milk-by-a-rapid-cost-effective-and-accurate-micromethod-translational-development
#1
JOURNAL ARTICLE
Mariela Valentina Cortez, Ana Veronica Scotta, Agustín Ramiro Miranda, Elio Andrés Soria
OBJECTIVE: To develop a rapid method for analysing polyphenols, which are potentially active antioxidants against neonatal oxidative stress, from small human milk (HM) volumes. METHODS: Acid and alkaline extractions were compared using two dyes: Folin-Ciocalteu and Fast Blue BB. Linearity, sensitivity, recovery percentage, polyphenol content, precision, and stability were assessed in 14 HM samples and compared using the Kruskal-Wallis H test (p<0.05). The best technique was applied to 284 HM samples to determine their polyphenolic content and its association with maternal diet by multifactorial linear regression...
2024: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/38535968/east-meets-west-effect-of-acupuncture-on-lactation-and-maternal-quality-of-life
#2
JOURNAL ARTICLE
Cindy Baker-Fox, Jennifer Hayakawa, Ruth McCarty, Michelle Hart, John Schomberg, Smriti Shamapant, Christine Bixby
Objective: To evaluate the impact of acupuncture as part of a traditional Chinese medicine (TCM) treatment plan on lactation and maternal well-being in pump-dependent mothers of hospitalized neonates during the first 30 days after delivery. Study Design: This single-center study was conducted in a level IV regional neonatal intensive care unit with access to integrative health services. Sixty-six mothers were prospectively enrolled in two nonparallel groups: (1) Standard lactation support and (2) standard lactation support augmented with acupuncture...
March 27, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38535907/antibiotic-residues-in-uk-foods-exploring-the-exposure-pathways-and-associated-health-risks
#3
JOURNAL ARTICLE
Jegak Seo, Frank Kloprogge, Andrew M Smith, Kersti Karu, Lena Ciric
While the use of antibiotics has been reported as extensive in the rearing of agricultural animals, insufficient information is available on the antibiotic residues in animal products and the adverse impact that consistent low-level exposure to antibiotics might have on the human body and its microbiome. The aim of this study was to estimate the antibiotic concentrations that humans are exposed to via their diet using the concentration of antibiotics in animal food products and water and an online survey on dietary intake...
February 24, 2024: Toxics
https://read.qxmd.com/read/38535887/multiple-drug-resistant-shiga-toxin-producing-e-coli-in-raw-milk-of-dairy-bovine
#4
JOURNAL ARTICLE
Safir Ullah, Saeed Ul Hassan Khan, Muhammad Jamil Khan, Baharullah Khattak, Fozia Fozia, Ijaz Ahmad, Mohammad Ahmad Wadaan, Muhammad Farooq Khan, Almohannad Baabbad, Sagar M Goyal
INTRODUCTION: Raw milk may contain pathogenic microorganisms harmful to humans, e.g., multidrug-resistant Escherichia coli non-O157:H7, which can cause severe colitis, hemolytic uremia, and meningitis in children. No studies are available on the prevalence of Shiga toxin-producing E. coli (STEC O157:H7) in sick or healthy dairy animals in the Khyber Pakhtunkhwa Province of Pakistan. AIM: This study aimed to isolate, characterize, and detect antibiotic resistance in STEC non-O157:H7 from unpasteurized milk of dairy bovines in this province...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535793/the-toxicokinetics-excretion-patterns-and-milk-transmission-of-ochratoxin-a-in-lactating-sows
#5
JOURNAL ARTICLE
Qiufeng Zhu, Honglei Qu, Ruifen Kang, Yunduo Zheng, Qiuying Guo, Shimeng Huang, Lihong Zhao, Qiugang Ma
Ochratoxin A (OTA), a mycotoxin commonly found in feedstuffs, is known for its detrimental effects on the kidneys and liver, posing significant health risks to animals and humans. This study investigated the toxicokinetics, excretion patterns, and milk transmission of Ochratoxin A (OTA) in lactating sows. The sows were administered a single oral dose of 500 μg/kg BW (body weight), followed by the systematic sampling of plasma, feces, urine, and milk. Plasma samples were collected at 0, 5, 15, and 30 min, and 1, 2, 3, 6, 9, 12, 24, 48, 72, 88, 96, and 120 h post administration...
March 1, 2024: Toxins
https://read.qxmd.com/read/38534686/antimicrobial-properties-of-colostrum-and-milk
#6
REVIEW
Furkan Eker, Emir Akdaşçi, Hatice Duman, Yalçın Mert Yalçıntaş, Ahmet Alperen Canbolat, Arda Erkan Kalkan, Sercan Karav, Dunja Šamec
The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed a cautious attitude towards chemical preservatives. Colostrum and milk are excellent sources of antibacterial components that help to strengthen the immunity of the offspring and accelerate the maturation of the immune system. It is possible to study these important defenses of milk and colostrum, such as lactoferrin, lysozyme, immunoglobulins, oligosaccharides, etc...
March 11, 2024: Antibiotics
https://read.qxmd.com/read/38533917/preventing-breast-milk-hiv-transmission-using-broadly-neutralizing-monoclonal-antibodies-one-size-does-not-fit-all
#7
JOURNAL ARTICLE
Philippe Van de Perre, Gabriella Scarlatti, Penny L Moore, Jean-Pierre Molès, Nicolas Nagot, Thorkild Tylleskär, Glenda Gray, Ameena Goga
No abstract text is available yet for this article.
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533729/a-novel-fluorescent-probe-with-a-large-stokes-shift-for-colorimetric-and-selective-detection-of-cysteine-in-water-milk-cucumber-pear-and-tomato
#8
JOURNAL ARTICLE
Lin Luo, Ranran Guo, Lianjie Wang, Xixi Song, Zhao Wang, Junliang Wu
Cysteine is an important amino acid that is related to human health and food safety. How to effectively detect Cys in food has received widespread attention. Compared with other methods, fluorescent probes have the advantages of simple operation, high sensitivity, and good selectivity. Therefore, a selective fluorescence probe 2 for Cys in food was designed and synthesized. Probe 2 employed the acrylate group as a thiol-recognition site for Cys, which endowed probe 2 with better selectivity for Cys over Hcy and GSH...
March 27, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38533463/association-between-maternal-stress-and-premature-milk-cortisol-milk-iga-and-infant-health-a-cohort-study
#9
JOURNAL ARTICLE
Casey B Rosen-Carole, Susan Greenman, Hongyue Wang, Sharvari Sonawane, Ravi Misra, Tom O'Connor, Kirsi Järvinen, Carl D'Angio, Bridget E Young
BACKGROUND: Maternal stress is pervasive in the neonatal intensive care unit (NICU). Maternal stress is associated with changes in human milk (HM) immunomodulatory agents, which may impact neonatal health. We sought to determine the association between maternal stress, HM immunoglobulin A (IgA) and cortisol, and to assess how these milk components correlate with infant immune and neurodevelopmental outcomes. We then compared how these associations persist over time. METHODS: The study design involved a cohort study of exclusively breastfeeding mothers and their singleton moderately preterm (28-34 weeks) infants admitted to the NICU...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38530632/level-of-aflatoxins-in-dairy-feeds-poultry-feeds-and-feed-ingredients-produced-by-feed-factories-in-addis-ababa-ethiopia
#10
JOURNAL ARTICLE
Genet Mengesha, Tilahun Bekele, Henok Ashagrie, Ashagrie Zewdu Woldegiorgis
Aflatoxins are one of the major factors that affect the quality and safety of feeds. They can be transferred into livestock through contaminated feed and then onto humans via animal sources of food such as milk, meat, and eggs. The objective of this study was to detect and quantify the level of aflatoxins (B1, B2, G1, G2, and total aflatoxin) in dairy feeds, poultry (layer and broiler) feeds, and feed ingredients produced in Addis Ababa. A total of 42 feeds and feed ingredients consisting of dairy feeds (n = 5), poultry broiler feeds (n = 6), layer feeds (n = 6), and feed ingredients (n = 25) were collected from feed factories in the city and analyzed in fresh weigh basis...
March 26, 2024: Mycotoxin Research
https://read.qxmd.com/read/38530054/microbiota-from-human-infants-consuming-secretors-or-non-secretors-mothers-milk-impacts-the-gut-and-immune-system-in-mice
#11
JOURNAL ARTICLE
Manoj Gurung, Brent Thomas Schlegel, Dhivyaa Rajasundaram, Renee Fox, Lars Bode, Tianming Yao, Stephen R Lindemann, Tanya LeRoith, Quentin D Read, Christy Simecka, Laura Carroll, Aline Andres, Laxmi Yeruva
UNLABELLED: Maternal secretor status is one of the determinants of human milk oligosaccharides (HMOs) composition, which, in turn, influences the gut microbiota composition of infants. To understand if this change in gut microbiota impacts immune cell composition, intestinal morphology, and gene expression, 21-day-old germ-free C57BL/6 mice were transplanted with fecal microbiota from infants whose mothers were either secretors (SMM) or non-secretors (NSM) or from infants consuming dairy-based formula (MFM)...
March 26, 2024: MSystems
https://read.qxmd.com/read/38529915/no-measurable-transfer-of-oxytocin-receptor-agonist-merotocin-detected-in-human-breast-milk
#12
JOURNAL ARTICLE
Teresa Baker, Ulrike Lorch, Yu Bagger, Carina Holmqvist, Daniël M Jonker, Lorien E Urban, Thomas W Hale
Objective: The study aimed to assess the transfer of merotocin from systemic circulation to breast milk in early postpartum women and women with established lactation. Methods: This was a two-part, multicenter, open-label, parallel-group study. Merotocin was administered as a single 90-minute intravenous (iv) infusion mimicking the intranasal pharmacokinetic profile. In Part A, 12 early postpartum women received doses of either 4 μg ( n = 6) or 16 μg ( n = 6) of merotocin within 4 days of delivery...
March 26, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38529622/rifampin-and-silymarin-mediated-pharmacokinetic-interactions-of-exogenous-and-endogenous-substrates-in-a-transgenic-oatp1b-mouse-model
#13
JOURNAL ARTICLE
Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Tyler N Graf, Nicholas H Oberlies, John D Clarke
Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3, encoded by the SLCO gene family of the solute carrier superfamily, are involved in the disposition of many exogenous and endogenous compounds. Preclinical rodent models help assess risks of pharmacokinetic interactions, but interspecies differences in transporter orthologs and expression limit direct clinical translation. An OATP1B transgenic mouse model comprising a rodent Slco1a/1b gene cluster knockout and human SLCO1B1 and SLCO1B3 gene insertions provides a potential physiologically relevant preclinical tool to predict pharmacokinetic interactions...
March 26, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38529196/human-milk-microbiome-associations-with-maternal-diet-and-infant-growth
#14
JOURNAL ARTICLE
Tamara T Ajeeb, Emmanuel Gonzalez, Noel W Solomons, Marieke Vossenaar, Kristine G Koski
INTRODUCTION: Ingestion of human milk (HM) is identified as a significant factor associated with early infant gut microbial colonization, which has been associated with infant health and development. Maternal diet has been associated with the HM microbiome (HMM). However, a few studies have explored the associations among maternal diet, HMM, and infant growth during the first 6 months of lactation. METHODS: For this cross-sectional study, Mam -Mayan mother-infant dyads ( n  = 64) were recruited from 8 rural communities in the Western Highlands of Guatemala at two stages of lactation: early (6-46 days postpartum, n  = 29) or late (109-184 days postpartum, n  = 35)...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38528146/phosphatidylserine-exposing-extracellular-vesicles-in-body-fluids-are-an-innate-defence-against-apoptotic-mimicry-viral-pathogens
#15
JOURNAL ARTICLE
Rüdiger Groß, Hanna Reßin, Pascal von Maltitz, Dan Albers, Laura Schneider, Hanna Bley, Markus Hoffmann, Mirko Cortese, Dhanu Gupta, Miriam Deniz, Jae-Yeon Choi, Jenny Jansen, Christian Preußer, Kai Seehafer, Stefan Pöhlmann, Dennis R Voelker, Christine Goffinet, Elke Pogge-von Strandmann, Uwe Bunz, Ralf Bartenschlager, Samir El Andaloussi, Konstantin M J Sparrer, Eva Herker, Stephan Becker, Frank Kirchhoff, Jan Münch, Janis A Müller
Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, or semen. We previously identified that extracellular vesicles (EVs) in semen and saliva inhibit Zika virus infection. However, the antiviral spectrum and underlying mechanism remained unclear. Here we applied lipidomics and flow cytometry to show that these EVs expose phosphatidylserine (PS). By blocking PS receptors, targeted by Zika virus in the process of apoptotic mimicry, they interfere with viral attachment and entry...
March 25, 2024: Nature Microbiology
https://read.qxmd.com/read/38526563/scabies-infection-while-expressing-human-milk-for-critically-ill-infants-is-it-safe
#16
JOURNAL ARTICLE
Rachel Chan, Adrienne E Hoyt-Austin
Background: Scabies infections of the breast in lactating individuals are not well described, especially how maternal infection can impact human milk feeding of hospitalized infants in the intensive care setting. Methods: This case report presents a critically ill female infant with a complex surgical history whose mother had an active scabies infection around the breast postpartum and wished to provide expressed human milk. Results: In this case report, human milk was recommended despite maternal scabies infection...
March 22, 2024: Breastfeeding Medicine
https://read.qxmd.com/read/38526507/an-electrochemical-biosensor-for-staphylococcus-aureus-detection-based-on-a-multilevel-surface-3d-micro-nanostructure
#17
JOURNAL ARTICLE
Caiyun Wang, Rui Yang, Guangtong Wang, Shaoqin Liu
Detection of pathogens is one of the key concerns for hospitals, the food industry, water suppliers, or other environmental engineering practices because pathogens can cause a wide range of infectious risks. Staphylococcus aureus ( S. aureus ) is one of the most common pathogens that are hazardous to human health and its existence is an important index to the safety of food, environmental sanitation, or medical products. In this study, we prepared an electrode with designed surface multilevel 3D micro/nano protrusions for facile and efficient S...
March 25, 2024: Analyst
https://read.qxmd.com/read/38524439/machine-learning-models-for-prediction-of-xenobiotic-chemicals-with-high-propensity-to-transfer-into-human-milk
#18
JOURNAL ARTICLE
Sudharsan Vijayaraghavan, Akshaya Lakshminarayanan, Naman Bhargava, Janani Ravichandran, R P Vivek-Ananth, Areejit Samal
Breast milk serves as a vital source of essential nutrients for infants. However, human milk contamination via the transfer of environmental chemicals from maternal exposome is a significant concern for infant health. The milk to plasma concentration (M/P) ratio is a critical metric that quantifies the extent to which these chemicals transfer from maternal plasma into breast milk, impacting infant exposure. Machine learning-based predictive toxicology models can be valuable in predicting chemicals with a high propensity to transfer into human milk...
March 19, 2024: ACS Omega
https://read.qxmd.com/read/38523376/comparison-of-prematurity-related-outcomes-and-complications-in-very-low-birth-weight-vlbw-neonates-fed-with-mother-s-own-milk-versus-donor-milk-a-comparative-study
#19
JOURNAL ARTICLE
Majid Karoobi, Amir Azimi, Hamed Zarei, Maryam Saboute, Nasrin Khalessi, Zahra Vahedi
BACKGROUND: When mother`s own milk (MOM) is unavailable or insufficient, donor milk (DM) from a human milk bank serves as an alternative feeding option. Our study sought to investigate and compare the outcomes and complications of very low birth weight (VLBW) preterm infants who receive MOM versus DM. METHODS: In this retrospective cohort study conducted between 2018 and 2022, we compared 70 VLBW preterm infants exclusively fed with DM to 70 randomly selected counterparts fed with MOM...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38523056/yb-tcpp-metal-organic-framework-as-fluorescence-sensor-for-detecting-tetracycline-in-milk
#20
JOURNAL ARTICLE
Ximan Zhang, Yun Zhang, Lina Zhao
Developing effective means for detecting contamination in milk during production, processing, and storage is both important and challenging. Tetracycline (TC), due to its use in treating animal infections, is among the most prevalent organic pollutants in milk, posing potential and significant threats to human health. However, efficient and in situ monitoring of TC remains lacking. Nevertheless, we have successfully developed a highly sensitive and selective fluorescence method for detecting TC in milk using a metal-organic framework material made from Yb-TCPP (ytterbium-tetra(4-carboxyphenyl)porphyrin)...
March 2024: Luminescence: the Journal of Biological and Chemical Luminescence
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