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Ethy Dorrepaal, Kathleen Thomaes, Adriaan W Hoogendoorn, Dick J Veltman, Nel Draijer, Anton J L M van Balkom
INTRODUCTION: Effective first-line treatments for posttraumatic stress disorder (PTSD) are well established, but their generalizability to child abuse (CA)-related Complex PTSD is largely unknown. METHOD: A quantitative review of the literature was performed, identifying seven studies, with treatments specifically targeting CA-related PTSD or Complex PTSD, which were meta-analyzed, including variables such as effect size, drop-out, recovery, and improvement rates...
2014: European Journal of Psychotraumatology
Fen-Fen Zhang, Yu-Qin Zhao, Jian-Ping Fan, Li-Gang Liu, Rui-Wen Li, Wen-Bin Shen, Ya Ding
The chemical structure studies on an important related substance of voglibose have been carried out using NMR spectroscopy and single crystal X-ray crystallography. For the structure identification study, hydrochloride monohydrate of this compound was isolated and purified. Its molecular structure was characterized and analyzed using 1D (1H NMR, 13C NMR, and DEPT) and 2D (1H,1H-COSY, HSQC, HMBC, TOCSY, and ROESY) NMR spectra. The signal crystal structure was detected by X-ray crystallography. All results indicated this related substance of voglibose was C17H27NO7·HCl·H2O, 5,6-dideoxy-4-benzyl-5-{[2-hydroxy-1-(hydroxymethyl)ethy]amino}-1-C-(hydroxymethyl)-D-epi-inositol hydrochloride monohydrate...
January 30, 2015: Carbohydrate Research
Pilar Pais, Massimo D'Amato
INTRODUCTION: A subcategory of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) is characterized by accumulation of fat accompanied by inflammatory infiltration and hepatocellular damage. The active complex of milk thistle is a lipophilic extract from its seeds, comprising three isomers, collectively known as silymarin. Silymarin has demonstrated antioxidant, anti-inflammatory, and antifibrotic properties, and has been extensively studied in the treatment of liver diseases...
December 2014: Drugs in R&D
Ying Song, Lijie Wu, Chunmei Lu, Na Li, Mingzhu Hu, Ziming Wang
An easy, quick, and green method, microwave-assisted liquid-liquid microextraction based on solidification of ionic liquid, was first developed and applied to the extraction of sulfonamides in environmental water samples. 1-Ethy-3-methylimidazolium hexafluorophosphate, which is a solid-state ionic liquid at room temperature, was used as extraction solvent in the present method. After microwave irradiation for 90 s, the solid-state ionic liquid was melted into liquid phase and used to finish the extraction of the analytes...
December 2014: Journal of Separation Science
Sylvain Prigent, Guillaume Collet, Simon M Dittami, Ludovic Delage, Floriane Ethis de Corny, Olivier Dameron, Damien Eveillard, Sven Thiele, Jeanne Cambefort, Catherine Boyen, Anne Siegel, Thierry Tonon
Brown algae (stramenopiles) are key players in intertidal ecosystems, and represent a source of biomass with several industrial applications. Ectocarpus siliculosus is a model to study the biology of these organisms. Its genome has been sequenced and a number of post-genomic tools have been implemented. Based on this knowledge, we report the reconstruction and analysis of a genome-scale metabolic network for E. siliculosus, EctoGEM ( This atlas of metabolic pathways consists of 1866 reactions and 2020 metabolites, and its construction was performed by means of an integrative computational approach for identifying metabolic pathways, gap filling and manual refinement...
October 2014: Plant Journal: for Cell and Molecular Biology
Mohd Rashid, Asif Husain, Mohammad Shaharyar, Mohd Sarafroz
The design and synthesis of substituted 1-(1-ethy-1H-benzimidazol-2-yl) ethanone (3a-f) and substituted 1-(2-bromoethyl)-2- (1-hydrazinylidene or ethylidene)-1H-benzimidazole (3g-j) have been successfully achieved under microwave irradiation with an aim for finding promising anticancer agents. Among the synthetic compounds, those with potential activity were selected and evaluated in-vitro for anticancer activity at the National Cancer Institute (NCI), USA, against 60 cancer cell lines from nine types of human cancer...
2014: Anti-cancer Agents in Medicinal Chemistry
Ethy Dorrepaal, Kathleen Thomaes, Johannes H Smit, Dick J Veltman, Adriaan W Hoogendoorn, Anton J L M van Balkom, Nel Draijer
No abstract text is available yet for this article.
2014: European Journal of Psychotraumatology
Kathleen Thomaes, Ethy Dorrepaal, Nel Draijer, Elise P Jansma, Dick J Veltman, Anton J van Balkom
While there is evidence of clinical improvement of posttraumatic stress disorder (PTSD) with treatment, its neural underpinnings are insufficiently clear. Moreover, it is unknown whether similar neurophysiological changes occur in PTSD specifically after child abuse, given its enduring nature and the developmental vulnerability of the brain during childhood. We systematically reviewed PTSD treatment effect studies on structural and functional brain changes from PubMed, EMBASE, PsycINFO, PILOTS and the Cochrane Library...
March 2014: Journal of Psychiatric Research
Xun Feng, Weiwei Gao, Shenghai Zhou, Hongyan Shi, Hao Huang, Wenbo Song
Tunable polymerization of ionic liquid on the surfaces of multi-walled carbon nanotubes (MWCNTs) was achieved by a mild thermal-initiation-free radical reaction of 3-ethy-1-vinylimidazolium tetrafluoroborate in the presence of MWCNTs. Successful modification of polymeric ionic liquid (PIL) on MWCNTs surfaces (PIL-MWCNTs) was demonstrated by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and X-ray photoelectron spectroscopy...
December 17, 2013: Analytica Chimica Acta
S Ritter, W H Hauthal, G Maurer
Partition coefficients PO,w ((i)) describing the distribution of a solute i onto coexisting phases of 1-octanol and water are needed in a large variety of applications. They can be measured directly by HPLC as long as log PO,w ((i))≧ 3.5. For more hydrophobic substances, several experimental procedures have been proposed in the literature. The reliability of those methods is questionable. Therefore, in the present work, PO,w ((i)) is determined experimentally by three HPLC methods using reversed-phase HPLC [1]...
November 1995: Environmental Science and Pollution Research International
Ethy Dorrepaal, Kathleen Thomaes, Johannes H Smit, Dick J Veltman, Adriaan W Hoogendoorn, Anton J L M van Balkom, Nel Draijer
BACKGROUND: In the empirical and clinical literature, complex posttraumatic stress disorder (PTSD) and personality disorders (PDs) are suggested to be predictive of drop-out or reduced treatment effectiveness in trauma-focused PTSD treatment. OBJECTIVE: In this study, we aimed to investigate if personality characteristics would predict treatment compliance and effectiveness in stabilizing complex PTSD treatment. METHOD: In a randomized controlled trial on a 20-week stabilizing group cognitive behavioral treatment (CBT) for child-abuse-related complex PTSD, we included 71 patients of whom 38 were randomized to a psycho-educational and cognitive behavioral stabilizing group treatment...
2013: European Journal of Psychotraumatology
Tin Aung, Ethi Paw, Nyo Me Aye, Willi McFarland
Cross-sectional surveys of female sex workers using time-location sampling in seven cities of Myanmar gauged coverage of HIV prevention programs. HIV testing in last year ranged from 28 to 73 %; attending peer educator talks ranged from 15 to 50 %; exposure to media campaigns varied by city and materials (e.g., lower for TV and radio, higher for printed materials). Consistent condom use with clients in last week was high (88-99 %) across all cities. The largest city, Yangon, lagged behind others in coverage of most programs...
January 2014: AIDS and Behavior
Marie Laure Hauhouot-Attoungbré, Eric Sagou Yayo, Jean-Louis Konan, Fatoumata Koné, Eugénie Siara, Dagui Monnet
Metabolic syndrome is a particular state of morbidity characterized by the association of several factors contributing to the increase in the cardiovascular risk. This constellation of factors associates the glucose intolerance and its corollary the hyperglycemia, the overweight, the hypertriglyceridemia, the fall of the HDL-cholesterol and arterial hypertension. In Africa, it is difficult to evaluate in the actual prevalence of the metabolic syndrome. The present study aims was to determine the prediction and prevalence of the metabolic syndrome in a group of nurse--lactating mothers--in Abidjan (Ivory Coast), who were submitted at a particularly rich food lipids...
March 2013: Annales de Biologie Clinique
Rishikesh Mankidy, Steve Wiseman, Hong Ma, John P Giesy
Esters of phthalic acid are chemical agents used to improve the plasticity of industrial polymers. Their ubiquitous use in multiple commercial products results in extensive exposure to humans and the environment. This study investigated cytotoxicity, endocrine disruption, effects mediated via AhR, lipid peroxidation and effects on expression of enzymes of xenobiotic metabolism caused by di-(2-ethy hexyl) phthalate (DEHP), diethyl phthalate (DEP), dibutyl phthalate (DBP) and benzyl butyl phthalate (BBP) in developing fish embryos...
February 13, 2013: Toxicology Letters
Ethy Dorrepaal, Kathleen Thomaes, Johannes H Smit, Anton J L M van Balkom, Dick J Veltman, Adriaan W Hoogendoorn, Nel Draijer
BACKGROUND: Evidence-based treatments for complex posttraumatic stress disorder (PTSD) related to childhood abuse are scarce. This is the first randomized controlled trial to test the efficacy of psycho-educational and cognitive behavioural stabilizing group treatment in terms of both PTSD and complex PTSD symptom severity. METHODS: Seventy-one patients with complex PTSD and severe comorbidity (e.g., 74% axis II comorbidity) were randomly assigned to either a 20-week group treatment in addition to treatment as usual or to treatment as usual only...
2012: Psychotherapy and Psychosomatics
Ethy Dorrepaal, Kathleen Thomaes, Johannes H Smit, Adriaan Hoogendoorn, Dick J Veltman, Anton J L M van Balkom, Nel Draijer
OBJECTIVE: Complex posttraumatic stress disorder (PTSD) involves a variety of personality disturbances presumed to result from repeated interpersonal trauma such as child abuse. As Complex PTSD patients are a heterogeneous population, we searched for clinically relevant personality-based subtypes. METHOD: This study used a cluster analysis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), Axis II features within a sample of 71 female outpatients with systematically assessed child abuse-related Complex PTSD...
2012: Journal of Trauma & Dissociation
Kathleen Thomaes, Ethy Dorrepaal, Nel Draijer, Michiel B de Ruiter, Bernet M Elzinga, Zsuzsika Sjoerds, Anton J van Balkom, Johannes H Smit, Dick J Veltman
Post-traumatic stress disorder (PTSD) is associated with impaired memory performance coupled with functional changes in brain areas involved in declarative memory and emotion regulation. It is not yet clear how symptom severity and comorbidity affect neurocognitive functioning in PTSD. We performed a functional magnetic resonance imaging (fMRI) study with an emotional declarative memory task in 28 Complex PTSD patients with comorbid depressive and personality disorders, and 21 healthy non-trauma-exposed controls...
February 2013: Social Cognitive and Affective Neuroscience
Kathleen Thomaes, Ethy Dorrepaal, Nel Draijer, Michiel B de Ruiter, Anton J van Balkom, Johannes H Smit, Dick J Veltman
OBJECTIVE: Classic posttraumatic stress disorder (PTSD) is associated with smaller hippocampus, amygdala, and anterior cingulate cortex (ACC) volumes. We investigated whether child abuse-related complex PTSD--a severe form of PTSD with affect dysregulation and high comorbidity--showed similar brain volume reductions. METHOD: We used voxel-based morphometry to measure gray matter concentrations in referred outpatients with child abuse-related complex PTSD (n = 31) compared to matched healthy nontraumatized controls (n = 28)...
December 2010: Journal of Clinical Psychiatry
Ethy Dorrepaal, Kathleen Thomaes, Johannes H Smit, Anton J L M van Balkom, Richard van Dyck, Dick J Veltman, Nel Draijer
OBJECTIVE: This study tests a Stabilizing Group Treatment protocol, designed for the management of the long-term sequelae of child abuse, that is, Complex Posttraumatic Stress Disorder (Complex PTSD). Evidence-based treatment for this subgroup of PTSD patients is largely lacking. This stabilizing treatment aims at improving Complex PTSD using psycho-education and cognitive behavioral interventions. METHOD: Thirty-six patients with a history of childhood abuse, Complex PTSD and severe co-morbidity entered a 20-week treatment with pre-, post-, and follow-up-assessments...
April 2010: Child Abuse & Neglect
U Bernabucci, N Lacetera, P P Danieli, P Bani, A Nardone, B Ronchi
Effects of different periods of exposure to hot environments on rumen function, diet digestibility and digesta passage rate were studied in four adult not-pregnant Sardinian ewes housed in a climatic chamber. The ewes were kept in individual metabolic cages. The trial lasted 83 days; 17 days were spent under thermal comfort conditions (TC) [temperature-humidity index (THI) = 65.0 +/- 2.0], followed by 49 days under elevated THI (ETHI: THI = 82.0 +/- 2.5) and 17 days under thermal comfort (TC; THI = 65.0 +/- 1...
September 2009: International Journal of Biometeorology
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