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https://www.readbyqxmd.com/read/29142540/clinical-audit-of-dengue-related-deaths-in-2011-mayo-hospital-lahore-pakistan
#1
Somia Iqtadar, Nabeel Akbar, Mehreen Mehmood, Sajid Abaidullah
Background and Objective: Dengue infection has evolved into an epidemic during last few years in Pakistan and has been associated with poor outcomes. Literature with respect to mortality risk factors in Dengue infection is not sufficient. This compelled us to conduct this study to find out major contributory factors to death in patients with dengue viral infection at one of Asia's ancient hospital setting with an aim to recognize complications at earliest and improve case management in future...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29141766/molecular-detection-and-characterization-of-wolbachia-pipientis-from-culex-quinquefasciatus-collected-from-lahore-pakistan
#2
Muhammad Sajjad Sarwar, Nusrat Jahan, Fatima Shahbaz
The gram-negative, pleomorphic endosymbiont Wolbachia is known to infect a large number of insects and other arthropods naturally. This bacterium modifies the host biology, mainly causing reproductive alterations including feminization, death of male, parthenogenesis, and importantly cytoplasmic incompatibility. Wolbachia-induced cytoplasmic incompatibility results in nonviable offspring and vector population suppression. In addition, this bacterium rapidly spreads and propagates within the host population...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29111183/asymptomatic-dengue-infection-in-adults-of-major-cities-of-pakistan
#3
Ibrar Rafique, Muhammad Arif Nadeem Saqib, Muhammad Arif Munir, Huma Qureshi, Ijaz-Ul-Haq Taseer, Rizwan Iqbal, Waqaruddin Ahmed, Tasleem Akhtar, Rizwanullah
OBJECTIVE: To determine the asymptomatic dengue infection in adults of Pakistani population. METHODS: This study was conducted in five major cities (Islamabad, Karachi, Lahore, Multan, and Peshawar) of Pakistan. A total of 5 230 adults aged 18 years and above without a history of dengue fever at any point in their life were enrolled from participating laboratories. Those who were confirmed for dengue previously were excluded. Of the total, 62.6% (n = 3 276) were male with an average age of 34...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29103928/surveillance-of-intensity-level-and-geographical-spreading-of-dengue-outbreak-among-males-and-females-in-punjab-pakistan-a-case-study-of-2011
#4
Shahbaz Ahmad, Muhammad Asif, Ramzan Talib, Muhammad Adeel, Muhammad Yasir, Muhammad Hasanain Chaudary
BACKGROUND: Dengue fever is viral disease which spreads due to the bite of the Aedes aegypti mosquito. In recent years, it has affected around 40% population of the world. Its endemic flow has led to a large disease burden, in terms of human and financial resources. METHODS: Geographical Information Systems (GIS) are normally used to develop epidemiological thematic maps. This study explores the patterns and hotspots, associated with the catastrophic outbreak of dengue, in Punjab, in 2011...
November 2, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29098145/emerging-and-reemerging-diseases-in-the-world-health-organization-who-eastern-mediterranean-region-progress-challenges-and-who-initiatives
#5
REVIEW
Evans Buliva, Mohamed Elhakim, Nhu Nguyen Tran Minh, Amgad Elkholy, Peter Mala, Abdinasir Abubakar, Sk Md Mamunur Rahman Malik
The Eastern Mediterranean Region (EMR) of the World Health Organization (WHO) continues to be a hotspot for emerging and reemerging infectious diseases and the need to prevent, detect, and respond to any infectious diseases that pose a threat to global health security remains a priority. Many risk factors contribute in the emergence and rapid spread of epidemic diseases in the Region including acute and protracted humanitarian emergencies, resulting in fragile health systems, increased population mobility, rapid urbanization, climate change, weak surveillance and limited laboratory diagnostic capacity, and increased human-animal interaction...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29097641/computer-aided-analysis-of-phytochemicals-as-potential-dengue-virus-inhibitors-based-on-molecular-docking-admet-and-dft-studies
#6
Iqra Qaddir, Nouman Rasool, Waqar Hussain, Sajid Mahmood
BACKGROUND & OBJECTIVES: Dengue fever, caused by dengue virus (DENV), has become a serious threat to human lives. Phytochemicals are known to have great potential to eradicate viral, bacterial and fungal-borne diseases in human beings. This study was aimed at in silico drug development against nonstructural protein 4B (NS4B) of dengue virus 4 (DENV4). METHODS: A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in human for long-time...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29076677/pattern-of-presentation-among-adults-hospitalized-with-dengue-disease
#7
Abdul Rauf, Nasir Hussain Shah Kazmi, Haidar Zaman, Saima Gillani, Tariq Shah, Faizan Malik, Shoaib Ismaeel
BACKGROUND: Dengue is a mosquito born viral infection that has rapidly spread in the world particularly in Southeast Asia. The aim of this hospital based study was to see the demographic, clinical and laboratory characteristics in adults with dengue infection in Hazara region of Northern Pakistan. METHODS: This is a descriptive study. Clinical, laboratory and demographic information were collected from adult patients with suspected dengue infection (n=100) and then managed in one of medical units of tertiary care hospital in Abbottabad from August to October 2015...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29026852/effect-of-climatic-conditions-and-water-bodies-on-population-dynamics-of-the-dengue-vector-aedes-aegypti-diptera-culicidae
#8
Shabab Nasir, Farhat Jabeen, Sadia Abbas, Iram Nasir, Mustapha Debboun
BACKGROUND: The population of mosquitoes is mainly influenced by the biotic and abiotic factors. Although Aedes aegypti was reported until 1960's in the Punjab, Pakistan, the population has increased dramatically since 2009 and caused severe epidemics in 2011 due to heavy floods and rains. Thus, this study was carried out to know the effect of biotic and abiotic factors on the population of Aedes aegypti. METHODS: Mosquitoes were collected from fresh, sewage, and rain water ponds, fish ponds, rice fields, tyres, tree holes, and manmade storage containers present in and around residential homes twice during every winter (October-February), summer (March-June) and monsoon season (July-September) from marked rural areas...
March 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28924518/clinical-spectrum-of-chikungunya-in-pakistan
#9
Syeda Naqvi, Shehroz Bashir, Chintan Rupareliya, Abdullah Shams, Pirthvi Raj Giyanwani, Zeeshan Ali, Faiza Qamar, Vijesh Kumar, Vikash Talib
Background Chikungunya fever is a pandemic disease caused by an arthropod-borne chikungunya virus (CHIKV). The virus spreads through mosquitoes. This mosquito induced viral illness is clinically suspected on symptoms from fever and severe polyarthralgia. The recent outbreak of chikungunya was reported in November 2016 in the metropolitan city Karachi, Pakistan. We emphasis on the awareness of the etiology and vector control to prevent serious consequences. Method A total number of 1275 patients were included in this cross-sectional study...
July 6, 2017: Curēus
https://www.readbyqxmd.com/read/28904577/acute-necrotizing-encephalopathy-of-childhood-secondary-to-dengue-infection-a-case-report-from-pakistan
#10
Qalab Abbas, Sidra Kaleem Jafri, Sidra Ishaque, Muhammad T Jamil
Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition mainly affecting children with a distinct clinico-radiologic pattern. Initially thought to be secondary to respiratory viral infections, there have been more insights to the pathogenesis of ANEC including genetics. We present a case of a girl who developed this condition with classical clinico-radiologic findings of ANEC secondary to severe dengue infection and could not survive. We report this case with the aim to raise awareness about this fatal complication of dengue infection as dengue has become a global health-care problem...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28892674/dengue-fever-again-in-pakistan-are-we-going-in-the-right-direction
#11
A Ahmed, M Tanveer, G M Khan, M Imran
No abstract text is available yet for this article.
November 2017: Public Health
https://www.readbyqxmd.com/read/28862033/random-forest-based-evaluation-of-raman-spectroscopy-for-dengue-fever-analysis
#12
Saranjam Khan, Rahat Ullah, Asifullah Khan, Anabia Sohail, Noorul Wahab, Muhammad Bilal, Mushtaq Ahmed
This work presents the evaluation of Raman spectroscopy using random forest (RF) for the analysis of dengue fever in the infected human sera. A total of 100 dengue suspected blood samples, collected from Holy Family Hospital, Rawalpindi, Pakistan, have been used in this study. Out of these samples, 45 were dengue-positive based on immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) tests. For highlighting the spectral differences between normal and infected samples, an effective machine learning system is developed that automatically learns the pattern of the shift in spectrum for the dengue compared to normal cases and thus is able to predict the unknown class based on the known example...
September 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28839300/sero-surveillance-of-dengue-in-the-city-lahore-pakistan
#13
Ejaz Mahmood Ahmad Qureshi, Amtul Bari Tabinda, Seemal Vehra
OBJECTIVE: To conduct sero-surveillance of dengue cases, and to find out the demographic and socio-economic status of dengue patients. METHODS: This community-based, cross-sectional, descriptive study was conducted at the Institute of Public Health, Lahore, Pakistan, from July to December each year in 2011, 2012 and 2013, and comprised patients suspected to have dengue. Blood samples of dengue patients in five randomly selected union councils of the 10 towns of the city were subjected to the dengue test...
August 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28754252/detection-of-selected-arboviral-infections-in-patients-with-history-of-persistent-fever-in-pakistan
#14
Tahir Yaqub, Muhammad Zubair Shabbir, Nadia Mukhtar, Zarfishan Tahir, Tariq Abbas, Ehab Amir, Gabriel Defang
Surveillance is a valuable tool for understanding prevailing and previously undiagnosed infections in a geographic area. We examined 480 archived serum samples from patients with history of persistent fever (>40°C, 60-72h) who were referred to hospitals in Rawalpindi/Islamabad, Lahore, and Faisalabad districts for dengue antibody detection in 2014-15. Each sample was processed for detection of antigens and seroconversion, using real-time polymerase chain reaction and enzyme linked immunosorbent assay, respectively, against dengue haemorrhagic fever (DHF) virus serotypes 1-4, West Nile virus fever (WNVF), Crimean-Congo haemorrhagic fever (CCHF), and Chikungunya virus (CGV)...
December 2017: Acta Tropica
https://www.readbyqxmd.com/read/28719296/analysis-of-dengue-serotype-4-in-sri-lanka-during-the-2012-2013-dengue-epidemic
#15
Anna Uehara, Hasitha Aravinda Tissera, Champica K Bodinayake, Ananda Amarasinghe, Ajith Nagahawatte, L Gayani Tillekeratne, Jie Cui, Megan E Reller, Paba Palihawadana, Sunethra Gunasena, Aruna Dharshan Desilva, Annelies Wilder-Smith, Duane J Gubler, Christopher W Woods, October M Sessions
The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks since the 1960s, but since 1989 epidemics have become progressively larger and associated with more severe disease. The dominant virus in the 2012 epidemic was DENV-1, but DENV-4 infections were also commonly observed. DENV-4 transmission was first documented in Sri Lanka when it was isolated from a traveler in 1978, but has been comparatively uncommon since dengue surveillance began in the early 1980s...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28636447/emerging-viral-infections-in-pakistan-issues-concerns-and-future-prospects
#16
Ali Talha Khalil, Muhammad Ali, Faouzia Tanveer, Muhammad Ovais, Muhammad Idrees, Zabta Khan Shinwari, James E Hollenbeck
Emerging infectious diseases pose a serious threat to public health security; this is especially true in the underdeveloped world because of limited resources to combat them. These emerging pathogens are characterized by a novel mode of pathogenesis and, in some cases, a broad host range. Over the past few decades, Pakistan has suffered a great deal from infectious diseases such as dengue, Crimean-Congo fever, hepatitis, measles, and polio. Changing climate conditions, environmental degradation, global warming, loss of biodiversity, and other ecological determinants have a direct effect on these diseases and result in the emergence and reemergence of infectious entities...
May 2017: Health Security
https://www.readbyqxmd.com/read/28586575/and-yet-one-more-adds-to-the-sorrow
#17
EDITORIAL
Muhammad Zeeshan Haroon, Mohammad Salim Wazir
Chikungunya is one of the vector borne diseases. It is caused by Chikungunya virus, an alpha virus, spread by the bite of female Aedes mosquito. Chikungunya is a non-fatal, self-limiting Dengue like illness which is characterized by high grade fever, headache, skin rash, and prolong debilitating arthralgia mostly affecting peripheral small joints. Treatment is usually supportive for the symptoms which includes antipyretic, analgesics and anti-inflammatory drugs. Current outbreak in Karachi is the first declared outbreak in Pakistan...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28552190/spatial-mapping-of-temporal-risk-to-improve-prevention-measures-a-case-study-of-dengue-epidemic-in-lahore
#18
Sidrah Hafeez, Muhammad Amin, Bilal Ahmed Munir
BACKGROUND: Dengue is identified as serious vector born infectious disease by WHO, threating around 2.5 billion people around the globe. Pakistan is facing dengue epidemic since 1994 but 2010 and 2011 dengue outbreaks were worst. During 2011 dengue outbreak 22,562 cases were reported and 363 died due to this fatal infection in Pakistan. In this study, Lahore District was chosen as it was severely affected in 2011 dengue outbreak with 14,000 reported cases and 300 deaths. There is no vaccine developed yet for the disease control, so only effective early warning, prevention and control measures can reduce the potential disease risk...
June 2017: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/28420913/increasing-usage-of-rapid-diagnostics-for-dengue-virus-detection-in-pakistan
#19
Zahra Hasan, Saher Razzak, Muhammad Farhan, Maryam Rahim, Nazneen Islam, Azra Samreen, Erum Khan
OBJECTIVE: To evaluate the trends in usage of dengue virus diagnostics in Pakistan. METHODS: This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised data for specimens tested for dengue virus from January 2012 to December 2015. Test for dengue virus ribonucleic acid by reverse transcription polymerase chain reaction, dengue virus antigen by immunochromatic assay and for human immunoglobulin M against dengue virus by enzyme-linked immunosorbent assay were reviewed...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28367194/evaluation-of-non-structural-protein-1-ns1-positive-patients-of-2013-dengue-outbreak-in-khyber-pakhtunkhwa-pakistan
#20
Ghosia Lutfullah, Jawad Ahmed, Aftab Khan, Hina Ihsan, Jamshed Ahmad
BACKGROUND & OBJECTIVE: Dengue infection is an arthropod borne disease caused by Dengue virus in humans. Dengue virus infection has more potential to produce severe form of the disease with more severe symptoms. Proper diagnosis of dengue fever is very important for its safe management. The objective of this study was to evaluate the non structural protein-1 (NS1) positive parameter for identification of dengue fever by using ELISA from 2013 dengue outbreak in Khyber Pakhtunkhwa. METHODS: It was a cross sectional study conducted among 384 patients tested for dengue admitted to different hospitals of Khyber Pakhtunkhwa April to December 2013 with symptoms related to classical dengue fever...
January 2017: Pakistan Journal of Medical Sciences Quarterly
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