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dengue pakistan

Ajeet Kumar Gadhwal, B S Ankit, Chitresh Chahar, Pankaj Tantia, P Sirohi, R P Agrawal
OBJECTIVE: Thrombocytopenia in dengue fever is a common and serious complication. However, no specific treatment is available for dengue fever induced thrombocytopenia. In few countries (Pakistan, Malaysia, Sri Lanka and other Asian countries) the leaf extract of Carica papaya has been effectively used for thrombocytopenia. So, the study is planned to access effect of Carica papaya leaf extract on platelet count in dengue fever patients. METHODS: All participants were randomised into two groups, study group and control group; the study group was given papaya leaf extract capsule of 500 mg once daily and routine supportive treatment for consecutive five days...
June 2016: Journal of the Association of Physicians of India
Muhammad Sohail Afzal
In Pakistan which ranked second in terms of hepatitis C virus (HCV) infection, it is highly needed to have an established diagnostic test for antiviral therapy response prediction. Interleukin 28B (IL-28B) genetic testing is widely used throughout the world for interferon based therapy prediction for HCV patients and is quite helpful not only for health care workers but also for the patients. There is a strong relationship between single nucleotide polymorphisms at or near the IL-28B gene and the sustained virological response with pegylated interferon plus ribavirin treatment for chronic hepatitis C...
September 18, 2016: World Journal of Hepatology
Nazish Bostan, Sundus Javed, Nabgha-E-Amen, Syed Ali Musstjab Akber Shah Eqani, Faheem Tahir, Habib Bokhari
Dengue fever is regarded as one of the most prominent emerging arboviral infections in Pakistan since its first epidemic almost 2 decades ago. Interplay between potential vectors, susceptible host, and lax environmental conditions may promote the infection, leading to an epidemic. These factors may indeed have played a major role in the spread of the disease in the country, which was limited to Karachi till 2006. With recent natural disasters such as the earthquake in 2005 and flooding in 2010, 2011 and 2012, numbers of vector-borne diseases and outbreaks including dengue fever are on the rise in Pakistan...
September 6, 2016: Reviews in Medical Virology
Amjad Ali, Habib Ahmad, Muhammad Idrees, Fazli Zahir, Ijaz Ali
BACKGROUND: Dengue virus is circulating in Pakistan since 1994, which causes major and minor outbreaks in many areas of the country. The incidence of dengue in Pakistan in past years mainly restricted to parts of Sindh and Punjab provinces. As such, a severe dengue outbreak appeared in Pakistan in 2011, particularly in Punjab province with Lahore as the most hit city (290 deaths). In 2013, for the first time in the history of Pakistan, dengue outbreak erupted in Swat District, Khyber Pakhtunkhwa, which claimed more than 57 lives...
2016: Virology Journal
Muhammad Zubair, Muhammad Ashraf, Aitezaz Ahsan, Noor-Ul-Ain Nazir, Hina Hanif, Haider Ali Khan
Infections due to Dengue virus are widespread throughout the world. Disease starts with mild flu like sickness to a severe intricate condition which results in the death of the patient. Dengue illness has high morbidity and mortality in Pakistan as well as in other Asian countries. The Review article is a discourse analysis that explores the facts about the history, emergence and impact of dengue in Pakistan and other Asian countries. Data was collected from internet sources, mainly using Science Direct and PubMed...
July 2016: JPMA. the Journal of the Pakistan Medical Association
Nabeel Abdur Rehman, Shankar Kalyanaraman, Talal Ahmad, Fahad Pervaiz, Umar Saif, Lakshminarayanan Subramanian
Thousands of lives are lost every year in developing countries for failing to detect epidemics early because of the lack of real-time disease surveillance data. We present results from a large-scale deployment of a telephone triage service as a basis for dengue forecasting in Pakistan. Our system uses statistical analysis of dengue-related phone calls to accurately forecast suspected dengue cases 2 to 3 weeks ahead of time at a subcity level (correlation of up to 0.93). Our system has been operational at scale in Pakistan for the past 3 years and has received more than 300,000 phone calls...
July 2016: Science Advances
Saranjam Khan, Rahat Ullah, Asifullah Khan, Noorul Wahab, Muhammad Bilal, Mushtaq Ahmed
The current study presents the use of Raman spectroscopy combined with support vector machine (SVM) for the classification of dengue suspected human blood sera. Raman spectra for 84 clinically dengue suspected patients acquired from Holy Family Hospital, Rawalpindi, Pakistan, have been used in this study.The spectral differences between dengue positive and normal sera have been exploited by using effective machine learning techniques. In this regard, SVM models built on the basis of three different kernel functions including Gaussian radial basis function (RBF), polynomial function and linear functionhave been employed to classify the human blood sera based on features obtained from Raman Spectra...
June 1, 2016: Biomedical Optics Express
Ali Arslan, Hamayun Rashid Rathor, Muhammad Uzair Mukhtar, Shumaila Mushtaq, Adil Bhatti, Muhammad Asif, Israr Arshad, Jam Farooq Ahmad
BACKGROUND & OBJECTIVES: Dengue is one of the most common arthropod-borne viral diseases which is transmitted mainly by two vector species, Aedes aegypti (Linnaeus 1762) and Ae. albopictus (Skuse, 1894) worldwide. As there is no effective medicine and vaccine available, vector control remains the most effective measure to prevent its transmission and outbreak. The aim of the study was to confirm the co-occurrence of Aedes aegypti and Ae. albopictus populations in the different localities of Rawalpindi, Pakistan and examine their susceptibility status against different groups of insecticides...
April 2016: Journal of Vector Borne Diseases
Catherine S Todd, Ghulam Farooq Mansoor, Cyril Buhler, Habiburrahman Rahimi, Rohullah Zekria, Stefan Fernandez, Amy F W Mikhail, Paul T Scott, Samuel L Yingst
OBJECTIVE: To measure prevalence of prior/current Plasmodium vivax and Plasmodium falciparum (PV and PF), Brucella spp. (BR), dengue virus (DENV), Leishmania donovani (visceral leishmaniasis; VL), and Crimean-Congo hemorrhagic fever (CCHF) virus exposure among Afghan National Army (ANA) recruits. METHODS: Randomly chosen, nationally representative serum samples from consenting men aged 18-40 years and who were screened between February 2010 and January 2011 were tested, with ∼25 samples/province...
August 2016: Vector Borne and Zoonotic Diseases
Umar Saeed, Zahra Zahid Piracha
Pakistan is a developing country that has a population of 190 million people and faces a huge burden of viral diseases. Every year during monsoon season heavy rain fall and lack of disaster management skills potentially increase the transmission of waterborne diseases, vector borne diseases and viral outbreaks. Due to severe flooding, thousands of people lose their lives and millions are displaced each year. In most of the cases the children who lose their family members are forced into illegal professions of begging, child labor and prostitution which make them prone to sexually transmitted infections...
May 12, 2016: World Journal of Virology
Carmen Koo, Simrandeep Kaur, Zhi-Yong Teh, Helen Xu, Amna Nasir, Yee-Ling Lai, Erum Khan, Lee-Ching Ng, Hapuarachchige C Hapuarachchi
Dengue fever is currently the most prevalent disease caused by mosquito-borne flaviviruses. Despite being potentially fatal, there are no specific antiviral therapies for Dengue virus (DENV) infections. Therefore, early, accurate, and rapid diagnosis plays an important role in proper patient management. In this study, we evaluated the performance of a probe-based real-time RT-PCR (rRT-PCR) assay against that of a conventional RT-PCR assay in three sample cohorts from Pakistan (n = 94) and Singapore (first cohort; n = 559, second cohort; n = 123)...
July 2016: Vector Borne and Zoonotic Diseases
Sherif A El-Kafrawy, Sayed S Sohrab, Said Abol Ela, Adly M M Abd-Alla, Rowa Alhabbab, Suha A Farraj, Norah A Othman, Ahmed M Hassan, Max Bergoin, Raphaelle Klitting, Remi N Charrel, Anwar M Hashem, Tariq A Madani, Esam I Azhar
INTRODUCTION: Dengue is a significant arboviral infection that represents a major public health concern worldwide. The infection is endemic in most parts of South East Asia, sub-Saharan Africa, and Latin America. Among the four dengue virus (DENV) serotypes, DENV-2 has been reported to be the predominant serotype in Saudi Arabia since 1992. However, virological and epidemiological data of DENV-2 from Saudi Arabia are severely deficient and require further investigations. METHODS: Full genome sequencing of a recent DENV-2 isolate and phylogenetic analysis of all available DENV-2 sequences from Saudi Arabia...
June 2016: Vector Borne and Zoonotic Diseases
Muhammad Suleman, Rani Faryal, Uzma Bashir Aamir, Muhammad Masroor Alam, Nadia Nisar, Salmaan Sharif, Shahzad Shaukat, Adnan Khurshid, Mehar Angez, Massab Umair, Ghulam Mujtaba, Mian Muhammad Sufian, Yasir Arshad, Lubna Rehman, Syed Sohail Zahoor Zaidi
OBJECTIVE: To high light some epidemiological, clinical and diagnostic features of dengue fever during an outbreak and the role of different diagnostic techniques to achieve the highest level of accuracy in results. METHODS: Blood samples (n = 323) were collected along with epidemiological and clinical data from suspected dengue patients who visited different hospitals in Swat and Mansehra district of Pakistan between May-November 2013 during a dengue outbreak...
April 2016: Asian Pacific Journal of Tropical Medicine
S N Mohsin, F Ghafoor, M Saleem, R Ghous, M Aasim
Dengue has become a global problem in past few decades, with half of the world's population at risk of infection. For some countries of Asia and Latin America, severe dengue is a major cause of serious illness and even death in children. Pakistan has been reported as a hyperendemic area for dengue infection. Our study aimed to find seroprevalence of past dengue infection in asymptomatic children of Lahore with no previous history of dengue infection. A total of 400 samples were collected from children aged 1-12 years in Lahore using random sampling...
August 2016: Epidemiology and Infection
Ambreen Tauseef, Naima Umar, Sana Sabir, Ayesha Akmal, Saadia Sajjad, Sibgha Zulfiqar
OBJECTIVE: To evaluate the plasma interleukin-10 (IL-10) levels in patients suffering from dengue hemorrhagic fever between 4 to 7 days of onset of disease and 24 hours after the first sample, to find out the association of plasma IL-10 levels with the outcome. STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: All major hospitals of Lahore, Pakistan, from August to November 2012. METHODOLOGY: Participants included 50 registered patients of dengue hemorrhagic fever (DHF) aged between 15 - 50 years...
March 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Madiha Akram, Muhammad Idrees
Dengue is currently one of the most important arthropod borne human viral diseases caused by a flavivirus named as dengue virus. It is now endemic in Pakistan since many dengue fever outbreaks have been observed in Pakistan during the last three decades. Major serotype of dengue virus circulating in Pakistan is serotype 2. Complete genome sequences of three Pakistani dengue virus serotype 2 isolates were generated. Analysis of complete genome sequences showed that Pakistani isolates of dengue virus serotype 2 belonged to cosmopolitan genotype...
March 2016: Virusdisease
Erum Khan, Joveria Q Farooqi, Kelli L Barr, Dhani Prakoso, Amna Nasir, Akbar Kanji, Sadia Shakoor, Faisal Riaz Malik, Rumina Hasan, John A Lednicky, Maureen T Long
Arboviral diseases are expanding worldwide, yet global surveillance is often limited due to diplomatic and cultural barriers between nations. With human encroachment into new habitats, mosquito-borne viruses are also invading new areas. The actual prevalence of expanding arboviruses is unknown in Pakistan due to inappropriate diagnosis and poor testing for arboviral diseases. The primary objective of this study was to document evidence of flavivirus infections as the cause of undifferentiated fever in Pakistan...
2016: Frontiers in Public Health
Moaz Aslam, Numra A Aleem, Mohammad F Zahid, Arshalooz J Rahman
Dengue fever (DF) is an acute febrile illness that follows a self-limiting course. However, some patients suffer from complications, including myocarditis, due to the involvement of other organs. A child presented at the Aga Khan University Hospital in Karachi, Pakistan, in June 2013 with a high-grade fever, malaise and epigastric pain radiating to the chest. Positive DF antigen and immunoglobulin M assays confirmed the diagnosis of DF. Persistent bradycardia with low blood pressure led to further cardiac investigations which showed a decreased ejection fraction and raised serum cardiac enzymes, indicating myocardial damage...
February 2016: Sultan Qaboos University Medical Journal
M A Ali, Z Ahsan, M Amin, S Latif, A Ayyaz, M N Ayyaz
OBJECTIVES: Globally, disease surveillance systems are playing a significant role in outbreak detection and response management of Infectious Diseases (IDs). However, in developing countries like Pakistan, epidemic outbreaks are difficult to detect due to scarcity of public health data and absence of automated surveillance systems. Our research is intended to formulate an integrated service-oriented visual analytics architecture for ID surveillance, identify key constituents and set up a baseline for easy reproducibility of such systems in the future...
May 2016: Public Health
Jehangir Khan, Inamullah Khan, Ibne Amin
BACKGROUND: Aedes aegypti and Aedes albopictus play a fundamental role in transmission of dengue virus to humans. A single infected Aedes mosquito is capable to act as a reservoir/amplifier host for dengue virus and may cause epidemics via horizontal and vertical modes of dengue virus (DENV) transmission. The present and future dengue development can be clarified by understanding the elements which help the dissemination of dengue transmission. The current study deals with molecular surveillance of dengue in addition to ecological and social context of 2013 dengue epidemics in Swat, Pakistan...
2016: PloS One
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