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https://www.readbyqxmd.com/read/28212305/epigenetic-landscape-during-coronavirus-infection
#1
Alexandra Schäfer, Ralph S Baric
Coronaviruses (CoV) comprise a large group of emerging human and animal pathogens, including the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) strains. The molecular mechanisms regulating emerging coronavirus pathogenesis are complex and include virus-host interactions associated with entry, replication, egress and innate immune control. Epigenetics research investigates the genetic and non-genetic factors that regulate phenotypic variation, usually caused by external and environmental factors that alter host expression patterns and performance without any change in the underlying genotype...
February 15, 2017: Pathogens
https://www.readbyqxmd.com/read/28209218/the-changing-landscape-for-stroke%C3%A2-prevention-in-af-findings-from-the-gloria-af-registry-phase-2
#2
Menno V Huisman, Kenneth J Rothman, Miney Paquette, Christine Teutsch, Hans-Christoph Diener, Sergio J Dubner, Jonathan L Halperin, Chang Sheng Ma, Kristina Zint, Amelie Elsaesser, Dorothee B Bartels, Gregory Y H Lip
BACKGROUND: GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non-vitamin K antagonist oral anticoagulant (NOAC), became available. OBJECTIVES: This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1...
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28208885/study-on-distribution-of-scorpions-to-provide-prevention-and-interventions-in-combating-scorpionism-in-poldokhtar-county-lorestan-province-iran
#3
Mansour Nazari, Rastgar Hassan
INTRODUCTION: Scorpions are arthropods of medical importance classified in the class Arachnida, inhabiting hot and dry environments. All scorpions have a venomous sting and several thousand people die each year from scorpion stings, but this mortality is due to the venom of about 25 species located in northern Africa, the Middle East, India, Mexico and parts of South America. Poldokhtar County belongs to one of the southern cities of Lorestan Province, providing suitable habitats for many different species of scorpions due to its specific climatic conditions...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203096/burden-of-methicillin-resistant-staphylococcus-aureus-pneumonia-among-hospitalized-patients-in-lebanon-and-saudi-arabia
#4
Abdulhakeem O Althaqafi, Madonna J Matar, Rima Moghnieh, Adel F Alothman, Thamer H Alenazi, Fayssal Farahat, Shelby Corman, Caitlyn T Solem, Nirvana Raghubir, Cynthia Macahilig, Seema Haider, Jennifer M Stephens
OBJECTIVES: The objective of this study is to describe the real-world treatment patterns and burden of suspected or confirmed methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in Saudi Arabia and Lebanon. METHODS: A retrospective chart review study evaluated 2011-2012 data from hospitals in Saudi Arabia and Lebanon. Patients were included if they had been discharged with a diagnosis of MRSA pneumonia, which was culture proven or suspected based on clinical criteria...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28203095/burden-and-treatment-patterns-of-invasive-fungal-infections-in-hospitalized-patients-in-the-middle-east-real-world-data-from-saudi-arabia-and-lebanon
#5
Adel F Alothman, Abdulhakeem O Althaqafi, Madonna J Matar, Rima Moghnieh, Thamer H Alenazi, Fayssal M Farahat, Shelby Corman, Caitlyn T Solem, Nirvana Raghubir, Cynthia Macahilig, Claudie Charbonneau, Jennifer M Stephens
OBJECTIVES: The objective of this study was to document the burden and treatment patterns associated with invasive fungal infections (IFIs) due to Candida and Aspergillus species in Saudi Arabia and Lebanon. METHODS: A retrospective chart review study was conducted using data recorded from 2011 to 2012 from hospitals in Saudi Arabia and Lebanon. Patients were included if they had been discharged with a diagnosis of IFI due to Candida or Aspergillus, which was culture proven or suspected based on clinical criteria...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28196630/preterm-birth-associated-with-maternal-fine-particulate-matter-exposure-a-global-regional-and-national-assessment
#6
Christopher S Malley, Johan C I Kuylenstierna, Harry W Vallack, Daven K Henze, Hannah Blencowe, Mike R Ashmore
Reduction of preterm births (<37 completed weeks of gestation) would substantially reduce neonatal and infant mortality, and deleterious health effects in survivors. Maternal fine particulate matter (PM2.5) exposure has been identified as a possible risk factor contributing to preterm birth. The aim of this study was to produce the first estimates of ambient PM2.5-associated preterm births for 183 individual countries and globally. To do this, national, population-weighted, annual average ambient PM2.5 concentration, preterm birth rate and number of livebirths were combined to calculate the number of PM2...
February 10, 2017: Environment International
https://www.readbyqxmd.com/read/28194585/prevalence-and-associations-of-psychological-distress-hiv-infection-and-hiv-care-service-utilization-in-east-zimbabwe
#7
Malebogo Tlhajoane, Jeffrey W Eaton, Albert Takaruza, Rebecca Rhead, Rufurwokuda Maswera, Nadine Schur, Lorraine Sherr, Constance Nyamukapa, Simon Gregson
The correlation between mental health and sexual risk behaviours for HIV infection remains largely unknown in low and middle income settings. The present study determined the prevalence of psychological distress (PD) in a sub-Saharan African population with a generalized HIV epidemic, and investigated associations with HIV acquisition risk and uptake of HIV services using data from a cross-sectional survey of 13,252 adults. PD was measured using the Shona Symptom Questionnaire. Logistic regression was used to measure associations between PD and hypothesized covariates...
February 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28193191/effective-inhibition-of-mers-cov-infection-by-resveratrol
#8
Shih-Chao Lin, Chi-Tang Ho, Wen-Ho Chuo, Shiming Li, Tony T Wang, Chi-Chen Lin
BACKGROUND: Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that causes severe morbidity and mortality. Up to date, there is no approved or licensed vaccine or antiviral medicines can be used to treat MERS-CoV-infected patients. Here, we analyzed the antiviral activities of resveratrol, a natural compound found in grape seeds and skin and in red wine, against MERS-CoV infection. METHODS: We performed MTT and neutral red uptake assays to assess the survival rates of MERS-infected Vero E6 cells...
February 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28191803/population-pharmacokinetics-of-imatinib-and-its-application-to-the-therapeutic-drug-monitoring-middle-east-cml-population
#9
Mehdi Ansari, Behjat Kalantary-Khandani, Abbas Pardakhty, Moein Safavi, Nabi Mosavi, Ehsan Mohajeri
INTRODUCTION: Despite the outstanding results generally obtained with Imatinib in the treatment of chronic myeloid leukemia, some patients show sub-optimal or no response. To evaluate the relationship between steady-state through plasma concentration and clinical response in CML patients. The objectives of this study were to assess the variability in Imatinib pharmacokinetics and to explore the effects of several demographic and biological covariates on the disposition of Imatinib. METHODS: A population pharmacokinetic analysis was performed on 170 plasma samples from 74 adult Iranian chronic myeloid leukemia patients...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28191331/development-of-dual-taqman-based-one-step-rrt-pcr-assay-panel-for-rapid-and-accurate-diagnostic-test-of-mers-cov-a-novel-human-coronavirus-ahead-of-hajj-pilgrimage
#10
Mohammad Sadegh Hashemzadeh, Rahimeh Rasouli, Bentolhoda Zahraei, Morteza Izadi, Mahdi Tat, Seyed Hassan Saadat, Mohammad Najarasl, Behzad Khansari Nejad, Ruhollah Dorostkar
BACKGROUND: Coronaviruses (CoVs) are large ribonucleic acid (RNA) viruses causing primarily respiratory disease in humans. A novel human coronavirus, subsequently named middle east respiratory syndrome coronavirus (MERS-CoV), was first reported in Saudi Arabia in September of 2012. With increasing numbers of infections and deaths from MERS-CoV, development of a rapid and reliable kit was crucial to prevent further spread of MERS-CoV. OBJECTIVES: In this study, we present two real-time reverse-transcription polymerase chain reaction (rRT-PCR) assays for in-house rapid and sensitive diagnostic testing of MERS-CoV, detecting the regions upstream of the envelope gene (upE) and open reading frame (ORF) 1b, respectively, for initial screening and final confirmation of MERS-CoV infection, as recommended by the world health organization (WHO)...
November 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28190501/middle-east-respiratory-syndrome-mers-coronavirus-and-dromedaries
#11
REVIEW
Ulrich Wernery, Susanna K P Lau, Patrick C Y Woo
Middle East Respiratory Syndrome (MERS) is a zoonotic viral disease that can be transmitted from dromedaries to human beings. More than 1500 cases of MERS have been reported in human beings to date. Although MERS has been associated with 30% case fatality in human beings, MERS coronavirus (MERS-CoV) infection in dromedaries is usually asymptomatic. In rare cases, dromedaries may develop mild respiratory signs. No MERS-CoV or antibodies against the virus have been detected in camelids other than dromedaries...
February 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28187215/spatiotemporal-trends-in-the-southwest-monsoon-wind-driven-upwelling-in-the-southwestern-part-of-the-south-china-sea
#12
Poh Heng Kok, Mohd Fadzil Mohd Akhir, Fredolin Tangang, Mohd Lokman Husain
This study analyzes two wind-induced upwelling mechanisms, namely, Ekman transport and Ekman pumping that occur during the southwest monsoon. The results suggest that the coastline of the east coast of Peninsular Malaysia (ECPM) is affected by upwelling with spatiotemporal variations. Characterization of upwelling by using wind-induced upwelling indexes (UIW) indicate the existence of favorable upwelling conditions from May to September. Upwelling intensity increased in May and peaked in August before declining in September, decreasing intensity from the southern tip towards the northern tip along the coastline of the ECPM...
2017: PloS One
https://www.readbyqxmd.com/read/28185821/public-response-to-mers-cov-in-the-middle-east-iphone-survey-in-six-countries
#13
Amani S Alqahtani, Harunor Rashid, Mada H Basyouni, Tariq M Alhawassi, Nasser F BinDhim
Gulf Cooperation Council (GCC) countries bear the heaviest brunt of MERS-CoV. This study aims to compare public awareness and practice around MERS-CoV across GCC countries. A cross-sectional survey was conducted using the Gulf Indicators (GI) smartphone app among people in the six GCC countries, namely Saudi Arabia, Kuwait, the United Arab Emirates, Qatar, Bahrain, and Oman. A total of 1812 participants recruited. All were aware of MERS-CoV, yet the perception and practice around MERS-CoV varied widely between countries...
February 6, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28184291/human-parvovirus-4-parv4-remains-elusive-despite-a-decade-of-study
#14
REVIEW
Philippa C Matthews, Colin Sharp, Peter Simmonds, Paul Klenerman
Human parvovirus 4 ('PARV4') is a small DNA tetraparvovirus, first reported in 2005. In some populations, PARV4 infection is uncommon, and evidence of exposure is found only in individuals with risk factors for parenteral infection who are infected with other blood-borne viruses. In other settings, seroprevalence studies suggest an endemic, age-associated transmission pattern, independent of any specific risk factors. The clinical impact of PARV4 infection remains uncertain, but reported disease associations include an influenza-like syndrome, encephalitis, acceleration of HIV disease, and foetal hydrops...
2017: F1000Research
https://www.readbyqxmd.com/read/28182960/paediatric-nurses-perceptions-and-practices-of-family-centred-care-in-saudi-hospitals-a-mixed-methods-study
#15
Hawa Alabdulaziz, Cheryle Moss, Beverley Copnell
BACKGROUND: Family-centred care is widely accepted as the underlying philosophy of paediatric nursing. Studies of family-centred care have mainly been conducted in western countries and little is known of its practice in other contexts. No studies have been undertaken in the Middle East. AIM: To explore family-centred care in the Saudi context from the perspectives of paediatric nurses. DESIGN: A mixed methodology was utilised with an explanatory sequential design...
January 30, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28182215/risk-factors-for-transmission-of-middle-east-respiratory-syndrome-coronavirus-infection-during-the-2015-outbreak-in-south-korea
#16
Seung Woo Kim, Jung Wan Park, Hee-Dong Jung, Jeong-Sun Yang, Yong-Shik Park, Changhwan Lee, Kyung Min Kim, Keon-Joo Lee, Donghyok Kwon, Young Joo Hur, BoYoul Choi, Moran Ki
No abstract text is available yet for this article.
February 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28178912/do-medical-students-receive-training-in-correct-use-of-personal-protective-equipment
#17
Amrita John, Myreen E Tomas, Aditya Hari, Brigid M Wilson, Curtis J Donskey
BACKGROUND: Healthcare personnel often use incorrect technique for donning and doffing of personal protective equipment (PPE). OBJECTIVE: We tested the hypothesis that medical students receive insufficient training on correct methods for donning and doffing PPE. METHODS: We conducted a cross-sectional survey of medical students on clinical rotations at two teaching hospitals to determine the type of training they received in PPE technique...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28178348/development-of-a-hydrolysis-probe-based-real-time-assay-for-the-detection-of-tropical-strains-of-fusarium-oxysporum-f-sp-cubense-race-4
#18
Jaime Aguayo, Diane Mostert, Céline Fourrier-Jeandel, Isabelle Cerf-Wendling, Bruno Hostachy, Altus Viljoen, Renaud Ioos
Fusarium oxysporum f. sp. cubense (Foc) is one of the most important threats to global banana production. Strategies to control the pathogen are lacking, with plant resistance offering the only long-term solution, if sources of resistance are available. Prevention of introduction of Foc into disease-free areas thus remains a key strategy to continue sustainable banana production. In recent years, strains of Foc affecting Cavendish bananas have destroyed plantations in a number of countries in Asia and in the Middle East, and one African country...
2017: PloS One
https://www.readbyqxmd.com/read/28177862/middle-east-respiratory-syndrome
#19
Yaseen M Arabi, Hanan H Balkhy, Frederick G Hayden, Abderrezak Bouchama, Thomas Luke, J Kenneth Baillie, Awad Al-Omari, Ali H Hajeer, Mikiko Senga, Mark R Denison, Jonathan S Nguyen-Van-Tam, Nahoko Shindo, Alison Bermingham, James D Chappell, Maria D Van Kerkhove, Robert A Fowler
Summary. Between September 2012 and January 20, 2017, the World Health Organization (WHO) received reports from 27 countries of 1879 laboratory-confirmed cases in humans of the Middle East respiratory syndrome (MERS) caused by infection with the MERS coronavirus (MERS-CoV) and at least 659 related..
9, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28177114/implementation-of-a-mentored-professional-development-programme-in-laboratory-leadership-and-management-in-the-middle-east-and-north-africa
#20
L A Perrone, D Confer, E Scott, L Livingston, C Bradburn, A McGee, T Furtwangler, A Downer, A H Mokdad, J F Flandin, S Shotorbani, H Asghar, H E Tolbah, H J Ahmed, A Alwan, R Martin
Laboratories need leaders who can effectively utilize the laboratories' resources, maximize the laboratories'capacity to detect disease, and advocate for laboratories in a fluctuating health care environment. To address this need, the University of Washington, USA, created the Certificate Program in Laboratory Leadership and Management in partnership with WHO Regional Office for the Eastern Mediterranean, and implemented it with 17 participants and 11 mentors from clinical and public health laboratories in 10 countries (Egypt, Iraq, Jordan, Lebanon, Morocco, Oman, Pakistan, Qatar, Saudi Arabia, and Yemen) in 2014...
February 1, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
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