keyword
MENU ▼
Read by QxMD icon Read
search

ACAP

keyword
https://www.readbyqxmd.com/read/27906609/glyphosate-adversely-affects-danio-rerio-males-acetylcholinesterase-modulation-and-oxidative-stress
#1
Fernanda Moreira Lopes, Sergiane Souza Caldas, Ednei Gilberto Primel, Carlos Eduardo da Rosa
It has been demonstrated that glyphosate-based herbicides are toxic to animals. In the present study, reactive oxygen species (ROS) generation, antioxidant capacity against peroxyl radicals (ACAP), and lipid peroxidation (LPO), as well as the activity and expression of the acetylcholinesterase (AChE) enzyme, were evaluated in Danio rerio males exposed to 5 or 10 mg/L of glyphosate for 24 and 96 h. An increase in ACAP in gills after 24 h was observed in the animals exposed to 5 mg/L of glyphosate. A decrease in LPO was observed in brain tissue of animals exposed to 10 mg/L after 24 h, while an increase was observed in muscle after 96 h...
December 1, 2016: Zebrafish
https://www.readbyqxmd.com/read/27783013/medical-student-mentorship-in-plastic-surgery-the-mentor-s-perspective
#2
Jeffrey E Janis, Jenny C Barker
BACKGROUND: The reproducible benefits of mentoring to mentees have been studied extensively. However, insights from the mentor perspective are less well described. This study evaluates mentorship of plastic surgery medical students from the attending surgeon's perspective. A comparison is made with a previous publication evaluating mentorship from the medical student's perspective. METHODS: An electronic survey was sent to 1025 active members of the American Council of Academic Plastic Surgeons (ACAPS) and the American Association of Plastic Surgeons (AAPS), with a combined response rate of 23 percent...
November 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27750093/effects-of-the-herbicide-roundup-on-the-polychaeta-laeonereis-acuta-cholinesterases-and-oxidative-stress
#3
Fábio de Melo Tarouco, Filipe Guilherme Andrade de Godoi, Robson Rabelo Velasques, Amanda da Silveira Guerreiro, Marcio Alberto Geihs, Carlos Eduardo da Rosa
Glyphosate based herbicides, including Roundup, are widely employed in agriculture and urban spaces. The objective of this study was to evaluate the toxicological effects of Roundup on the estuarine polychaeta Laeonereis acuta. Biomarkers of oxidative stress as well as acetylcholinesterase and propionilcholinesterase activities were analyzed. Firstly, the LC50 96h for L. acuta was established (8.19mg/L). After, the animals were exposed to two Roundup concentrations: 3.25mg/L (non-observed effect concentration - NOEC) and 5...
October 14, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27429116/oxidative-status-of-the-myocardium-in-response-to-different-intensities-of-physical-training
#4
L F Guerreiro, A M Rocha, C N Martins, J de P Ribeiro, C Wally, D L Strieder, C G Carissimi, M G Oliveira, A A Pereira, H S Biondi, J M Monserrat, C An Gonçalves
The intensity of exercise determines the metabolic pathway and the energetic substrate that is spent. Our study sought to identify the effects of different intensities of swimming on myocardial oxidative status and the blood lipid profile. Eighty Wistar rats (male and female) submitted to different intensities of a swimming regimen (low, LS; moderate, MS; or high, HS) for 16 weeks. Samples of blood and myocardium from the left ventricle were collected to determine lipid profiles and oxidative status. Reactive oxygen species (ROS) and antioxidant capacity against peroxyl radicals (ACAP), lipid profiles and lipid peroxidation was analyzed...
July 15, 2016: Physiological Research
https://www.readbyqxmd.com/read/27394943/effect-of-calving-process-on-the-outcomes-of-delivery-and-postpartum-health-of-dairy-cows-with-unassisted-and-assisted-calvings
#5
L Kovács, F L Kézér, O Szenci
Welfare aspects of obstetrical assistance were studied in multiparous Holstein-Friesian cows (n=176) with (1) unassisted calving in an individual pen (UCIP; n=42), (2) unassisted calving in a group pen (UCG; n=48), (3) assisted calving with appropriately timed obstetrical assistance (ACAP; n=50), and (4) assisted calving with inappropriately timed (premature) obstetrical assistance (ACIN; n=36). Duration of the stages of calving, the prevalence and the degree of dystocia, stillbirth ratio, newborn calf vitality, and the occurrence of postpartum health problems (i...
September 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27330119/acap3-regulates-neurite-outgrowth-through-its-gap-activity-specific-to-arf6%C3%A2-in-mouse-hippocampal-neurons
#6
Yuki Miura, Tsunaki Hongu, Yohei Yamauchi, Yuji Funakoshi, Naohiro Katagiri, Norihiko Ohbayashi, Yasunori Kanaho
ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and pleckstrin homology domains 3) belongs to the ACAP family of GAPs (GTPase-activating proteins) for the small GTPase Arf (ADP-ribosylation factor). However, its specificity to Arf isoforms and physiological functions remain unclear. In the present study, we demonstrate that ACAP3 plays an important role in neurite outgrowth of mouse hippocampal neurons through its GAP activity specific to Arf6. In primary cultured mouse hippocampal neurons, knockdown of ACAP3 abrogated neurite outgrowth, which was rescued by ectopically expressed wild-type ACAP3, but not by its GAP activity-deficient mutant...
September 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27315435/roundup-%C3%A2-in-zebrafish-effects-on-oxidative-status-and-gene-expression
#7
Robson Rabelo Velasques, Juliana Zomer Sandrini, Carlos Eduardo da Rosa
The objective of the present study was to determine the effects of Roundup on oxidative status in adult Danio rerio liver and gills. Reactive oxygen species (ROS) and antioxidant capacity (ACAP) were measured in fish after exposure to Roundup (5 and 10 mg/L) for 24, 48, 72, and 96 h. Furthermore, gene expression related to antioxidant response was evaluated after 24 and 96 h. In gills, an increase in ACAP was observed after 96 h in the highest concentration. In the liver, a reduction in ROS and ACAP was observed after 24 h, whereas an increase in ACAP was observed after 48 h in the highest concentration...
October 2016: Zebrafish
https://www.readbyqxmd.com/read/27273966/molecular-assays-in-detecting-egfr-gene-aberrations-an-updated-her2-dependent-algorithm-for-interpreting-gene-signals-a-short-technical-report
#8
REVIEW
Evangelos Tsiambas, Vasileios Ragos, Alicia Y Lefas, Stavros N Georgiannos, Dimitrios N Rigopoulos, Georgios Georgakopoulos, Athanasios Stamatelopoulos, Dimitra Grapsa, Konstantinos Syrigos
Purpose: Among oncogenes that have already been identified and cloned, Epidermal Growth Factor Receptor (EGFR) remains one of the most significant. Understanding its deregulation mechanisms improves critically patients' selection for personalized therapies based on modern molecular biology and oncology guidelines. Anti-EGFR targeted therapeutic strategies have been developed based on specific genetic profiles and applied in subgroups of patients suffering by solid cancers of different histogenetic origin. Detection of specific EGFR somatic mutations leads to tyrosine kinase inhibitors (TKIs) application in subsets of them...
March 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27017137/uptake-metabolism-and-sub-lethal-effects-of-bde-47-in-two-estuarine-invertebrates-with-different-trophic-positions
#9
M Díaz-Jaramillo, K S B Miglioranza, M Gonzalez, E Barón, J M Monserrat, E Eljarrat, D Barceló
Two microcosm types -sediment-biota and biota-biota- were constructed to simulate different pathways of BDE-47 uptake, metabolism and oxidative stress effects in two key estuarine invertebrates (polychaete Laeonereis acuta and crab Cyrtograpsus angulatus). In the sediment-biota experiment, both species were exposed to spiked sediments; an environmentally reported and a high concentration of BDE-47 for 2 weeks. In the biota-biota experiment, crabs were fed with polychaetes pre-exposed to BDE-47 in the sediment-biota experiment...
June 2016: Environmental Pollution
https://www.readbyqxmd.com/read/26980113/glyphosate-based-herbicide-exposure-causes-antioxidant-defence-responses-in-the-fruit-fly-drosophila-melanogaster
#10
Lais Mattos de Aguiar, Fernanda Hernandes Figueira, Marco Silva Gottschalk, Carlos Eduardo da Rosa
Glyphosate is a non-selective and post-emergent herbicide that affects plant growth. Animal exposure to this herbicide can lead to adverse effects, such as endocrine disruption, oxidative stress and behavioural disorders. Drosophilids have been utilized previously as an effective tool in toxicological tests. In the present study, the effects of a glyphosate-based herbicide (Roundup [Original]) were investigated regarding oxidative stress, the antioxidant defence system and acetylcholinesterase (AChE) activity in Drosophila melanogaster...
July 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/26831792/-in-vitro-selected-macrocyclic-peptides-tools-for-regulating-the-conformational-freedom-of-transmembrane-proteins
#11
Christopher John Hipolito, Kosuke Nishio, Hiroaki Suga
Membrane proteins allow a cell to communicate with its environment by relaying a signal or transporting a molecule through the cell membrane. Elucidation of the three-dimensional structure of a membrane protein provides a greater understanding of its function and mechanisms. Ultimately, this knowledge will enlighten researchers on how these proteins can be regulated to elicit a desired cellular response, which could lead to novel therapeutic medicine. Unfortunately, the determination of the high-resolution crystal structures of transmembrane proteins remains a challenge due to their poor solubility and high conformational flexibility...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/26725004/effects-of-cryotherapy-combined-with-therapeutic-ultrasound-on-oxidative-stress-and-tissue-damage-after-musculoskeletal-contusion-in-rats
#12
C N Martins, M B Moraes, M Hauck, L F Guerreiro, D D Rossato, A S Varela, C E da Rosa, L U Signori
OBJECTIVE: To investigate the combined effects of cryotherapy and pulsed ultrasound therapy (PUT) on oxidative stress parameters, tissue damage markers and systemic inflammation after musculoskeletal injury. DESIGN: Experimental animal study. SETTING: Research laboratory. PARTICIPANTS: Seventy male Wistar rats were divided into five groups: control, lesion, cryotherapy, PUT, and cryotherapy+PUT. INTERVENTIONS: The gastrocnemius muscle was injured by mechanical crushing...
November 29, 2015: Physiotherapy
https://www.readbyqxmd.com/read/26615366/metal-contamination-as-a-possible-etiology-of-fibropapillomatosis-in-juvenile-female-green-sea-turtles-chelonia-mydas-from-the-southern-atlantic-ocean
#13
Cinthia Carneiro da Silva, Roberta Daniele Klein, Indianara Fernanda Barcarolli, Adalto Bianchini
Environmental contaminants have been suggested as a possible cause of fibropapillomatosis (FP) in green sea turtles. In turn, a reduced concentration of serum cholesterol has been indicated as a reliable biomarker of malignancy in vertebrates, including marine turtles. In the present study, metal (Ag, Cd, Cu, Fe, Ni, Pb and Zn) concentrations, oxidative stress parameters [antioxidant capacity against peroxyl radicals (ACAP), protein carbonyls (PC), lipid peroxidation (LPO), frequency of micronucleated cells (FMC)], water content, cholesterol concentration and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) activity were analyzed in the blood/serum of juvenile (29...
January 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/26306460/developments-in-amphibian-captive-breeding-and-reintroduction-programs
#14
Gemma Harding, Richard A Griffiths, Lissette Pavajeau
Captive breeding and reintroduction remain high profile but controversial conservation interventions. It is important to understand how such programs develop and respond to strategic conservation initiatives. We analyzed the contribution to conservation made by amphibian captive breeding and reintroduction since the launch of the International Union for Conservation of Nature (IUCN) Amphibian Conservation Action Plan (ACAP) in 2007. We assembled data on amphibian captive breeding and reintroduction from a variety of sources including the Amphibian Ark database and the IUCN Red List...
April 2016: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/26146599/identification-of-best-practices-for-resident-aesthetic-clinics-in-plastic-surgery-training-the-acaps-national-survey
#15
C Scott Hultman, Cindy Wu, Michael L Bentz, Richard J Redett, R Bruce Shack, Lisa R David, Peter J Taub, Jeffrey E Janis
INTRODUCTION: Resident aesthetic clinics (RACs) have demonstrated good outcomes and acceptable patient satisfaction, but few studies have evaluated their educational, financial, or medicolegal components. We sought to determine RAC best practices. METHODS: We surveyed American Council of Academic Plastic Surgeon members (n = 399), focusing on operational details, resident supervision, patient safety, medicolegal history, financial viability, and research opportunities...
March 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/26037328/biochemical-responses-over-time-in-common-carp-cyprinus-carpio-teleostei-cyprinidae-during-fed-supplementation-with-%C3%AE-lipoic-acid
#16
Alain D Enamorado, Atila C Martins, Juliana A Flores, Marcelo Borges Tesser, Sergiane S Caldas, Ednei G Primel, José Maria Monserrat
The current study aimed to evaluate the influence of lipoic acid (LA) supplementation (439.84±6.71 mg LA/kg feed) on antioxidants responses throughout the time in intestine, liver and muscle of juvenile common carp Cyprinus carpio. Two experimental groups were fed during four weeks with a diet with or without LA. Glutathione-S-transferase (GST) activity, glutathione (GSH) content, antioxidant capacity against peroxyl radicals (ACAP) and lipid peroxidation (TBARS) were evaluated in these organs. Also, a technique to measure protein disulfide bonds and sulfhydryl groups was optimized for intestine samples...
October 2015: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/25988331/sorting-of-clathrin-independent-cargo-proteins-depends-on-rab35-delivered-by-clathrin-mediated-endocytosis
#17
Dipannita Dutta, Julie G Donaldson
Clathrin-mediated endocytosis (CME) and clathrin-independent endocytosis (CIE) co-exist in most cells but little is known about their communication and coordination. Here we show that when CME was inhibited, endocytosis by CIE continued but endosomal trafficking of CIE cargo proteins was altered. CIE cargo proteins that normally traffic directly into Arf6-associated tubules after internalization and avoid degradation (CD44, CD98 and CD147) now trafficked to lysosomes and were degraded. The endosomal tubules were also absent and Arf6-GTP levels were elevated...
September 2015: Traffic
https://www.readbyqxmd.com/read/25878923/2014-acaps-congress-abstracts
#18
(no author information available yet)
No abstract text is available yet for this article.
March 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/25730469/a-novel-alkaline-hemicellulosic-heteroxylan-isolated-from-alfalfa-medicago-sativa-l-stem-and-its-thermal-and-anti-inflammatory-properties
#19
Lei Chen, Jie Liu, Yaqiong Zhang, Yuge Niu, Bona Dai, Liangli Lucy Yu
A novel hemicellulosic polysaccharide (ACAP) was purified from the cold alkali extraction of alfalfa stems and characterized as a heteroxylan with a weight-average molecular weight of 7.94 × 10(3) kDa and a radius of 58 nm. Structural analysis indicated that ACAP consisted of a 1,4-linked β-D-Xylp backbone with 4-O-MeGlcpA and T-L-Araf substitutions at O-2 and O-3 positions, respectively. Transmission electron microscopy (TEM) examination revealed the entangled chain morphology of ACAP molecules. The evaluation of thermal degradation property revealed a primary decomposition temperature range of 238...
March 25, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25671007/routine-repeat-head-ct-may-not-be-indicated-in-patients-on-anticoagulant-antiplatelet-therapy-following-mild-traumatic-brain-injury
#20
Kevin C McCammack, Charlotte Sadler, Yueyang Guo, Raja S Ramaswamy, Nikdokht Farid
INTRODUCTION: Evaluation recommendations for patients on anticoagulant and antiplatelet (ACAP) therapy that present after mild traumatic brain injury (TBI) are controversial. At our institution, an initial noncontrast head computed tomography (HCT) is performed, with a subsequent HCT performed six hours later to exclude delayed intracranial hemorrhage (ICH). This study was performed to evaluate the yield and advisability of this approach. METHODS: We performed a retrospective review of subjects undergoing evaluation for ICH after mild TBI in patients on ACAP therapy between January of 2012 and April of 2013...
January 2015: Western Journal of Emergency Medicine
keyword
keyword
81803
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"