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https://www.readbyqxmd.com/read/27893675/a-multicenter-randomized-double-blind-trial-comparing-the-efficacy-and-safety-of-tudca-and-udca-in-chinese-patients-with-primary-biliary-cholangitis
#1
Hong Ma, Minde Zeng, Ying Han, Huiping Yan, Hong Tang, Jifang Sheng, Heping Hu, Liufang Cheng, Qing Xie, Youfu Zhu, Guofeng Chen, Zhiliang Gao, Wen Xie, Jiyao Wang, Shanming Wu, Guiqiang Wang, Xiaohui Miao, Xiaoqing Fu, Liping Duan, Jie Xu, Lai Wei, Guangfeng Shi, Chengwei Chen, Minhu Chen, Qin Ning, Chen Yao, Jidong Jia
AIM: Tauroursodeoxycholic acid (TUDCA) is a taurine conjugated form of ursodeoxycholic acid (UDCA) with higher hydrophility. To further evaluate the efficacy and safety of TUDCA for primary biliary cholangitis (PBC), we performed this study on Chinese patients. METHODS: 199 PBC patients were randomly assigned to either 250 mg TUDCA plus UDCA placebo or 250 mg UDCA plus TUDCA placebo, 3 times per day for 24 weeks. The primary endpoint was defined as percentage of patients achieving serum alkaline phosphatase (ALP) reduction of more than 25% from baseline...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27890958/nonhealing-genital-ulcer-in-aids-a-diagnostic-dilemma
#2
Yogesh S Marfatia, Devi Sathianadha Menon, Sheethal Jose, Brijesh Kumar Patel
HIV/AIDS-related immune alteration poses many diagnostic and therapeutic challenges. HIV-positive 44-year-old male, on second-line antiretroviral therapy (ART) presented with asymptomatic non healing, well-defined, erythematous ulcer over penis since 8 months with serosanguinous discharge. Inguinal lymph nodes were not palpable. Tzanck smear was negative. Biopsy was not done as the patient was not willing for the same. Acyclovir was given considering herpes infection to which there was no response, and hence azithromycin and metronidazole were given, without improvement...
July 2016: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27854272/impact-of-dendrimer-terminal-group-chemistry-on-blockage-of-the-anthrax-toxin-channel-a-single-molecule-study
#3
Goli Yamini, Nnanya Kalu, Ekaterina M Nestorovich
Nearly all the cationic molecules tested so far have been shown to reversibly block K⁺ current through the cation-selective PA63 channels of anthrax toxin in a wide nM-mM range of effective concentrations. A significant increase in channel-blocking activity of the cationic compounds was achieved when multiple copies of positively charged ligands were covalently linked to multivalent scaffolds, such as cyclodextrins and dendrimers. Even though multivalent binding can be strong when the individual bonds are relatively weak, for drug discovery purposes we often strive to design multivalent compounds with high individual functional group affinity toward the respective binding site on a multivalent target...
November 15, 2016: Toxins
https://www.readbyqxmd.com/read/27845027/clinical-effectiveness-and-cost-effectiveness-of-use-of-therapeutic-monitoring-of-tumour-necrosis-factor-alpha-tnf-%C3%AE-inhibitors-lisa-tracker%C3%A2-enzyme-linked-immunosorbent-assay-elisa-kits-tnf-%C3%AE-blocker-elisa-kits-and-promonitor%C3%A2-elisa-kits-versus-standard-care
#4
Karoline Freeman, Martin Connock, Peter Auguste, Sian Taylor-Phillips, Hema Mistry, Deepson Shyangdan, Rachel Court, Ramesh Arasaradnam, Paul Sutcliffe, Aileen Clarke
BACKGROUND AND OBJECTIVES: Systematic reviews and economic modelling of clinical effectiveness and cost-effectiveness of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [using LISA-TRACKER(®) enzyme-linked immunosorbent assay (ELISA) kits (Theradiag, Marne La Vallee, France, or Alpha Laboratories, Heriot, UK), TNF-α-Blocker ELISA kits (Immundiagnostik AG, Bensheim, Germany) and Promonitor(®) ELISA kits (Proteomika, Progenika Biopharma, Bizkaia, Spain)] versus standard care for Crohn's disease (CD)...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27828695/mindfulness-based-cognitive-therapy-for-patients-with-depression-decreases-the-need-for-outpatient-visits
#5
Robert G Bota, Jessica Hazen, Ryan Tieu, Andrei Novac
OBJECTIVE: To determine if the use of mindfulness-based cognitive therapy (MBCT) in patients with a history of 2 or more episodes of major depressive disorder and other mood disorders will decrease the need for medication management and other interventions and will also decrease the need for outpatient services and the overall cost of treatment. METHODS: The study patients completed MBCT group sessions between January 1, 2010, and December 31, 2013. Patients who had 2 or more episodes of major depressive disorder (recurrent MDD) were categorized into a group...
August 25, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27805592/in-vitro-recording-of-mesenteric-afferent-nerve-activity-in-mouse-jejunal-and-colonic-segments
#6
Sara Nullens, Annemie Deiteren, Wen Jiang, Christopher Keating, Hannah Ceuleers, Sven Francque, David Grundy, Joris G De Man, Benedicte Y De Winter
Afferent nerves not only convey information concerning normal physiology, but also signal disturbed homeostasis and pathophysiological processes of the different organ systems from the periphery towards the central nervous system. As such, the increased activity or 'sensitization' of mesenteric afferent nerves has been allocated an important role in the pathophysiology of visceral hypersensitivity and abdominal pain syndromes. Mesenteric afferent nerve activity can be measured in vitro in an isolated intestinal segment that is mounted in a purpose-built organ bath and from which the splanchnic nerve is isolated, allowing researchers to directly assess nerve activity adjacent to the gastrointestinal segment...
October 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27770883/multifunctional-magnetic-nanostructured-hardystonite-scaffold-for-hyperthermia-drug-delivery-and-tissue-engineering-applications
#7
Ali Farzin, Mohammadhossein Fathi, Rahmatollah Emadi
Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for killing cancer cells. The development of bioactive materials such as Hardystonite (HT) with magnetic and drug delivery properties can potentially meet this target. This new class of magnetic bioceramic can replace the widely used magnetic iron oxide nanoparticles, whose long-term biocompatibility is not clear. Magnetic HT can be potentially employed to develop new ceramic scaffolds for bone surgery and anticancer therapies...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27754195/br-06-1-clinical-applications-of-visit-to-visit-blood-pressure-variability
#8
Jinho Shin
Since the introduction of visit to visit blood pressure variability (VVBPV) for cardiovascular outcome, it has long been awaited for prospective intervention trial to reduce VVBPV for evidence based medicine. But because of several hurdles, most importantly, pending measure to reduce VVBPV, such trial may not be available in the near future. It means that current understanding on the VVBPV is not casual but related to the cardiovascular outcome.Waiting for more sound evidence, which can be remained in a clinician's mind struggling not to be indifferent for potential benefit? Firstly, the most important potential confounder in spite of the strict statistical analyses to be published may be the mean blood pressure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27754014/me-02-3-extending-sprint-results-to-diabetics
#9
Guido Grassi
The Systolic Blood Pressure Intervention Trial (SPRINT), sponsored by the National Heart, Lung and Blood Institute in the USA, allocated 9361 hypertensive patients (mean age 68 years) to two systolic blood pressure treatment targets (either < 120mmHg or < 140mmHg). Although SPRINT intended to enrol hypertensive patients at high cardiovascular risk, it specifically excluded patients with diabetes mellitus or prior stroke. SPRINT was stopped earlier than planned, after a mean follow-up of 3.26 years, on the recommendation of its data and safety monitoring board, and data were published on 9 November 2015...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748772/peptides-conjugated-to-silver-nanoparticles-in-biomedicine-a-value-added-phenomenon
#10
Suhas Ramesh, Marcelo Grijalva, Alexis Debut, Beatriz G de la Torre, Fernando Albericio, Luis H Cumbal
Nanotechnology is gaining impetus in the present century and particularly the use of nanoparticles (NPs), whose properties are significantly different from the larger matter. These have found wider and potential applications in the fields of medicine, energy, cosmetics, environment and biomedicine. Among the NPs, silver nanoparticles (AgNPs) are of particular interest for scientists and technologists due to their unique physico-chemical and biological properties. Besides, AgNPs by themselves also possess broad-spectrum microbial activity, which has further expanded their application in both academia and industries...
October 17, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27732639/transactivation-assays-to-assess-canine-and-rodent-pregnane-x-receptor-pxr-and-constitutive-androstane-receptor-car-activation
#11
Marija Pinne, Elsa Ponce, Judy L Raucy
The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake of both endogenous substrates and xenobiotics. Activation of these receptors can lead to adverse drug effects as well as drug-drug interactions. Depending on which nuclear receptor is activated will determine which adverse effect could occur, making identification important...
2016: PloS One
https://www.readbyqxmd.com/read/27716946/new-opportunities-and-challenges-in-the-assessment-of-drugs-for-atopic-diseases
#12
REVIEW
T Bieber, S Vieths, K Broich
Atopic conditions (atopic dermatitis, rhinitis, and asthma) belong to the most common noncommunicable diseases and are driven by chronic inflammatory reactions. They have a strong impact on the quality of life and represent a substantial and growing socio-economic burden. Interestingly, there is an increasing interest in the development of new therapeutic options with a number of biologics and small molecules targeting potential key mechanisms in atopic conditions. However, besides the safety issue, most of the new active substances are still evaluated according to the traditional efficacy paradigm focusing on the success in treating exacerbations and flares...
December 2016: Allergy
https://www.readbyqxmd.com/read/27707730/discordance-between-tender-and-swollen-joint-count-as-well-as-patient-s-and-evaluator-s-global-assessment-may-reduce-likelihood-of-remission-in-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis-data-from-the-prospective-multicentre-nor-dmard-study
#13
Brigitte Michelsen, Eirik Klami Kristianslund, Hilde Berner Hammer, Karen Minde Fagerli, Elisabeth Lie, Ada Wierød, Synøve Kalstad, Erik Rødevand, Frode Krøll, Glenn Haugeberg, Tore K Kvien
OBJECTIVE: To investigate the predictive value of discordance between (1) tender and swollen joint count and (2) patient's and evaluator's global assessment on remission in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). METHODS: From the prospective, multicentre Norwegian-Disease-Modifying Antirheumatic Drug study, we included patients with RA and PsA starting first-time tumour necrosis factor inhibitors and DMARD-naïve patients starting methotrexate between 2000 and 2012...
October 4, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27703966/marked-qtc-prolongation-and-torsades-de-pointes-in-patients-with-chronic-inflammatory-arthritis
#14
Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Iacopo Bertolozzi, Gabriella Morozzi, Sauro Lorenzini, Antonella Simpatico, Enrico Selvi, Maria Romana Bacarelli, Maurizio Acampa, Deana Lazaro, Nabil El-Sherif, Mohamed Boutjdir, Franco Laghi-Pasini
Mounting evidence indicates that in chronic inflammatory arthritis (CIA), QTc prolongation is frequent and correlates with systemic inflammatory activation. Notably, basic studies demonstrated that inflammatory cytokines induce profound changes in potassium and calcium channels resulting in a prolonging effect on cardiomyocyte action potential duration, thus on the QT interval on the electrocardiogram. Moreover, it has been demonstrated that in rheumatoid arthritis (RA) patients, the risk of sudden cardiac death is significantly increased when compared to non-RA subjects...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27696359/pica-in-rats-as-a-preclinical-model-of-emesis
#15
T Gregg Davis
The ability to assess the potential for gastrointestinal adverse events in a preclinical setting is a challenge in the development of new drugs, as the vast majority of in vivo research is conducted in rodent species lacking a vomiting reflex. The use of higher species capable of emesis is often limited by cost, technical experience, and relevant efficacy models to define a therapeutic index. Additionally, investigators should be mindful of ethical considerations when using more sentient species when an alternative in lower species is available...
October 3, 2016: Current Protocols in Neuroscience
https://www.readbyqxmd.com/read/27686311/proton-pump-inhibitors-use-beware-of-side-effects
#16
Iftikhar Ahmad Asim Syed, Syed Hasan Abbas Naqvi
Proton pump inhibitors are most widely prescribed medicines all over the world. Since their introduction in pharmacy, life of millions of people has changed completely. Their ability to inhibit acid secretion in stomach has changed the natural history of many once-dreaded conditions like peptic ulcer and gastroesophageal reflux disease. Operation like gastrectomy and partial gastrectomy are carried out very rarely. These medicines are considered very cost-effective, have excellent safety profile, and provide prompt symptomatic relief...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27681351/loperamide-induced-hypopituitarism
#17
Catherine Napier, Earn H Gan, Simon H S Pearce
Loperamide is the most commonly used antidiarrhoeal medication in the UK. We report a serious and hitherto undocumented adverse effect of chronic use in a 45-year-old man with inflammatory bowel disease. He presented to the endocrine clinic with fatigue and low libido; biochemical assessment revealed hypogonadism and adrenal insufficiency without any elevated adrenocorticotropic hormone. When symptoms allowed, loperamide was reduced and a short synacthen test (SST) showed a 'clear pass' with a normal peak cortisol of 833 nmol/L...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27663817/cbt-dbt-skills-training-for-adults-with-attention-deficit-hyperactivity-disorder-adhd
#18
Pierre Cole, Sebastien Weibel, Rosetta Nicastro, Roland Hasler, Alexandre Dayer, Jean-Michel Aubry, Paco Prada, Nader Perroud
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is associated with marked impairments in familial, social, and professional functioning. Although stimulant treatments can be effective in adult ADHD, some patients will respond poorly or not at all to medication. Previous studies demonstrated that cognitive behavioural therapy- (CBT) and dialectical behavior therapy- (DBT) oriented interventions are effective in reducing the burden of the disease, which is mainly marked by depression, interpersonal difficulties, low self-esteem, and low quality of life...
September 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27647337/drug-eluting-stents-in-superficial-femoral-artery-treatment-could-they-be-the-standard-of-care
#19
Marc Bosiers, Koen Deloose, Joren Callaert, Patrick Peeters, Michel Bosiers
Endovascular techniques have improved markedly over the past several decades. Plain old balloon angioplasty can only reach patencies around 40% after 1 year. Scaffolding stents have resulted in improved short-term results but encountered limitations for longer-term durability. With the introduction of drug-eluting technologies the process of intimal hyperplasia might be slowed, resulting in improved long-term patency results. At first, limus-eluting technologies were not able to transfer the enthusiasm from the coronaries to the infrainguinal vascular bed...
December 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27643152/br-06-1-clinical-applications-of-visit-to-visit-blood-pressure-variability
#20
Jinho Shin
Since the introduction of visit to visit blood pressure variability (VVBPV) for cardiovascular outcome, it has long been awaited for prospective intervention trial to reduce VVBPV for evidence based medicine. But because of several hurdles, most importantly, pending measure to reduce VVBPV, such trial may not be available in the near future. It means that current understanding on the VVBPV is not casual but related to the cardiovascular outcome.Waiting for more sound evidence, which can be remained in a clinician's mind struggling not to be indifferent for potential benefit? Firstly, the most important potential confounder in spite of the strict statistical analyses to be published may be the mean blood pressure...
September 2016: Journal of Hypertension
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