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https://www.readbyqxmd.com/read/29651257/mindfulness-based-interventions-for-the-treatment-of-substance-and-behavioral-addictions-a-systematic-review
#1
Marta Sancho, Marta De Gracia, Rita C Rodríguez, Núria Mallorquí-Bagué, Jéssica Sánchez-González, Joan Trujols, Isabel Sánchez, Susana Jiménez-Murcia, Jose M Menchón
Background: Emotion (dys)regulation as well as the interventions for improving these difficulties are receiving a growing attention in the literature. The aim of the present paper was to conduct a systematic review about the efficacy of mindfulness-based interventions (MBIs) in both substance and behavioral addictions (BAs). Method: A literature search was conducted using Cochrane, PubMed, and Web of Science. Fifty-four randomized controlled trials published in English since 2009 to April 2017 were included into a narrative synthesis...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29644528/a-novel-semi-synthetic-diterpenoid-16-r-and-s-phenylamino-cleroda-3-13-14-z-dien-15-16-olide-pgea-an-inhibits-the-growth-and-cell-survival-of-human-neuroblastoma-cell-line-sh-sy5y-by-modulating-p53-pathway
#2
Syed Saad Hussain, Kinza Rafi, Shaheen Faizi, Zaid Abdul Razzak, Shabana U Simjee
Neuroblastoma being the most common extracranial pediatric solid tumor accounts for 15% of overall cancer-related childhood mortalities. Resistance to chemotherapeutic drugs is one of the limiting factors for positive prognosis for neuroblastoma. Therefore, there is always a need for developing new therapeutic moieties which can become a future prospect of neuroblastoma therapy. Terpenoids being the largest natural compounds have demonstrated many biological activities including anticancer activity. Keeping in mind the role of terpenoids in biological system, we aimed to identify novel semi-synthetic terpenoid derived from cleroda diterpene, 16-oxo-cleroda-3,13(14)E-diene-15-oic acid (1) as a potential anticancer moiety against neuroblastoma...
April 11, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29616881/the-use-of-ketamine-xylazine-or-butorphanol-azaperone-medetomidine-to-immobilize-american-black-bears-ursus-americanus
#3
Ryan H Williamson, Lisa L Muller, Coy Blair
  Wildlife anesthetic protocols must offer rapid inductions and recoveries, be physiologically safe, and be minimally regulated. With this in mind, we evaluated differences in induction and recovery times and physiological parameters in 33 American black bears ( Ursus americanus) anesthetized with ketamine-xylazine (KX) or immobilized with a commercial drug combination of butorphanol, azaperone, and medetomidine (BAM). Dose was based on mass estimated from field observations. Bears were housed at Appalachian Bear Rescue, Townsend, Tennessee, US, or free-ranging within the Great Smoky Mountains National Park (Tennessee and North Carolina, US) and chemically immobilized for management purposes...
April 4, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29616846/specific-transcriptome-changes-associated-with-blood-pressure-reduction-in-hypertensive-patients-after-relaxation-response-training
#4
Manoj K Bhasin, John W Denninger, Jeff C Huffman, Marie G Joseph, Halsey Niles, Emma Chad-Friedman, Roberta Goldman, Beverly Buczynski-Kelley, Barbara A Mahoney, Gregory L Fricchione, Jeffery A Dusek, Herbert Benson, Randall M Zusman, Towia A Libermann
OBJECTIVE: Mind-body practices that elicit the relaxation response (RR) have been demonstrated to reduce blood pressure (BP) in essential hypertension (HTN) and may be an adjunct to antihypertensive drug therapy. However, the molecular mechanisms by which the RR reduces BP remain undefined. DESIGN: Genomic determinants associated with responsiveness to an 8-week RR-based mind-body intervention for lowering HTN in 13 stage 1 hypertensive patients classified as BP responders and 11 as nonresponders were identified...
April 4, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29614706/yoga-and-meditation-based-lifestyle-intervention-increases-neuroplasticity-and-reduces-severity-of-major-depressive-disorder-a-randomized-controlled-trial
#5
Madhuri R Tolahunase, Rajesh Sagar, Muneeb Faiq, Rima Dada
BACKGROUND: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. OBJECTIVES: To determine the effects of 12-week yoga- and meditation- based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29593204/modafinil-dependence-a-case-with-attention-deficit-hyperactivity-disorder
#6
Huseyin Alacam, Omer Basay, Selim Tumkaya, Mehmet Mart, Gokce Kar
Modafinil is generally known as a drug with low addiction potential. There are few case reports in the literature demonstrating that Modafinil, stated being capable of diminishing symptoms of attention deficit/hyperactivity disorder (ADHD), causes addiction. In the present article a Modafinil addicted ADHD case, consuming usurious doses (5,000 mg/per day) of Modafinil is presented. The case presented to our psychiatry outpatient clinic due to: requirement of in taking high dose Modafinil in order to achieve the initial effects, difficulty in obtaining the drug, irritability, anxiousness, sleep irregularities, fatigue and unpleasant vivid dreams when he did not use the drug...
March 30, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29563100/effect-of-tai-chi-versus-aerobic-exercise-for-fibromyalgia-comparative-effectiveness-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Chenchen Wang, Christopher H Schmid, Roger A Fielding, William F Harvey, Kieran F Reid, Lori Lyn Price, Jeffrey B Driban, Robert Kalish, Ramel Rones, Timothy McAlindon
OBJECTIVES: To determine the effectiveness of tai chi interventions compared with aerobic exercise, a current core standard treatment in patients with fibromyalgia, and to test whether the effectiveness of tai chi depends on its dosage or duration. DESIGN: Prospective, randomized, 52 week, single blind comparative effectiveness trial. SETTING: Urban tertiary care academic hospital in the United States between March 2012 and September 2016...
March 21, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29556256/spinal-muscular-atrophy-type-i-and-the-dual-role-of-viruses-an-interview-with-professor-basil-t-darras-professor-of-neurology-pediatrics-at-harvard-medical-school
#8
Ioannis N Mammas, Demetrios A Spandidos
According to Professor Basil T. Darras, Professor of Neurology (Pediatrics) at Harvard Medical School and Director of the Spinal Muscular Atrophy (SMA) Program at Boston Children's Hospital in Boston (MA, USA), the diagnosis of SMA type I is clinical and is based on detailed general physical and neurological examinations. SMA type I remains the most common genetic disease resulting in death in infancy and is really devastating for the child, the parents, as well as the medical professionals with the privilege of caring for patients with SMA and their parents...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29552749/miscellaneous-treatments-for-antipsychotic-induced-tardive-dyskinesia
#9
REVIEW
Karla Soares-Weiser, John Rathbone, Yusuke Ogawa, Kiyomi Shinohara, Hanna Bergman
BACKGROUND: Antipsychotic (neuroleptic) medication is used extensively to treat people with chronic mental illnesses. Its use, however, is associated with adverse effects, including movement disorders such as tardive dyskinesia (TD) - a problem often seen as repetitive involuntary movements around the mouth and face. This review, one in a series examining the treatment of TD, covers miscellaneous treatments not covered elsewhere. OBJECTIVES: To determine whether drugs, hormone-, dietary-, or herb-supplements not covered in other Cochrane reviews on TD treatments, surgical interventions, electroconvulsive therapy, and mind-body therapies were effective and safe for people with antipsychotic-induced TD...
March 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29545008/the-international-society-for-the-study-of-women-s-sexual-health-process-of-care-for-management-of-hypoactive-sexual-desire-disorder-in-women
#10
REVIEW
Anita H Clayton, Irwin Goldstein, Noel N Kim, Stanley E Althof, Stephanie S Faubion, Brooke M Faught, Sharon J Parish, James A Simon, Linda Vignozzi, Kristin Christiansen, Susan R Davis, Murray A Freedman, Sheryl A Kingsberg, Paraskevi-Sofia Kirana, Lisa Larkin, Marita McCabe, Richard Sadovsky
The International Society for the Study of Women's Sexual Health process of care (POC) for management of hypoactive sexual desire disorder (HSDD) algorithm was developed to provide evidence-based guidelines for diagnosis and treatment of HSDD in women by health care professionals. Affecting 10% of adult females, HSDD is associated with negative emotional and psychological states and medical conditions including depression. The algorithm was developed using a modified Delphi method to reach consensus among the 17 international panelists representing multiple disciplines...
March 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29538595/ophthalmic-adverse-effects-of-nasal-decongestants-on-an-experimental-rat-model
#11
Ayse Ipek Akyuz Unsal, Yesim Basal, Serap Birincioglu, Tolga Kocaturk, Harun Cakmak, Alparslan Unsal, Gizem Cakiroz, Nüket Eliyatkın, Ozden Yukselen, Buket Demirci
PURPOSE: To investigate the potential effects of chronic exposure to a nasal decongestant and its excipients on ocular tissues using an experimental rat model. METHODS: Sixty adult male Wistar rats were randomized into six groups. The first two groups were control (serum physiologic) and Otrivine® groups. The remaining four groups received the Otrivine excipients xylometazoline, benzalkonium chloride, sorbitol, and ethylene diamine tetra acetic acid. Medications were applied into both nostrils twice a day for 8 weeks...
January 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29535952/consensus-recommendations-on-sulfonylurea-and-sulfonylurea-combinations-in-the-management-of-type-2-diabetes-mellitus-international-task-force
#12
REVIEW
Sanjay Kalra, Silver Bahendeka, Rakesh Sahay, Sujoy Ghosh, Fariduddin Md, Abbas Orabi, Kaushik Ramaiya, Sameer Al Shammari, Dina Shrestha, Khalid Shaikh, Sachitha Abhayaratna, Pradeep K Shrestha, Aravinthan Mahalingam, Mazen Askheta, Aly Ahmed A Rahim, Fatimah Eliana, Hari K Shrestha, Sandeep Chaudhary, Nancy Ngugi, Jean Claude Mbanya, Than Than Aye, Tint Swe Latt, Zhanay A Akanov, Abbas Raza Syed, Nikhil Tandon, A G Unnikrishnan, S V Madhu, Ali Jawa, Subhankar Chowdhury, Sarita Bajaj, Ashok Kumar Das
For decades, sulfonylureas (SUs) have been important drugs in the antidiabetic therapeutic armamentarium. They have been used as monotherapy as well as combination therapy. Focus on newer drugs and concerns about the risk of severe hypoglycemia and weight gain with some SUs have led to discussion on their safety and utility. It has to be borne in mind that the adverse events associated with SUs should not be ascribed to the whole class, as many modern SUs, such as glimepiride and gliclazide modified release, are associated with better safety profiles...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29535646/randomized-clinical-trial-with-e-motionaltraining-%C3%A2-1-0-for-social-cognition-rehabilitation-in-schizophrenia
#13
Yolanda Maroño Souto, Miriam Vázquez Campo, Francisco Díaz Llenderrozas, Marina Rodríguez Álvarez, Raimundo Mateos, Alejandro García Caballero
Background: Schizophrenia patients present deficits in social cognition (SC), emotion and social perception, theory of mind (ToM), and attributional style. This study tested the efficacy, in real clinical conditions, of a online self-training program in SC, e-Motional Training® , in comparison with treatment as usual. Method: A randomized single-blinded multicenter clinical trial was conducted with 60 schizophrenia stable outpatients. All patients (control and intervention) were treated with drug therapy, case management, and individual and group psychotherapy (not focused on SC)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29528553/design-of-a-drug-discovery-course-for-non-science-majors
#14
Danielle H Dube
"Drug Discovery" is a 13-week lecture and laboratory-based course that was developed to introduce non-science majors to foundational chemistry and biochemistry concepts as they relate to the unifying theme of drug discovery. The first part of this course strives to build students' understanding of molecules, their properties, the differences that enable them to be separated from one another, and their abilities to bind to biological receptors and elicit physiological effects. After building students' molecular worldview, the course then focuses on four classes of drugs: antimicrobials, drugs that affect the mind, steroid-based drugs, and anti-cancer drugs...
March 12, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29523775/a-case-of-levo%C3%AF-oxacin-induced-hepatotoxicity
#15
Michael Schloss, Daniel Becak, Sebastian T Tosto, Arash Velayati
BACKGROUND Levofloxacin covers a broad spectrum of pathogens and is readily prescribed by clinicians. Hepatotoxicity is a known but unusual complication of levofloxacin use. Here, we present a case of severe transaminitis caused by levofloxacin. CASE REPORT A young man in his thirties with a history of asthma, chronic alcoholism, methamphetamine intravenous drug abuse (IVDA), and non-compliant insulin-dependent diabetes mellitus (IDDM) presented to an emergency department with suicidal ideation. Vital signs were stable and the patient was noted to have cellulitis of the right forearm, for which cultures were drawn, and he received IV clindamycin...
March 10, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29519873/phosphodiesterase-5-inhibitors-and-the-heart-compound-cardioprotection
#16
REVIEW
David Charles Hutchings, Simon George Anderson, Jessica L Caldwell, Andrew W Trafford
Novel cardioprotective agents are needed in both heart failure (HF) and myocardial infarction. Increasing evidence from cellular studies and animal models indicate protective effects of phosphodiesterase-5 (PDE5) inhibitors, drugs usually reserved as treatments of erectile dysfunction and pulmonary arterial hypertension. PDE5 inhibitors have been shown to improve contractile function in systolic HF, regress left ventricular hypertrophy, reduce myocardial infarct size and suppress ischaemia-induced ventricular arrhythmias...
March 8, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29515439/clinical-interpretations-of-patient-experience-in-a-trial-of-psilocybin-assisted-psychotherapy-for-alcohol-use-disorder
#17
Michael P Bogenschutz, Samantha K Podrebarac, Jessie H Duane, Sean S Amegadzie, Tara C Malone, Lindsey T Owens, Stephen Ross, Sarah E Mennenga
After a hiatus of some 40 years, clinical research has resumed on the use of classic hallucinogens to treat addiction. Following completion of a small open-label feasibility study, we are currently conducting a double-blind placebo-controlled clinical trial of psilocybin-assisted treatment of alcohol use disorder. Although treatment effects cannot be analyzed until the study is complete, descriptive case studies provide a useful window into the therapeutic process of psychedelic-assisted treatment of addiction...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29493820/reversible-nanogate-system-for-mesoporous-silica-nanoparticles-based-on-diels-alder-adducts
#18
Rafael R Castillo, David Henrández-Escobar, Sergio Gómez-Graña, Maria Vallet-Regi
The implementation of nanoparticles as nanomedicines require from surface modifications to obtain immune stealthiness and recognition abilities. In addition to that, Mesoporous Silica nanoparticles present the potential to incorporate advanced gating functionalities aimed at diminishing undesired leakages. This increasing complexity limits the development of drug delivery devices based on Mesoporous Silica. With this problematic in mind, we decided to face the development of a triggerable and tunable system which could be implemented for drug delivery with slight modifications...
March 1, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29485795/drug-induced-photosensitivity-a-continuing-diagnostic-challenge
#19
REVIEW
Liborija Lugović-Mihić, Tomislav Duvančić, Iva Ferček, Petra Vuković, Iva Japundžić, Diana Ćesić
When taking different drugs, their possible side effects on the skin should be considered, including skin reactions connected to photosensitivity. This photosensitivity caused by drugs can appear as phototoxic reactions (which occur more often) or photoallergic reactions (which occur less often and include allergic mechanisms). The following drugs stand out as medications with a high photosensitivity potential: nonsteroidal anti-inflammatory drugs (NSAIDs), cardiovascular drugs (such as amiodarone), phenothiazines (especially chlorpromazine), retinoids, antibiotics (sulfonamides, tetracyclines, especially demeclocycline and quinolones), etc...
June 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29485009/oral-submucous-fibrosis-as-an-overhealing-wound-implications-in-malignant-transformation
#20
Mohit Sharma, Smitha Sammith Shetty, Raghu Radhakrishnan
BACKGROUND: Oral submucous fibrosis is an oral potentially malignant disorder with high incidence of malignant transformation and rising global prevalence. However, the genesis of oral submucous fibrosis is still unclear despite superfluity of literature. In the background of ineffective treatment, it is necessary to decode its onset and progression before designing customized treatment regimens. OBJECTIVE: The objective of this article is to decipher the pathogenesis of oral submucous fibrosis in order to identify novel drug targets...
February 26, 2018: Recent Patents on Anti-cancer Drug Discovery
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