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https://www.readbyqxmd.com/read/28218672/photodynamic-synergistic-effect-of-pheophorbide-a-and-doxorubicin-in-combined-treatment-against-tumoral-cells
#1
Rubén Ruiz-González, Paula Milán, Roger Bresolí-Obach, Juan Carlos Stockert, Angeles Villanueva, Magdalena Cañete, Santi Nonell
A combination of therapies to treat cancer malignancies is at the forefront of research with the aim to reduce drug doses (ultimately side effects) and diminish the possibility of resistance emergence given the multitarget strategy. With this goal in mind, in the present study, we report the combination between the chemotherapeutic drug doxorubicin (DOXO) and the photosensitizing agent pheophorbide a (PhA) to inactivate HeLa cells. Photophysical studies revealed that DOXO can quench the excited states of PhA, detracting from its photosensitizing ability...
February 17, 2017: Cancers
https://www.readbyqxmd.com/read/28208695/the-role-of-inhaled-loxapine-in-the-treatment-of-acute-agitation-in-patients-with-psychiatric-disorders-a-clinical-review
#2
REVIEW
Domenico de Berardis, Michele Fornaro, Laura Orsolini, Felice Iasevoli, Carmine Tomasetti, Andrea de Bartolomeis, Nicola Serroni, Alessandro Valchera, Alessandro Carano, Federica Vellante, Stefano Marini, Monica Piersanti, Giampaolo Perna, Giovanni Martinotti, Massimo Di Giannantonio
Loxapine is a first generation antipsychotic, belonging to the dibenzoxazepine class. Recently, loxapine has been reformulated at a lower dose, producing an inhaled powder that can be directly administered to the lungs to treat the agitation associated with psychiatric disorders, such as schizophrenia and bipolar disorder. Thus, the aim of this narrative and clinical mini-review was to evaluate the efficacy and tolerability of inhaled loxapine in the treatment of acute agitation in patients with psychiatric disorders...
February 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28202353/the-potential-clinical-promise-of-multimodality-metronomic-chemotherapy-revealed-by-preclinical-studies-of-metastatic-disease
#3
Robert S Kerbel, Yuval Shaked
We present a rationale for further clinical development and assessment of metronomic chemotherapy on the basis of unexpected results obtained in translational mouse models of cancer involving treatment of advanced metastatic disease. Historically, mouse cancer therapy models have been dominated by treating established primary tumors or early stage low volume microscopic disease. Treatment of primary tumors is also almost always the case when using genetically engineered mouse models (GEMMS) of cancer or patient-derived xenografts (PDXs)...
February 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28192789/noninvasive-treatments-for-acute-subacute-and-chronic-low-back-pain-a-clinical-practice-guideline-from-the-american-college-of-physicians
#4
Amir Qaseem, Timothy J Wilt, Robert M McLean, Mary Ann Forciea
Description: The American College of Physicians (ACP) developed this guideline to present the evidence and provide clinical recommendations on noninvasive treatment of low back pain. Methods: Using the ACP grading system, the committee based these recommendations on a systematic review of randomized, controlled trials and systematic reviews published through April 2015 on noninvasive pharmacologic and nonpharmacologic treatments for low back pain. Updated searches were performed through November 2016...
February 14, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28184152/drug-delivery-in-overcoming-the-blood-brain-barrier-role-of-nasal-mucosal-grafting
#5
REVIEW
Carlotta Marianecci, Federica Rinaldi, Patrizia Nadia Hanieh, Luisa Di Marzio, Donatella Paolino, Maria Carafa
The blood-brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed: invasive techniques, such as temporary disruption of the BBB or direct intraventricular and intracerebral administration of the drug, as well as noninvasive techniques. Preliminary results, reported in the large number of studies on the potential strategies for brain delivery, are encouraging, but it is far too early to draw any conclusion about the actual use of these therapeutic approaches...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28183077/restructuring-hedonic-dysregulation-in-chronic-pain-and-prescription-opioid-misuse-effects-of-mindfulness-oriented-recovery-enhancement-on-responsiveness-to-drug-cues-and-natural-rewards
#6
Eric L Garland, Matthew O Howard, Jon-Kar Zubieta, Brett Froeliger
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28162094/persistent-graves-hyperthyroidism-despite-rapid-negative-conversion-of-thyroid-stimulating-hormone-binding-inhibitory-immunoglobulin-assay-results-a-case-report
#7
Nobumasa Ohara, Masanori Kaneko, Masaru Kitazawa, Yasuyuki Uemura, Shinichi Minagawa, Masashi Miyakoshi, Kenzo Kaneko, Kyuzi Kamoi
BACKGROUND: Graves' disease is an autoimmune thyroid disorder characterized by hyperthyroidism, and patients exhibit thyroid-stimulating hormone receptor antibody. The major methods of measuring circulating thyroid-stimulating hormone receptor antibody include the thyroid-stimulating hormone-binding inhibitory immunoglobulin assays. Although the diagnostic accuracy of these assays has been improved, a minority of patients with Graves' disease test negative even on second-generation and third-generation thyroid-stimulating hormone-binding inhibitory immunoglobulins...
February 6, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28151873/bimatoprost-induced-late-onset-choroidal-detachment-after-trabeculectomy-a-case-report-and-review-of-the-literature
#8
Shunsuke Nakakura, Asuka Noguchi, Hitoshi Tabuchi, Yoshiaki Kiuchi
BACKGROUND: Choroidal detachment (CD) is often observed at an early period particularly after trabeculectomy and glaucoma drainage implant surgery. However, topical antiglaucoma eye drop-induced CD is a rare complication. Here, we report a case of topical bimatoprost-induced late-onset CD after trabeculectomy and review the literature. CASE REPORT: A 74-year-old man who suffered from primary open-angle glaucoma underwent his initial trabeculectomy with mitomycin-C in the right eye...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28142302/outcomes-of-modified-metatarsal-shortening-offset-osteotomy-for-forefoot-deformity-in-patients-with-rheumatoid-arthritis-short-to-mid-term-follow-up
#9
Makoto Hirao, Kosuke Ebina, Hideki Tsuboi, Akihide Nampei, Junichi Kushioka, Takaaki Noguchi, Shigeyoshi Tsuji, Hajime Owaki, Jun Hashimoto, Hideki Yoshikawa
OBJECTIVES: Advances in drug therapy for rheumatoid arthritis (RA) have been encouraging us to preserve the metatarsopharangeal (MTP) joint in correction of forefoot deformities, and original metatarsal shortening offset osteotomy was recommended as one of the conventional surgical options for forefoot deformities in RA cases. The objective of this study was to evaluate short- to mid-term outcomes of modified metatarsal shortening offset osteotomy. METHODS: A retrospective observational study was completed for 80 RA cases (mean follow-up period: 3...
February 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28137212/diagnosis-and-treatment-of-dyslipidaemias-in-athletes
#10
Georgios A Christou, Evangelia J Kouidi, Asterios P Deligiannis, Dimitrios N Kiortsis
The beneficial effects of chronic exercise training on lipoprotein metabolism include a considerable increase in serum high density lipoprotein-cholesterol and a reduction in serum triglyceride levels. These changes are mostly reported in athletes participating in dynamic sports, especially in the endurance ones. Diagnosis and treatment of dyslipidaemias in athletes should follow the main principles of management of dyslipidaemias for the general population, while specific considerations for athletes should be taken into account...
27, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28130152/is-it-time-to-consider-the-food-use-disorder
#11
Laurence J Nolan
In the contemporary milieu, the term "addiction" brings to mind issues of physical dependence, uncontrolled behavior, psychoactive substances, and disease. Thus, the use of the term "food addiction" which has become common in research on binge eating and obesity, suggests a disease state characterized by craving, compulsive eating and, possibly, the presence of food constituents with drug-like properties which weaken the will power to abstain from consumption. In this commentary, the case is made that, following the trends in substance use disorder terminology, adoption of "food use disorder" as a term for compulsive eating associated with subjective loss of control may foster continued research in this area without the connotations suggested by "food addiction...
January 24, 2017: Appetite
https://www.readbyqxmd.com/read/28099654/meanings-and-vulnerability-to-hiv-aids-among-long-distance-truck-drivers-in-brazil
#12
Laio Magno, Marcelo Eduardo Pfeiffer Castellanos
OBJECTIVE: To understand the meanings assigned by long-distance truck drivers to HIV/AIDS and its transmission and prevention, bearing in mind different contexts of vulnerability. METHODS: Qualitative research with 22 truck drivers. Semi-structured interviews and participant observation were conducted in highways of the state of Bahia in 2013. We selected male truck drivers, with one year or more of work experience in long-distance routes. We carried out the thematic analysis of the interviews, to identify different contexts of vulnerability...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28078528/reducing-stress-among-mothers-in-drug-treatment-a-description-of-a-mindfulness-based-parenting-intervention
#13
Vanessa L Short, Meghan Gannon, Wendy Weingarten, Karol Kaltenbach, Marianna LaNoue, Diane J Abatemarco
Background Parenting women with substance use disorder could potentially benefit from interventions designed to decrease stress and improve overall psychosocial health. In this study we assessed whether a mindfulness based parenting (MBP) intervention could be successful in decreasing general and parenting stress in a population of women who are in treatment for substance use disorder and who have infants or young children. Methods MBP participants (N = 59) attended a two-hour session once a week for 12 weeks...
January 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28077147/the-political-and-scientific-challenges-in-evaluating-compulsory-drug-treatment-centers-in-southeast-asia
#14
Thu Vuong, Nhu Nguyen, Giang Le, Marian Shanahan, Robert Ali, Alison Ritter
BACKGROUND: In Vietnam, like many countries in Southeast Asia, the commonly used approach of center-based compulsory drug treatment (CCT) has been criticized on human rights ground. Meanwhile, community-based voluntary methadone maintenance treatment (MMT) has been implemented for nearly a decade with promising results. Reform-minded leaders have been seeking empirical evidence of the costs and effectiveness associated with these two main treatment modalities. Conducting evaluations of these treatments, especially where randomization is not ethical, presents challenges...
January 11, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28066110/assessment-of-impact-of-pharmacophilia-and-pharmacophobia-on-medication-adherence-in-patients-with-psychiatric-disorders-a-cross-sectional-study
#15
Mini Johnson Christudas, Balaji Sathyanarayana Gupta, Krishna Undela, Noel M Isaac, Dushad Ram, Madhan Ramesh
AIMS: To investigate the impact of pharmacophilia and pharmacophobia on medication adherence among patients with psychiatric disorders. MATERIALS AND METHODS: A cross-sectional, observational study was conducted in the Department of Psychiatry over a period of 2 months. Patients above 18 years of age with a psychiatric diagnosis as per the International Classification of Diseases 10 and receiving at least one psychotropic medication (any medication capable of affecting the mind, emotions, and behavior) for >1 month were enrolled in the study...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28065792/the-analgesic-effects-of-oxytocin-in-the-peripheral-and-central-nervous-system
#16
Qing Xin, Bo Bai, Wenyan Liu
Pain is a ubiquitously unpleasant feeling among humans as well as many animal species often caused by actual and potential tissue damage. However, it is absolutely crucial for our survival in many ways. Acute pain can signal the presence of danger or life-threatenting events, which help escape noxious stimuli. By contrast, when pain becomes chronic or persistent, it becomes an encumbrance and exerts deleterious effects to the body and mind, often co-occured with anxiety and depression. Additionaly, chronic pain is more or less an economic burden for the patients because it requires immediate medical treatments and seriously hinders pepople in their work...
February 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28039598/patient-acceptability-and-experiences-of-therapeutic-switching-of-proton-pump-inhibitors-within-the-national-preferred-drugs-initiative-in-ireland
#17
G O'Connor, D O'Keeffe, C Darker, B O'Shea
INTRODUCTION: A 'Preferred Drugs' initiative was introduced into Ireland in 2013. This identified a single recommended drug to be prescribed to patients requiring treatment from a particular class of drugs. AIMS: This study investigates how patients on established proton pump inhibitor (PPI) therapy experienced the therapeutic switching of their medication to the 'preferred drug', and the extent to which they regarded it as an acceptable practice. METHODS: The experiences of 61 patients on established proton pump inhibitor (PPI) therapy were sought before and after their drug was switched to the 'preferred drug'...
December 30, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28008350/safety-profile-of-lamotrigine-in-overdose
#18
REVIEW
Akintunde Alabi, Adam Todd, Andrew Husband, Joe Reilly
BACKGROUND: Lamotrigine is an anticonvulsant as well as a mood stabilizer. Apart from its established use in the treatment of epilepsy, there has been an expansion of its use in the treatment of mental disorders. Patients with epilepsy as well as those with mental disorders are at increased risk of deliberate drug overdoses. An evidence base for the safety profile of lamotrigine in overdose is an essential tool for prescribers. The objective of this study was to carry out a narrative synthesis of the existing evidence for the safety profile of lamotrigine in overdose...
December 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28000903/pluripotent-human-stem-cells-standing-on-the-shoulders-of-giants
#19
Ivan Damjanov, Peter W Andrews
The advent of human pluripotent stem cells, with the first derivation of human embryonic stem cells in 1998, and of human induced pluripotent stem cells in 2007, has ushered in an era of considerable excitement about the prospects of using these cells to develop new opportunities for healthcare, from their potential for regenerative medicine to their use as tools for studying the cellular basis of many diseases and the discovery of new drugs. But as with the flowering of many new areas in science, the biology of human pluripotent stem cells has its roots in a long history of, sometimes, less fêted research...
2016: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/27978655/divergent-synthesis-and-real-time-biological-annotation-of-optically-active-tetrahydrocyclopenta-c-pyranone-derivatives
#20
Shawn D Nelson, Mathias J Wawer, Stuart L Schreiber
Sp(3)-rich compounds are underrepresented in libraries for probe- and drug-discovery, despite their promise of extending the range of accessible molecular shapes beyond planar geometries. With this in mind, a collection of single-enantiomer bicyclic, fused cyclopentenones underpinned by a complexity-generating Pauson-Khand cyclization was synthesized. A fingerprint of biological actions of these compounds was determined immediately after synthesis using real-time annotation-a process relying on multiplexed measurements of alterations in cell morphological features...
December 16, 2016: Organic Letters
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