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https://www.readbyqxmd.com/read/27918166/-breast-self-examination-yes-or-no
#1
P Šašková, D Pavlišta
OBJECTIVE: The rising number of breast cancer is the worldwide problem. The screening mammography is considered as the most effective method to decrease the mortality of the disease. For many years, the breast self-examination has been promoted as the simplest method for breast cancer development in women. In this review article, we provide the results of studies on the effectiveness of breast self-examination. DESIGN: Review article. SETTING: Departmnet of Gynecologic and Obstetrition, General Faculty Hospital and 1st Faculty of Medicine, Charles University Prague...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27918161/-current-options-of-preimplantion-genetic-screening-and-preimplantation-genetic-diagnostics
#2
V Šimečková
OBJECTIVE: The aim of this work is to summarize the current knowledge about preimplantation genetic screening and diagnostics. DESIGN: A review article. SETTING: Department of Gynecology and Obstetrics, District Hospital Šternberk, IVF Clinic, Olomouc. RESULTS: Preimplantation genetic testing is a complex of genetic and molecular cytogenetic examinations, which can help to detect abnormalities in embryos before transfer into the uterus of the mother...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27899963/recent-perspectives-of-epithelial-ovarian-carcinoma
#3
Xiao-Ying Zhang, Pei-Ying Zhang
Epithelial ovarian tumours have been reported to mainly arise from the simple cuboidal surface epithelium of the ovary, and account for 75% of all ovarian tumours, and 90-95% of ovarian malignancies. Epithelial ovarian carcinoma (EOC) is responsible for the highest number of deaths in women due to gynecologic malignancy, with a low 5-year relative survival of only 44%. The possible reasons for these low survival rates are the high incidence of chemoresistance found with EOC and a lack of consideration of the high degree of heterogeneity of EOC in the current standard of care...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899185/genetic-predisposition-in-gynecologic-cancers
#4
REVIEW
Molly S Daniels, Karen H Lu
This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27896986/network-map-of-adverse-health-effects-among-victims-of-intimate-partner-violence
#5
Kathleen Whiting, Larry Y Liu, Mehmet Koyutürk, Günnur Karakurt
Intimate partner violence (IPV) is a serious problem with devastating health consequences. Screening procedures may overlook relationships between IPV and negative health effects. To identify IPV-associated women's health issues, we mined national, aggregated de-identified electronic health record data and compared female health issues of domestic abuse (DA) versus non-DA records, identifying terms significantly more frequent for the DA group. After coding these terms into 28 broad categories, we developed a network map to determine strength of relationships between categories in the context of DA, finding that acute conditions are strongly connected to cardiovascular, gastrointestinal, gynecological, and neurological conditions among victims...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27894165/practice-guidelines-for-management-of-uterine-corpus-cancer-in-korea-a-korean-society-of-gynecologic-oncology-consensus-statement
#6
Shin Wha Lee, Taek Sang Lee, Dae Gy Hong, Jae Hong No, Dong Choon Park, Jae Man Bae, Seok Ju Seong, So Jin Shin, Woong Ju, Keun Ho Lee, Yoo Kyung Lee, Hanbyoul Cho, Chulmin Lee, Jiheum Paek, Hyun Jung Kim, Jeong Won Lee, Jae Weon Kim, Duk Soo Bae
OBJECTIVE: Clinical practice guidelines for gynecologic cancers have been developed by many organizations. Although these guidelines have much in common in terms of the practice of standard of care for uterine corpus cancer, practice guidelines that reflect the characteristics of patients and healthcare and insurance systems are needed for each country. The Korean Society of Gynecologic Oncology (KSGO) published the first edition of practice guidelines for gynecologic cancer treatment in late 2006; the second edition was released in July 2010 as an evidence-based recommendation...
October 27, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27882769/-current-issues-of-reproductive-medicine-in-the-czech-republic
#7
P Ventruba, J Žáková, M Ješeta, D Rumpík, M Brandejská, I Crha, D Hlinka, L Jelínková, E Oráčová, J Pavelková, K Řežábek, K Veselá
INTRODUCTION: During the 25th symposium of assisted reproduction in Brno was lunch time organised as the lunch table discussion on the selected topics of assisted reproduction. More than 150 specialists reviewed themes related to gynecology and embryology.Discussed topics: Lunch table discussion covered the following topics: (1) Cross-border health care in assisted reproduction; (2) Indication for PGS (preimplantation genetic screening) in the context of actual information; (3) Does ovarian stimulation belong to the ambulance of registering gynecologists? (4) Therapy with clomifen - only for IVF specialists? (5) How and with whom should psychological support be directed during IVF? (6) Stimulation in women with low ovarian reserve; (7) Is basic semen analyses sufficient? (8) Time-lapse systems as relevant markers of embryonic development; (9) How to be oriented with choices of media and consumables in the IVF lab, and (10) "Freeze All" - is this new trend in cryopreservation suitable for all? CONCLUSIONS: Panel conclusions were presented during the afternoon session, which had great attendance, featured lively commentary, and produced some definitive consensus...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27875034/risk-factors-of-post-traumatic-stress-symptoms-in-patients-with-cancer
#8
Yu-Hua Lin, Chia-Chan Kao, Shu-Fen Wu, Shu-Ling Hung, Hsing-Yu Yang, Hong-Yu Tung
AIM AND OBJECTIVES: To determine the level of PTSS and to identify demographics, disease history, and clinical symptoms that were associated with PTSS among gynecological, breast, or colorectal cancer patients in Taiwan. BACKGROUND: Literature indicated that 7.3 % to 35.2% of patients with cancer had experienced level of post-traumatic stress symptoms (PTSS). However, the PTSS among patients with cancer in Taiwan was not documented. DESIGN: A cross-sectional study...
November 22, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27869688/comparison-of-secular-trends-in-cervical-cancer-mortality-in-china-and-the-united-states-an-age-period-cohort-analysis
#9
Jinyao Wang, Zhiqiang Bai, Zhenkun Wang, Chuanhua Yu
Background: As one of the most common cancers in the female population, cervical cancer has ranked as the second most incident gynecological cancer in recent years, trailing only breast cancer. We aimed to assess and compare the secular trends in cervical cancer mortality in China and the United States and analyze the independent effects of chronological age, time period and birth cohort using age-period-cohort (APC) analysis. Methods: We performed an age-period-cohort analysis using the intrinsic estimator method to estimate the independent effects of age, time period, and birth cohort on cervical cancer mortality...
November 17, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27861753/screening-for-depression-in-cancer-patients-receiving-radiotherapy-feasibility-and-identification-of-effective-tools-in-the-nrg-oncology-rtog-0841-trial
#10
Lynne I Wagner, Stephanie L Pugh, William Small, Jeffrey Kirshner, Kulbir Sidhu, Martin J Bury, Albert S DeNittis, Tracy E Alpert, Binh Tran, Beatrice F Bloom, Julie Mai, Alexander Yeh, Kalika Sarma, Mark Becker, Jennifer James, Deborah Watkins Bruner
BACKGROUND: Brief tools are needed to screen oncology outpatients for depressive symptoms. METHODS: Patients starting radiotherapy for the first diagnosis of any tumor completed distress screening tools, including the 9-item Patient Health Questionnaire (PHQ-9), the 2-item Patient Health Questionnaire (PHQ-2), the National Comprehensive Cancer Network Distress Thermometer (NCCN-DT), and the Hopkins Symptom Checklist (HSCL) (25-item version). Patients exceeding validated cutoff scores and a systematic sample of patients whose screening was negative completed the Structured Clinical Interview for DSM-IV (SCID) mood disorder modules via telephone...
November 10, 2016: Cancer
https://www.readbyqxmd.com/read/27861705/the-temporal-and-age-dependent-patterns-of-hysterectomy-corrected-cervical-cancer-incidence-rates-in-denmark-a-population-based-cohort-study
#11
Anne Hammer, Johnny Kahlert, Anne Rositch, Lars Pedersen, Patti Gravitt, Jan Blaakaer, Mette Soegaard
INTRODUCTION: Hysterectomy is a common gynecological procedure, however, the incidence of total and subtotal hysterectomy varies across countries, by age, and over time. Since only women with an intact cervix are at risk of cervical cancer, failing to remove hysterectomized women from the denominator may underestimate the cervical cancer incidence. We aimed to describe the temporal and age-dependent patterns of cervical cancer incidence in Denmark before and after correction for hysterectomy...
November 14, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27861200/imaging-of-hereditary-tumors-of-the-female-genital-system
#12
Sarah M Rothan, Christine O Menias, Yehia M ElGuindy, Corey T Jensen, Akram Shaaban, Priya Bhosale, Michelle V Lee, Venkata S Katabathina, Khaled M Elsayes
Cancers of the female genital system, particularly endometrial and ovarian cancers, can be associated with hereditary cancer syndromes such as hereditary breast and ovarian cancer and Lynch syndrome. Cancers that are found in the setting of a hereditary cancer syndrome are often unique in presentation, clinical features, and pathologic profiles when compared with sporadic tumors. This article reviews the hereditary cancer syndromes associated with gynecological malignancies, as well as the imaging findings and staging system of endometrial and ovarian cancers...
November 17, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27858131/barriers-to-urogynecological-care-in-a-population-of-gynecological-oncology-patients
#13
Paula Jaye Doyle, Sajeena G Thomas, Gunhilde M Buchsbaum
INTRODUCTION AND HYPOTHESIS: The objective was to identify barriers to urogynecological evaluation in a population of new patients presenting to a gynecological oncology practice with symptoms of pelvic floor dysfunction. METHODS: A pelvic floor dysfunction screening questionnaire was given to new patients presenting to a university-based gynecological oncology practice between 1 August 2010 and 31 August 2012. Patients indicating symptoms related to pelvic floor dysfunction in the survey were offered urogynecological evaluations...
November 17, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27847479/understanding-molecular-landscape-of-endometrial-cancer-through-next-generation-sequencing-what-we-have-learned-so-far
#14
Siti-Syazani Suhaimi, Nurul-Syakima Ab Mutalib, Rahman Jamal
Endometrial cancer (EC) is among the most common gynecological cancers affecting women worldwide. Despite the early detection and rather high overall survival rate, around 20% of the cases recur with poor prognosis. The Next Generation Sequencing (NGS) technology, also known as massively parallel sequencing, symbolizes a high-throughput, fast, sensitive and accurate way to study the molecular landscape of a cancer and this has indeed revolutionized endometrial cancer research. Understanding the potential, advantages, and limitations of NGS will be crucial for the healthcare providers and scientists in providing the genome-driven care in this era of precision medicine and pharmacogenomics...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27835625/use-of-treponemal-screening-assay-strength-of-signal-to-avoid-unnecessary-confirmatory-testing
#15
Gregory J Berry, Michael J Loeffelholz
BACKGROUND: Our reverse syphilis testing algorithm consists of a treponemal IgG multiplex flow immunoassay (MFI) followed by both rapid plasma reagin titer and the Treponema pallidum particle agglutination (TPPA) test on specimens with a reactive MFI result. We report here the impact of a modified reverse algorithm, in which the strength of signal of the MFI is used to avoid unnecessary TPPA testing. METHODS: The Bioplex syphilis IgG MFI was used as the syphilis screening assay, and specimens with equivocal (antibody index 0...
December 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27831834/role-of-imaging-in-fertility-sparing-treatment-of-gynecologic-malignancies
#16
Andrea G Rockall, Mahrukh Qureshi, Ioanna Papadopoulou, Srdjan Saso, Nicholas Butterfield, Isabelle Thomassin-Naggara, Alan Farthing, J Richard Smith, Nishat Bharwani
Treatments for gynecologic cancer usually result in loss of fertility due to surgery or radical radiation therapy in the pelvis. In countries with an established screening program for cervical cancer, the majority of gynecologic malignancies occur in postmenopausal women. However, a substantial number of affected women are of childbearing age and have not completed their families. In these younger women, consideration of fertility preservation may be important. This article describes the fertility-sparing treatment options that are currently available and outlines the role of imaging in the selection of eligible patients on the basis of a review of the literature...
November 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27822431/development-implementation-and-assessment-of-a-genetics-curriculum-across-institutions
#17
Sarah Dotters-Katz, Ginger Hocutt, C Michael Osborne, Emily E Hardisty, Laurie Demmer, Neeta Vora
Objective Many residency programs offer limited exposure and minimal didactic time genetics, despite its frequent use in obstetrics and gynecology. The objective of this study was to develop, pilot, and assess a three-module women's health genetics curriculum for residents that was easily transferable between institutions. Methods An interactive three-module genetics curriculum covering basic principles, prenatal screening/diagnosis, and cancer genetics was developed. A pre- and posttests were used to assess improvement in knowledge...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/27819411/development-of-the-short-version-of-the-gynecologic-cancer-lymphedema-questionnaire-gclq-7
#18
Se Ik Kim, Namjoo Kim, Seonjoo Lee, Sujung Lee, Jungnam Joo, Sang Soo Seo, Seung Hyun Chung, Sang Yoon Park, Myong Cheol Lim
OBJECTIVE: The Gynecologic Cancer Lymphedema Questionnaire (GCLQ) was designed to identify gynecologic cancer patients with lower limb lymphedema (LLL). The questionnaire consists of 20 items distributed over 7 symptom clusters. The present study aimed to develop an abridged form of the GCLQ for simpler screening and more effective follow-up of LLL. METHODS: Data that had been collected for the development and validation of the Korean version of the GCLQ (GCLQ-K) were used in this study...
October 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27817223/discovery-of-biomarkers-for-endometrial-cancer-current-status-and-prospects
#19
Tea Lanišnik Rižner
Endometrial cancer is the most frequent gynecological malignancy in the developed world. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid noninvasive diagnostic methods available. Biomarkers for endometrial cancer would be invaluable for screening of high-risk women, detection of primary and recurrent disease, and preoperative stratification of patients as high-risk and low-risk categories, enabling personalized therapeutic approaches. Areas covered: This report reviews publications of blood biomarkers evaluated in patients with endometrial cancer and/or control patients, over the last five years...
December 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27813114/the-value-of-the-first-trimester-ultrasound-in-the-era-of-cell-free-dna-screening
#20
Rashmi R Rao, Stephanie G Valderramos, Neil S Silverman, Christina S Han, Lawrence D Platt
OBJECTIVE: To describe the clinically relevant findings detected by the first trimester ultrasound (FTU) and to determine the additional value of the FTU compared to cell free DNA (cfDNA) alone. METHOD: Retrospective cohort study of patients undergoing a FTU at a maternal-fetal medicine referral practice. Fetal, gynecologic, and placental findings detected by ultrasound were analyzed with available cfDNA and diagnostic testing results. A subgroup analysis of positive ultrasound findings and cfDNA results was performed to assess the additional benefit of ultrasound evaluation in FT prenatal screening...
November 3, 2016: Prenatal Diagnosis
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