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https://www.readbyqxmd.com/read/28817690/resveratrol-and-caloric-restriction-prevent-hepatic-steatosis-by-regulating-sirt1-autophagy-pathway-and-alleviating-endoplasmic-reticulum-stress-in-high-fat-diet-fed-rats
#1
Shibin Ding, Jinjin Jiang, Guofu Zhang, Yongjun Bu, Guanghui Zhang, Xiangmei Zhao
BACKGROUND: Studies have demonstrated that resveratrol (a natural polyphenol) and caloric restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Furthermore, autophagy is induced by the SIRT1-FoxO signaling pathway and was recently shown to be a critical protective mechanism against non-alcoholic fatty liver disease (NAFLD) development. We aimed to compare the effects of resveratrol and caloric restriction on hepatic lipid metabolism and elucidate the mechanism by which resveratrol supplementation and caloric restriction alleviate hepatosteatosis by examining the molecular interplay between SIRT1 and autophagy...
2017: PloS One
https://www.readbyqxmd.com/read/28806949/case-report-of-ocular-kaposi-s-sarcoma
#2
Jing Yang, Xiao-Fang Yin, Yong-Ping Li, Shi-You Zhou
BACKGROUND: Kaposi's sarcoma (KS) is generally considered a neoplastic disorder of vascular origin and occurs in patients with acquired immunodeficiency syndrome (AIDS) or who have received immunosuppressive treatments after an organ transplant (Soulier et al., Blood 86(4):1276-80, 1995; Viejo-Borbolla and Schulz, AIDS Rev 5(4):222-9, 2003; Schulz, J Antimicrob Chemother 45(Suppl T3):15-27, 2000; Aversa et al. Crit Rev Oncol Hematol 53(3):253-65, 2005; Mbulaiteye and Engels, Int J Cancer 119(11):2685-91, 2006; Tessari et al...
August 14, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28777810/green-tea-polyphenol-treatment-attenuates-atherosclerosis-in-high-fat-diet-fed-apolipoprotein-e-knockout-mice-via-alleviating-dyslipidemia-and-up-regulating-autophagy
#3
Shibin Ding, Jinjin Jiang, Pengxin Yu, Guofu Zhang, Guanghui Zhang, Xiaoting Liu
BACKGROUND: Green tea polyphenol (GTP) is a polyphenol source from green tea that has drawn wide attention owing to epidemiological evidence of its beneficial effects in the prevention of cardiovascular disease; the underlying molecular mechanisms of these effects are not well understood. This study aimed to investigate the effects of GTP treatment on autophagy regulation in the vessel wall and lipid metabolism of HFD-fed male ApoE-knockout mice. METHODS: Adult male ApoE-knockout mice (n = 30) fed with a high-fat diet (HFD) were treated with either vehicle or GTP (3...
2017: PloS One
https://www.readbyqxmd.com/read/28612588/analysis-of-knowledge-level-in-brazilian-students-about-human-papillomavirus-infection-and-development-of-penile-cancer
#4
George Kemil Abdalla, Emanuella Francisco Fajardo, Bruno Belmonte Martinelli Gomes, Thiago Mantello Bianco, Ana Karina Marques Salge, Eduardo Elias Vieira de Carvalho, Marlize Moura Dos Reis, Dayana Pousa Siqueira Abrahão, Douglas Reis Abdalla
Introduction: Human papillomavirus (HPV), belonging to the Papovavirida family, is the most prevalent sexually transmitted disease (STD) agent worldwide. In Brazil, it is estimated that there are 3-6 million people infected with HPV. Aim: The aim of this study was to evaluate the knowledge of young male students about penis cancer related to HPV infection. Methods: This exploratory and quantitative study was conducted to analyze answers of 242 male students attending a private college located in Uberaba city, Minas Gerais state, Brazil, during 2015...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28608786/new-human-immunodeficiency-virus-diagnosis-independently-associated-with-rectal-gonorrhea-and-chlamydia-in-men-who-have-sex-with-men
#5
Lindley A Barbee, Christine M Khosropour, Julia C Dombrowksi, Matthew R Golden
BACKGROUND: Rectal sexually transmitted infections (STI) have been associated with human immunodeficiency virus (HIV) diagnosis, but inferring a causal association requires disentangling them from receptive anal intercourse (RAI). METHODS: We conducted a stratified case-control study by frequency matching 4 controls to each case within year using clinical data from men who have sex with men (MSM) attending the Seattle STD Clinic 2001 to 2014. Cases were MSM with a new HIV diagnosis and negative HIV test at 12 months or less...
July 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28499291/a-survey-of-25-north-carolina-health-departments-districts-on-knowledge-attitudes-and-current-practices-to-seeking-reimbursement-from-third-party-payers-for-sexually-transmitted-disease-services
#6
Cheryl L Kovar, Susan Carter
BACKGROUND: North Carolina Administrative Code 10A Chapter 41A.0204 (a) states "local health departments shall provide diagnosis, testing, treatment, follow-up, and preventive services for syphilis, gonorrhea, chlamydia, … These services shall be provided upon request and at no charge to the patient." Although health departments/districts may bill governmental or nongovernmental insurance providers for sexually transmitted disease (STD) services, current billing practices are unknown...
June 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28442801/treatment-outcomes-and-loss-to-follow-up-rate-of-male-patients-with-gonococcal-and-nongonococcal-urethritis-who-attended-the-sexually-transmitted-disease-clinic-an-8-year-retrospective-study
#7
Charussri Leeyaphan, Sukhum Jiamton, Pattriya Chanyachailert, Theetat Surawan, Viboon Omcharoen
BACKGROUND: Poor follow-up compliance of patients with infectious urethritis is a recognized and serious public health problem in Thailand. AIM: The aim of this study was to determine treatment outcomes and loss to follow-up rate of male patients with gonococcal urethritis (GU) and non-GU (NGU) at a sexually transmitted disease (STD) clinic at Thailand's tertiary hospital. METHODS: This retrospective chart review of male patients who sought treatment at STDs Clinic, Siriraj Hospital, and who were diagnosed with GU and/or NGU was conducted during January 2007 to December 2014 study period...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28327799/prevalence-and-factors-associated-with-syphilis-in-a-reference-center
#8
Natália Carolina Rodrigues Colombo Gomes, Denise Andrade Pereira Meier, Flávia Meneguetti Pieri, Elaine Alves, Silvia Paulino Ribeiro Albanese, Edvilson Cristiano Lentine, Ricardo Alexandre Arcêncio, Elma Mathias Dessunti
INTRODUCTION: The implementation of the rapid test (RT) for syphilis increases access of vulnerable populations to early diagnosis and treatment, impacting the outcomes of infection. We aimed to assess the prevalence of and factors associated with syphilis in a Center for Testing and Counseling (CTC). METHODS: We conducted a cross-sectional study at a Reference Center for sexually transmitted disease (STD) and acquired immune deficiency syndrome in Londrina, Northern Paraná State, Southern Brazil...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28290950/survey-of-sexually-transmitted-disease-laboratory-methods-in-u-s-army-laboratories-2012
#9
Nicole K Leamer, Nikki N Jordan, Laura A Pacha, Nabil H Latif, Eric C Garges, Joel C Gaydos
INTRODUCTION: Sexually transmitted diseases (STD) affect primarily young people (17-24 years). The U.S. Military, with many young people, strives to maintain effective STD treatment and prevention programs using current methods. Laboratory testing technology and capacity are important for appropriate clinical management and to provide data to direct prevention programs. STD laboratory capabilities are assessed in civilian and military laboratories using surveys. An Army laboratory survey was conducted in 2007...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28208724/assessing-the-knowledge-level-attitudes-risky-behaviors-and-preventive-practices-on-sexually-transmitted-diseases-among-university-students-as-future-healthcare-providers-in-the-central-zone-of-malaysia-a-cross-sectional-study
#10
Adigun Temiloluwa Folasayo, Afolayan John Oluwasegun, Suhailah Samsudin, Siti Nor Sakinah Saudi, Malina Osman, Rukman Awang Hamat
This study was done to assess the knowledge, attitudes, risky behaviors and preventive practices related to sexually-transmitted diseases (STDs) among health and non-health sciences university students as future healthcare providers in Malaysia. A total of 700 health and non-health sciences university students (255 male; 445 female) aged between 17 and 30 years were surveyed by using a self-administered questionnaire. The majority (86.6%) had heard of STDs, and 50.4% knew STDs could present without symptoms...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28199417/physical-activity-prevents-alterations-in-mitochondrial-ultrastructure-and-glucometabolic-parameters-in-a-high-sugar-diet-model
#11
Karina Barbosa de Queiroz, Kinulpe Honorato-Sampaio, Joamyr Victor Rossoni Júnior, Diego Andrade Leal, Angélica Barbosa G Pinto, Lenice Kappes-Becker, Elisio Alberto Evangelista, Renata Guerra-Sá
Endurance exercise is a remarkable intervention for the treatment of many diseases. Mitochondrial changes on skeletal muscle are likely important for many of the benefits provided by exercise. In this study, we aimed to evaluate the effects that a regular physical activity (swimming without workload) has on mitochondrial morphological alterations and glucometabolic parameters induced by a high-sugar diet (HSD). Weaned male Wistar rats fed with a standard diet or a HSD (68% carbohydrate) were subjected to 60 minutes of regular physical activity by swimming (without workload) for four- (20 sessions) or eight-week (40 sessions) periods...
2017: PloS One
https://www.readbyqxmd.com/read/28178118/microscopy-of-stained-urethral-smear-in-male-urethritis-which-cutoff-should-be-used
#12
Harald Moi, Usha Hartgill, Kristin Helene Skullerud, Elina J Reponen, Line Syvertsen, Amir Moghaddam
BACKGROUND: The microscopical diagnosis of male urethritis was recently questioned by Rietmeijer and Mettenbrink, lowering the diagnostic criteria of the diagnosis to ≥2 polymorphonuclear leucocytes (PMNL) per high power field (HPF), and adopted by Centers for Disease Control and Prevention in their 2015 STD Treatment Guidelines. The European Non-Gonococcal Urethritis Guideline advocates a limit of ≥5 PMNL/HPF. OBJECTIVE: To determine if syndromic treatment of urethritis should be considered with a cutoff value of ≥2 PMNL/HPF in urethral smear...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27968882/effects-of-patient-load-and-travel-distance-on-hiv-transmission-in-a-cohort-of-serodiscordant-couples-in-rural-china-a-longitudinal-analysis
#13
M Kumi Smith, William C Miller, Huixin Liu, Chuanyi Ning, Wensheng He, Myron S Cohen, Ning Wang
BACKGROUND: Sustained viral suppression through antiretroviral therapy (ART) reduces the risk of sexual HIV transmission. However, it can require routine access to reliable and effective medical care, which can be difficult to obtain in resource-constrained areas. We investigated the effects of patient load and travel distance to an HIV care clinic on transmission risk in HIV serodiscordant couples in the Henan Province, China. METHODS: The study cohort arises from a population of HIV-infected individuals in central rural China where regional blood selling scandals in the 1990s led to mass HIV transmission of up to 30 000 people though unsanitary blood collection practices...
October 2016: Lancet
https://www.readbyqxmd.com/read/27925128/-incidence-and-mortality-of-children-and-teenagers-with-aids-challenges-in-the-southern-region-of-brazil
#14
Márcio Cristiano de Melo, Rosemeire de Olanda Ferraz, Juliana Luporini do Nascimento, Maria Rita Donalisio
The objective of this study is to describe the time trend of coefficients of incidence and mortality associated with AIDS in children and adolescents. An ecological time trend study was conducted among individuals under 14 living in the regional context of high incidence of AIDS - Porto Alegre and the State of Rio Grande do Sul - from 1996 to 2012. For this purpose, a segmented regression model was adjusted for age categories and place of residence. AIDS morbidity and mortality indicators in Porto Alegre are still higher than those registered in the State, the southern region and other areas of the country...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27832703/hiv-and-sti-knowledge-testing-and-risk-among-adult-crack-users-in-mexico-city-baseline-findings-from-a-feasibility-study
#15
Alice Cepeda, Jessica Frankeberger, Jennifer L Bailey, Kathryn M Nowotny, Guillermina Natera-Rey, Avelardo Valdez
Recent research has documented crack cocaine's increasing spread in Mexico, which is likely to contribute to the rapid transmission of HIV and other sexually transmitted infections (STIs). In Mexico, crack use is increasing most rapidly in vulnerable, hard-to-reach populations, where little is known about risk behaviors. This report aims to present baseline data regarding HIV and STI knowledge and testing prevalence from an innovative projection mapping HIV intervention, in which 3-D illusions, animation, and visual text graphics and sound are projected onto buildings with health messages that were designed to disrupt everyday life and connect with the target population...
March 2017: AIDS Care
https://www.readbyqxmd.com/read/27677620/proanthocyanidins-potentiate-hypothalamic-leptin-stat3-signalling-and-pomc-gene-expression-in-rats-with-diet-induced-obesity
#16
M Ibars, A Ardid-Ruiz, M Suárez, B Muguerza, C Bladé, G Aragonès
OBJECTIVE: Dietary obesity is usually linked with hypothalamic leptin resistance, in which the primary impact is an interference in the homeostatic control of body weight and appetite. Notably, proanthocyanidins (PACs), which are the most abundant phenolic compounds present in human diet, modulate adiposity and food intake. The aim of this study was to assess whether PACs could re-establish appropriate leptin signalling in both the hypothalamus and peripheral tissues. DESIGN: Male Wistar rats were fed either a standard chow diet (STD group, n=7) or a cafeteria diet (CD) for 13 weeks...
January 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27419816/etiology-of-genital-ulcer-disease-in-male-patients-attending-a-sexually-transmitted-diseases-clinic-first-assessment-in-cuba
#17
Angel A Noda, Orestes Blanco, Consuelo Correa, Lissette Pérez, Vivian Kourí, Islay Rodríguez
BACKGROUND: Sexually transmitted diseases (STDs) and in particular genital ulcer disease (GUD) have a major impact on morbidity and mortality in developing countries. The World Health Organization recommends the use of syndromic guidelines for the treatment of sexually transmitted infections (STIs) in resource-constrained countries. Surveillance of autochthonous etiologies provides epidemiological information contributing to the prevention and treatment of STIs. We investigated the etiology and factors associated with GUD among male patients attending a STD clinic in Havana, Cuba...
August 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27414503/neisseria-gonorrhoeae-antimicrobial-susceptibility-surveillance-the-gonococcal-isolate-surveillance-project-27-sites-united-states-2014
#18
Robert D Kirkcaldy, Alesia Harvey, John R Papp, Carlos Del Rio, Olusegun O Soge, King K Holmes, Edward W Hook, Grace Kubin, Stefan Riedel, Jonathan Zenilman, Kevin Pettus, Tremeka Sanders, Samera Sharpe, Elizabeth Torrone
PROBLEM/CONDITION: Gonorrhea is the second most commonly reported notifiable disease in the United States; 350,062 gonorrhea cases were reported in 2014. Sexually transmitted infections caused by Neisseria gonorrhoeae are a cause of pelvic inflammatory disease in women, which can lead to serious reproductive complications including tubal infertility, ectopic pregnancy, and chronic pelvic pain. Prevention of sequelae and of transmission to sexual partners relies largely on prompt detection and effective antimicrobial treatment...
July 15, 2016: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/27208390/secondary-syphilis-in-the-oral-cavity-and-the-role-of-the-dental-surgeon-in-std-prevention-diagnosis-and-treatment-a-case-series-study
#19
Creta Elisa Seibt, Maria Cristina Munerato
Syphilis is an infectious disease caused by the bacterium Treponema pallidum. Syphilis has three clinical stages and may present various oral manifestations, mainly at the secondary stage. The disease mimics other more common oral mucosa lesions, going undiagnosed and with no proper treatment. Despite the advancements in medicine toward prevention, diagnosis, and treatment syphilis remains a public health problem worldwide. In this sense, dental surgeons should be able to identify the most common manifestations of the disease in the oral cavity, pointing to the role of this professional in prevention and diagnosis...
July 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27184061/ultraviolet-b-irradiation-in-the-prevention-of-alloimmunization-in-a-dog-platelet-transfusion-model
#20
Sherrill J Slichter, Kraig Abrams, Irena Gettinger, Todd Christoffel, Lakshmi Gaur, Yvette Latchman, Karen Nelson, Esther Pellham, S Lawrence Bailey, Doug Bolgiano
BACKGROUND: Alloimmune platelet (PLT) refractoriness remains a significant problem for chronically transfused patients with thrombocytopenia. STUDY DESIGN AND METHODS: In a dog PLT transfusion model, we evaluated ultraviolet B irradiation (UV-B) of donor PLTs-either alone or in combination with centrifuge leukoreduction (C-LR) or filtration leukoreduction (F-LR)-to prevent refractoriness to donor PLTs and to induce tolerance to standard (STD) PLTs from the same donor or to tertiary donors...
June 2016: Transfusion
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