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https://www.readbyqxmd.com/read/28107772/a-preliminary-randomized-controlled-trial-of-contingency-management-for-alcohol-use-reduction-using-a-transdermal-alcohol-sensor
#1
Nancy P Barnett, Mark A Celio, Jennifer W Tidey, James G Murphy, Suzanne M Colby, Robert M Swift
AIMS: We tested the efficacy of daily contingent reinforcement for reducing alcohol use compared with (yoked) noncontingent reinforcement (NR) using a transdermal alcohol sensor to detect alcohol use. DESIGN: Pilot randomized controlled design with one baseline week, three intervention weeks, and one-month follow up. SETTING: New England, USA. PARTICIPANTS: Heavy drinking adults (47% female) not seeking treatment were randomized to 1) an escalating schedule of cash reinforcement (CR; n =15) for days on which alcohol was neither reported nor detected or 2) yoked NR (n =15)...
January 20, 2017: Addiction
https://www.readbyqxmd.com/read/28107768/arabidopsis-protein-s-acyl-transferase4-mediates-root-hair-growth
#2
Zhi-Yuan Wan, Sen Chai, Fu-Rong Ge, Qiang-Nan Feng, Yan Zhang, Sha Li
Polar growth of root hairs is critical for plant survival and necessitates fine-tuned ROP signaling. Multiple ROP regulators participate in root hair growth. However, protein S-acyl transferases (PATs), mediating the S-acylation and membrane partitioning of ROPs, are yet to be found. By using a reverse genetic approach, combining fluorescence probes, pharmacological drugs, site-directed mutagenesis, and genetic analysis with related root-hair mutants, we have identified and characterized an Arabidopsis PAT, which may be responsible for ROP2 S-acylation in root hairs...
January 20, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28107740/ambient-air-pollution-and-primary-liver-cancer-incidence-in-four-european-cohorts-within-the-escape-project
#3
Marie Pedersen, Zorana J Andersen, Massimo Stafoggia, Gudrun Weinmayr, Claudia Galassi, Mette Sørensen, Kirsten T Eriksen, Anne Tjønneland, Steffen Loft, Andrea Jaensch, Gabriele Nagel, Hans Concin, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Ranjeet Sokhi, Roel Vermeulen, Kees de Hoogh, Meng Wang, Rob Beelen, Paolo Vineis, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
BACKGROUND: Tobacco smoke exposure increases the risk of cancer in the liver, but little is known about the possible risk associated with exposure to ambient air pollution. OBJECTIVES: We evaluated the association between residential exposure to air pollution and primary liver cancer incidence. METHODS: We obtained data from four cohorts with enrolment during 1985-2005 in Denmark, Austria and Italy. Exposure to nitrogen oxides (NO2 and NOX), particulate matter (PM) with diameter of less than 10µm (PM10), less than 2...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28107737/contrast-enhanced-spectral-mammography-cesm-versus-mri-in-the-high-risk-screening-setting-patient-preferences-and-attitudes
#4
Jordana Phillips, Matthew M Miller, Tejas S Mehta, Valerie Fein-Zachary, Audrey Nathanson, Wendy Hori, Rita Monahan-Earley, Priscilla J Slanetz
PURPOSE: Our study evaluates patient preferences toward screening CESM versus MRI. MATERIALS AND METHODS: As part of a prospective study, high-risk patients had breast MRI and CESM. Patients completed an anonymous survey to evaluate preferences regarding the two modalities. RESULTS: 88% of participants completed the survey. 79% preferred CESM over MRI if the exams had equal sensitivity. 89% would be comfortable receiving contrast as part of an annual screening test...
December 28, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/28107730/systemic-atherosclerosis-and-voiding-symptom
#5
A Ozgur Yeniel, A Mete Ergenoglu, Reci Meseri, Anıl Ari, Ceren Sancar, Ismail Mete Itil
OBJECTIVE: To evaluate the effect of atherosclerosis on the storage and voiding symptoms of the bladder in women with overactive bladder (OAB). STUDY DESIGN: We retrospectively reviewed the charts of women with OAB who were evaluated between 2013 and 2015 in our urogynecology unit. Charts were assessed for history, examination findings, urinary diary, quality of life (QOL) questionnaires, urodynamic studies (UDSs), and four main risk factors for atherosclerosis: hypertension, diabetes mellitus, smoking, and hyperlipidemia...
January 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28107693/attrition-among-iranian-nursing-students-a-qualitative-study
#6
Mansoureh Ashghali Farahani, Fatemeh Ghaffari, Fatemeh Oskouie, Mansoureh Zagheri Tafreshi
Attrition is a major challenge facing nursing students that results in substantial costs on the education, health, and treatment systems across countries and can have an unwanted effect on the quality and quantity of health services provided as well as on the health of citizens. This descriptive study investigated nursing students' perceptions toward factors influencing attrition. We conducted a qualitative study using a content analysis approach. Nineteen students enrolled in nursing bachelor program were recruited using purposive and snowball sampling...
January 6, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28107684/non-invasive-brain-stimulation-targeting-the-right-fusiform-gyrus-selectively-increases-working-memory-for-faces
#7
Tad T Brunyé, Joseph M Moran, Amanda Holmes, Caroline R Mahoney, Holly A Taylor
The human extrastriate cortex contains a region critically involved in face detection and memory, the right fusiform gyrus. The present study evaluated whether transcranial direct current stimulation (tDCS) targeting this anatomical region would selectively influence memory for faces versus non-face objects (houses). Anodal tDCS targeted the right fusiform gyrus (Brodmann's Area 37), with the anode at electrode site PO10, and cathode at FP2. Two stimulation conditions were compared in a repeated-measures design: 0...
January 17, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28107681/enhancement-of-numeric-cognition-in-children-with-low-achievement-in-mathematic-after-a-non-instrumental-musical-training
#8
Fabiana Silva Ribeiro, Flávia H Santos
Studies suggest that musical training enhances spatial-temporal reasoning and leads to greater learning of mathematical concepts. The aim of this prospective study was to verify the efficacy of a Non-Instrumental Musical Training (NIMT) on the Numerical Cognition systems in children with low achievement in math. For this purpose, we examined, with a cluster analysis, whether children with low scores on Numerical Cognition would be grouped in the same cluster at pre and post-NIMT. Participants were primary school children divided into two groups according to their scores on an Arithmetic test...
January 17, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28107680/a-randomized-clinical-trial-of-buprenorphine-for-prisoners-findings-at-12-months-post-release
#9
Michael S Gordon, Timothy W Kinlock, Robert P Schwartz, Kevin E O'Grady, Terrence T Fitzgerald, Frank J Vocci
BACKGROUND: This study examined whether starting buprenorphine treatment prior to prison and after release from prison would be associated with better drug treatment outcomes and whether males and females responded differently to the combination of in-prison treatment and post-release service setting. METHODS: Study design was a 2 (In-Prison Treatment: Condition: Buprenorphine Treatment: vs. Counseling Only)×2 [Post-Release Service Setting Condition: Opioid Treatment: Program (OTP) vs...
January 11, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28107654/examining-the-link-between-nonmedical-use-of-sedatives-tranquilizers-and-pain-relievers-with-dispositions-toward-impulsivity-among-college-students
#10
Brittany E Blanchard, Angela K Stevens, Andrew K Littlefield, Amelia E Talley, Jennifer L Brown
BACKGROUND: The association between impulsive dispositions and the use of the central nervous system (CNS) depressant alcohol has been examined extensively; however, the links between other depressant use (sedatives, tranquilizers, and pain relievers) and impulsivity have been less studied, and findings have been equivocal. This may be due, in part, to varying operationalizations of "impulsivity," as well as issues related to the lumping versus splitting of various depressant substances when assessing use...
January 6, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28107601/predictors-of-liver-histological-changes-and-a-sustained-response-to-peginterferon-among-chronic-hepatitis-b-e-antigen-positive-patients-with-normal-or-minimally-elevated-alanine-aminotransferase-levels
#11
Jie Chen, Cheng-Run Xu, Min Xi, Wei-Wei Hu, Zheng-Hao Tang, Guo-Qing Zhang
BACKGROUND: A proportion of chronic hepatitis B (CHB) patients with normal or only minimally elevated ALT levels display significant histologic changes, and would benefit from antiviral therapy. OBJECTIVES: We aim to evaluate the histologic abnormalities seen in these patients, and then determine which of them would most likely respond to peginterferon therapy. METHODS: One hundred and thirteen hepatitis B e antigen (HBeAg)-positive patients with a normal or minimally elevated ALT level and moderate to severe histologic changes in their liver tissue were selected to receive peginterferon monotherapy and participate in a followup analysis...
January 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28107599/the-prevalence-and-impact-of-chronic-neuropathic-pain-on-daily-and-social-life-a-nationwide-study-in-a-japanese-population
#12
S Inoue, T Taguchi, T Yamashita, M Nakamura, T Ushida
BACKGROUND: This study marks the first epidemiological evaluation of the prevalence and burden of chronic neuropathic pain (NeP) in an Asian population. The objective of this nationwide cross-sectional study was to identify the characteristics of individuals with NeP, detect the NeP features that affect their quality of life (QOL), and demonstrate the negative effects of NeP on social and daily living as well as comorbidities including depression, anxiety and sleep disorders. METHODS: We mailed a cross-sectional, population-based epidemiological survey to a random nationwide sample of 10,000 Japanese adults over 20 years old...
January 20, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28107598/dropout-in-clinical-trials-of-pharmacologic-treatment-for-methamphetamine-dependence-the-role-of-initial-abstinence
#13
Ryan Cook, Brendan Quinn, Keith Heinzerling, Steve Shoptaw
BACKGROUND AND AIMS: High rates of loss to follow-up represent a significant challenge to clinical trials of pharmacologic treatments for methamphetamine (MA) use disorder. We aimed to estimate and test the relationship between achieving and maintaining abstinence in the initial weeks of study participation and subsequent retention in such trials, hypothesizing that participants able to achieve early abstinence would be less likely to drop out. DESIGN: Data from four randomized controlled trials (RCTs) of pharmacologic treatments for MA use disorder were pooled and analyzed using a random-effects approach...
January 20, 2017: Addiction
https://www.readbyqxmd.com/read/28107596/attrition-during-a-randomized-controlled-trial-of-reduced-nicotine-content-cigarettes-as-a-proxy-for-understanding-acceptability-of-nicotine-product-standards
#14
Melissa Mercincavage, E Paul Wileyto, Megan L Saddleson, Kirsten Lochbuehler, Eric C Donny, Andrew A Strasser
AIMS: To determine (1) if nicotine content affects study attrition - a potential behavioral measure of acceptability - in a trial that required compliance with three levels of reduced nicotine content (RNC) cigarettes, and (2) if attrition is associated with subjective and behavioral responses to RNC cigarettes. DESIGN: Secondary analysis of a 35-day, parallel design, open-label, randomized controlled trial. After a 5-day baseline period, participants were randomized to smoke for three, 10-day periods: their preferred brand (control group), or RNC cigarettes with three nicotine levels in a within-subject, stepdown (1 group: high-moderate-low) or non-stepdown (5 groups: high-low-moderate, low-moderate-high, low-high-moderate, moderate-low-high, moderate-high-low) fashion...
January 20, 2017: Addiction
https://www.readbyqxmd.com/read/28107561/beta-blockers-for-hypertension
#15
REVIEW
Charles S Wiysonge, Hazel A Bradley, Jimmy Volmink, Bongani M Mayosi, Lionel H Opie
BACKGROUND: Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension. However, the benefit of beta-blockers as first-line therapy for hypertension without compelling indications is controversial...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28107556/do-post-concussion-like-symptom-responses-change-following-exercise-or-sports-participation-in-a-non-concussed-cohort
#16
Arun Prasad Balasundaram, Josie Athens, Anthony G Schneiders, Paul McCrory, S John Sullivan
The purpose of this study were; 1) To determine the reliable change in post concussion-like symptoms reported following self-selected exercise or sports activities. 2) To explore the potential influence of gender and exercise parameters on post concussion-like symptoms reported by a non-concussed cohort following exercise/training. A pre-post observational design was used. A convenience sample of students aged 18-30 years who visited a university recreation centre to engage in their chosen exercise activity, and a purposeful sample of men's and women's rugby union players engaged in their regular training sessions...
January 20, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28107555/participation-in-sports-body-composition-and-fitness-characteristics-in-children-according-to-ethnic-background
#17
Stefania Toselli, Maria Giovanna Belcastro
Participation in sports has important implications, being associated with health and social features. The objectives of this study were to verify whether there were any differences in sport participation between immigrant and Italian children, and if there was any relation with their body composition and fitness characteristics. A survey was conducted on 1432 children attending primary school in the Emilia-Romagna (northern Italy). Anthropometric measurements, fitness characteristics and data about participation in sports were considered...
January 20, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28107540/impact-of-adding-a-decision-aid-to-patient-education-in-adults-with-asthma-a-randomized-clinical-trial
#18
Myriam E Gagné, France Légaré, Jocelyne Moisan, Louis-Philippe Boulet
BACKGROUND: Not providing adequate patient education interventions to asthma patients remains a major care gap. To help asthma patients and caregivers discuss inhaled controller medication use, our team has previously developed a decision aid (DA). We sought to assess whether adding this DA to education interventions improved knowledge, decisional conflict, and asthma control among adults with asthma. METHODS: A parallel clinical trial (NCT02516449). We recruited adults with asthma, aged 18 to 65 years, prescribed inhaled controller medication to optimize asthma control...
2017: PloS One
https://www.readbyqxmd.com/read/28107493/white-matter-abnormalities-in-two-different-subtypes-of-amnestic-mild-cognitive-impairment
#19
Jianghong Liu, Peipeng Liang, Linlin Yin, Ni Shu, Tengda Zhao, Yi Xing, Fangyu Li, Zhilian Zhao, Kuncheng Li, Ying Han
White matter (WM) degeneration has been found during the course of cognitive decline in both Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), however, it is unclear whether there are different WM microstructural abnormalities between two subtypes of aMCI, including single domain aMCI (aMCI-s) and multiple domain aMCI (aMCI-m). Thirty-two patients of aMCI single-domain (aMCI-s), twenty-three patients of aMCI multiple-domain (aMCI-m) and twenty-three healthy normal controls (NC) participated in this study...
2017: PloS One
https://www.readbyqxmd.com/read/28107459/associations-of-health-club-membership-with-physical-activity-and-cardiovascular-health
#20
Elizabeth C Schroeder, Gregory J Welk, Warren D Franke, Duck-Chul Lee
INTRODUCTION: This study evaluates whether a health club membership is associated with meeting the US physical activity (PA) guidelines and/or favorable cardiovascular health. METHODS: Using cross-sectional data of health club members (n = 204) and non-members (n = 201) from April to August 2013, this is the first study to our knowledge to examine a health club membership in relation to objectively measured cardiovascular health indicators including resting blood pressure, resting heart rate, body mass index, waist circumference, and cardiorespiratory fitness based on a non-exercise test algorithm...
2017: PloS One
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