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https://www.readbyqxmd.com/read/28211035/resveratrol-decreases-foxo-protein-expression-through-pi3k-akt-dependent-pathway-inhibition-in-h2o2-treated-synoviocytes
#1
Bin Xu, Gaoyuan Wang, Junqiang Zhang, Wei Cao, Xiaoyu Chen
The aim of this study was to investigate the effects of resveratrol (Res) on hydrogen peroxide (H2O2)-treated fibroblast-like synoviocytes (FLSs) in vitro. We studied the phosphoinositide 3-kinase (PI3K)-Akt pathway inhibition-mediated effects of Res on forkhead box O (FoXO) mRNA expression levels. FLS viability was determined by Cell Counting Kit-8 (CCK-8) assay, and FLS apoptosis was measured by terminal deoxyribo nucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and flow cytometry...
February 17, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28206976/lipid-and-alzheimer-s-disease-genes-associated-with-healthy-aging-and-longevity-in-healthy-oldest-old
#2
Lauren C Tindale, Stephen Leach, John J Spinelli, Angela R Brooks-Wilson
Several studies have found that long-lived individuals do not appear to carry lower numbers of common disease-associated variants than ordinary people; it has been hypothesized that they may instead carry protective variants. An intriguing type of protective variant is buffering variants that protect against variants that have deleterious effects. We genotyped 18 variants in 15 genes related to longevity or healthy aging that had been previously reported as having a gene-gene interaction or buffering effect...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28202394/platelet-rich-plasma-prp-induces-chondroprotection-via-increasing-autophagy-anti-inflammatory-markers-and-decreasing-apoptosis-in-human-osteoarthritic-cartilage
#3
Mayssam Moussa, Daniel Lajeunesse, George Hilal, Oula El Atat, Gaby Haykal, Rim Serhal, Antonio Chalhoub, Charbel Khalil, Nada Alaaeddine
OBJECTIVES: Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage. Several cytokines and transcription factors are linked to autophagy and play an important role in the degradative cascade in osteoarthritis (OA). Cell therapy such as platelet rich plasma (PRP) has recently emerged as a promising therapeutic tool for many diseases including OA. However, its mechanism of action on improving cartilage repair remains to be determined. The purpose of this study is to investigate the effect of PRP on osteoarthritic chondrocytes and to elucidate the mechanism by which PRP contributes to cartilage regeneration...
February 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28170423/nur77-deletion-impairs-muscle-growth-during-developmental-myogenesis-and-muscle-regeneration-in-mice
#4
Omar Cortez-Toledo, Caitlin Schnair, Peer Sangngern, Daniel Metzger, Lily C Chao
Muscle atrophy is a prevalent condition in illness and aging. Identifying novel pathways that control muscle mass may lead to therapeutic advancement. We previously identified Nur77 as a transcriptional regulator of glycolysis in skeletal muscle. More recently, we showed that Nur77 expression also controls myofiber size in mice. It was unknown, however, whether Nur77's regulation of muscle size begins during developmental myogenesis or only in adulthood. To determine the importance of Nur77 throughout muscle growth, we examined myofiber size at E18...
2017: PloS One
https://www.readbyqxmd.com/read/28163294/metabolic-suppression-by-3-iodothyronamine-induced-muscle-cell-atrophy-via-activation-of-foxo-proteasome-signaling-and-downregulation-of-akt1-s6k-signaling
#5
Hyunwoo Ju, Taewan Kim, Chan-Moon Chung, Junsoo Park, Takeshi Nikawa, Kyoungsook Park, Inho Choi
The homeostasis of muscle properties depends on both physical and metabolic stresses. Whereas physical stress entails metabolic response for muscle homeostasis, the latter does not necessarily involve the former and may thus solely affect the homeostasis. We here report that metabolic suppression by the hypometabolic agent 3-iodothyronamine (T1AM) induced muscle cell atrophy without physical stress. We observed that the oxygen consumption rate of C2C12 myotubes decreased 40% upon treatment with 75 μM T1AM for 6 h versus 10% in the vehicle (dimethyl sulfoxide) control...
February 3, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28157684/cdk5-foxo3-axis-initially-neuroprotective-eventually-neurodegenerative-in-alzheimer-s-disease-models
#6
Chun Shi, Keith Viccaro, Hyoung-Gon Lee, Kavita Shah
Deregulated Cdk5 causes neurotoxic amyloid beta peptide (Aβ) processing and cell death, two hallmarks of Alzheimer's disease, through the Foxo3 transcriptional factor in hippocampal cells, primary neurons and an Alzheimer's disease mouse model. Using an innovative chemical genetic screen, we identified Foxo3 as a direct substrate of Cdk5 in brain lysates. Cdk5 directly phosphorylates Foxo3, which increased its levels and nuclear translocation. Nuclear Foxo3 initially rescued cells from ensuing oxidative stress by upregulating MnSOD (also known as SOD2)...
May 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/28124088/carboxyamidotriazole-alleviates-muscle-atrophy-in-tumor-bearing-mice-by-inhibiting-nf-%C3%AE%C2%BAb-and-activating-sirt1
#7
Chen Chen, Rui Ju, Lei Zhu, Juan Li, Wei Chen, De-Chang Zhang, Cai-Ying Ye, Lei Guo
Cancer cachexia is a complex disorder characterized by inflammatory responses, and it is associated with poor performance status and high mortality rate of cancer patients. Carboxyamidotriazole (CAI), a noncytotoxic chemotherapy agent, shows anti-inflammatory features in the treatment of many diseases. Here, we investigated the preventive and therapeutic effects of CAI on muscle loss that occurred in mice with advanced Lewis lung carcinoma (LLC). The carcass weights of CAI-treated mice were significantly higher than that of mice in the vehicle group from Day 19 to the end of the study...
January 25, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28118678/effect-of-sex-on-the-acute-skeletal-muscle-response-to-sprint-interval-exercise
#8
Lauren E Skelly, Jenna B Gillen, Martin J MacInnis, Brian J Martin, Adeel Safdar, Mahmood Akhtar, Maureen J MacDonald, Mark A Tarnopolsky, Martin J Gibala
What is the central question of this study? Are there sex-based differences in the acute skeletal muscle response to sprint interval training (SIT)? What is the main finding and its importance? In response to a SIT protocol that involved three 20 s bouts of 'all-out' cycling, the expression of multiple genes associated with mitochondrial biogenesis, metabolic control and structural remodelling was largely similar between men and women matched for fitness. Our findings cannot explain previous reports of sex-based differences in the adaptive response to SIT and suggest that the mechanistic basis for these differences remains to be elucidated...
January 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28112228/hormetic-effect-of-panaxatriol-saponins-confers-neuroprotection-in-pc12-cells-and-zebrafish-through-pi3k-akt-mtor-and-ampk-sirt1-foxo3-pathways
#9
Chao Zhang, Chuwen Li, Shenghui Chen, Zhiping Li, Lijuan Ma, Xuejing Jia, Kai Wang, Jiaolin Bao, Yeer Liang, Meiwan Chen, Peng Li, Huanxing Su, Simon Ming Yuen Lee, Kechun Liu, Jian-Bo Wan, Chengwei He
Hormesis is an adaptive response of living organisms to a moderate stress. However, its biomedical implication and molecular mechanisms remain to be intensively investigated. Panaxatriol saponins (PTS) is the major bioactive components extracted from Panax notoginseng, a widely used herbal medicine for cerebrovascular diseases. This study aims to examine the hormetic and neuroprotective effects of PTS in PC12 cells and zebrafish Parkinson's disease (PD) models. Our results demonstrated that PTS stimulated PC12 cell growth by about 30% at low doses, while PTS at high doses inhibited cell growth, which is a typical hormetic effect...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102354/a-signature-of-renal-stress-resistance-induced-by-short-term-dietary-restriction-fasting-and-protein-restriction
#10
F Jongbloed, T C Saat, M Verweij, C Payan-Gomez, J H J Hoeijmakers, S van den Engel, C T van Oostrom, G Ambagtsheer, S Imholz, J L A Pennings, H van Steeg, J N M IJzermans, M E T Dollé, R W F de Bruin
During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day fasting, or received a protein-, carbohydrate- or fat-free diet for various periods of time. After completion of each diet, renal gene expression was investigated using microarrays...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087388/unravelling-the-role-of-fatty-acid-metabolism-in-cancer-through-the-foxo3-foxm1-axis
#11
Paula Saavedra-García, Katie Nichols, Zimam Mahmud, Lavender Yuen-Nam Fan, Eric W-F Lam
Obesity and cachexia represent divergent states of nutritional and metabolic imbalance but both are intimately linked to cancer. There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer. Forkhead box (FOX) proteins are responsible of a wide range of transcriptional programmes during normal development, and the FOXO3-FOXM1 axis is associated with cancer initiation, progression and drug resistance. Free fatty acids (FFAs), FA synthesis and β-oxidation are associated with cancer development and progression...
January 10, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28076456/propofol-inhibits-lung-cancer-cell-viability-and-induces-cell-apoptosis-by-upregulating-microrna-486-expression
#12
N Yang, Y Liang, P Yang, T Yang, L Jiang
Propofol is a frequently used intravenous anesthetic agent. Recent studies show that propofol exerts a number of non-anesthetic effects. The present study aimed to investigate the effects of propofol on lung cancer cell lines H1299 and H1792 and functional role of microRNA (miR)-486 in these effects. H1299 and/or H1792 cells were treated with or without propofol and transfected or not with miR-486 inhibitor, and then cell viability and apoptosis were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry...
January 5, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28055019/rep1-inhibits-foxo3-mediated-apoptosis-to-promote-cancer-cell-survival
#13
Kwon-Ho Song, Seon Rang Woo, Joon-Yong Chung, Hyo-Jung Lee, Se Jin Oh, Soon-Oh Hong, Jaegal Shim, Yong Nyun Kim, Seung Bae Rho, Seung-Mo Hong, Hanbyoul Cho, Masahiko Hibi, Dong-Jun Bae, Sang-Yeob Kim, Min Gyu Kim, Tae Woo Kim, Young-Ki Bae
Rab escort protein 1 (REP1) is a component of Rab geranyl-geranyl transferase 2 complex. Mutations in REP1 cause a disease called choroideremia (CHM), which is an X-linked eye disease. Although it is postulated that REP1 has functions in cell survival or death of various tissues in addition to the eye, how REP1 functions in normal and cancer cells remains to be elucidated. Here, we demonstrated that REP1 is required for the survival of intestinal cells in addition to eyes or a variety of cells in zebrafish, and also has important roles in tumorigenesis...
January 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28017736/comparative-and-temporal-transcriptome-analysis-of-peste-des-petits-ruminants-virus-infected-goat-peripheral-blood-mononuclear-cells
#14
Siddappa Manjunath, Bishnu Prasad Mishra, Bina Mishra, Aditya Prasad Sahoo, Ashok K Tiwari, Kaushal Kishore Rajak, D Muthuchelvan, Shikha Saxena, Lakshman Santra, Amit Ranjan Sahu, Sajad Ahmad Wani, R P Singh, Y P Singh, Aruna Pandey, Sonam Kanchan, R K Singh, Gandham Ravi Kumar, Sarath Chandra Janga
Peste des petits ruminanats virus (PPRV), a morbillivirus causes an acute, highly contagious disease - peste des petits ruminants (PPR), affecting goats and sheep. Sungri/96 vaccine strain is widely used for mass vaccination programs in India against PPR and is considered the most potent vaccine providing long-term immunity. However, occurrence of outbreaks due to emerging PPR viruses may be a challenge. In this study, the temporal dynamics of immune response in goat peripheral blood mononuclear cells (PBMCs) infected with Sungri/96 vaccine virus was investigated by transcriptome analysis...
February 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27994057/foxo3-is-essential-for-protecting-hematopoietic-stem-and-progenitor-cells-from-oxidative-dna-damage
#15
Carolina L Bigarella, Jianfeng Li, Pauline Rimmelé, Raymond Liang, Robert W Sobol, Saghi Ghaffari
Accumulation of damaged DNA in hematopoietic stem cells (HSC) is associated with chromosomal abnormalities, genomic instability and HSC aging, and might promote hematological malignancies with age. Despite this importance, the regulatory pathways implicated in the HSC DNA damage response have not been fully elucidated. One of the sources of DNA damage is reactive oxygen species (ROS) generated by both exogenous and endogenous insults. Balancing ROS levels in HSC requires FOXO3, which is an essential transcription factor for HSC maintenance implicated in HSC aging...
December 19, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27978877/-detection-and-screen-of-pulmonary-metastasis-related-signature-genes-in-nasopharyngeal-carcinoma
#16
C Xu, H W Xiao, L H Zhang, P Wu, Y Fang, D W Li, W F Li, Z S Liao
Objective: To establish an animal model of pulmonary metastasis from nasopharyngeal carcinoma (NPC) and to investigate differential genes associated with pulmonary metastasis. Methods: CNE cell line was used to construct the stable metastasis CNE/Luc cell line which steadily expresses the fluorescent enzyme genes. The CNE/Luc cells were injected into immunodeficiency mice through tail vein, and with the in vivo imaging technology, the mice with pulmonary metastasis were filtered out. The pulmonary metastasis cells, were separated and injected into the tail vein of other nude mice to obtain the tissue-specificity metastasis cells confirmed by fluorescent imaging system...
December 7, 2016: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/27976725/modulation-of-gut-microbiota-and-delayed-immunosenescence-as-a-result-of-syringaresinol-consumption-in-middle-aged-mice
#17
Si-Young Cho, Juewon Kim, Ji Hae Lee, Ji Hyun Sim, Dong-Hyun Cho, Il-Hong Bae, Hyunbok Lee, Min A Seol, Hyun Mu Shin, Tae-Joo Kim, Dae-Yong Kim, Su-Hyung Lee, Song Seok Shin, Sin-Hyeog Lm, Hang-Rae Kim
Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and the gut microbiota associated with this effect in middle-aged mice. Compared with age-matched control mice, SYR treatment delayed immunosenescence by enhancing the numbers of total CD3(+) T cells and naïve T cells. SYR treatment induced the expression of Bim as well as activation of FOXO3 in Foxp3(+) regulatory T cells (Tregs)...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27956699/dormant-pluripotent-cells-emerge-during-neural-differentiation-of-embryonic-stem-cells-in-a-foxo3-dependent-manner
#18
Megumi Ikeda, Fumiko Toyoshima
One major concern for clinical applications of embryonic stem cell (ESC)-derived cells is residual undifferentiated cells potentiating latent tumorigenicity. Despite intensive methodological approaches to eliminate residual undifferentiated cells, properties of these cells remain elusive. Here, we show that in a serum-free neural differentiation condition, residual undifferentiated cells markedly delay their cell cycle progression without compromising their pluripotency. This dormant pluripotency was maintained during reculture of the cells in a serum-free condition, whereas upon serum stimulation, the cells exit the dormant state, and restart proliferation and differentiation into all three germ layers...
December 12, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27936216/genetic-association-analysis-of-common-variants-in-foxo3-related-to-longevity-in-a-chinese-population
#19
Rong Lin, Yunxia Zhang, Dongjing Yan, Xiaoping Liao, Xianshou Wang, Yunxin Fu, Wangwei Cai
Recent studies suggested that forkhead box class O3 (FOXO3) functions as a key regulator for the insulin/insulin-like growth factor-1signaling pathway that influence aging and longevity. This study aimed to comprehensively elucidate the association of common genetic variants in FOXO3 with human longevity in a Chinese population. Eighteen single-nucleotide polymorphisms (SNPs) in FOXO3 were successfully genotyped in 616 unrelated long-lived individuals and 846 younger controls. No nominally significant effects were found...
2016: PloS One
https://www.readbyqxmd.com/read/27922192/evidence-for-pipecolate-oxidase-in-mediating-protection-against-hydrogen-peroxide-stress
#20
Sathish Kumar Natarajan, Ezhumalai Muthukrishnan, Oleh Khalimonchuk, Justin L Mott, Donald F Becker
Pipecolate, an intermediate of the lysine catabolic pathway, is oxidized to Δ(1) -piperideine-6-carboxylate (P6C) by the flavoenzyme l-pipecolate oxidase (PIPOX). P6C spontaneously hydrolyzes to generate α-aminoadipate semialdehyde, which is then converted into α-aminoadipate acid by α-aminoadipatesemialdehyde dehydrogenase. l-pipecolate was previously reported to protect mammalian cells against oxidative stress. Here, we examined whether PIPOX is involved in the mechanism of pipecolate stress protection...
December 6, 2016: Journal of Cellular Biochemistry
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