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https://www.readbyqxmd.com/read/29160038/endoplasmic-reticulum-in-health-and-disease-the-12th-international-calreticulin-workshop-delphi-greece
#1
REVIEW
Aristidis S Charonis, Marek Michalak, Jody Groenendyk, Luis B Agellon
Starting from 1994, every 2 years, an international workshop is organized focused on calreticulin and other endoplasmic reticulum chaperones. In 2017, the workshop took place at Delphi Greece. Participants from North and South America, Europe, Asia and Australia presented their recent data and discussed them extensively with their colleagues. Presentations dealt with structural aspects of calreticulin and calnexin, the role of Ca(2+) in cellular signalling and in autophagy, the endoplasmic reticulum stress and the unfolded protein response, the role of calreticulin in immune responses...
November 21, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29155068/a-noncanonical-poly-a-rna-polymerase-gene-affects-morphology-in-phoma-medicaginis
#2
Kihyuck Choi, Stephen M Marek
Phoma medicaginis (syn. Ascochyta medicaginicola Qchen &L. Cai) causes spring black stem and leaf spot, an important disease of alfalfa and annual medics. P. medicaginis forms uninucleate conidia in melanized pycnidia and is genetically tractable using Agrobacterium mediated transformation (ATMT), resulting in random integration of T-DNA that occasionally generates pycnidial mutants. The T-DNA tagged mutant, P265 displayed smaller pycnidia and more aerial hyphae than the wild type. A single T-DNA disrupted a putative noncanonical poly(A) RNA polymerase gene, Pmncpap1, which in yeast interacts with ribonucleotide reductase (RNR)...
November 15, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29154680/cardiovascular-disease-predictors-and-adipose-tissue-macrophage-polarization-is-there-a-link
#3
Ivana Kralova Lesna, Marek Petras, Sona Cejkova, Anna Kralova, Jiri Fronek, Libor Janousek, Filip Thieme, Tomas Tyll, Rudolf Poledne
Background The risk of cardiovascular disease is closely connected to adipose tissue inflammation. The links between cardiovascular risk predictors and pro and anti-inflammatory macrophages in human adipose tissue were analysed to gain an insight into the pathophysiology of cardiovascular disease. Design Subcutaneous and visceral adipose tissues were obtained from 79 subjects, 52 living kidney donors (during nephrectomy) and 27 patients with peripheral artery disease (during arterial tree reconstruction). Methods Macrophage subsets were isolated from adipose tissues and analysed by flow cytometry using CD14, CD16, CD36 and CD163 monoclonal antibodies...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29154277/potential-of-low-dose-leuco-methylthioninium-bis-hydromethanesulphonate-lmtm-monotherapy-for-treatment-of-mild-alzheimer-s-disease-cohort-analysis-as-modified-primary-outcome-in-a-phase-iii-clinical-trial
#4
Gordon K Wilcock, Serge Gauthier, Giovanni B Frisoni, Jianping Jia, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Bjoern O Schelter, Damon J Wischik, Charles S Davis, Roger T Staff, Vesna Vuksanovic, Trevor Ahearn, Luc Bracoud, Kohkan Shamsi, Ken Marek, John Seibyl, Gernot Riedel, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: LMTM is being developed as a treatment for AD based on inhibition of tau aggregation. OBJECTIVES: To examine the efficacy of LMTM as monotherapy in non-randomized cohort analyses as modified primary outcomes in an 18-month Phase III trial in mild AD. METHODS: Mild AD patients (n = 800) were randomly assigned to 100 mg twice a day or 4 mg twice a day. Prior to unblinding, the Statistical Analysis Plan was revised to compare the 100 mg twice a day as monotherapy subgroup (n = 79) versus 4 mg twice a day as randomized (n = 396), and 4 mg twice a day as monotherapy (n = 76) versus 4 mg twice a day as add-on therapy (n = 297), with strong control of family-wise type I error...
November 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29151863/a-phylogenomic-analysis-of-marek-s-disease-virus-reveals-independent-paths-to-virulence-in-eurasia-and-north-america
#5
Jakob Trimpert, Nicole Groenke, Maria Jenckel, Shulin He, Dusan Kunec, Moriah L Szpara, Stephen J Spatz, Nikolaus Osterrieder, Dino P McMahon
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus (MDV), a herpesvirus commonly afflicting chickens and rarely other avian species. The history of MDV in the 20th century represents an important case study in the evolution of virulence. The severity of MDV infection in chickens has been rising steadily since the adoption of intensive farming techniques and vaccination programs in the 1950s and 1970s, respectively...
December 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29147972/plasma-osteopontin-levels-in-patients-with-dilated-and-hypertrophic-cardiomyopathy
#6
J Podzimkova, T Palecek, P Kuchynka, J Marek, B A Danek, M Jachymova, M Kalousova, T Zima, A Linhart
BACKGROUND: Osteopontin (OPN) is an extracellular matrix glycoprotein that plays a role in a variety of cellular activities associated with inflammatory and fibrotic responses. Increased OPN levels in myocardium and plasma have been demonstrated in patients with dilated cardiomyopathy (DCM). However, nothing is known about OPN levels in patients with hypertrophic cardiomyopathy (HCM). Therefore, the aim of our study was to compare plasma OPN levels in patients with these two most common cardiomyopathies...
November 16, 2017: Herz
https://www.readbyqxmd.com/read/29146406/central-nervous-involvement-by-chronic-lymphocytic-leukaemia
#7
Dariusz Szczepanek, Ewa Wąsik-Szczepanek, Agnieszka Szymczyk, Małgorzata Wach, Maria Cioch, Monika Podhorecka, Ewelina Grywalska, Marek Hus
Inclusion of the central nervous system (CNS) in the course of chronic lymphocytic leukaemia (CLL) is rare. At the moment no risk factors or proven treatment methods are known. The disease is described both in its early phase and during its acceleration period, thus it has been suggested that there might be independent mechanisms influencing the development of this condition. As there are no unified diagnostic procedure algorithms each patient needs to be assessed individually. CLL can manifest mostly in elderly people, for whom a possibility of development of neurological disorders with their aetiology different from leukaemia, should also be taken into consideration...
November 1, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29146158/plasma-microrna-155-5p-is-increased-among-patients-with-chronic-kidney-disease-and-nocturnal-hypertension
#8
Dominika Klimczak, Marek Kuch, Tomasz Pilecki, Dorota Żochowska, Agnieszka Wirkowska, Leszek Pączek
MicroRNAs play multiple roles in the regulation of blood pressure (BP). Nevertheless, to date, no study has assessed the association between microRNA plasma expression and BP control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type I, in CKD patients, to determine the association between miR-155-5p level and BP control. In this single-center cross-sectional study, we analyzed the miR-155-5p concentration by quantitative reverse transcriptase polymerase chain reaction using the U6 snRNA as a reference gene and 24-hour ambulatory blood pressure monitoring in CKD patients (stage ≥2) in relation to a control group of healthy age-matched and gender-matched individuals, with normal BP proven by the ambulatory blood pressure monitoring...
October 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29144514/catheter-ablation-of-atrial-fibrillation-in-elderly-population
#9
Josef Kautzner, Petr Peichl, Marek Sramko, Robert Cihak, Bashar Aldhoon, Dan Wichterle
Background: Although elderly patients have been included in published series of catheter ablation for atrial fibrillation (AF), clinical benefit and safety remain still less defined in this population. A retrospective analysis of the results of catheter ablation for AF in a large volume center focused on comparison of elderly patients with the rest of the patient cohort was conducted in this study. Methods: Consecutive patients who underwent catheter ablation for AF between January 2001 and December 2016 were analysed...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29128796/nanomechanical-testing-of-drug-activities-at-the-cellular-level-case-study-for-endothelium-targeted-drugs
#10
Agnieszka M Kolodziejczyk, Marta Targosz-Korecka, Marek Szymonski
BACKGROUND: The pharmacological treatment of cardiovascular diseases that may potentially be attributed to endothelial dysfunction often requires the application of endothelium-targeted drugs. Simvastatin is one of such drugs currently on the market due to its established anti-inflammatory activities. The nanomechanical response to drug treatment at the cellular level is not yet known. However, this response mechanism is promising as a prospective testing method for newly developing drugs...
June 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29125828/comprehensive-analysis-of-gene-expression-patterns-in-friedreich-s-ataxia-fibroblasts-by-rna-sequencing-reveals-altered-levels-of-protein-synthesis-factors-and-solute-carriers
#11
Jill Sergesketter Napierala, Yanjie Li, Yue Lu, Kevin Lin, Lauren A Hauser, David R Lynch, Marek Napierala
Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease usually caused by large homozygous expansions of GAA repeat sequences in intron 1 of the frataxin (FXN) gene. FRDA patients homozygous for GAA expansions have low FXN mRNA and protein levels when compared with heterozygous carriers or healthy controls. Frataxin is a mitochondrial protein involved in iron-sulfur cluster synthesis, and many FRDA phenotypes result from deficiencies in cellular metabolism due to lowered expression of FXN Presently, there is no effective treatment for FRDA, and biomarkers to measure therapeutic trial outcomes and/or to gauge disease progression are lacking...
November 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29123581/surgical-treatment-of-hepatic-echinococcus-granulosus
#12
Waldemar Patkowski, Maciej Krasnodębski, Michał Grąt, Łukasz Masior, Marek Krawczyk
Introduction: Infections caused by metacestode stage of the Echinococcus granulosus in humans result in disease named cystic echinococcosis. Aim: To present the outcomes of patients treated surgically for cystic echinococcosis of the liver. Material and methods: One hundred and nineteen patients treated in the period between 1989 and 2014 due to E. granulosus infection in the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw were selected for this retrospective study...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29123580/the-impact-of-age-and-sex-on-the-occurrence-of-pathology-in-the-wall-of-the-upper-gastrointestinal-tract
#13
Przemysław Dyrla, Jerzy Gil, Stanisław Niemczyk, Marek Saracyn, Krzysztof Kosik, Sebastian Czarkowski, Arkadiusz Lubas
Introduction: The growing incidence of gastrointestinal diseases forces to improve both imaging techniques and the identification of the population with a greater risk of a disease. Identification of lesions located inside the wall of intestinal tract or in close proximity often was not possible using endoscopy or computed tomography. Aim: The study was a retrospective evaluation of the occurrence of submucosal lesions (SML) and thickened wall (TW) of the upper gastrointestinal tract (UGIT) depending on age and sex...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29121035/ischemic-conditioning-of-human-heart-muscle-depends-on-opioid-receptor-system
#14
Marcin Kunecki, Tomasz Oleksy, Jolanta Biernat, Paweł Kukla, Katarzyna Szwajkos, Piotr Podolec, Marek Deja, Krzysztof Gołba, Wojciech Płazak
BACKGROUND: Despite progress in the invasive treatment of ischemic heart disease, the ability to limit ischemia-reperfusion (I/R) injury remains largely unrealized. Ischemic pre-conditioning (IPC) and post-conditioning (POC) induce the protective mechanisms of resistance against I/R injury. Stimulation of opioid receptors mimic the protective effect of IPC or POC in an animal models. We tested the hypothesis, that IPC and POC provide cardioprotection in opioid-dependent mechanism in human myocardium...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29114721/observations-on-a-2-step-approach-to-screening-for-parkinson-disease-reply
#15
Danna Jennings, Andrew Siderowf, Kenneth Marek
No abstract text is available yet for this article.
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29112186/connection-between-bone-remodeling-and-inflammatory-markers-in-obstructive-sleep-apnea-in-relation-to-disease-severity
#16
Barbara Bromińska, Ewa Cyrańska-Chyrek, Barbara Kuźnar-Kamińska, Magdalena Kostrzewska, Hanna Winiarska, Nadia Sawicka-Gutaj, Ariadna Zybek-Kocik, Aleksandra Hernik, Elżbieta Wrotkowska, Zbigniew Krasiński, Marek Ruchała, Halina Batura-Gabryel
INTRODUCTION    There is growing evidence that obstructive sleep apnea (OSA) influences both bone metabolism and structure. Chitinase-3-like protein 1 (YKL-40) is a novel inflammatory and remodeling marker, which was shown to increase in OSA. YKL-40 can probably alter the bone turnover.   OBJECTIVES    Assessment of a possible interplay between YKL-40 and bone turnover markers in patients with different stages of OSA. Evaluation of the relation among bone mass, OSA severity, and YKL-40 level. PATIENTS AND METHODS    The study is based on 72 male OSA patients divided into three groups according to disease severity using apnea-hypopnea index (AHI): OSA 1 n = 18 (5 ≤ AHI < 15), OSA 2 n = 25 (15 ≤ AHI < 30), OSA 3 n = 29 (AHI ≥ 30)...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29112183/leukotrienes-biosynthesis-in-coronary-artery-disease-results-of-leukotrienes-and-thromboxane-in-myocardial-infarction-ltimi-study
#17
Edyta Stodółkiewicz, Barbara Rewerska, Marcin Rzeszutko, Marek Tomala, Anton Chrustowicz, Krzysztof Żmudka, Marek Sanak, Wojciech Szczeklik
INTRODUCTION    Leukotrienes (LTs) play a potential role in atherosclerosis and may contribute to cardiovascular outcomes in coronary artery disease.  OBJECTIVES    1) to compare the baseline production of LTs in stable coronary artery disease (sCAD) and myocardial infarction (MI), and 2) assess whether increased production of LTs is associated with major adverse cardiovascular events (MACE) in one-year follow up from MI.  PATIENTS AND METHODS    LTIMI (Leukotrienes and Thromboxane In Myocardial Infarction) was single-center, prospective, observational study of patients with stable sCAD and MI...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29112072/an-advanced-blt-humanized-mouse-model-for-extended-hiv-1-cure-studies
#18
Kerry J Lavender, Craig Pace, Kathrin Sutter, Ronald J Messer, Dakota L Pouncey, Nathan W Cummins, Sekar Natesampillai, Jim Zheng, Joshua Goldsmith, Marek Widera, Erik S Van Dis, Katie Phillips, Brent Race, Ulf Dittmer, George Kukolj, Kim J Hasenkrug
OBJECTIVE: Although BLT-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies dependent on endogenous immune responses, most mice develop graft versus host disease (GVHD), limiting their utility for extended HIV cure studies. This study aimed to: 1) Evaluate the GVHD-resistant C57BL/6 Rag2γcCD47 triple knockout (TKO)-BLT mouse as a model to establish HIV-1 latency. 2) Determine whether TKO-BLT mice could be maintained on ART for extended periods of time...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29109358/burnout-syndrome-as-an-occupational-disease-in-the-european-union-an-exploratory-study
#19
Andrea Lastovkova, Melanie Carder, Hans Martin Rasmussen, Lars Sjoberg, Gerda J de Groene, Riitta Sauni, Jiri Vevoda, Sarka Vevodova, Gerard Lasfargues, Magnus Svartengren, Marek Varga, Claudio Colossio, Daniela Pelclova
The risk of psychological disorders influencing the health of workers increases in accordance with growing requirements on employees across various professions. This study aimed to compare approaches to the burnout syndrome in European countries. A questionnaire focusing on stress-related occupational diseases was distributed to national experts of 28 European Union countries. A total of 23 countries responded. In 9 countries (Denmark, Estonia, France, Hungary, Latvia, Netherlands, Portugal, Slovakia and Sweden) burnout syndrome may be acknowledged as an occupational disease...
November 3, 2017: Industrial Health
https://www.readbyqxmd.com/read/29108512/individual-surgeon-experience-yields-bimodal-effects-on-patient-outcomes-after-deceased-donor-liver-transplant-results-of-a-quantile-regression-for-survival-data
#20
Michał Grąt, Zbigniew Lewandowski, Waldemar Patkowski, Karolina Grąt, Karolina Maria Wronka, Maciej Krasnodębski, Tadeusz Wróblewski, Paweł Nyckowski, Marek Krawczyk
OBJECTIVES: Data on the relevance of surgeon experience in liver transplant procedures are scarce. In this study, we evaluated the effects of individual surgeon experience on survival outcomes after deceased-donor liver transplant. MATERIALS AND METHODS: In this retrospective analysis of 1193 liver transplant procedures, quantile regression for survival data was performed to assess the effects of surgeon experience. Conditional quantiles of mortality and graft loss were set as primary and secondary outcome measures, respectively, which were categorized as early, midterm, and late...
October 31, 2017: Experimental and Clinical Transplantation
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