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Marek's disease

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https://www.readbyqxmd.com/read/28317488/association-between-periodontal-health-status-and-cognitive-abilities-the-role-of-cytokine-profile-and-systemic-inflammation
#1
Marta Sochocka, Maciej Sobczyński, Aleksandra Sender-Janeczek, Katarzyna Zwolińska, Olga Błachowicz, Tomasz Tomczyk, Marek Ziętek, Jerzy Leszek
BACKGROUND: Contemporary neurobiology, periodontal medicine, and immunology are now focusing on the relationship between chronic periodontitis and systemic diseases, that also include Alzheimer's disease (AD). However a causative relationship between dementia and periodontitis has yet to be confirmed. OBJECTIVE: The aim of the study was to determine whether periodontal health status and cognitive abilities are correlated with the relative changes in systemic measures of pro- and anti-inflammatory cytokines as a reflection of systemic inflammation...
March 16, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28301499/svip-regulates-z-variant-alpha-1-antitrypsin-retro-translocation-by-inhibiting-ubiquitin-ligase-gp78
#2
Nazli Khodayari, Rejean Liqun Wang, George Marek, Karina Krotova, Mariana Kirst, Chen Liu, Farshid Rouhani, Mark Brantly
Alpha-1 antitrypsin deficiency (AATD) is an inherited disorder characterized by early-onset emphysema and liver disease. The most common disease-causing mutation is a single amino acid substitution (Glu/Lys) at amino acid 342 of the mature protein, resulting in disruption of the 290-342 salt bridge (an electrophoretic abnormality defining the mutation [Z allele, or ZAAT]), protein misfolding, polymerization, and accumulation in the endoplasmic reticulum of hepatocytes and monocytes. The Z allele causes a toxic gain of function, and the E3 ubiquitin ligase gp78 promotes degradation and increased solubility of endogenous ZAAT...
2017: PloS One
https://www.readbyqxmd.com/read/28301231/evaluation-and-identification-of-marek-s-disease-virus-bac-clones-as-standardized-reagents-for-research
#3
John R Dunn, Sanjay M Reddy, Masahiro Niikura, Venugopal Nair, Janet E Fulton, Hans H Cheng
Marek's disease virus (MDV) is an alphaherpesvirus that causes Marek's disease (MD), a lymphoproliferative disease in chickens. Understanding of MDV gene function advanced significantly following the cloning of the MDV genome as either a series of overlapping cosmids or as a bacterial artificial chromosome (BAC), both of which could produce viable MDV. The objectives of this study were to compare multiple virulent MDV BAC clones using the Avian Disease and Oncology Laboratory's pathotyping assay, and to demonstrate the use of these clones as standardized reagents for a modified pathotyping assay by other laboratories...
March 2017: Avian Diseases
https://www.readbyqxmd.com/read/28300764/predictors-of-posttraumatic-stress-and-posttraumatic-growth-in-childhood-cancer-survivors
#4
Veronika Koutná, Martin Jelínek, Marek Blatný, Tomáš Kepák
This longitudinal study aims to analyze predictors of posttraumatic stress symptoms (PTSS) and posttraumatic growth (PTG) among gender, age, objective factors of the disease and its treatment, family environment factors and negative emotionality. The sample consisted of 97 childhood cancer survivors (50 girls and 47 boys) aged 11-25 years who were in remission 1.7 to seven years at T1 and four to 12.5 years at T2. Survivors completed a set of questionnaires including the Benefit Finding Scale for Children and the University of California at Los Angeles Posttraumatic Stress Disorder Index...
March 16, 2017: Cancers
https://www.readbyqxmd.com/read/28283855/the-role-of-human-parainfluenza-virus-infections-in-the-immunopathology-of-the-respiratory-tract
#5
REVIEW
Malgorzata Pawełczyk, Marek Leszek Kowalski
Viral infections are leading causes of both upper and lower airway acute illness in all age groups of healthy persons, and have also been implicated in the acute exacerbations of chronic respiratory disorders like asthma and COPD. Human rhinovirus, respiratory syncytial virus, influenza virus and coronavirus have been considered as the most important respiratory pathogens and relatively little attention has been paid to the role of parainfluenza viruses (hPIVs). Human parainfluenza viruses are single-stranded RNA viruses belonging to the paramyxovirus family that may evoke lower respiratory infections in infants, children and immunocompromised individuals...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28283733/high-sensitive-crp-as-a-predictive-marker-of-long-term-outcome-in-juvenile-idiopathic-arthritis
#6
Mikel Alberdi-Saugstrup, Marek Zak, Susan Nielsen, Troels Herlin, Ellen Nordal, Lillemor Berntson, Anders Fasth, Marite Rygg, Klaus Müller
To evaluate whether C-reactive protein (CRP), including variation within the normal range, is predictive of long-term disease outcome in Juvenile Idiopathic Arthritis (JIA). Consecutive patients with newly diagnosed JIA were included prospectively from defined geographic areas of the Nordic countries from 1997 to 2000. Inclusion criteria were availability of a baseline serum sample within 12 months after disease onset and 8-year clinical assessment data. Systemic onset JIA was not included. CRP was measured by high-sensitive ELISA (detection limit of 0...
March 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28282424/mental-health-and-adjustment-to-juvenile-idiopathic-arthritis-level-of-agreement-between-parent-and-adolescent-reports-according-to-strengths-and-difficulties-questionnaire-and-adolescent-outcomes-questionnaire
#7
Ewa Misterska, Dominika Kaminiarczyk-Pyzałka, Karolina Adamczak, Katarzyna A Adamczyk, Marek Niedziela, Maciej Głowacki, Jakub Głowacki
The aims of this study were threefold. Firstly, to analyze the psychometric properties of the Polish-language Pediatric Outcomes Data Collection Instrument (PODCI) questionnaire in the self-report Adolescent Outcomes Questionnaire (adolescents, 11-18 years of age) and in the parent-report Adolescent Outcomes Questionnaire (completed by a parent or guardian of an adolescent aged 11-18 years). Secondly, to determine the level of agreement between parents and adolescents in rating dysfunction in juvenile idiopathic arthritis (JIA) and thirdly, to examine associations between psychological adjustments of patients to JIA and disease as well as their socio-demographic characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28276714/diagnostic-significance-of-serum-concentrations-of-soluble-fas-ligand-sfasl-in-children-with-autoimmune-thyroid-disease
#8
Hanna Mikos, Marcin Mikos, Marek Niedziela
INTRODUCTION: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD). DESIGN: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control group: 11 with hypothyroidism (10 girls and 1 boy, aged 12.2 ± 1.9 years), 19 children with hyperthyroidism (15 girls and 4 boys, aged 12.4 ± 4.9 years) and 15 healthy subjects (7 girls and 8 boys, aged 10...
February 21, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28270823/mlpa-based-analysis-of-copy-number-variation-in-plant-populations
#9
Anna Samelak-Czajka, Malgorzata Marszalek-Zenczak, Malgorzata Marcinkowska-Swojak, Piotr Kozlowski, Marek Figlerowicz, Agnieszka Zmienko
Copy number variants (CNVs) are intraspecies duplications/deletions of large DNA segments (>1 kb). A growing number of reports highlight the functional and evolutionary impact of CNV in plants, increasing the need for appropriate tools that enable locus-specific CNV genotyping on a population scale. Multiplex ligation-dependent probe amplification (MLPA) is considered a gold standard in genotyping CNV in humans. Consequently, numerous commercial MLPA assays for CNV-related human diseases have been created...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28267620/cancer-associated-circulating-large-extracellular-vesicles-in-cholangiocarcinoma-and-hepatocellular-carcinoma
#10
Henrike Julich-Haertel, Sabine K Urban, Marcin Krawczyk, Arnulf Willms, Krzysztof Jankowski, Waldemar Patkowski, Beata Kruk, Maciej Krasnodębski, Joanna Ligocka, Robert Schwab, Ines Richardsen, Sebastian Schaaf, Angelina Klein, Sebastian Gehlert, Hanna Sänger, Markus Casper, Jesus M Banales, Detlef Schuppan, Piotr Milkiewicz, Frank Lammert, Marek Krawczyk, Veronika Lukacs-Kornek, Miroslaw Kornek
BACKGROUND AND AIMS: we previously reported that large extracellular vesicles, specifically AnnexinV(+)EpCAM(+)CD147(+) tumour-associated microparticles (taMPs), facilitate the detection of colorectal carcinoma (CRC), non-small cell lung carcinoma (NSCLC) as well as pancreas carcinoma (PaCa). Here we assess the diagnostic value of taMPs for detection and monitoring of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Specifically, we aim to differentiate liver taMPs from other cancer taMPs, such as CRC and NSCLC...
March 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28265227/pet-ct-imaging-in-polymyalgia-rheumatica-praepubic-18-f-fdg-uptake-correlates-with-pectineus-and-adductor-longus-muscles-enthesitis-and-with-tenosynovitis
#11
Zdenek Rehak, Andrea Sprlakova-Pukova, Zbynek Bortlicek, Zdenek Fojtik, Tomas Kazda, Marek Joukal, Renata Koukalova, Jiri Vasina, Jana Eremiasova, Petr Nemec
BACKGROUND: The role of (18)F-fluorodeoxyglucose positron emission computed tomography ((18)F-FDG PET/CT) is increasing in the diagnosis of polymyalgia rheumatica (PMR), one of the most common inflammatory rheumatic diseases. In addition to other locations, increased (18)F-FDG accumulation has been detected in the praepubic region in some patients. However, a deeper description and pathophysiological explanation of this increased praepubic accumulation has been lacking. The aim of the presented study is to confirm a decrease in praepubic (18)F-FDG accumulation in response to therapy and to describe potential correlations to other (18)F-FDG PET/CT scan characteristics during the course of disease...
March 1, 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28263843/comparison-of-different-sites-in-recombinant-marek-s-disease-virus-for-the-expression-of-green-fluorescent-protein
#12
Yongzhen Liu, Kai Li, Hongyu Cui, Li Gao, Changjun Liu, Yanping Zhang, Yulong Gao, Xiaomei Wang
Marek's disease virus (MDV) is a preferred vector for recombinant vaccine construction, and insertion site is the main factor influencing foreign gene expression and vaccine efficacy. In this study, recombinant MDVs inserted with the enhanced green fluorescent protein (eGFP) gene at different sites in its genome were generated from overlapping fosmid DNAs and the eGFP expression was compared. The results showed that the eGFP expression levels from the sites in the unique long (UL) region (within UL41, between UL45 and UL46, and between UL55 and LORF10) were comparable, which were significantly higher than those from the sites in the unique short (US) region (US2 and US10), and the eGFP expression level from US2 was significantly higher than that from US10...
March 2, 2017: Virus Research
https://www.readbyqxmd.com/read/28261284/sterile-leukocyturia-affects-urine-neutrophil-gelatinase-associated-lipocalin-concentration-in-type-2-diabetic-patients
#13
Agnieszka Gala-Błądzińska, Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Magdalena Barbara Kaziuk, Marek Kuźniewski
INTRODUCTION: Increased urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations are associated with the early phase of kidney damage. Urine NGAL may increase due to production by neutrophils present in urine, particularly in patients with urinary tract infections. The aim of the study was to assess the relationship between sterile leukocyturia and uNGAL concentrations in patients with type 2 diabetes (DMt2) at early stages of diabetic kidney disease. MATERIAL AND METHODS: The study included 115 DMt2 patients aged 60...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28258178/international-criteria-for-electrocardiographic-interpretation-in-athletes
#14
Jonathan A Drezner, Sanjay Sharma, Aaron Baggish, Michael Papadakis, Mathew G Wilson, Jordan M Prutkin, Andre La Gerche, Michael J Ackerman, Mats Borjesson, Jack C Salerno, Irfan M Asif, David S Owens, Eugene H Chung, Michael S Emery, Victor F Froelicher, Hein Heidbuchel, Carmen Adamuz, Chad A Asplund, Gordon Cohen, Kimberly G Harmon, Joseph C Marek, Silvana Molossi, Josef Niebauer, Hank F Pelto, Marco V Perez, Nathan R Riding, Tess Saarel, Christian M Schmied, David M Shipon, Ricardo Stein, Victoria L Vetter, Antonio Pelliccia, Domenico Corrado
Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete...
March 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28257602/the-biomarkers-of-lupus-disease-study-a-bold-approach-may-mitigate-interference-of-background-immunosuppressants-in-clinical-trials
#15
Joan T Merrill, Fred Immermann, Maryann Whitley, Tianhui Zhou, Andrew Hill, Margot O'Toole, Padmalatha Reddy, Marek Honczarenko, Aikaterini Thanou, Joe Rawdon, Joel M Guthridge, Judith A James, Sudhakar Sridharan
OBJECTIVES: Molecular medicine raised expectations for strategically targeted biologics in systemic lupus erythematosus (SLE), but clinical trials have been disappointing and difficult to interpret. Most studies add investigational agents to various, often effective, standard of care (SoC) immunosuppressants used at baseline, with unknown treatment interactions. Eliminating polypharmacy in trials of active lupus patients remains controversial. The BOLD study tested immunosuppressant withdrawal as a novel approach to interpretable SLE trials...
March 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28256044/striato-cortical-connections-in-parkinson-s-and-alzheimer-s-diseases-relation-to-cognition
#16
Lubomira Anderkova, Marek Barton, Irena Rektorova
BACKGROUND: Functional connectivity is abnormal in PD and in early Alzheimer's disease. OBJECTIVES: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. METHODS: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI...
March 3, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28255981/bilateral-primary-pigmented-nodular-adrenal-disease-as-a-component-of-carney-syndrome-case-report
#17
Dorota Sikorska, Lucyna Bednarek-Papierska, Ewa Mojs, Ewa Makowska, Marek Ruchała, Włodzimierz Samborski
We report a case of a 20-year-old patient with Cushing's syndrome as a component of Carney syndrome. Carney syndrome is an autosomal dominant disease with co-existing bilateral pigmented nodular adrenal disease, heart and skin myxoma, skin pigmentation, breast fibroadenoma, testicular and ovarian tumours, thyroid tumours, and pituitary adenomas. (Endokrynol Pol 2017; 68 (1): 70-72).
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28255974/thyroid-lesions-in-patients-with-acromegaly-case-control-study-and-update-to-the-meta-analysis
#18
Kosma Woliński, Adam Stangierski, Edyta Gurgul, Barbara Bromińska, Agata Czarnywojtek, Martha Lodyga, Marek Ruchała
INTRODUCTION: Acromegaly results from oversecretion of growth hormone and subsequently insulin growth factor-1. According to some authors, the disease can cause increased prevalence of nodular goitre and thyroid cancer (TC). However, the number of studies comparing acromegalic patients with control groups is low. We aimed to assess the prevalence of thyroid lesions in patients with acromegaly in comparison to an age- and sex-matched control group and to update the meta-analysis previously performed in our department by the same authors...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28243970/erratum-to-cd28-ctla-4-icos-haplotypes-confers-susceptibility-to-graves-disease-and-modulates-clinical-phenotype-of-disease
#19
Edyta Pawlak-Adamska, Irena Frydecka, Marek Bolanowski, Anna Tomkiewicz, Anna Jonkisz, Lidia Karabon, Anna Partyka, Oskar Nowak, Marek Szalinski, Jacek Daroszewski
No abstract text is available yet for this article.
February 27, 2017: Endocrine
https://www.readbyqxmd.com/read/28243595/cns-metastases-from-bone-and-soft-tissue-sarcomas-in-children-adolescents-and-young-adults-are-they-really-so-rare
#20
Monika Bekiesinska-Figatowska, Agnieszka Duczkowska, Marek Duczkowski, Hanna Bragoszewska, Anna Romaniuk-Doroszewska, Beata Iwanowska, Sylwia Szkudlinska-Pawlak, Jaroslaw Madzik, Katarzyna Bilska, Anna Raciborska
Purpose. To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas' metastases in children is as rare as described and to present various morphological forms of bone/soft tissue sarcomas' CNS metastases. Methods. Patients with first diagnosis in 1999-2014 treated at single center were included with whole course of disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography were performed in cases suspicious for CNS metastases. Extension from skull/vertebral column metastases was excluded...
2017: BioMed Research International
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