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https://www.readbyqxmd.com/read/28931175/fibroblast-growth-factor-21-in-patients-with-acromegaly
#1
Jowita Halupczok-Żyła, Aleksandra Jawiarczyk-Przybyłowska, Marek Skrzypski, Mathias Z Strowski, Marek Bolanowski
Introduction The goal of the study was to investigate fibroblast growth factor-21 (FGF-21) levels in acromegalic patients in relation to the disease activity and to compare them with controls. Further, we aimed to evaluate the associations between FGF-21 and random growth hormone (GH), insulin-like growth factor-1 (IGF-1), metabolic and anthropometric parameters. Materials and methods The study group consisted of 50 acromegalic patients divided into 3 subgroups on the basis of disease activity (AA - active acromegaly, CD - controlled disease, CA - cured acromegaly)...
September 20, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28930088/comparison-of-pcr-methods-for-the-detection-of-genetic-variants-of-carp-edema-virus
#2
Mikolaj Adamek, Marek Matras, Verena Jung-Schroers, Felix Teitge, Max Heling, Sven M Bergmann, Michal Reichert, Keith Way, David M Stone, Dieter Steinhagen
The infection of common carp and its ornamental variety, koi, with the carp edema virus (CEV) is often associated with the occurrence of a clinical disease called 'koi sleepy disease'. The disease may lead to high mortality in both koi and common carp populations. To prevent further spread of the infection and the disease, a reliable detection method for this virus is required. However, the high genetic variability of the CEV p4a gene used for PCR-based diagnostics could be a serious obstacle for successful and reliable detection of virus infection in field samples...
September 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28927094/genomic-markers-of-ovarian-adenocarcinoma-and-its-relevancy-to-the-effectiveness-of-chemotherapy
#3
Monika Englert-Golon, Bartosz Burchardt, Bartlomiej Budny, Szymon Dębicki, Blanka Majchrzycka, Elzbieta Wrotkowska, Piotr Jasiński, Katarzyna Ziemnicka, Radosław Słopień, Marek Ruchała, Stefan Sajdak
Ovarian cancer is the eighth most common cancer and the seventh highest cause of cancer-associated mortality in women worldwide. It is the second highest cause of mortality among female reproductive malignancies. The current standard first-line treatment for advanced ovarian cancer includes a combination of surgical debulking and standard systemic platinum-based chemotherapy with carboplatin and paclitaxel. Although a deeper understanding of this disease has been attained, relapse occurs in 70% of patients 18 months subsequent to the first-line treatment...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28916599/directional-atherectomy-followed-by-a-paclitaxel-coated-balloon-to-inhibit-restenosis-and-maintain-vessel-patency-twelve-month-results-of-the-definitive-ar-study
#4
Thomas Zeller, Ralf Langhoff, Krishna J Rocha-Singh, Michael R Jaff, Erwin Blessing, Beatrice Amann-Vesti, Marek Krzanowski, Patrick Peeters, Dierk Scheinert, Giovanni Torsello, Sebastian Sixt, Gunnar Tepe
BACKGROUND: Studies assessing drug-coated balloons (DCB) for the treatment of femoropopliteal artery disease are encouraging. However, challenging lesions, such as severely calcified, remain difficult to treat with DCB alone. Vessel preparation with directional atherectomy (DA) potentially improves outcomes of DCB. METHODS AND RESULTS: DEFINITIVE AR study (Directional Atherectomy Followed by a Paclitaxel-Coated Balloon to Inhibit Restenosis and Maintain Vessel Patency-A Pilot Study of Anti-Restenosis Treatment) was a multicenter randomized trial designed to estimate the effect of DA before DCB to facilitate the development of future end point-driven randomized studies...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28913579/association-between-fto-gene-polymorphisms-and-hdl-cholesterol-concentration-may-cause-higher-risk-of-cardiovascular-disease-in-patients-with-acromegaly
#5
Aleksandra Franczak, Katarzyna Kolačkov, Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski
INTRODUCTION: Cardiovascular diseases are main cause of morbidity and mortality in acromegaly. Polymorphisms of FTO gene are associated with obesity and increased risk of CVD (independently of BMI). Aim of this study was to investigate the allele frequencies of two FTO gene polymorphisms: rs9939609 and rs9930506 in patients with acromegaly and to examine the association of FTO gene polymorphisms with BMI and selected metabolic parameters. MATERIALS AND METHODS: Identification of two single nucleotide polymorphisms of FTO gene was carried out in 51 patients with acromegaly using the minisequencing method...
September 14, 2017: Pituitary
https://www.readbyqxmd.com/read/28912500/dynamic-changes-in-the-splenic-transcriptome-of-chickens-during-the-early-infection-and-progress-of-marek-s-disease
#6
Lu Dang, Man Teng, Hua-Wei Li, Hui-Zhen Li, Sheng-Ming Ma, Pu Zhao, Xiu-Jie Li, Rui-Guang Deng, Gai-Ping Zhang, Jun Luo
Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek's disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumorigenesis, the dynamic splenic transcriptome of GaHV2-infected chickens during early infection and pathogenic phases has been determined utilizing RNA-seq. Based on the significant differentially expressed genes (DEGs), analysis of gene ontology, KEGG pathway and protein-protein interaction network has demonstrated that the molecular events happening during GaHV2 infection are highly relevant to the disease course...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912414/polish-experience-with-liver-transplantation-and-post-transplant-outcomes-in-children-with-urea-cycle-disorders
#7
Edyta Szymańska, Piotr Kaliciński, Joanna Pawłowska, Sylwia Szymańska, Maciej Pronicki, Marek Stefanowicz, Joanna Teisseyre, Dorota Broniszczak, Dariusz Rokicki
BACKGROUND Liver transplantation (LT) is recommended for various metabolic diseases, including urea cycle disorders (UCDs). The aim of this study was to determine indications and outcomes of LT for UCDs in the tertiary reference Children's Hospital in Warsaw, Poland. MATERIAL AND METHODS Medical charts of children with UCD who underwent LT between 2008 and July 2016 were retrospectively reviewed. The following parameters were analyzed: symptoms at time of diagnosis, age at diagnosis, age at transplantation, graft characteristics and survival, postsurgical complications, and biochemical and laboratory results before and after transplantation...
September 15, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28910208/immunohistochemical-and-immunocytochemical-findings-associated-with-marek-s-disease-virus-in-naturally-infected-laying-hens
#8
O Yavuz, H Erer
We compared immunohistochemical (IHC) staining of tissue sections of liver, kidney, spleen, lung, proventriculus, sciatic nerve, bursa of Fabricius, brain, heart, intestine and skin; immunocytochemical (ICC) staining of peripheral blood samples and touch preparations of liver, spleen and kidney of laying hens naturally infected with Marek's disease (MD) virus. We used one hundred and fifty 5-17-week-old commercial hens. IHC and ICC staining were performed using polymer-based techniques. IHC staining exhibited mostly free immunopositive reactions in tumor cells and in the cytoplasm of the parenchymal cells of liver, kidney, spleen and bursa of Fabricius...
September 14, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28906483/possible-under-treatment-of-women-in-poland-with-crohn-s-disease-a-subgroup-analysis-from-a-prospective-multicenter-study-of-the-use-of-anti-tnfs
#9
Piotr Eder, Maria Kłopocka, Maria Wiśniewska-Jarosińska, Renata Talar-Wojnarowska, Dariusz Maj, Iga Detka-Kowalska, Jarosław Kierkuś, Andrzej Śliwczyński, Paulina Wieszczy, Marek Bugajski, Maciej Gonciarz, Edyta Zagórowicz
No abstract text is available yet for this article.
August 31, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28906025/vitamin-d-in-the-parkinson-associated-risk-syndrome-pars-study
#10
Michelle E Fullard, Sharon X Xie, Ken Marek, Matthew Stern, Danna Jennings, Andrew Siderowf, Allison W Willis, Alice S Chen-Plotkin
BACKGROUND: Lower vitamin D levels have been associated with manifest Parkinson's disease, prompting the hypothesis that vitamin D insufficiency or deficiency may increase risk for PD. OBJECTIVES: To evaluate vitamin D levels in a population at risk for developing PD. METHODS: Plasma vitamin D levels were measured in the Parkinson Associated Risk Syndrome Study, a cohort of asymptomatic individuals, some of whom are at high risk for PD. Vitamin D levels were compared between subjects at high risk for PD (hyposmia and dopamine transporter scan deficit) versus all others and examined for correlations with dopaminergic system integrity...
September 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28905096/comparison-of-suction-blistering-and-tape-stripping-for-analysis-of-epidermal-genes-proteins-and-lipids
#11
Marek Svoboda, Marta Hlobilová, Markéta Marešová, Michaela Sochorová, Andrej Kováčik, Kateřina Vávrová, Iva Dolečková
Analysis of epidermal genes, proteins and lipids is important in the research and diagnosis of skin diseases. Although punch biopsy is the first-choice technique for the skin sampling, it is unnecessarily invasive for obtaining a sample just for the epidermal analysis. Here we compare two less invasive methods, suction blistering (SB) and tape stripping (TS), for the analysis of selected epidermal genes (quantitative real-time reverse transcription PCR, qRT-PCR), proteins (western blotting, WB), and lipids in ten healthy volunteers...
September 13, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28905042/social-demographic-and-clinical-characteristics-of-patients-suffering-from-peripheral-vascular-disease-treated-surgically-compared-to-patients-treated-with-endovascular-angioplasty
#12
Renata Piotrkowska, Marek Dobosz, Janina Książek, Grzegorz Halena
INTRODUCTION: Atherosclerosis is the most common cause of chronic lower limb ischaemia. Many factors that have a crucial influence on the development of the disease, its course and prognosis have been identified. The risk factors seem to be subject to interventions due to their susceptibility to changes. It is important to increase the engagement of doctors and nurses performing the screening oriented on risk factors, medical consultation regarding giving up smoking, changing the diet and undertaking physical activity...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28902467/eaaci-guidelines-on-allergen-immunotherapy-prevention-of-allergy
#13
REVIEW
Susanne Halken, Desiree Larenas-Linnemann, Graham Roberts, Moises A Calderón, Elisabeth Angier, Oliver Pfaar, Dermot D Ryan, Ioana Agache, Ignacio J I J Ansotegui, Stefania Arasi, George Du Toit, Montserrat Fernandez-Rivas, Roy Geerth van Wijk, Marek Jutel, Jörg Kleine-Tebbe, Susanne Lau, Paolo M Matricardi, Giovanni B Pajno, Nikolaos G Papadopoulos, Martin Penagos, Alexandra F Santos, Gunter J Sturm, Frans Timmermans, R Van Ree, Eva-Maria Varga, Ulrich Wahn, Maria Kristiansen, Sangeeta Dhami, Aziz Sheikh, Muraro Antonella
Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence-based recommendations for AIT for prevention of i) development of allergic comorbidities in those with established allergic diseases, ii) development of first allergic condition and iii) allergic sensitization...
September 13, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28895996/transcatheter-aortic-valve-implantation-expert-consensus-of-the-association-of-cardiovascular-interventions-of-the-polish-cardiac-society-and-the-polish-society-of-cardio-thoracic-surgeons-approved-by-the-board-of-the-polish-cardiac-society%C3%A2
#14
Radosław Parma, Michał O Zembala, Maciej Dąbrowski, Dariusz Jagielak, Adam Witkowski, Piotr Suwalski, Dariusz Dudek, Piotr Olszówka, Wojciech Wojakowski, Roman Przybylski, Robert Gil, Mariusz Kuśmierczyk, Maciej Lesiak, Jerzy Sadowski, Sławomir Dobrzycki, Andrzej Ochała, Piotr Hoffman, Bogusław Kapelak, Jarosław Kaźmierczak, Marek Jasiński, Janina Stępińska, Piotr Szymański, Tomasz Hryniewiecki, Janusz Kochman, Marek Grygier, Marian Zembala, Jacek Legutko, Jacek Różański
Patients with severe symptomatic aortic stenosis have a poor prognosis with medical management alone, and surgical aortic valve replacement can improve symptoms and survival. In recent years, transcatheter aortic valve implantation (TAVI) has been demonstrated to improve survival in inoperable patients and to be an alternative treatment in patients in whom the risk of surgical morbidity or mortality is high or intermediate. A representative expert committee, summoned by the Association of Cardiovascular Interventions of the Polish Cardiac Society (ACVI) and the Polish Society of Cardio-Thoracic Surgeons, devel-oped this Consensus Statement in transcatheter aortic valve implantation...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28893257/preoperative-single-ventricle-function-determines-early-outcome-after-second-stage-palliation-of-single-ventricle-heart
#15
Jacek Pająk, Michał Buczyński, Piotr Stanek, Grzegorz Zalewski, Marek Wites, Lesław Szydłowski, Bogusław Mazurek, Lidia Tomkiewicz-Pająk
BACKGROUND: Second-stage palliation with hemi-Fontan or bidirectional Glenn procedures has improved the outcomes of patients treated for single-ventricle heart disease. The aim of this study was to retrospectively analyze risk factors for death after second-stage palliation of single-ventricle heart and to compare therapeutic results achieved with the hemi-Fontan and bidirectional Glenn procedures. MATERIAL AND METHODS: We analyzed 60 patients who had undergone second-stage palliation for single-ventricle heart...
September 11, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28892507/extreme-genome-diversity-in-the-hyper-prevalent-parasitic-eukaryote-blastocystis
#16
Eleni Gentekaki, Bruce A Curtis, Courtney W Stairs, Vladimír Klimeš, Marek Eliáš, Dayana E Salas-Leiva, Emily K Herman, Laura Eme, Maria C Arias, Bernard Henrissat, Frédérique Hilliou, Mary J Klute, Hiroshi Suga, Shehre-Banoo Malik, Arthur W Pightling, Martin Kolisko, Richard A Rachubinski, Alexander Schlacht, Darren M Soanes, Anastasios D Tsaousis, John M Archibald, Steven G Ball, Joel B Dacks, C Graham Clark, Mark van der Giezen, Andrew J Roger
Blastocystis is the most prevalent eukaryotic microbe colonizing the human gut, infecting approximately 1 billion individuals worldwide. Although Blastocystis has been linked to intestinal disorders, its pathogenicity remains controversial because most carriers are asymptomatic. Here, the genome sequence of Blastocystis subtype (ST) 1 is presented and compared to previously published sequences for ST4 and ST7. Despite a conserved core of genes, there is unexpected diversity between these STs in terms of their genome sizes, guanine-cytosine (GC) content, intron numbers, and gene content...
September 11, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28888846/diagnostic-accuracy-of-urinary-lte4-measurement-to-predict-aspirin-exacerbated-respiratory-disease-in-patients-with-asthma
#17
Grazyna Bochenek, Tomasz Stachura, Krystyna Szafraniec, Hanna Plutecka, Marek Sanak, Ewa Nizankowska-Mogilnicka, Krzysztof Sladek
BACKGROUND: Patients with aspirin-exacerbated respiratory disease (AERD) are distinguished from patients with aspirin-tolerant asthma (ATA) by significantly higher baseline concentrations of urinary leukotriene E4 (uLTE4). However, an overlap between the individual values of the groups exists. OBJECTIVE: The objective of this study was to estimate the discriminative value of uLTE4 concentration in differentiating between patients with AERD and patients with ATA and evaluate the diagnostic accuracy of uLTE4 measurement alone and added to clinical parameters to predict AERD diagnosis in patients with asthma...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28887905/past-present-and-future-of-parkinson-s-disease-a-special-essay-on-the-200th-anniversary-of-the-shaking-palsy
#18
REVIEW
J A Obeso, M Stamelou, C G Goetz, W Poewe, A E Lang, D Weintraub, D Burn, G M Halliday, E Bezard, S Przedborski, S Lehericy, D J Brooks, J C Rothwell, M Hallett, M R DeLong, C Marras, C M Tanner, G W Ross, J W Langston, C Klein, V Bonifati, J Jankovic, A M Lozano, G Deuschl, H Bergman, E Tolosa, M Rodriguez-Violante, S Fahn, R B Postuma, D Berg, K Marek, D G Standaert, D J Surmeier, C W Olanow, J H Kordower, P Calabresi, A H V Schapira, A J Stoessl
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority...
September 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28880397/transcranial-doppler-a-stethoscope-for-the-brain-neurocritical-care-use
#19
REVIEW
Chiara Robba, Danilo Cardim, Mypinder Sekhon, Karol Budohoski, Marek Czosnyka
Transcranial Doppler (TCD) ultrasonography is a noninvasive bedside monitoring technique that can evaluate cerebral blood flow hemodynamics in the intracranial arterial vasculature. TCD allows assessment of linear cerebral blood flow velocity, with a high temporal resolution and is inexpensive, reproducible, and portable. The aim of this review is to provide an overview of the most commonly used TCD derived signals and measurements used commonly in neurocritical care. We describe both basic (flow velocity, pulsatility index) and advanced concepts, including critical closing pressure, wall tension, autoregulation, noninvasive intracranial pressure, brain compliance, and cerebrovascular time constant; we also describe the clinical applications of TCD to highlight their utility in the diagnosis and monitoring of cerebrovascular diseases as the "stethoscope for the brain...
September 7, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28879648/is-there-any-difference-in-acromegaly-and-other-chronic-disease-in-quality-of-life-and-psychiatric-morbidity
#20
Dorota Maria Szcześniak, Aleksandra Jawiarczyk-Przybyłowska, Łukasz Matusiak, Anna Bolanowska, Julian Maciaszek, Małgorzata Siemińska, Joanna Rymaszewska, Marek Bolanowski
INTRODUCTION: The study aimed to evaluate the psychological profile of patients with acromegaly in comparison to other chronic diseases such as non-functioning pituitary adenomas, Cushing disease, plaque psoriasis, and to the healthy control group. MATERIALS AND METHODS: A total sample of 153 participants in clinical groups underwent a cross-sectional assessment including the quality of life (AcroQoL, WHOQoL-BREF), psychiatric morbidity (GHQ-28) and the acceptance of illness (AIS) and 65 participants in the healthy control group...
September 7, 2017: Endokrynologia Polska
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