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https://www.readbyqxmd.com/read/29691948/lifestyle-factors-and-the-course-of-depression-in-older-adults-a-nesdo-study
#1
REVIEW
Myrthe C Bruin, Hannie C Comijs, Rob M Kok, Roos C Van der Mast, Julia F Van den Berg
OBJECTIVES: To investigate whether lifestyle indicators including physical exercise, sleep duration, alcohol use, body mass index, smoking status, and a composite lifestyle index are associated with the depression course in older adults. METHODS: Data of 283 older adults were used from the Netherlands Study of Depression in Older Persons. Depressive disorders at baseline were assessed with the Composite International Diagnostic Interview. The depression course at 2-year follow-up was assessed with the Inventory of Depressive Symptoms (IDS, score 0-84) every 6 months; physical exercise with the International Physical Activity Questionnaire; alcohol use with the Alcohol Use Disorders Identification Test; body mass index by anthropometry; and sleep duration and smoking status by interview questions...
April 24, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29691705/retinal-dysfunction-in-a-presymptomatic-patient-with-huntington-s-disease
#2
Jonelle Knapp, Dean A VanNasdale, Keith Ramsey, Julie Racine
PURPOSE: Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric disturbances. Studies have shown retinal abnormalities in patients and mouse models with HD; however, to our knowledge, no prior research papers evaluated retinal structure and function in a presymptomatic patient with HD. The aim of this report is to present a case of retinal dysfunction in a presymptomatic patient with HD...
April 24, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29691439/reversal-of-memory-and-neuropsychiatric-symptoms-and-reduced-tau-pathology-by-selenium-in-3xtg-ad-mice
#3
Ann Van der Jeugd, Arnaldo Parra-Damas, Raquel Baeta-Corral, Carlos M Soto-Faguás, Tariq Ahmed, Frank M LaFerla, Lydia Giménez-Llort, Rudi D'Hooge, Carlos A Saura
Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer's disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an essential antioxidant element reduced in the aging brain, prevents development of neuropathology in AD transgenic mice at early disease stages. The therapeutic potential of selenium for ameliorating or reversing neuropsychiatric and cognitive behavioral symptoms at late AD stages is largely unknown...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691410/control-of-mechanical-pain-hypersensitivity-in-mice-through-ligand-targeted-photoablation-of-trkb-positive-sensory-neurons
#4
Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G Lechner, Paul A Heppenstall
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optogenetic activation of these neurons after nerve injury evokes marked nociceptive behavior...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29690770/repeated-interoceptive-exposure-in-individuals-with-high-and-low-anxiety-sensitivity
#5
Katharina Holtz, Alfons O Hamm, Christiane A Pané-Farré
Interoceptive exposure is one component in cognitive behavioral therapy of panic disorder. The present investigation addressed changes in defensive mobilization during repeated interoceptive exposure using a standardized hyperventilation procedure. 26 high and 22 low anxiety sensitive persons (ASI, Peterson & Reiss, 1992) went through two guided hyperventilation and normoventilation procedures, spaced one week apart. Breathing parameters, startle response magnitudes and symptom reports were measured. All participants successfully adhered to the guided breathing procedures...
April 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29690578/depressive-symptoms-increase-the-risk-of-mortality-for-white-but-not-black-older-adults
#6
Shervin Assari
Introduction. Long-term studies have shown that depressive symptoms predict the risk of mortality. However, it is unknown if this effect is present in shorter time intervals. In addition, recent research suggests that the salience of the negative affect on the risk of mortality is not similar across racial groups. The current study uses data from a national study of Black and White older adults to examine racial differences in the effect of baseline depressive symptoms on mortality risk over three years in the United States...
April 23, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29689719/the-behavioral-and-psychological-symptoms-of-dementia-in-down-syndrome-bpsd-ds-scale-comprehensive-assessment-of-psychopathology-in-down-syndrome
#7
Alain D Dekker, Silvia Sacco, Angelo Carfi, Bessy Benejam, Yannick Vermeiren, Gonny Beugelsdijk, Mieke Schippers, Lyanne Hassefras, José Eleveld, Sharina Grefelman, Roelie Fopma, Monique Bomer-Veenboer, Mariángeles Boti, G Danielle E Oosterling, Esther Scholten, Marleen Tollenaere, Laura Checkley, André Strydom, Gert Van Goethem, Graziano Onder, Rafael Blesa, Christine Zu Eulenburg, Antonia M W Coppus, Anne-Sophie Rebillat, Juan Fortea, Peter P De Deyn
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29689518/characterizing-anxiety-subtypes-and-the-relationship-to-behavioral-phenotyping-in-major-depression-results-from-the-embarc-study
#8
Joseph M Trombello, Diego A Pizzagalli, Myrna M Weissman, Bruce D Grannemann, Crystal M Cooper, Tracy L Greer, Ashley L Malchow, Manish K Jha, Thomas J Carmody, Benji T Kurian, Christian A Webb, Daniel G Dillon, Patrick J McGrath, Gerard Bruder, Maurizio Fava, Ramin V Parsey, Melvin G McInnis, Phil Adams, Madhukar H Trivedi
The current study aimed to characterize the multifaceted nature of anxiety in patients with major depression by evaluating distinct anxiety factors. We then related these derived anxiety factors to performance on a Flanker Task of cognitive control, in order to further validate these factors. Data were collected from 195 patients with nonpsychotic chronic or recurrent major depression or dysthymic disorder. At baseline, participants completed self-report measures of anxiety, depression, and other related symptoms (mania, suicidality) and clinicians administered a structured diagnostic interview and the Hamilton Rating Scale for Depression, including anxiety/somatization items...
April 6, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29689295/behavioral-and-biochemical-effects-of-ethanol-withdrawal-in-zebrafish
#9
Suianny Nayara da Silva Chaves, Gabriel Felício Rocha, Bruna Patrícia Dutra Costa, Witallo Etevaldo Araújo de Oliveira, Monica Gomes Lima, Diógenes Henrique de Siqueira Silva, Caio Maximino
Chronic alcohol use induces adaptations and toxicity that can induce symptoms of anxiety, autonomic hyperarousal, and epileptic seizures when alcohol is removed (withdrawal syndrome). Zebrafish has recently gained wide attention as a behavioral model to study the neurobehavioral effects of acute and chronic alcohol use, including withdrawal. The literature, however, is very contradictory on findings regarding withdrawal effects, with some studies reporting increased anxiety, while others report no effect. A meta-analytic approach was taken to find the sources of this heterogeneity, and ethanol concentration during exposure and exposure duration were found to be the main sources of variation...
April 21, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29688816/psychosocial-stressors-and-sexual-health-among-southern-african-american-women-who-have-sex-with-women
#10
Christina A Muzny, Ashley E Pérez, Ellen F Eaton, Madina Agénor
PURPOSE: We examined the association of psychosocial stressors (depressive symptoms, incarceration, and intimate partner violence [IPV]) with sexual behaviors, sexually transmitted infection (STI) history, and STI diagnoses among African American women who have sex with women (AAWSW). METHODS: This was a secondary analysis from a study of AAWSW ≥16 years. Multivariable Poisson regression estimated risk ratios (RRs) for the association between depressive symptoms, incarceration, and IPV and sexual behaviors, STI history, and STI diagnosis at enrollment, adjusting for age and sexual orientation identity...
April 24, 2018: LGBT Health
https://www.readbyqxmd.com/read/29688411/relevance-of-rodent-models-of-depression-in-clinical-practice-can-we-overcome-the-obstacles-in-translational-neuropsychiatry
#11
Johan Söderlund, Maria Lindskog
The diagnosis of a mental disorder generally depends on clinical observations and phenomenological symptoms reported by the patient. The definition of a given diagnosis is criteria based and relies on the ability to accurately interpret subjective symptoms and complex behavior. This type of diagnosis comprises a challenge to translate to reliable animal models, and these translational uncertainties hamper the development of new treatments. In this review, we will discuss how depressive-like behavior can be induced in rodents, and the relationship between these models and depression in humans...
April 23, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29687895/affective-disturbances-during-withdrawal-from-chronic-intermittent-ethanol-inhalation-in-c57bl-6j-and-dba-2j-male-mice
#12
Harpreet Sidhu, Max Kreifeldt, Candice Contet
BACKGROUND: Alcohol use disorders are characterized by a complex behavioral symptomatology, which includes the loss of control over alcohol consumption and the emergence of a negative affective state when alcohol is not consumed. Some of these symptoms can be recapitulated in rodent models, for instance following chronic intermittent exposure to ethanol vapor inhalation (CIE). However, the detection of negative affect in mice withdrawn from CIE has proven challenging and variable between strains...
April 24, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29687527/amygdala-real-time-fmri-neurofeedback-for-major-depressive-disorder-a-review
#13
Kymberly D Young, Vadim Zotev, Raquel Phillips, Masaya Misaki, Wayne C Drevets, Jerzy Bodurka
Advances in imaging technologies have allowed for the analysis of fMRI data in real-time (rtfMRI), leading to the development of neurofeedback (nf) training. This rtfMRI-nf training utilizes fMRI tomographic localization capacity to allow a person to see and regulate the localized hemodynamic signal from his or her own brain. In this review, we summarize the results of several studies that have developed and applied neurofeedback training to healthy and depressed individuals with the amygdala as the neurofeedback target and the goal to increase the hemodynamic response during positive autobiographical memory recall...
April 23, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29687457/a-randomized-waitlist-controlled-trial-of-cognitive-behavior-therapy-to-improve-emotion-regulation-in-children-with-autism
#14
Jonathan A Weiss, Kendra Thomson, Priscilla Burnham Riosa, Carly Albaum, Victoria Chan, Andrea Maughan, Paula Tablon, Karen Black
BACKGROUND: Mental health problems are common among individuals with autism spectrum disorder (ASD), and difficulties with emotion regulation processes may underlie these issues. Cognitive behavior therapy (CBT) is considered an efficacious treatment for anxiety in children with ASD. Additional research is needed to examine the efficacy of a transdiagnostic treatment approach, whereby the same treatment can be applied to multiple emotional problems, beyond solely anxiety. The purpose of the present study was to examine the efficacy of a manualized and individually delivered 10-session, transdiagnostic CBT intervention, aimed at improving emotion regulation and mental health difficulties in children with ASD...
April 23, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29687429/combat-experience-and-posttraumatic-stress-symptoms-among-military-serving-parents-a-meta-analytic-examination-of-associated-offspring-and-family-outcomes
#15
REVIEW
Tessa K Kritikos, Jonathan S Comer, Meiqi He, Laura C Curren, Martha C Tompson
In this meta-analysis, we review findings on the relationships between parental combat exposure and PTSD/PTSS in military-serving families and (1) parenting problems, (2) family maladjustment, and (3) offspring problems. We systematically searched for studies in PsycInfo, PsychArticles, Psychology and Behavior Sciences Collection, Published International Literature on Traumatic Stress (PILOTS), and PubMed/Medline as well as conducted manual searches. Search procedures identified 22 eligible studies, including 20 studies examining relationships between parental PTSD/PTSS and parenting, family, and/or offspring outcomes and 8 studies examining relationships between parental combat exposure and parenting, family, and/or offspring outcomes...
April 24, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29687346/long-term-cognitive-outcomes-after-sepsis-a-translational-systematic-review
#16
REVIEW
Tatiana Barichello, Pavani Sayana, Vijayasree V Giridharan, Anithachristy S Arumanayagam, Boomadevi Narendran, Amanda Della Giustina, Fabricia Petronilho, João Quevedo, Felipe Dal-Pizzol
Sepsis is systemic inflammatory response syndrome with a life-threatening organ dysfunction that is caused by an unbalanced host immune response in an attempt to eliminate invasive microorganisms. We posed questions, "Does sepsis survivor patients have increased risk of neuropsychiatric manifestations?" and "What is the mechanism by which sepsis induces long-term neurological sequelae, particularly substantial cognitive function decline in survivor patients and in pre-clinical sepsis models?" The studies were identified by searching PubMed/MEDLINE (National Library of Medicine), PsycINFO, EMBASE (Ovid), LILACS (Latin American and Caribbean Health Sciences Literature), IBECS (Bibliographical Index in Spanish in Health Sciences), and Web of Science databases for peer-reviewed journals that were published until January 2018...
April 23, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29687202/attenuation-of-aluminum-chloride-induced-neuroinflammation-and-caspase-activation-through-the-akt-gsk-3%C3%AE-pathway-by-hesperidin-in-wistar-rats
#17
Arokiasamy Justin-Thenmozhi, Mathiyazahan Dhivya Bharathi, Ramaraj Kiruthika, Thamilarasan Manivasagam, Anupom Borah, Musthafa Mohamed Essa
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our laboratory indicated the neuroprotective effect of hesperidin against aluminum chloride (AlCl3 )-induced memory loss, acetylcholine esterase hyperactivity, oxidative stress, and enhanced expression of amyloid β protein biosynthesis-related markers. However, their role on AlCl3 -induced inflammation, caspase activation, Tau pathology, altered Akt/GSK 3β signaling pathway, and Aβ clearance marker has not yet been fully elucidated...
April 23, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29686658/gut-microbiota-profiling-and-gut-brain-crosstalk-in-children-affected-by-pediatric-acute-onset-neuropsychiatric-syndrome-and-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#18
Andrea Quagliariello, Federica Del Chierico, Alessandra Russo, Sofia Reddel, Giulia Conte, Loris R Lopetuso, Gianluca Ianiro, Bruno Dallapiccola, Francesco Cardona, Antonio Gasbarrini, Lorenza Putignani
Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) are conditions that impair brain normal neurologic function, resulting in the sudden onset of tics, obsessive-compulsive disorder, and other behavioral symptoms. Recent studies have emphasized the crosstalk between gut and brain, highlighting how gut composition can influence behavior and brain functions. Thus, the present study investigates the relationship between PANS/PANDAS and gut microbiota ecology...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29686643/inhibition-of-mtorc1-signaling-reverts-cognitive-and-affective-deficits-in-a-mouse-model-of-parkinson-s-disease
#19
Débora Masini, Alessandra Bonito-Oliva, Maëlle Bertho, Gilberto Fisone
Non-motor symptoms, including cognitive deficits and affective disorders, are frequently diagnosed in Parkinson's disease (PD) patients and are only partially alleviated by dopamine replacement therapy. Here, we used a 6-hydroxydopamine (6-OHDA) mouse model of PD to examine the effects exerted on non-motor symptoms by inhibition of the mammalian target of rapamycin complex 1 (mTORC1), which is involved in the control of protein synthesis, cell growth, and metabolism. We show that rapamycin, which acts as an allosteric inhibitor of mTORC1, counteracts the impairment of novel object recognition...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29686598/sleep-related-problems-as-a-nonmotor-symptom-of-dentatorubropallidoluysian-atrophy
#20
Hyeyun Kim, Ji Young Yun, Kyoung-Gyu Choi, Heasoo Koo, Hyun Jeong Han
Dentatorubropallidoluysian atrophy (DRPLA) is a neurodegenerative disease caused by an expansion of a cytosine-adenine-guanine (CAG) repeat encoding a polyglutamine tract in the atrophin-1 protein. Unlike other CAG repeat diseases, sleep related problems have not been reported in patients with DRPLA. There was a 65-year-old man and his family with DRPLA. They suffered from seizure, gait disturbance, and cognitive decline. The patients commonly showed dream enacting sleep disorder, insomnia. The results from overnight polysomnography showed rapid eye movement (REM) without atonia in patients with DRPLA...
April 23, 2018: Journal of Korean Medical Science
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