Kathryn A Wyman-Chick, Parichita Chaudhury, Ece Bayram, Carla Abdelnour, Elie Matar, Shannon Y Chiu, Daniel Ferreira, Calum A Hamilton, Paul C Donaghy, Federico Rodriguez-Porcel, Jon B Toledo, Annegret Habich, Matthew J Barrett, Bhavana Patel, Alberto Jaramillo-Jimenez, Gregory D Scott, Joseph P M Kane
This pragmatic review synthesises the current understanding of prodromal dementia with Lewy bodies (pDLB) and prodromal Alzheimer's disease (pAD), including clinical presentations, neuropsychological profiles, neuropsychiatric symptoms, biomarkers, and indications for disease management. The core clinical features of dementia with Lewy bodies (DLB)-parkinsonism, complex visual hallucinations, cognitive fluctuations, and REM sleep behaviour disorder are common prodromal symptoms. Supportive clinical features of pDLB include severe neuroleptic sensitivity, as well as autonomic and neuropsychiatric symptoms...
May 8, 2024: Neurology and Therapy