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https://www.readbyqxmd.com/read/29054974/laryngeal-closure-impedes-non-invasive-ventilation-at-birth
#1
Jessica R Crawshaw, Marcus J Kitchen, Corinna Binder-Heschl, Marta Thio, Megan J Wallace, Lauren T Kerr, Charles C Roehr, Katie L Lee, Genevieve A Buckley, Peter G Davis, Andreas Flemmer, Arjan B Te Pas, Stuart B Hooper
BACKGROUND: Non-invasive ventilation is sometimes unable to provide the respiratory needs of very premature infants in the delivery room. While airway obstruction is thought to be the main problem, the site of obstruction is unknown. We investigated whether closure of the larynx and epiglottis is a major site of airway obstruction. METHODS: We used phase contrast X-ray imaging to visualise laryngeal function in spontaneously breathing premature rabbits immediately after birth and at approximately 1 hour after birth...
October 20, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29017981/prolonged-intracisternal-papaverine-toxicity-index-case-description-and-proposed-mechanism-of-action
#2
REVIEW
Xiaofei Zhou, Vilakshan Alambyan, Thomas Ostergard, Jonathan Pace, Maryo Kohen, Sunil Manjila, Ciro Ramos-Estebanez
Intracisternal papaverine (iPPV) is a vasodilator used for prophylaxis of intra-operative vasospasm during aneurysmal clipping. Its post-operative side effects include transient cranial nerve palsies, most commonly mydriasis due to oculomotor nerve involvement with rapid resolution. We critically review the current literature on the adverse effects of iPPV in aneurysmal surgery, with a focus on oculomotor nerve involvement. In addition, this manuscript portrays the index case of prolonged bilateral mydriasis secondary to iPPV irrigation toxicity and its putative underlying mechanism...
October 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28994676/does-bilevel-positive-airway-pressure-improve-outcome-of-acute-respiratory-failure-after-open-heart-surgery
#3
Ahmed Said Elgebaly
BACKGROUND: Respiratory failure is of concern in the postoperative period after cardiac surgeries. Invasive ventilation (intermittent positive pressure ventilation [IPPV]) carries the risks and complications of intubation and mechanical ventilation (MV). AIMS: Noninvasive positive pressure ventilation (NIPPV) is an alternative method and as effective as IPPV in treating insufficiency of respiration with less complications and minimal effects on respiratory and hemodynamic parameters next to open-heart surgery...
October 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28983829/mechanical-ventilation-during-resuscitation-how-manual-chest-compressions-affect-a-ventilator-s-function
#4
Tillmann Speer, Wolfgang Dersch, Björn Kleine, Christian Neuhaus, Clemens Kill
INTRODUCTION: Guidelines for resuscitation recommend positive-pressure ventilation with a fixed ventilation rate as provided by an automated transport ventilator during cardiopulmonary resuscitation (CPR) with a secured airway. We investigated the influence of manual chest compressions (CC) on the accuracy of ventilator presets and the quality of CC with intermittent positive-pressure ventilation (IPPV), bilevel ventilation (BiLevel), and the novel ventilation mode chest compression synchronized ventilation (CCSV) in a simulation model...
October 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28936966/-progress-of-mechanical-ventilation-during-cardiopulmonary-resuscitation
#5
Cai Wen, Tao Yu, Lixiang Wang
Mechanical ventilation is regarded as an effective means of replacing artificial ventilation during cardiopulmonary resuscitation (CPR), and has been widely used in the treatment of cardiac arrest (CA) patients. However, there are still some controversial issues remaining to be settled, such as the assessment of the effectiveness of mechanical ventilation, the selection of the optimal oxygen concentration (FiO2), tidal volume (VT), respiratory frequency, and mode of ventilation during the CPR process. The pros and cons of positive pressure ventilation are also inconclusive...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28601712/supporting-inter-topic-entity-search-for-biomedical-linked-data-based-on-heterogeneous-relationships
#6
Nansu Zong, Sungin Lee, Jinhyun Ahn, Hong-Gee Kim
OBJECTIVE: The keyword-based entity search restricts search space based on the preference of search. When given keywords and preferences are not related to the same biomedical topic, existing biomedical Linked Data search engines fail to deliver satisfactory results. This research aims to tackle this issue by supporting an inter-topic search-improving search with inputs, keywords and preferences, under different topics. METHODS: This study developed an effective algorithm in which the relations between biomedical entities were used in tandem with a keyword-based entity search, Siren...
August 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27784445/-clinical-features-of-acute-respiratory-failure-due-to-pneumocystis-pneumonia-in-non-hiv-immunocompromised-patients
#7
X Huang, L Weng, L Yi, M Li, Y Y Feng, Y Tian, J G Xia, Q Y Zhan, B Du
Objective: To examine the clinical features of patients with acute respiratory failure (ARF) caused by pneumocystis pneumonia (PCP) admitted into two medical intensive care units (ICU) in non- human immunodeficiency virus (HIV) infected immunocompromised patients. Methods: A retrospective review was conducted among 92 non-HIV patients with ARF caused by PCP in medical ICU of Peking Union Medical College Hospital and China-Japan Friendship Hospital between Jan 2010 and Dec 2015. Patient characteristics, clinical presentation, laboratory and radiological findings, complications, as well as therapy and mortality were included in the analysis...
October 18, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27707439/factors-associated-with-changes-in-invasive-and-noninvasive-positive-airway-pressure-therapy-settings-during-pediatric-polysomnograms
#8
Suhail Al-Saleh, Priya Sayal, Derek Stephens, Joshua Florence, Aman Sayal, Adele Baker, Faiza Syed, Indra Narang, Reshma Amin
STUDY OBJECTIVES: Our aim was to identify clinical predictors associated with changes in settings for pediatric invasive and noninvasive positive airway pressure therapy, which could help inform the allocation of limited polysomnogram (PSG) resources. METHODS: A retrospective review was conducted in children who underwent one or more PSGs for technology titration. Children were included if they were using continuous positive airway pressure (CPAP) therapy, bilevel positive airway pressure (BPAP) therapy, or invasive positive pressure ventilation (IPPV) the night of the PSG...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27473968/histopathological-changes-and-mrna-expression-in-lungs-of-horses-after-inhalation-anaesthesia-with-different-ventilation-strategies
#9
K Hopster, B Jacobson, C Hopster-Iversen, K Rohn, S B R Kästner
Inappropriate mechanical ventilation can lead to ventilator-induced lung injury (VILI). Aim of this study was to evaluate the effects of inhalation anaesthesia and ventilation with and without recruitment (RM) and PEEP titration on alveolar integrity in horses. Twenty-three horses were divided into 4 groups (group OLC ventilated with OLC, group IPPV ventilated with intermittent positive pressure ventilation, group NV non-ventilated, and group C non-anaesthetized control group). After sedation with xylazine and induction with diazepam and ketamine anaesthetized horses were under isoflurane anaesthesia for 5...
August 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27386061/efficiency-and-outcome-of-non-invasive-versus-invasive-positive-pressure-ventilation-therapy-in-respiratory-failure-due-to-chronic-obstructive-pulmonary-disease
#10
Valiollah Amri Maleh, Mahmood Monadi, Behzad Heidari, Parviz Amri Maleh, Ali Bijani
BACKGROUND: Application noninvasive ventilation in the patients with exacerbation of chronic obstructive pulmonary disease (COPD) reduced mortality. This case-control study was designed to compare efficiency and outcome of non-invasive (NIV) versus invasive positive pressure ventilation (IPPV) in respiratory failure due to COPD. METHODS: The patients were assigned to NIV or IPPV intermittantly.The clinical parameters, including RR (respiratory rate), BP (blood pressure), HR (heart rate) and PH, PaCO2, PaO2 before and 1, 4 and 24 h after treatment were measured...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27315509/prophylactic-nasal-continuous-positive-airway-pressure-for-preventing-morbidity-and-mortality-in-very-preterm-infants
#11
REVIEW
Prema Subramaniam, Jacqueline J Ho, Peter G Davis
BACKGROUND: Cohort studies have suggested that nasal continuous positive airways pressure (CPAP) starting in the immediate postnatal period before the onset of respiratory disease (prophylactic CPAP) may be beneficial in reducing the need for intubation and intermittent positive pressure ventilation (IPPV) and in preventing bronchopulmonary dysplasia (BPD) in preterm or low birth weight infants. OBJECTIVES: To determine if prophylactic nasal CPAP started soon after birth regardless of respiratory status in the very preterm or very low birth weight infant reduces the use of IPPV and the incidence of bronchopulmonary dysplasia (BPD) without adverse effects...
June 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27105430/ventilation-induced-brain-injury-in-preterm-neonates-a-review-of-potential-therapies
#12
REVIEW
Samantha K Barton, Mary Tolcos, Suzanne L Miller, Charles Christoph-Roehr, Georg M Schmölzer, Timothy J M Moss, Stuart B Hooper, Euan M Wallace, Graeme R Polglase
Mechanical ventilation is a risk factor for cerebral inflammation and brain injury in preterm neonates. The risk increases proportionally with the intensity of treatment. Recent studies have shown that cerebral inflammation and injury can be initiated in the delivery room. At present, initiation of intermittent positive pressure ventilation (IPPV) in the delivery room is one of the least controlled interventions a preterm infant will likely face. Varying pressures and volumes administered shortly after birth are sufficient to trigger pathways of ventilation-induced lung and brain injury...
2016: Neonatology
https://www.readbyqxmd.com/read/26991259/optimizing-lung-aeration-at-birth-using-a-sustained-inflation-and-positive-pressure-ventilation-in-preterm-rabbits
#13
Arjan B Te Pas, Marcus J Kitchen, Katie Lee, Megan J Wallace, Andreas Fouras, Robert A Lewis, Naoto Yagi, Kentaro Uesugi, Stuart B Hooper
BACKGROUND: A sustained inflation (SI) facilitates lung aeration, but the most effective pressure and duration are unknown. We investigated the effect of gestational age (GA) and airway liquid volume on the required inflation pressure and SI duration. METHODS: Rabbit kittens were delivered at 27, 29, and 30 d gestation, intubated and airway liquid was aspirated. Either no liquid (control) or 30 ml/kg of liquid was returned to the airways. Lung gas volumes were measured by plethysmography and phase-contrast X-ray-imaging...
July 2016: Pediatric Research
https://www.readbyqxmd.com/read/26860113/occult-pneumothorax-in-blunt-trauma-is-there-a-need-for-tube-thoracostomy
#14
M Zhang, L T Teo, M H Goh, J Leow, K T S Go
INTRODUCTION/BACKGROUND: Occult pneumothorax (OPTX) is defined as air within the pleural cavity that is undetectable on normal chest X-rays, but identifiable on computed tomography. Currently, consensus is divided between tube thoracostomy and conservative management for OPTX. METHODS: The aim of this retrospective study is to determine whether OPTX can be managed conservatively and whether any adverse events occur under conservative management. Data on all trauma patients from 1 Jan 2010 to 31 December 2012 were obtained from our hospital's trauma registry...
December 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26702425/effects-of-methacholine-infusion-on-desflurane-pharmacokinetics-in-piglets
#15
Alf Kozian, Moritz Kretzschmar, James E Baumgardner, Jens Schreiber, Göran Hedenstierna, Anders Larsson, Thomas Hachenberg, Thomas Schilling
The data of a corresponding animal experiment demonstrates that nebulized methacholine (MCh) induced severe bronchoconstriction and significant inhomogeneous ventilation and pulmonary perfusion (V̇A/Q̇) distribution in pigs, which is similar to findings in human asthma. The inhalation of MCh induced bronchoconstriction and delayed both uptake and elimination of desflurane (Kretzschmar et al., 2015) [1]. The objective of the present data is to determine V̇A/Q̇ matching by Multiple Inert Gas Elimination Technique (MIGET) in piglets before and during methacholine- (MCh-) induced bronchoconstriction, induced by MCh infusion, and to assess the blood concentration profiles for desflurane (DES) by Micropore Membrane Inlet Mass Spectrometry (MMIMS)...
December 2015: Data in Brief
https://www.readbyqxmd.com/read/26377057/neonatal-outcome-of-the-late-preterm-infant-34-to-36-weeks-the-singapore-story
#16
Nirmal Kavalloor Visruthan, Pratibha Agarwal, Bhavani Sriram, Victor Samuel Rajadurai
INTRODUCTION: Late preterm (LP) neonates (34 to 36 weeks gestation) are often managed like term neonates though current literature has identified them to have greater complications. The primary objective of our study was to evaluate and compare morbidity and resource utilisation in LPs especially in view of paucity of Asian studies in this regard. MATERIALS AND METHODS: A retrospective audit was carried out on 12,459 neonates born in KK Women's and Children's Hospital (KKWCH)...
July 2015: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/26312896/factors-associated-with-early-provision-of-respiratory-support-in-deteriorating-ward-patients-with-chest-sepsis
#17
Myura Nagendran, Pubudu de Silva, Steve Harris
BACKGROUND: Implementation of the National Early Warning Score in the National Health Service (NHS) has renewed focus on prompt identification and referral of the deteriorating ward patient. A large body of published work suggests that delay in both referral and admission to critical care can be associated with poor outcomes. We sought to explore factors associated with early provision of respiratory support in a cohort of deteriorating ward patients referred to the critical care team...
February 26, 2015: Lancet
https://www.readbyqxmd.com/read/26180157/arterial-switch-for-transposition-of-the-great-arteries-with-large-ventricular-septal-defect-and-for-taussig-bing-anomaly-experience-from-a-tertiary-care-center-in-the-developing-world
#18
Mohammad Eliyas Patwary, Mohammad Shahbaz Khan, Ashutosh Marwah, Vishal Singh, Sudhir Shekhawat, Rajesh Sharma
BACKGROUND: Results of the arterial switch operation (ASO) for transposition of the great arteries (TGA) with large ventricular septal defect (VSD) and for Taussig Bing anomaly (TBA) in a tertiary care center of a developing country were retrospectively analyzed. METHODS: From January 2007 through June 2013, a total of 30 patients with TBA and 54 patients having TGA with large VSD underwent ASO with VSD closure. Age at surgery for TBA was 27 days to 7 years (median age 3 months) and for TGA with VSD it was 1 day to 6 years (median age 2 months)...
July 2015: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/26141572/continuous-distending-pressure-for-respiratory-distress-in-preterm-infants
#19
REVIEW
Jacqueline J Ho, Prema Subramaniam, Peter G Davis
BACKGROUND: Respiratory distress syndrome (RDS) is the single most important cause of morbidity and mortality in preterm infants. In infants with progressive respiratory insufficiency, intermittent positive pressure ventilation (IPPV) with surfactant is the standard treatment for the condition, but it is invasive, potentially resulting in airway and lung injury. Continuous distending pressure (CDP) has been used for the prevention and treatment of RDS, as well as for the prevention of apnoea, and in weaning from IPPV...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26011525/chest-compression-synchronized-ventilation-versus-intermitted-positive-pressure-ventilation-during-cardiopulmonary-resuscitation-in-a-pig-model
#20
Clemens Kill, Monika Galbas, Christian Neuhaus, Oliver Hahn, Pascal Wallot, Karl Kesper, Hinnerk Wulf, Wolfgang Dersch
BACKGROUND: Guidelines recommend mechanical ventilation with Intermitted Positive Pressure Ventilation (IPPV) during resuscitation. The influence of the novel ventilator mode Chest Compression Synchronized Ventilation (CCSV) on gas exchange and arterial blood pressure compared with IPPV was investigated in a pig model. METHODS: In 12 pigs (general anaesthesia/intubation) ventricular fibrillation was induced and continuous chest compressions were started after 3 min...
2015: PloS One
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