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https://www.readbyqxmd.com/read/29232024/myocardial-perfusion-reserve-index-in-children-with-kawasaki-disease
#1
Richard M Friesen, Michal Schäfer, Pei-Ni Jone, Nana Appiawiah, Daniel Vargas, Brian Fonseca, Michael V DiMaria, Uyen Truong, LaDonna Malone, Lorna P Browne
BACKGROUND: Coronary artery lesions in patients with Kawasaki disease (KD) can impair myocardial perfusion, yet evaluation of perfusion defects by cardiac magnetic resonance (MR) in children is often qualitative. PURPOSE: In this study we aimed to use a quantitative method of myocardial perfusion using stress cardiac MR-derived myocardial perfusion reserve index (MPRI) in children with KD and compare MPRI with ventricular mechanical performance evaluated by cardiac MR strain analysis...
December 12, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29231060/combined-effects-of-ovariectomy-and-streptozotocin-induced-diabetes-in-the-articular-cartilage-of-rats
#2
A Saeki Fernandes, C C N Fonseca, G Rodrigues da Silva Sasso, L Carvalho Cezar, M Aparecida Dos Santos, M J Simões, R S Simões, R Florencio-Silva
AIM: To evaluate the combined effects of streptozotocin-induced diabetes (Di) and ovariectomy in the articular cartilage of rats. METHODS: Forty adult female Wistar rats were ovariectomized (OVX) or sham-operated. After recovery from surgery, the animals were assigned randomly into four groups: OVX control (OVX-C); OVX treated with 10 µg/kg/day of 17β-estradiol (OVX-E); sham-operated subjected to Di (Sham-Di); and OVX subjected to Di (OVX-Di). After 60 days of treatment, the animals were euthanized and the distal femurs with articular cartilage were processed for paraffin-embedding...
December 12, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29230685/calcitriol-reverses-the-down-regulation-pattern-of-tuberous-sclerosis-complex-genes-in-an-in-vitro-calcification-model
#3
Eraldo Fonseca Dos Santos Junior, Roberta Rodrigues de Lemos Gitirana, Darlene Paiva Bezerra, João Ricardo Mendes de Oliveira
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome with autosomal dominant inheritance, and most of the cases are related to loss of function of the TSC1 and TSC2 genes. TSC may occur with a wide range of clinical findings and skin, kidney, brain, and heart are the most commonly affected organs. Brain calcifications in TSC are also described and reported as diffuse and without pattern of symmetry or bilaterality. Recently, a new discovery opened the possibility of using vitamin D (VitD) for treating cerebral calcifications...
December 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29229604/transcription-factor-activities-enhance-markers-of-drug-sensitivity-in-cancer
#4
Luz M Garcia-Alonso, Francesco Iorio, Angela Matchan, Nuno A Fonseca, Patricia Jaaks, Gareth Peat, Miguel Pignatelli, Fiammetta Falcone, Cyril H Benes, Ian Dunham, Graham R Bignell, Simon McDade, Mathew J Garnett, Julio Saez-Rodriguez
Transcriptional dysregulation induced by aberrant Transcription factors (TFs) is a key feature of cancer, but its global influence on drug sensitivity has not been examined. Here we infer the transcriptional activity of 127 TFs through analysis of RNA-seq gene expression data newly generated for 448 cancer cell lines, combined with publicly available datasets to survey a total of 1,056 cancer cell lines and 9,250 primary tumors. Predicted TF activities are supported by their agreement with independent shRNA essentiality profiles and homozygous gene deletions, and recapitulate mutant-specific mechanisms of transcriptional dysregulation in cancer...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29229601/a2ar-adenosine-signaling-suppresses-natural-killer-cell-maturation-in-the-tumor-microenvironment
#5
Arabella Young, Shin Foong Ngiow, Yulong Gao, Ann-Marie Patch, Deborah S Barkauskas, Meriem Messaoudene, Gene Lin, Jerome David Coudert, Kimberley A Stannard, Laurence Zitvogel, Mariapia A Degli-Esposti, Eric Vivier, Nicola Waddell, Joel Linden, Nicholas D Huntington, Fernando Souza-Fonseca Guimaraes, Mark J Smyth
Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs anti-tumor immune responses. Here, we show that engagement of A2A adenosine receptor (A2AR) acts as a checkpoint that limits the maturation of natural killer (NK) cells. Both global and NK cell-specific conditional deletion of A2AR enhanced proportions of terminally mature NK cells at homeostasis, following reconstitution, and in the tumor microenvironment. Notably, A2AR-deficient, terminally mature NK cells retained proliferative capacity and exhibited heightened reconstitution in competitive transfer assays...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29229449/treatment-of-persistent-cutaneous-atrophy-after-corticosteroid-injection-with-fat-graft
#6
Nádia Martins, Joaquim Polido-Pereira, Manuel Caneira, João Eurico Fonseca
Subcutaneous fat atrophy and hypopigmentation are potential adverse side effects of local corticosteroid injection that may resolve spontaneously within 1-2 years. This report shows that fat grafting provides a simple, effective and safe correction of corticosteroid induced cutaneous atrophy with very satisfying esthetic and functional results.
December 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29225685/retromammary-fat-axillary-and-arm-metastases-from-a-retroperitoneal-leiomyosarcoma-report-of-a-case-with-an-indolent-behaviour
#7
Walberto Monteiro Neiva Eulálio Filho, Samuel Madeira Campos Melo, Rafaela de Brito Alves, Luiz Ayrton Santos Junior, Danilo da Fonseca Reis Silva
Leiomyosarcomas are sarcomas that originate within smooth muscle cells and generally occur in older patients. These tumours account for 10% of all soft-tissue sarcomas. Metastases occur most commonly to the lungs, kidneys, and liver. Cutaneous metastases may also occur but are usually a very rare and late event. We present a case of a 46-year-old woman who developed subcutaneous metastasis to the axilla, arm and breast after surgical resection of the primary tumour. The patient maintained controlled disease with surgical resections and clinical follow-up, initiating chemotherapy one year after the diagnosis of metastatic disease...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29225105/interpretation-of-b-type-natriuretic-peptides-in-the-era-of-angiotensin-receptor-neprilysin-inhibitors
#8
Paulo Bettencourt, Cândida Fonseca, Fátima Franco, Aurora Andrade, Dulce Brito
Assessment of serum levels of natriuretic peptides, especially the amino-terminal portion (NT-proBNP) and the carboxy-terminal portion (BNP) of pro-B-type natriuretic peptide, has had a highly significant clinical impact on the diagnosis and prognostic stratification of patients with heart failure (HF). They are now an instrument with recognized value in this context and several studies have demonstrated their value in tailoring therapy for these patients. Following the recent advent of angiotensin receptor-neprilysin inhibitors (ARNIs), there is a need to review how these two biomarkers are interpreted in HF...
December 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29224977/corrigendum-to-molecular-and-phylogenetic-analyses-of-salmonella-gallinarum-trace-the-origin-and-diversification-of-recent-outbreaks-of-fowl-typhoid-in-poultry-farms-vet-microbiol-212-2017-80-86
#9
Silvia De Carli, Tiago Gräf, Diéssy Kipper, Fernanda Kieling Moreira Lehmann, Nathalie Zanetti, Franciele Maboni Siqueira, Samuel Cibulski, André Salvador Kazantzi Fonseca, Nilo Ikuta, Vagner Ricardo Lunge
No abstract text is available yet for this article.
December 7, 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29224620/exploring-trichoderma-and-aspergillus-secretomes-proteomics-approaches-for-the-identification-of-enzymes-of-biotechnological-interest
#10
REVIEW
Nicholas de Mojana di Cologna, Diana Paola Gómez-Mendoza, Fabiana Fonseca Zanoelo, Giovana Cristina Giannesi, Nelciele Cavalieri de Alencar Guimarães, Leonora Rios de Souza Moreira, Edivaldo Ximenes Ferreira Filho, Carlos André Ornelas Ricart
Filamentous fungal secretomes comprise highly dynamic sets of proteins, including multiple carbohydrate active enzymes (CAZymes) which are able to hydrolyze plant biomass polysaccharides into products of biotechnological interest such as fermentable sugars. In recent years, proteomics has been used to identify and quantify enzymatic and non-enzymatic polypeptides present in secretomes of several fungi species. The resulting data have widened the scientific understanding of the way filamentous fungi perform biomass degradation and offered novel perspectives for biotechnological applications...
February 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29221731/white-adipose-tissue-is-a-reservoir-for-memory-t-cells-and-promotes-protective-memory-responses-to-infection
#11
Seong-Ji Han, Arielle Glatman Zaretsky, Vinicius Andrade-Oliveira, Nicholas Collins, Amiran Dzutsev, Jahangheer Shaik, Denise Morais da Fonseca, Oliver J Harrison, Samira Tamoutounour, Allyson L Byrd, Margery Smelkinson, Nicolas Bouladoux, James B Bliska, Jason M Brenchley, Igor E Brodsky, Yasmine Belkaid
White adipose tissue bridges body organs and plays a fundamental role in host metabolism. To what extent adipose tissue also contributes to immune surveillance and long-term protective defense remains largely unknown. Here, we have shown that at steady state, white adipose tissue contained abundant memory lymphocyte populations. After infection, white adipose tissue accumulated large numbers of pathogen-specific memory T cells, including tissue-resident cells. Memory T cells in white adipose tissue expressed a distinct metabolic profile, and white adipose tissue from previously infected mice was sufficient to protect uninfected mice from lethal pathogen challenge...
November 30, 2017: Immunity
https://www.readbyqxmd.com/read/29220439/text-mining-and-expert-curation-to-develop-a-database-on-psychiatric-diseases-and-their-genes
#12
Alba Gutiérrez-Sacristán, Àlex Bravo, Marta Portero-Tresserra, Olga Valverde, Antonio Armario, M C Blanco-Gandía, Adriana Farré, Lierni Fernández-Ibarrondo, Francina Fonseca, Jesús Giraldo, Angela Leis, Anna Mané, M A Mayer, Sandra Montagud-Romero, Roser Nadal, Jordi Ortiz, Francisco Javier Pavon, Ezequiel Jesús Perez, Marta Rodríguez-Arias, Antonia Serrano, Marta Torrens, Vincent Warnault, Ferran Sanz, Laura I Furlong
Database URL: http://www.psygenet.org. PsyGeNET corpus: http://www.psygenet.org/ds/PsyGeNET/results/psygenetCorpus.tar.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29218822/european-academy-of-neurology-european-stroke-organisation-consensus-statement-and-practical-guidance-for-pre-hospital-management-of-stroke
#13
A Kobayashi, A Czlonkowska, G A Ford, A C Fonseca, G J Luijckx, J Korv, N Pérez de la Ossa, C Price, D Russell, A Tsiskaridze, M Messmer-Wullen, J De Keyser
Reduction of delay between onset and hospital arrival and adequate pre-hospital care of persons with acute stroke are important for improving chances of a favorable outcome. The objective is to recommend evidence-based practices for the management of patients with suspected stroke in the pre-hospital setting. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology was used to define the key clinical questions. An expert panel then reviewed the literature, established the quality of the evidence, and made recommendations...
December 7, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29218641/mixed-guanine-adenine-base-quartets-possible-roles-of-protons-and-metal-ions-in-their-stabilization
#14
Dominik A Megger, Patrick M Lax, Jeroen Paauwe, Célia Fonseca Guerra, Bernhard Lippert
Structural variations of the well-known guanine quartet (G4) motif in nucleic acid structures, namely substitution of two guanine bases (G) by two adenine (A) nucleobases in mutual trans positions, are discussed and studied by density functional theory (DFT) methods. This work was initiated by three findings, namely (1) that GA mismatches are compatible with complementary pairing patterns in duplex-DNA structures and can, in principle, be extended to quartet structures, (2) that GA pairs can come in several variations, including with a N1 protonated adeninium moiety (AH), and (3) that cross-linking of the major donor sites of purine nucleobases (N1 and N7) by transition metal ions of linear coordination geometries produces planar purine quartets, as demonstrated by some of us in the past...
December 7, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29218627/top-ten-errors-of-statistical-analysis-in-observational-studies-for-cancer-research
#15
REVIEW
A Carmona-Bayonas, P Jimenez-Fonseca, A Fernández-Somoano, F Álvarez-Manceñido, E Castañón, A Custodio, F A de la Peña, R M Payo, L P Valiente
Observational studies using registry data make it possible to compile quality information and can surpass clinical trials in some contexts. However, data heterogeneity, analytical complexity, and the diversity of aspects to be taken into account when interpreting results makes it easy for mistakes to be made and calls for mastery of statistical methodology. Some questionable research practices that include poor analytical data management are responsible for the low reproducibility of some results; yet, there is a paucity of information in the literature regarding specific statistical pitfalls of cancer studies...
December 7, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29218618/metal-artifact-reduction-mri-of-total-ankle-arthroplasty-implants
#16
Cesar de Cesar Netto, Lucas F Fonseca, Benjamin Fritz, Steven E Stern, Esther Raithel, Mathias Nittka, Lew C Schon, Jan Fritz
OBJECTIVES: To assess high-bandwidth and compressed sensing-(CS)-SEMAC turbo spin echo (TSE) techniques for metal artifact reduction MRI of total ankle arthroplasty (TAA) implants. METHODS: Following institutional approval and consent, 40 subjects with TAA implants underwent 1.5-T MRI prospectively. Evaluations included bone-implant interfaces, anatomical structures, abnormal findings and differential diagnoses before and after MRI. AUCs of P-P plots were used to determine superiority...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29218309/kinematic-changes-during-prolonged-fast-walking-in-old-and-young-adults
#17
Camila Fonseca Oliveira, Edgar Ramos Vieira, Filipa Manuel Machado Sousa, João Paulo Vilas-Boas
Walking biomechanics is known to be influenced by speed. However, most of the research examining the effects of walking speed and gait characteristics has been conducted after a fast-walking task, neglecting the changes that may occur during the task. The aim of the present study was to determine the impact of fast-walking over time on kinematics in young and old adults. Twenty-seven young adults (26.6 ± 6.0 years) and 23 old adults (71.0 ± 5.6 years) walked at 70% of their maximum heart rate for 20 min or until exhaustion, and the effects of fast-walking on temporospatial parameters and on angular kinematics were analyzed during the activity...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29216699/-diagnostic-value-of-a-predictive-model-for-complete-ruptures-of-the-rotator-cuff-associated-to-subacromial-impingement
#18
I R Águila-Ledesma, J L Córdova-Fonseca, O Medina-Pontaza, D A Núñez-Gómez, C Calvache-García, J M Pérez-Atanasio, R Torres-González
Pathology related to the rotator cuff remains among the most prevalent musculoskeletal diseases. There is an increasing need for imaging studies (MRI, US, arthroscopy) to test the diagnostic performance of the medical history and physical examination. OBJECTIVE: To prove the diagnostic value of a clinical-radiographic predictive model to find complete ruptures of the rotator cuff. MATERIAL AND METHODS: Descriptive, observational, prospective, transversal and analytical study...
May 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29214166/mirnas-important-targets-for-oral-cancer-pain-research
#19
REVIEW
Cláudia Maria Pereira, Dayany Sehnem, Estevão Oliveira da Fonseca, Heráclito Fernando Gurgel Barboza, Antônio Carlos Pires de Carvalho, Alexandre F M DaSilva, Vivaldo Moura-Neto, Marcos F DosSantos
Pain is a symptom shared by an incredible number of diseases. It is also one of the primary conditions that prompt individuals to seek medical treatment. Head and neck squamous cell carcinoma (HNSCC) corresponds to a heterogeneous disease that may arise from many distinct structures of a large, highly complex, and intricate region. HNSCC affects a great number of patients worldwide and is directly associated with chronic pain, which is especially prominent during the advanced stages of oral squamous cell carcinoma (OSCC), an anatomical and clinical subtype that corresponds to the great majority oral cancers...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29213498/program-of-neuropsychological-stimulation-of-cognition-in-students-emphasis-on-executive-functions-development-and-evidence-of-content-validity
#20
Caroline de Oliveira Cardoso, Natália Martins Dias, Alessandra Gotuzo Seabra, Rochele Paz Fonseca
Objective: The goal of this study was to describe the construction process and content validity evidence of an early and preventive intervention program for stimulating executive functions (EF) in Elementary School children within the school environment. Methods: The process has followed the recommended steps for creating neuropsychological instruments: internal phase of program organization, with literature search and analyses of available materials in the classroom; program construction; analysis by expert judges; data integration and program finalization...
January 2017: Dementia & Neuropsychologia
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