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Leandra Natália de Oliveira Neves, Rafael Marques, Paulo Henrique Fonseca da Silva, Marcone Augusto Leal de Oliveira
Lactulose is not found naturally in milk, but it has been detected in small quantities in heated dairy products. It can therefore be used as an indicator of the severity of heat treatment for dairy products. This study proposes an alternative method for lactulose quantification in milk using capillary zone electrophoresis with ultraviolet detection (CZE-UV). The investigation used several Brazilian UHT milk samples, and various sample pretreatment methods and injection conditions were considered. Optimal separation results were achieved using Carrez clarification solutions...
August 30, 2018: Food Chemistry
Alexandra C G Fonseca, Margaret I Engelhardt, Zhen J Huang, Zi Yang Jiang, Sancak Yuksel, Soham Roy
PURPOSE: To review rates of post-tonsillectomy hemorrhage (PTH) at a quaternary medical center, including the impact of narcotic versus nonsteroidal anti-inflammatory drug (NSAID) postoperative pain management. MATERIALS AND METHODS: A retrospective review was performed of tonsillectomies conducted at a single institution between 1/1/2013 and 1/1/2017. The rates of PTH and subsequent intervention were calculated. These were categorized into patients having surgery pre- and post-July 1, 2015, the former group receiving narcotics and the latter ibuprofen with acetaminophen...
April 5, 2018: American Journal of Otolaryngology
María Reig, Leonardo Gomes da Fonseca, Sandrine Faivre
No abstract text is available yet for this article.
April 10, 2018: Journal of Hepatology
P Jimenez-Fonseca, C Calderón, R Hernández, T Ramón Y Cajal, M Mut, A Ramchandani, O Donnay, A Carmona-Bayonas
OBJECTIVE: Anxiety and depression affect cancer patients' quality of life. Our objectives were to determine the prevalence of anxiety and depression and analyze the association between positive psychological factors, sociodemographic factors, and clinical factors in oncological patients initiating adjuvant treatment. METHODS: A prospective, multicenter cohort of 600 consecutive patients completed the Brief Symptom Inventory, Mini-Mental Adjustment to Cancer, Life Orientation Scale-Revised, and Multidimensional Scale of Perceived Social Support questionnaires...
April 12, 2018: Clinical & Translational Oncology
Ömer Dursun, Tamer Çankaya
GOAL: The aim of this study was to assess temporomandibular joint dysfunction in patients with stroke. MATERIALS AND METHODS: Total of 100 participants, 50 healthy and 50 who had stroke, were recruited into this study. Digital caliper and algometer were used to assess temporomandibular joint range of motion and masticatory muscle pressure pain threshold. Labial commissure angle measurement was used for the assessment of facial paralysis severity. Fonseca questionnaire was used for temporomandibular joint dysfunction assessment and categorization...
April 9, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Taíse Sousa Pamplona da Silva, Roberta Fonseca de Castro, Marcela Baraúna Magno, Lucianne Copple Maia, Mário Honorato da Silva E Souza
OBJECTIVES: To determine through a systematic review if HEMA-free adhesive systems have better clinical performance than HEMA-containing ones in non-carious cervical lesion (NCCL) restorations. SOURCES: We systematically searched PubMed, The Cochrane Library, Scopus, Web of Science, and Open Grey databases, using MeSH terms, synonyms, and keywords, with no language or date restriction. The reference lists of included articles were manually searched. STUDY SELECTION: Randomized controlled clinical trials comparing the effectiveness of HEMA-free and HEMA-containing adhesive systems in NCCL restorations, were included...
April 9, 2018: Journal of Dentistry
Abbas Agaimy, Isabel Fonseca, Carmo Martins, Khin Thway, Ryan Barrette, Kevin J Harrington, Arndt Hartmann, Christopher A French, Cyril Fisher
NUT carcinoma (NC) represents a rare subset of highly aggressive poorly differentiated carcinomas characterized by rearrangement of the NUT (aka NUTM1, nuclear protein in testis) gene, most commonly fused to BRD4. Originally described as a mediastinal/thymic malignancy, NC has been reported at a variety of anatomic regions including the upper and lower aerodigestive tract. To date, only 7 NC cases of probable salivary gland origin have been reported. We herein describe 3 new cases (all affecting the parotid gland) in 2 women (39- and 55-y old) and 1 man (35-y old)...
April 11, 2018: American Journal of Surgical Pathology
Musa Abubakar Kana, Carina Rodrigues, Maria João Fonseca, Ana Cristina Santos, Henrique Barros
Background: Maternal country of birth has been associated with perinatal health outcomes but less is known regarding breastfeeding practices in contemporary European settings. This study investigated effect of maternal country of birth on breastfeeding initiation and duration by comparing native Portuguese and migrant mothers. Methods: We analyzed data of 7065 children of the Generation XXI (GXXI) birth cohort recruited at birth (2005-06) and followed-up 4 years later...
2018: International Breastfeeding Journal
Alexandre Morrot, Leonardo Marques da Fonseca, Eduardo J Salustiano, Luciana Boffoni Gentile, Luciana Conde, Alessandra Almeida Filardy, Tatiany Nunes Franklim, Kelli Monteiro da Costa, Celio Geraldo Freire-de-Lima, Leonardo Freire-de-Lima
The tumor microenvironment (TME) is composed by cellular and non-cellular components. Examples include the following: (i) bone marrow-derived inflammatory cells, (ii) fibroblasts, (iii) blood vessels, (iv) immune cells, and (v) extracellular matrix components. In most cases, this combination of components may result in an inhospitable environment, in which a significant retrenchment in nutrients and oxygen considerably disturbs cell metabolism. Cancer cells are characterized by an enhanced uptake and utilization of glucose, a phenomenon described by Otto Warburg over 90 years ago...
2018: Frontiers in Oncology
Leticia Garcia-Alvarez, María Paz Garcia-Portilla, Pilar Alejandra Saiz, Eduardo Fonseca-Pedrero, María Teresa Bobes-Bascaran, Jesús Gomar, José Muñiz, Julio Bobes
INTRODUCTION: Negative symptoms are prevalent in schizophrenia and associated with a poorer outcome. Validated newer psychometric instruments could contribute to better assessment and improved treatment of negative symptoms. The Negative Symptom Assessment-16 (NSA-16) has been shown to have strong psychometric properties, but there is a need for validation in non-English languages. This study aimed to examine the psychometric properties of a Spanish version of the NSA-16 (Sp-NSA-16). MATERIAL AND METHOD: Observational, cross-sectional validation study in a sample of 123 outpatients with schizophrenia...
April 5, 2018: Revista de Psiquiatrí́a y Salud Mental
Pedro Fonseca, Flavio Romano, John S Schreck, Thomas E Ouldridge, Jonathan P K Doye, Ard A Louis
Inspired by recent successes using single-stranded DNA tiles to produce complex structures, we develop a two-step coarse-graining approach that uses detailed thermodynamic calculations with oxDNA, a nucleotide-based model of DNA, to parametrize a coarser kinetic model that can reach the time and length scales needed to study the assembly mechanisms of these structures. We test the model by performing a detailed study of the assembly pathways for a two-dimensional target structure made up of 334 unique strands each of which are 42 nucleotides long...
April 7, 2018: Journal of Chemical Physics
Camille Hilliere, Daniel Collado-Mateo, Santos Villafaina, Paulo Duque-Fonseca, José A Parraça
OBJECTIVE: To provide an up-to-date research analysis on equine-assisted therapies and horse riding simulation exercise in older adults, and to suggest future directions in clinical practice and research. TYPE: Systematic Review. LITERATURE SURVEY: A comprehensive search of studies was performed in 4 electronic databases (Cochrane, PubMed, PEDro and Web of Science) regarding the effects of equine-assisted therapies and horse riding simulation exercise in older adults...
April 4, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
Lino Fonseca, Rafael Najarro-Quispe, Ana Rodríguez-Hernández, Ramon Torné, Dario Gándara-Sabatini, Fuat Arikan, Pilar Baños-Carrasco
Microsurgical clipping is still regarded as the gold-standard treatment for broad-neck intracranial aneurysms. New endovascular techniques like balloon or stent assisted coiling are quickly rising to the challenge and showing promising outcomes. As a result, broad-neck aneurysms are increasingly addressed by these techniques despite they have not been tested against clipping in a randomized controlled trial and long-term complications might be unknown yet. Intraprocedural coil migration has been well documented in the literature, but the same complication in a delayed fashion is scarcely reported...
April 3, 2018: Neurocirugía
Rebeca Fernández Regueiro, Eva María Fonseca Aizpuru, Carolina Estrada Menéndez, Loreto Buznego Suárez
No abstract text is available yet for this article.
April 3, 2018: Reumatología Clinica
Sandro Queirós, Pedro Morais, Christophe Dubois, Jens-Uwe Voigt, Wolfgang Fehske, Andreas Kuhn, Tobias Achenbach, Jaime C Fonseca, João L Vilaça, Jan D'hooge
BACKGROUND: Accurate aortic annulus (AoA) sizing is crucial for transcatheter aortic valve implantation planning. Three-dimensional (3D) transesophageal echocardiography (TEE) is a viable alternative to the standard multidetector row computed tomography (MDCT) for such assessment, with few automatic software solutions available. The aim of this study was to present and evaluate a novel software tool for automatic AoA sizing by 3D TEE. METHODS: One hundred one patients who underwent both preoperative MDCT and 3D TEE were retrospectively analyzed using the software...
April 2018: Journal of the American Society of Echocardiography
A Burgeiro, A C Fonseca, D Espinoza, L Carvalho, N Lourenço, M Antunes, E Carvalho
BACKGROUND: Cardiovascular diseases (CVDs) are leading cause of death and primary cause of morbidity and mortality in diabetic population. Epicardial adipose tissue (EAT) covers the heart's surface and is a source of biomolecules regulating heart and blood vessel physiology. The protective activation of the unfolded protein response (UPR) and autophagy allows the cardiomyocyte reticular network to restore energy and/or nutrient homeostasis and to avoid cell death. However, an excessive or prolonged UPR activation can trigger cell death...
April 3, 2018: Biochimica et Biophysica Acta
Vicente J Aran, Cristina Fonseca-Berzal, Alexandra Ibáñez-Escribano, Nerea Vela, José Cumella, Juan José Nogal-Ruiz, José Antonio Escario, Patrícia Bernardino da Silva, Marcos Meuser Batista, Maria de Nazaré C Soeiro, Sergio Sifontes-Rodriguez, Alfredo Meneses-Marcel, Alicia Gómez-Barrio
Three different series of new 5-nitroindazole derivatives, 1-(ω-aminoalkyl)-2-benzylindazolin-3-ones (series A; 10 compounds), 3-(ω-aminoalkoxy)-2-benzylindazoles (series B; 4 compounds) and 3-alkylamino-2-benzylindazoles (series C; 5 compounds), have been synthesized and evaluated against the protozoan parasites Trypanosoma cruzi, Leishmania amazonensis and Trichomonas vaginalis, etiological agents of Chagas disease, cutaneous leishmaniasis and trichomoniasis, respectively. Many indazoles of series A, B and C were efficient against T...
April 6, 2018: ChemMedChem
Rodrigo C Moreira, José G Mill, Beatriz Grinsztejn, Valdilea Veloso, Maria de Jesus Fonseca, Rosane H Griep, Isabela Bensenor, Sandra W Cardoso, Paulo Lotufo, Dora Chor, Antonio G Pacheco
INTRODUCTION: Aortic stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) is a marker of subclinical atherosclerosis. We propose to assess whether HIV infection is associated with arterial stiffness and their determinants in HIV-infected subjects. METHODS: We compared data from an HIV cohort (644 patients, HIV+) in Rio de Janeiro with 2 groups: 105 HIV-negative (HIV-) individuals and 14,873 participants of the ELSA-Brasil study. We used multivariable linear regression to investigate factors associated with cf-PWV and whether HIV was independently associated with aortic stiffness and propensity score weighting to control for imbalances between groups...
May 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Verónica González-Calle, Abigail Slack, Niamh Keane, Susan Luft, Kathryn E Pearce, Rhett P Ketterling, Tania Jain, Sintosebastian Chirackal, Craig Reeder, Joseph Mikhael, Pierre Noel, Angela Mayo, Roberta H Adams, Gregory Ahmann, Esteban Braggio, A Keith Stewart, P Leif Bergsagel, Scott A Van Wier, Rafael Fonseca
The International Myeloma Working Group has proposed the Revised International Staging System (R-ISS) for risk stratification of multiple myeloma (MM) patients. There are a limited number of studies that have validated this risk model in the autologous stem cell transplant (ASCT) setting. In this retrospective study, we evaluated the applicability and value for predicting survival of the R-ISS model in 134 MM patients treated with new agents and ASCT at the Mayo Clinic in Arizona and the University Hospital of Salamanca in Spain...
April 6, 2018: Annals of Hematology
Júnior Mário Baltazar de Oliveira, Tatiana Rozental, Elba Regina Sampaio de Lemos, Danielle Forneas, Luis Miguel Ortega-Mora, Wagnner José Nascimento Porto, Andréa Alice da Fonseca Oliveira, Rinaldo Aparecido Mota
Coxiella burnetii, an intracellular bacterium, is the agent of Q fever/coxiellosis, a worldwide zoonosis. Dairy animals are the primary reservoirs of C. burnetii, and although the disease is usually asymptomatic or subclinical, abortion is a serious clinical outcome among small ruminants. This study was conducted to investigate C. burnetii seroprevalence and infection In a flock of dairy goats in Brazil. Serum samples from 312 goats collected from a dairy goat flock with a history of reproductive failure were tested by a commercial ELISA (LSIVet Ruminant Q Fever - Serum/Milk; Thermo Fisher Scientific, Lissieu, France) for anti-C...
April 3, 2018: Acta Tropica
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