Romaric Larcher, Anne-Sophie Bargnoux, Stephanie Badiou, Noemie Besnard, Vincent Brunot, Delphine Daubin, Laura Platon, Racim Benomar, Matthieu Amalric, Anne-Marie Dupuy, Kada Klouche, Jean-Paul Cristol
Tubular injury is the main cause of acute kidney injury (AKI) in critically ill COVID-19 patients. Proximal tubular dysfunction (PTD) and changes in urinary biomarkers, such as NGAL, TIMP-2, and IGFBP7 product ([TIMP-2]•[IGFBP7]), could precede AKI. We conducted a prospective cohort study from 2020/03/09 to 2020/05/03, which consecutively included all COVID-19 patients who had at least one urinalysis, to assess the incidence of PTD and AKI, and the effectiveness of PTD, NGAL, and [TIMP-2]•[IGFBP7] in AKI and persistent AKI prediction using the area under the receiver operating characteristic curves (AUCs), Kaplan-Meier methodology (log-rank tests), and Cox models...
2023: Renal Failure