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post partum cardiomyopathy

I Labbene, M Arrigo, M Tavares, Z Hajjej, J L Brandão, H Tolppanen, E Feliot, E Gayat, M Ferjani, A Mebazaa
BACKGROUND: Catecholamines and/or levosimendan have been proposed for haemodynamic restoration during cardiogenic shock (CS). In CS induced by post-partum cardiomyopathy (PPCM), levosimendan might be particularly favourable. The aim of this study was to evaluate the haemodynamic and echocardiographic effects of levosimendan in patients with CS, in particular in patients with PPCM-induced CS. METHODS: Twenty-eight patients with refractory CS were retrospectively included in the study...
July 17, 2016: Anaesthesia, Critical Care & Pain Medicine
Anne-Sophie Ducloy-Bouthors, Max Gonzalez-Estevez, Benjamin Constans, Alexandre Turbelin, Catherine Barre-Drouard
No abstract text is available yet for this article.
July 5, 2016: Anaesthesia, Critical Care & Pain Medicine
Julie Damp, Michael M Givertz, Marc Semigran, Rami Alharethi, Gregory Ewald, G Michael Felker, Biykem Bozkurt, John Boehmer, Jennifer Haythe, Hal Skopicki, Karen Hanley-Yanez, Jessica Pisarcik, Indrani Halder, John Gorcsan, Sarosh Rana, Zoltan Arany, James D Fett, Dennis M McNamara
OBJECTIVES: This study explored the association of vascular hormones with myocardial recovery and clinical outcomes in peripartum cardiomyopathy (PPCM). BACKGROUND: PPCM is an uncommon disorder with unknown etiology. Angiogenic imbalance may contribute to its pathophysiology. METHODS: In 98 women with newly diagnosed PPCM enrolled in the Investigation in Pregnancy Associated Cardiomyopathy study, serum was obtained at baseline for analysis of relaxin-2, prolactin, soluble fms-like tyrosine kinase 1 (sFlt1), and vascular endothelial growth factor (VEGF)...
May 2016: JACC. Heart Failure
Harshida Patel, Marie Berg, Anders Barasa, Cecily Begley, Maria Schaufelberger
OBJECTIVE: Peripartum Cardiomyopathy is a form of cardiac disease often associated with cardiac failure, occurring in late pregnancy or after childbirth. The anatomical and physiological changes in the mother associated with normal pregnancy are profound, and this may result in symptoms and signs that overlap with Peripartum Cardiomyopathy, leading to missed or delayed diagnosis. Women's experiences of Peripartum Cardiomyopathy symptoms remain poorly studied. The aim of this study was to explore and describe women's experiences of symptoms in Peripartum Cardiomyopathy...
January 2016: Midwifery
Nadia Bouabdallaoui, Frederic Mouquet, Guillaume Lebreton, Pierre Demondion, Thierry H Le Jemtel, Pierre V Ennezat
Heart failure with left ventricular dysfunction occurring during pregnancy or during the post-partum period in patients without history of cardiovascular disease defines peripartum cardiomyopathy (PPCM). PPCM carries a high morbidity and mortality rate as well as the possibility of recovery ad integrum. Its incidence shows ethnic variations, with a greater prevalence of the disease among women with African descent. Pathogenesis of PPCM remains poorly understood. Both "oxidative stress-prolactin axis" and "anti-angiogenic-signaling excess" hypotheses are currently being investigated...
October 16, 2015: European Heart Journal. Acute Cardiovascular Care
Supriya Shore, Maria V Grau-Sepulveda, Deepak L Bhatt, Paul A Heidenreich, Zubin J Eapen, Adrian F Hernandez, Clyde W Yancy, Gregg C Fonarow
OBJECTIVES: The authors sought to describe characteristics, treatments, and in-hospital outcomes of hospitalized heart failure (HF) patients stratified by etiology. BACKGROUND: Whether characteristics and outcomes of HF patients differ by cardiomyopathy etiology is unknown. METHODS: The authors analyzed data on 156,013 hospitalized HF patients from 319 U.S. hospitals participating in Get With The Guidelines-HF between 2005 and 2013. Characteristics, treatments, and in-hospital outcomes were assessed by HF etiology...
November 2015: JACC. Heart Failure
Abhishek Bhaskaran, Monique Bartlett, Pramesh Kovoor, Lloyd M Davis
BACKGROUND: Wearable Cardioverter Defibrillators (WCD) have been effectively used for more than a decade in North America and Europe for prevention of sudden cardiac death (SCD) due to ventricular arrhythmias. This device has only recently been available in Australia. METHOD: At Westmead hospital, WCD has been used since 2013 as a bridging therapy to an implantable cardioverter defibrillator (ICD) for those at high risk, but are temporarily not suitable for an implantable device...
February 2016: Heart, Lung & Circulation
Dennis M McNamara, Uri Elkayam, Rami Alharethi, Julie Damp, Eileen Hsich, Gregory Ewald, Kalgi Modi, Jeffrey D Alexis, Gautam V Ramani, Marc J Semigran, Jennifer Haythe, David W Markham, Josef Marek, John Gorcsan, Wen-Chi Wu, Yan Lin, Indrani Halder, Jessica Pisarcik, Leslie T Cooper, James D Fett
BACKGROUND: Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. OBJECTIVES: This study sought to prospectively evaluate recovery of the left ventricular ejection fraction (LVEF) and clinical outcomes in the multicenter IPAC (Investigations of Pregnancy Associated Cardiomyopathy) study. METHODS: We enrolled and followed 100 women with PPCM through 1 year post-partum. The LVEF was assessed by echocardiography at baseline and at 2, 6, and 12 months post-partum...
August 25, 2015: Journal of the American College of Cardiology
T Haddad, D Hakem, A Berrah
INTRODUCTION: The pregnancies in systemic erythematous lupus (SLE) disease is a situation of high risk and involve both the mother and the fetus. The prematurity and the miscarriage are there more frequent, with increase risks of eclampsia, acute hypertension, HELP syndrome and of worsening renal disease. So the morbimortality is multiplied particularly when a anti-phospholipid syndrome 'APLS' is associated. The pregnancy remains however authorized when the SLE is in remission for more than 6 months with a validated treatment and successful means of monitoring...
July 2012: Pregnancy Hypertension
Joan Robinson, Lisa Hartling, Ben Vandermeer, Terry P Klassen
BACKGROUND: This is an update of a previous review. Case reports and case series have described dramatic responses to intravenous immunoglobulin (IVIG) in people with presumed viral myocarditis, and its administration has become commonplace. OBJECTIVES: The primary objective of this review was to compare transplant-free survival of adults and children with presumed viral myocarditis treated with IVIG versus those who did not receive IVIG. A secondary objective was to determine if a group of patients with presumed viral myocarditis could be identified (on the basis of age, duration of symptoms, acuity of onset of symptoms, cardiac function at presentation, virological results or the presence or absence of histological evidence of acute myocarditis on cardiac biopsy in patients in whom a biopsy was performed) who would be the most likely to benefit from IVIG...
2015: Cochrane Database of Systematic Reviews
Akanksha Dutt, Akshi Agarwal, Rama Chatterji, Farid Ahmed
Peripartum cardiomyopathy (PPCM) is a disease of unknown etiology which affects pregnant females during late pregnancy or during the first 5 months post-partum. The clinical presentation of these patients is similar to that of patients with dilated cardiomyopathy. Anesthetic management of such cases poses a challenge; due to the increased risk of various perioperative complications. We report the successful anesthetic management of lower segment caesarean section in a patient with PPCM.
May 2013: Anesthesia, Essays and Researches
Tasneem Z Naqvi
Research in pregnancy is challenging as it involves a special 'vulnerable' group due to the involvement of the mother and the fetus. These challenges, which are inherent in studying pregnancy in physiologic and pathologic states, have contributed to the scant research in pregnancy. Until recently, most studies in pregnancy were nonrandomized and retrospective in nature, representing prevailing clinical standards of practice and clinicians' biases. Prospective studies were generally limited to single centers, comprising of small sample sizes and were observational in nature, rather than randomized studies involving therapy...
November 2014: Future Cardiology
Rajiv Bharat Kharwar, Sharad Chandra, Sudhanshu Kumar Dwivedi, Ram Kirti Saran
Peripartum cardiomyopathy is a cardiac condition characterized by development of heart failure during the last month of pregnancy or during the first five months of post partum period without any other identifiable cause of heart failure. The hypercoagulable state in the pregnancy along with left ventricular (LV) systolic dysfunction predisposes the patient to thromboembolic complications like intraventricular thrombi. We report a case of a 30-year-old female with peripartum cardiomyopathy along with a highly mobile mass in the LV cavity on two dimensional echocardiography...
September 2014: Journal of Cardiovascular Ultrasound
J Miessau, Q Yang, S Unai, J W C Entwistle, N C Cavarocchi, H Hirose
We report a unique utilization of a double-lumen, bi-caval Avalon cannula for veno-venous (VV) extracorporeal membrane oxygenation (ECMO) during placement of a total artificial heart (TAH, SynCardia, Tucson, AZ). A 22-year-old female with post-partum cardiomyopathy was rescued on veno-arterial (VA) ECMO because of cardiogenic shock. The inability to wean ECMO necessitated implantation of the TAH as a bridge to transplant. In addition, the patient continued to have respiratory failure and concomitant VV ECMO was planned with the implant...
July 2015: Perfusion
Zoltan P Arany, Christopher M Walker, Lin Wang
Presentation of Case. Dr. Daniel S. Ong (Cardiology): A 40-year-old woman was admitted to this hospital 10 days post partum, because of dyspnea and hypoxemia. Ten days before admission, the patient went into labor at 39 weeks of gestation. A low transverse cesarean section and tubal ligation were..
July 17, 2014: New England Journal of Medicine
Miki Minatoguchi, Atsuo Itakura, Eiji Takagi, Manabu Nishibayashi, Mariko Kikuchi, Osamu Ishihara
Takotsubo cardiomyopathy (TCM) primarily affects postmenopausal women and is an important differential diagnosis of acute coronary syndrome. We describe a rare case of post-partum TCM, and present a published work review of the cases of pregnancy-associated TCM. A 24-year-old Japanese woman pregnant with twins suffered from premature membrane rupture at 31 gestational weeks. Following emergency cesarean delivery, she complained of sudden dyspnea. Transthoracic echocardiography revealed an inverted Takotsubo pattern (ejection fraction, 46%)...
June 2014: Journal of Obstetrics and Gynaecology Research
Ronny Cohen, Thierry Mallet, Brooks Mirrer, Pablo Loarte, Michael Gale, Paul Kastell
Peripartum cardiomyopathy is a life-threatening cardiac condition affecting pregnant women either late in pregnancy or early in the post-partum period. The latest studies show a dramatic improvement in the mortality rates of women affected with this disorder, which has been correlated with advances in medical therapy for heart failure. However, patients continue to die of this condition. The following case report describes a typical patient with peripartum cardiomyopathy diagnosed on clinical grounds, along with echocardiogram findings of severe systolic dysfunction and global hypokinesis consistent with dilated cardiomyopathy...
June 2014: Acute Cardiac Care
A K M Monwarul Islam, Mohammad A Hasnat, Fatema Doza, Humayra Jesmin
Sheehan's syndrome is a rare condition characterized by post-partal panhypopituitarism due to necrosis of adenohypophysis resulting from severe post-partum hemorrhage. Lethargy, amenorrhea and failure of lactation are the usual presenting features. Cardiac involvement in Sheehan's syndrome is rare. The case presented here describes dilated cardiomyopathy in a 36-year-old lady who failed to respond adequately to the standard anti-failure treatment. Further investigation revealed the diagnosis of Sheehan's syndrome...
April 2014: Journal of the Saudi Heart Association
Stéphane Boulé, Lionel Ovart, Christelle Marquié, Edward Botcherby, Didier Klug, Claude Kouakam, François Brigadeau, Laurence Guédon-Moreau, Ludivine Wissocque, Jonathan Meurice, Dominique Lacroix, Salem Kacet
AIMS: To describe obstetric/neonatal and cardiac outcomes for a cohort of women carrying implantable cardioverter-defibrillators (ICDs) during pregnancy. METHODS AND RESULTS: All women in routine follow-up at our institution for ICD implantation who became pregnant between 2006 and 2013 were included in this study. All ICDs were pre-pectoral devices with bipolar endocardial leads. Obstetric/neonatal and cardiac outcomes were assessed during pregnancy and post-partum...
November 2014: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Karen Sliwa, Michael Böhm
Worldwide, the numbers of women who have a pre-existing cardiovascular disease or develop cardiac problems during pregnancy are increasing and, due to the lack of evidenced-based data, this provides challenges for the treating physician. Cardiovascular disease in pregnancy is a complex topic as women can present either pre- or post-partum, due to a pre-existing heart disease such as operated on or unoperated on congenital heart disease, valvular heart disease, chronic hypertension, or familial dilated cardiomyopathy...
March 15, 2014: Cardiovascular Research
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