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https://www.readbyqxmd.com/read/29667690/metal-organic-frameworks-as-affinity-agents-to-enhance-the-microdialysis-sampling-efficiency-of-fatty-acids
#1
Hui Yang, Tuo Li, Lu Liu, Na Li, Ming Guan, Yangyang Zhang, Zhenpeng Wang, Zhenwen Zhao
Microdialysis (MD) has been extensively used for in vivo sampling of hydrophilic analytes such as neurotransmitters and drug metabolites. In contrast, there have been few reports on sampling of lipophilic analytes by MD. Lipophilic analytes are easily adsorbed on the surfaces of the dialysis membrane and the inner wall of tubing, which leads to a very low relative recovery (RR). In this work, a strategy to develop an enhanced MD sampling of fatty acids (FAs) by using metal-organic frameworks (MOFs) as affinity agents in the perfusion fluid was investigated...
April 18, 2018: Analyst
https://www.readbyqxmd.com/read/29667222/exploring-concussion-awareness-in-hockey-with-a-first-nations-community-in-canada
#2
Cindy Hunt, Alicja Michalak, Chrissy Lefkimmiatis, Elaine Johnston, Leila Macumber, Tony Jocko, Donna Ouchterlony
OBJECTIVE: The purpose of this pilot study was twofold: (1) to begin to understand concussion in youth hockey in a First Nations community in Canada and (2) to determine the impact of a novel concussion education workshop. DESIGN: A one-group quasiexperimental time series study was undertaken. SAMPLE: A total of 41 participants consented, with 71% (n = 29) completing data collection at all three study time points. MEASUREMENT AND INTERVENTIONS: Two nurses one from the First Nations community and one from the tertiary care center collaborated to develop and deliver the intervention on concussion specifically general, hockey and symptom knowledge...
April 17, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29665819/examination-of-the-roles-and-capacities-of-duty-bearers-responsible-for-protecting-the-human-rights-to-adequate-food-nutritional-health-and-wellbeing-in-ugandan-children-s-homes
#3
Monica Olafsen, Archangel Byaruhanga Rukooko, Per Ole Iversen, Bård A Andreassen
BACKGROUND: The majority of Ugandan children face vulnerability and malnutrition. As a State Party to international human rights treaties, Uganda has legal obligations of guaranteeing the fundamental rights and the best interest of the nation's children. Despite being protected under international and national law, Uganda is not providing adequate child protection, including safeguarding children's food security. Numerous privately owned and unregulated children's homes face this problem...
April 17, 2018: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/29665528/optimizing-photon-dose-and-frequency-to-enhance-lipid-productivity-of-thermophilic-algae-for-biofuel-production
#4
Said Abu-Ghosh, Zvy Dubinsky, Gabi Banet, David Iluz
The aim of this work was to examine the potential of the thermophilic green microalga Micractinium sp. to accumulate triacylglycerols (TAGs) and to develop a light strategy to increase TAG productivity in this alga. To this end, dense cultures of Micractinium sp. were grown at 37 °C under nitrogen (N) starvation and exposed to a light intensity of 1000 µmol photons m-2  s-1 of different light regimes. The highest per-biomass TAG-content and maximal volumetric productivities of TAG were displayed by the cultures grown under flashing light of 5 Hz with 50% duty cycle...
March 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29665277/the-expression-of-endogenous-voltage-gated-potassium-channels-in-hek293-cells-is-affected-by-culture-conditions
#5
Arturo Ponce, Aida Castillo, Lorena Hinojosa, Jacqueline Martinez-Rendon, Marcelino Cereijido
HEK293 cells are widely used as a host for expression of heterologous proteins; yet, little care has been taken to characterize their endogenous membrane components, including ion channels. In this work, we aimed to describe the biophysical and pharmacological properties of endogenous, voltage-dependent potassium currents (IKv). We also examined how its expression depends on culture conditions. We used the electrophysiological technique of whole-cell patch clamp to record ion currents from HEK293 cells. We found that HEK cells express endogenous, voltage-dependent potassium currents...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29664347/which-melodic-universals-emerge-from-repeated-signaling-games-a-note-on-lumaca-and-baggio-2017-%C3%A2
#6
Andrea Ravignani, Tessa Verhoef
Music is a peculiar human behavior. While very common in our species, we still know very little as to why and how music emerged. For centuries, the study of music has been the sole prerogative of the humanities. Lately, however, music is being increasingly investigated by psychologists, neuroscientists, biologists, and computer scientists. One possible approach to study the origins of music is to hypothesize and empirically test the mechanisms behind this structured behavior. Recent experiments in the lab have shown how musical rhythm and melody can emerge via the process of cultural transmission...
April 17, 2018: Artificial Life
https://www.readbyqxmd.com/read/29663865/proactive-prevention-in-occupational-safety-and-health-how-to-identify-tomorrow-s-prevention-priorities-and-preventive-measures
#7
Angelika Hauke, Eva Flaspöler, Dietmar Reinert
INTRODUCTION: Global trends such as digitalisation, globalisation and demographic change are changing workplaces, and accordingly occupational safety and health (OSH) needs. To better prepare for the future and to foster proactive prevention, the German Social Accident Insurance (DGUV) established an OSH risk observatory (RO OSH). METHODS: The RO OSH relies on an online survey and calls upon the expertise of labour inspectors. 398 labour inspectors participated in the first RO OSH enquiry...
April 17, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29662475/the-luxr-regulators-pcor-and-rfia-co-regulate-antimicrobial-peptide-and-alginate-production-in-pseudomonas-corrugata
#8
Grazia Licciardello, Andrea Caruso, Patrizia Bella, Rodolpho Gheleri, Cinzia P Strano, Alice Anzalone, Emmanouil A Trantas, Panagiotis F Sarris, Nalvo F Almeida, Vittoria Catara
Cyclic lipopeptides (CLPs) are considered as some of the most important secondary metabolites in different plant-associated bacteria, thanks to their antimicrobial, cytotoxic, and surfactant properties. In this study, our aim was to investigate the role of the Quorum Sensing (QS) system, PcoI/PcoR, and the LuxR-type transcriptional regulator RfiA in CLP production in the phytopatogenic bacterium, Pseudomonas corrugata based on our previous work where we reported that the pcoR and rfiA mutants were devoid of the CLPs cormycin and corpeptin production...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29662472/direct-growth-of-bacteria-in-headspace-vials-allows-for-screening-of-volatiles-by-gas-chromatography-mass-spectrometry
#9
Collin M Timm, Evan P Lloyd, Amanda Egan, Ray Mariner, David Karig
Bacterially produced volatile organic compounds (VOCs) can modify growth patterns of eukaryotic hosts and competing/cohabiting microbes. These compounds have been implicated in skin disorders and attraction of biting pests. Current methods to detect and characterize VOCs from microbial cultures can be laborious and low-throughput, making it difficult to understand the behavior of microbial populations. In this work we present an efficient method employing gas chromatography/mass spectrometry with autosampling to characterize VOC profiles from solid-phase bacterial cultures...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29662124/stag2-deficiency-induces-interferon-responses-via-cgas-sting-pathway-and-restricts-virus-infection
#10
Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F Brulois, Linda L Yasukawa, Xingnan Li, Calvin J Kuo, David A Solomon, Jan E Carette, Harry B Greenberg
Cohesin is a multi-subunit nuclear protein complex that coordinates sister chromatid separation during cell division. Highly frequent somatic mutations in genes encoding core cohesin subunits have been reported in multiple cancer types. Here, using a genome-wide CRISPR-Cas9 screening approach to identify host dependency factors and novel innate immune regulators of rotavirus (RV) infection, we demonstrate that the loss of STAG2, an important component of the cohesin complex, confers resistance to RV replication in cell culture and human intestinal enteroids...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29661510/cftr-rescue-with-vx-809-and-vx-770-favors-the-repair-of-primary-airway-epithelial-cell-cultures-from-patients-with-class-ii-mutations-in-the-presence-of-pseudomonas-aeruginosa-exoproducts
#11
Damien Adam, Claudia Bilodeau, Laura Sognigbé, Émilie Maillé, Manon Ruffin, Emmanuelle Brochiero
BACKGROUND: Progressive airway damage due to bacterial infections, especially with Pseudomonas aeruginosa remains the first cause of morbidity and mortality in CF patients. Our previous work revealed a repair delay in CF airway epithelia compared to non-CF. This delay was partially prevented after CFTR correction (with VRT-325) in the absence of infection. Our goals were now to evaluate the effect of the Orkambi combination (CFTR VX-809 corrector + VX-770 potentiator) on the repair of CF primary airway epithelia, in infectious conditions...
April 13, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29661005/ethopathology-and-civilization-diseases-niko-and-elisabeth-tinbergen-on-autism
#12
Marga Vicedo
The idea that some diseases result from a poor fit between modern life and our biological make-up is part of the long history of what historian of medicine Charles Rosenberg has called the "progress-and-pathology narrative." This article examines a key episode in that history: 1973 Nobel laureate Niko Tinbergen's use of an evolutionary framework to identify autism as a pathogenic effect of progress. Influenced by British psychiatrist John Bowlby's work, Tinbergen and his wife Elisabeth saw autistic children as victims of environmental stress caused mainly by mothers' failure to bond with their children and to protect them from conflicting situations...
April 16, 2018: Canadian Bulletin of Medical History, Bulletin Canadien D'histoire de la Médecine
https://www.readbyqxmd.com/read/29660564/closing-the-gap-a-whole-of-school-approach-to-aboriginal-and-torres-strait-islander-inclusivity-in-higher-education
#13
Amanda C Fowler, Beverley Ewens, Caroline Vafeas, Leitha Delves, Colleen Hayward, Noel Nannup, Gwen Baum
The recruitment and retention of Aboriginal and Torres Strait Islander nurses and midwives is key to the delivery of culturally appropriate health care and improving the health outcomes of Aboriginal and Torres Strait Islander people. A working group to address inclusion and engagement of Aboriginal and Torres Strait Islander students at a West Australian University has impacted on the curricula, faculty staff and Aboriginal and Torres Strait Islander students within the School of Nursing and Midwifery. The University's Reconciliation Action Plan was the foundation and catalysed the group to promote cultural safety education for staff and provide inclusive activities for Aboriginal and Torres Strait Islander students...
April 9, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29660445/development-of-a-new-tool-for-the-long-term-in-vitro-ecotoxicity-testing-of-nanomaterials-using-a-rainbow-trout-cell-line-rtl-w1
#14
L Galbis-Martínez, M L Fernández-Cruz, L Alte, A Valdehita, I Rucandio, J M Navas
The current wide use of manufactured nanomaterials (MNs) is leading to the release of nanoparticles (NPs) to water bodies. Aquatic organisms, including fish, are exposed to low concentrations of NPs for long periods of time being necessary to develop laboratory toxicity tests reflecting realistic conditions. Additionally, today there is a demand of in vitro assays respecting the 3Rs principle. Thus, the main aim of this work was to stablish an in vitro tool for the assessment of long-term NPs ecotoxicity. Considering the key role of liver in detoxification, a rainbow trout liver cell line, RTL-W1, was used...
April 13, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29660312/the-egf-ras-pathway-controls-growth-in-drosophila-via-ribosomal-rna-synthesis
#15
Shrivani Sriskanthadevan-Pirahas, Joshua Lee, Savraj S Grewal
The Ras small G-protein is a conserved regulator of cell and tissue growth during animal development. Studies in Drosophila have shown how Ras can stimulate a Raf-MEK-ERK signaling pathway to control cell growth and proliferation in response to epidermal growth factor (EGF) stimulation. This work has also defined several transcription factors that can function as downstream growth effectors of EGF/Ras/ERK pathway by stimulating mRNA transcription. Here we report on stimulation of RNA polymerase I (Pol I)-mediated ribosomal RNA (rRNA) synthesis as a growth effector of Ras/ERK signalling in Drosophila...
April 13, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29660008/exosomal-mir-214-from-endometrial-stromal-cells-inhibits-endometriosis-fibrosis
#16
Di Wu, Pan Lu, Xue Mi, Jinwei Miao
STUDY QUESTION: Is it possible to improve fibrosis in endometriosis by microRNA-214 delivery in exosomes? SUMMARY ANSWER: Upregulation of miR-214 may inhibit fibrogenesis and its delivery by exosomes derived from ectopic endometrial stromal cells, offers an alternative therapeutic approach for endometriosis fibrosis. WHAT IS KNOWN ALREADY: Fibrosis is the primary pathological feature of endometriosis. MiR-214 plays an important role in fibrotic disease...
April 11, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29659418/enhancing-lesbian-gay-bisexual-and-transgender-cultural-competence-in-a-midwestern-primary-care-clinic-setting
#17
Denise R Felsenstein
The process of initiating lesbian, gay, bisexual, and transgender (LGBT) cultural competencies and educational interventions developed to increase staff knowledge on LGBT culture and health issues is discussed, including a computer-based module and panel discussion. The module intervention showed a statistically significant increase (p = .033) of staff LGBT knowledge from pretest to posttest scores. An evaluation after the panel discussion showed that 72% of staff indicated they were more prepared for LGBT patient care...
April 13, 2018: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/29658991/novel-de-novo-synthesized-phosphate-carrier-compound-aba-peg20k-pi20-suppresses-collagenase-production-in-enterococcus-faecalis-and-prevents-colonic-anastomotic-leak-in-an-experimental-model
#18
M Wiegerinck, S K Hyoju, J Mao, A Zaborin, C Adriaansens, E Salzman, N H Hyman, O Zaborina, H van Goor, J C Alverdy
BACKGROUND: Previous work has demonstrated that anastomotic leak can be caused by collagenolytic bacteria such as Enterococcus faecalis via an effect on wound collagen. In humans, E. faecalis is the organism cultured most commonly from a leaking anastomosis, and is not routinely eliminated by standard oral or intravenous antibiotics. Novel strategies are needed to contain the virulence of this pathogen when present on anastomotic tissues. METHODS: Polyphosphorylated polymer ABA-PEG20k-Pi20 was tested in mice for its ability to prevent anastomotic leak caused by collagenolytic E...
April 16, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29658739/child-inhibitory-control-and-maternal-acculturation-moderate-effects-of-maternal-parenting-on-chinese-american-children-s-adjustment
#19
Jing Yu, Charissa S L Cheah, Craig H Hart, Chongming Yang
The goals of this study were to examine: (a) bidirectional associations between maternal parenting (physical punishment and guilt induction) and Chinese American preschool children's psychosocial adjustment and (b) the role of maternal cultural orientation and child temperament in moderating parenting effects. Participants were Chinese American mothers and children (N = 163, Mage = 4.56, 53% boys). Mothers reported on their parenting practices at both Wave 1 (W1) and Wave 2 (W2) and their cultural orientations and children's inhibitory control at W1...
April 16, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29657874/the-reliability-and-validity-of-the-turkish-version-of-the-fibromyalgia-participation-questionnaire
#20
Lale Altan, Reyhan Çeliker, İlker Ercan, Murat Birtane, Kenan Akgün, Coşkun Zateri, Nurettin Taştekin, Aylin Rezvani, İlknur Aktaş, Şenay Özdolap, Erbil Dursun, Nigar Dursun, Selda Sarıkaya
Objective: The objective of this study was to test the reliability and validity of the Turkish version of the Fibromyalgia Participation Questionnaire (FPQ). Methods: One hundred and eighty-four female patients with fibromyalgia syndrome were included in the study. All patients filled out the Turkish FPQ (FPQ-T) questionnaire, which was obtained by translation from German according to the guideline for the process of cross-cultural adaptation The patients filled out the revised Fibromyalgia Impact Questionnaire (FIQ) and reevaluated the FPQ-T two hours later...
March 2018: European Journal of Rheumatology
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