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https://www.readbyqxmd.com/read/29236232/%C3%AE-1%C3%A2-6-d-glucan-secreted-during-the-optimised-production-of-exopolysaccharides-by-paecilomyces-variotii-has-immunostimulatory-activity
#1
Erica F Osaku, Rafael A Menolli, Claudia R L de M Costa, Fernando Henrique G Tessaro, Renan H de Melo, Alex E do Amaral, Péricles A D Duarte, Arquimedes Paixão de Santana Filho, Andrea Caroline Ruthes, José Luis da C Silva, Rosiane G Mello
Paecilomyces variotii is a filamentous fungus that occurs worldwide in soil and decaying vegetation. Optimization of the fermentation process for exopolysaccharide (EPS) production from the fungus P. variotii, structure determination and immuno-stimulating activity of EPS were performed. Response surface methodology (RSM) coupled with central composite design (CCD) was used to optimize the physical and chemical factors required to produce EPS in submerged fermentation. Preliminary investigations to choose the three factors for the present work were made using a factorial experimental design...
December 13, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29236192/inhibitory-effect-of-streptococci-on-the-growth-of-m-catarrhalis-strains-and-the-diversity-of-putative-bacteriocin-like-gene-loci-in-the-genomes-of-s-pneumoniae-and-its-relatives
#2
L N Ikryannikova, M V Malakhova, G G Lominadze, I Yu Karpova, E S Kostryukova, N A Mayansky, A N Kruglov, E A Klimova, E S Lisitsina, E N Ilina, V M Govorun
S. pneumoniae is a facultative human pathogen causing a wide range of infections including the life-threatening pneumoniae or meningitis. It colonizes nasopharynx as well as its closest phylogenetic relatives S. pseudopneumoniae and S. mitis. Both the latter, despite the considerable morphological and phenotypic similarity with the pneumococcus, are considerably less pathogenic for humans and cause infections mainly in the immunocompromized hosts. In this work, we compared the inhibitory effect of S. pneumoniae and its relatives on the growth of Moraxella catarrhalis strains using the culture-based antagonistic test...
December 13, 2017: AMB Express
https://www.readbyqxmd.com/read/29235677/michel-de-m-uzan-and-origins-of-identity
#3
Richard B Simpson
Michel de M'Uzan describes a way to think about identity in which two distinct sources of our sense of identity must be considered. His innovation is the concept of the vital-identital, which he suggests is equally foundational with the sense of identity derived from the early human environment. The term endogenous identity is used to unify under one heading the ideas that de M'Uzan employs to build his concept of vital-identital. The author summarizes de M'Uzan's earlier work, elaborates on his more recent ideas, and illustrates the use of de M'Uzan's ideas with a cultural and a clinical example...
October 2017: Psychoanalytic Quarterly
https://www.readbyqxmd.com/read/29235409/engaging-indigenous-maori-and-inward-migrating-asian-professionals-into-a-pakeha-white-european-dominated-balint-community-in-new-zealand
#4
Timothy McMichael
This inquiry began with two questions: How can the established predominately Pakeha/Caucasian (White European) Balint community in New Zealand more successfully engage both indigenous populations of both Maori and Pacifica origin into Balint work? And what is the existing Balint community doing to address the lack of Asian members of the Balint community in New Zealand, at a time when Asian health professionals are being recruited into the health sector at an increasingly high rate in comparison to White European entrants to the profession? These questions, and their preliminary answers presented here, invite the reader to reflect on both the challenges and opportunities in reaching out to groups different from our own...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29234982/a-multicellular-model-of-intestinal-crypt-buckling-and-fission
#5
Axel A Almet, Barry D Hughes, Kerry A Landman, Inke S Näthke, James M Osborne
Crypt fission is an in vivo tissue deformation process that is involved in both intestinal homeostasis and colorectal tumourigenesis. Despite its importance, the mechanics underlying crypt fission are currently poorly understood. Recent experimental development of organoids, organ-like buds cultured from crypt stem cells in vitro, has shown promise in shedding light on crypt fission. Drawing inspiration from observations of organoid growth and fission in vivo, we develop a computational model of a deformable epithelial tissue layer...
December 12, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29234062/development-of-erasin-a-chromone-based-stat3-inhibitor-which-induces-apoptosis-in-erlotinib-resistant-lung-cancer-cells
#6
Christian Lis, Stefan Rubner, Martin Roatsch, Angela Berg, Tyler Gilcrest, Darwin Fu, Elizabeth Nguyen, Anne-Marie Schmidt, Harald Krautscheid, Jens Meiler, Thorsten Berg
Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug development. One of the fundamental challenges of this research field is the broad lack of available lead structures from nature. Here, we demonstrate that modifications of a chromone-based inhibitor of the Src homology 2 (SH2) domain of the transcription factor STAT5 confer inhibitory activity against STAT3. The binding mode of the most potent STAT3 inhibitor Erasin was analyzed by the investigation of structure-activity relationships, which was facilitated by chemical synthesis and biochemical activity analysis, in combination with molecular docking studies...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233898/prophages-and-growth-dynamics-confound-experimental-results-with-antibiotic-tolerant-persister-cells
#7
Alexander Harms, Cinzia Fino, Michael A Sørensen, Szabolcs Semsey, Kenn Gerdes
Bacterial persisters are phenotypic variants that survive antibiotic treatment in a dormant state and can be formed by multiple pathways. We recently proposed that the second messenger (p)ppGpp drives Escherichia coli persister formation through protease Lon and activation of toxin-antitoxin (TA) modules. This model found considerable support among researchers studying persisters but also generated controversy as part of recent debates in the field. In this study, we therefore used our previous work as a model to critically examine common experimental procedures to understand and overcome the inconsistencies often observed between results of different laboratories...
December 12, 2017: MBio
https://www.readbyqxmd.com/read/29233448/introducing-problem-based-learning-into-a-canadian-accredited-middle-eastern-educational-setting
#8
Ziad G Nasr, Kyle John Wilby
BACKGROUND AND PURPOSE: Adaption of active learning strategies into new cultures and contexts requires careful consideration to maximize effectiveness and meet intended objectives. The aim of this paper was to describe the adaption and implementation of problem-based learning (PBL) within a pharmacy curriculum in a Middle Eastern context. EDUCATIONAL ACTIVITY AND SETTING: PBL was implemented into the curriculum at Qatar University in 2014 and expanded in subsequent years to include differing courses and contexts...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233370/female-pharmacists-career-perceptions-in-saudi-arabia-a-survey-at-an-academic-center-in-jeddah
#9
Waleed F Al Ghazzawi, Alaa Abuzaid, Ohood A Al-Shareef, Sama M Al-Sayagh
OBJECTIVES: This study aimed to describe existing patterns of female pharmacy students' perceptions and their expectations regarding employment, job sectors, salaries, difficulties, and burdens, and to understand students' long-term prospects for employment in the pharmaceutical sector. The second objective was to assess students' perceptions of their careers in the short- and long-term. METHODS: This prospective survey was conducted on female pharmacy students at King Abdulaziz University, Jeddah from January 12, 2013 through January 21, 2013...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233299/how-a-more-detailed-understanding-of-culture-is-needed-before-successful-educational-change-can-be-made
#10
Meagen Rosenthal, Shane Desselle, Erin Holmes
INTRODUCTION: The profession of pharmacy is being afforded many important opportunities, and continues to face many challenges. To successfully address these issues schools and colleges of pharmacy must have a complete understanding of their current context, which includes culture. However, little of the work on culture in pharmacy education specifically defines what these cultures are, and equally importantly how this understanding of culture can be used to make changes, improve student learning, and ultimately develop pharmacists better prepared to improve patient outcomes...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233263/discovery-of-pet-radiopharmaceuticals-at-the-academia-industry-interface
#11
REVIEW
Vadim Bernard-Gauthier, Thomas L Collier, Steven H Liang, Neil Vasdev
Project-specific collaborations between academia and pharmaceutical partners are a growing phenomenon within molecular imaging and in particular in the positron emission tomography (PET) radiopharmaceutical community. This cultural shift can be attributed in part to decreased public funding in academia in conjunction with the increased reliance on outsourcing of chemistry, radiochemistry, pharmacology and molecular imaging studies by the pharmaceutical industry. This account highlights some of our personal experiences working with industrial partners to develop new PET radiochemistry methodologies for drug discovery and neuro-PET research studies...
November 2017: Drug Discovery Today. Technologies
https://www.readbyqxmd.com/read/29233009/microbial-consortia-a-critical-look-at-microalgae-co-cultures-for-enhanced-biomanufacturing
#12
Gloria Padmaperuma, Rahul Vijay Kapoore, Daniel James Gilmour, Seetharaman Vaidyanathan
Monocultures have been the preferred production route in the bio-industry, where contamination has been a major bottleneck. In nature, microorganisms usually exist as part of organized communities and consortia, gaining benefits from co-habitation, keeping invaders at bay. There is increasing interest in the use of co-cultures to tackle contamination issues, and simultaneously increase productivity and product diversity. The feasibility of extending the natural phenomenon of co-habitation to the biomanufacturing industry in the form of co-cultures requires careful and systematic consideration of several aspects...
December 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29232917/lactobacillus-plantarum-with-broad-antifungal-activity-as-a-protective-starter-culture-for-bread-production
#13
Pasquale Russo, Clara Fares, Angela Longo, Giuseppe Spano, Vittorio Capozzi
Bread is a staple food consumed worldwide on a daily basis. Fungal contamination of bread is a critical concern for producers since it is related to important economic losses and safety hazards due to the negative impact of sensorial quality and to the potential occurrence of mycotoxins. In this work, Lactobacillus plantarum UFG 121, a strain with characterized broad antifungal activity, was analyzed as a potential protective culture for bread production. Six different molds belonging to Aspergillus spp., Penicillium spp...
December 11, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29232694/hyperbranched-poly-%C3%AF%C2%B5-lysine-substrate-presenting-the-laminin-sequence-yigsr-induces-the-formation-of-spheroids-in-adult-bone-marrow-stem-cells
#14
Valeria Perugini, Steve T Meikle, Anna L Guildford, Matteo Santin
Unlike the fibroblast-like cells formed upon monolayer culture of human mesenchymal stem cells, the natural stem cell niche of the bone marrow and other types of tissues favours the formation of 3-dimensional (3D) cell clusters. The structuring and biological activity of these clusters are regulated by the contacts established by cells with both the basement membrane and neighbour cells and results in their asymmetric division and the consequent maintenance of both a stem population and a committed progeny...
2017: PloS One
https://www.readbyqxmd.com/read/29232387/improved-sample-treatment-protocol-for-accurate-detection-of-live-salmonella-spp-in-food-samples-by-viability-pcr
#15
Mai Dinh Thanh, Gemma Agustí, Anneluise Mader, Bernd Appel, Francesc Codony
Culture-based detection is still considered as the standard way for detection of Salmonella in foods, although molecular methods, such as viability PCR (vPCR), have been introduced to overcome some disadvantages of traditional culture methods. Despite the success of the vPCR methodology, the problem of false-positive results is a major drawback, especially when applied to environmental samples, hindering the interpretation of the results. To improve the efficiency of vPCR, many approaches have been introduced by several authors during the last years...
2017: PloS One
https://www.readbyqxmd.com/read/29231719/clay-catalyzed-disruption-of-quorum-sensing-in-vibrio-harveyi-bacteria
#16
Sajo Naik, Jonathon Scholin, San Ching, Fang Chi, Marc Herpfer
This work describes clay catalyzed degradation of N- (3-Oxooctanoyl)-DL-homoserine lactone, a quorum sensing (QS) molecule that Gram negative bacteria employ during the QS process. The disruption of QS by clay in Gram-negative Vibrio harveyi bacterium culture was also studied by monitoring luminescence and population density of the bacteria.
December 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29230816/how-grinding-levels-and-brewing-methods-espresso-american-turkish-could-affect-the-antioxidant-activity-and-bioactive-compounds-in-a-coffee-cup
#17
Antonio Derossi, Ilde Ricci, Rossella Caporizzi, Anna Fiore, Carla Severini
BACKGROUND: Depending on geographical origins and cultural traditions, different brewing procedures are used all over the world to prepare a coffee cup. In this work, we explored as three grinding levels of coffee powder and three coffee preparation methods such as by filtration (American), by boiling (Turkish) and by extraction under pressure (Espresso) affect healthy compounds and physicochemical attributes in coffee cup served to consumers. RESULTS: the grinding level slightly affects the quality of coffees, while the preparation methods significantly influenced all in-cup attributes...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29230711/hospital-wide-education-committees-and-high-quality-residency-training-a%C3%A2-qualitative-study
#18
Milou E W M Silkens, Irene A Slootweg, Albert J J A Scherpbier, Maas Jan Heineman, Kiki M J M H Lombarts
INTRODUCTION: High-quality residency training is of utmost importance for residents to become competent medical specialists. Hospital-wide education committees have been adopted by several healthcare systems to govern postgraduate medical education and to support continuous quality improvement of residency training. To understand the functioning and potential of such committees, this study examined the mechanisms through which hospital-wide education committees strive to enable continuous quality improvement in residency training...
December 11, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29230410/sera-from-visceral-leishmaniasis-patients-display-oxidative-activity-and-affect-the-tnf-%C3%AE-production-by-macrophages-in-vitro
#19
Neci M Soares, Joelma N de Souza, Tatiana F Leal, Eliana A G Reis, Maria S Miranda, Washington L C Dos Santos, Márcia C A Teixeira
Mammalian protection against leishmanial infection depends on the development of an effective immune response. Zoonotic visceral leishmaniasis (ZVL) patients are usually unable to mount an effective immune response against the parasite and indeed appear to be severely immunosuppressed. This suppression has strong nonspecific and specific components mediated by serum factors and leishmanicidal activity of infected macrophages, respectively. The lipid profile has been shown to be altered in ZVL patients' sera...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29230379/cross-cultural-and-hemispheric-laterality-effects-on-the-ensemble-coding-of-emotion-in-facial-crowds
#20
Hee Yeon Im, Sang Chul Chong, Jisoo Sun, Troy G Steiner, Daniel N Albohn, Reginald B Adams, Kestutis Kveraga
In many social situations, we make a snap judgment about crowds of people relying on their overall mood (termed "crowd emotion"). Although reading crowd emotion is critical for interpersonal dynamics, the sociocultural aspects of this process have not been explored. The current study examined how culture modulates the processing of crowd emotion in Korean and American observers. Korean and American (non-East Asian) participants were briefly presented with two groups of faces that were individually varying in emotional expressions and asked to choose which group between the two they would rather avoid...
October 2017: Culture and Brain
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