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https://www.readbyqxmd.com/read/28636246/stretchable-electrochemical-sensor-for-inducing-and-monitoring-cell-mechanotransduction-in-real-time
#1
Yan-Ling Liu, Yu Qin, Zi-He Jin, Xue-Bo Hu, Miao-Miao Chen, Rong Liu, Christian Amatore, Wei-Hua Huang
Existing methods offer little direct and real-time information about stretch-triggered biochemical responses during cell mechanotransduction. Herein, we report a novel stretchable electrochemical sensor that takes advantage of a hierarchical percolation network of carbon nanotubes and gold nanotubes (CNTs- Au NTs). This hybrid nano-structure provides the sensor with excellent time-reproducible mechanical and electrochemical performances while granting very good cellular compatibility, making it perfectly apt to induce and monitor simultaneously transient biochemical signals...
June 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28636060/developing-mobile-clinical-decision-support-for-nursing-home-staff-assessment-of-urinary-tract-infection-using-goal-directed-design
#2
Wallace Jones, Cynthia Drake, David Mack, Blaine Reeder, Barbara Trautner, Heidi Wald
BACKGROUND: Unique characteristics of nursing homes (NHs) contribute to high rates of inappropriate antibiotic use for asymptomatic bacteriuria (ASB), a benign condition. A mobile clinical decision support system (CDSS) may support NH staff in differentiating urinary tract infections (UTI) from ASB and reducing antibiotic days. OBJECTIVES: We used Goal-Directed Design to: 1) Characterize information needs for UTI identification and management in NHs; 2) Develop UTI Decide, a mobile CDSS prototype informed by personas and scenarios of use constructed from Aim 1 findings; 3) Evaluate the UTI Decide prototype with NH staff...
June 20, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28635967/social-behaviour-involving-drug-resistance-the-role-of-initial-density-initial-frequency-and-population-structure-in-shaping-the-effect-of-antibiotic-resistance-as-a-public-good
#3
I L Domingues, J A Gama, L M Carvalho, F Dionisio
Bacteria sometimes cooperate with co-inhabiting cells. Pathogenic bacteria, for example, often produce and excrete virulence factors, eventually benefitting both producer and non-producer cells. The role of social interactions involving antibiotic resistance, however, has been more elusive. Enzymes that inactivate β-lactam antibiotics such as ampicillin or penicillin (β-lactamases) are good candidates as public goods. Nonetheless, it has been claimed that bacteria harbouring plasmids of natural origin coding for β-lactamase almost do not protect sensitive bacteria...
June 21, 2017: Heredity
https://www.readbyqxmd.com/read/28635570/quality-dementia-care-prerequisites-and-relational-ethics-among-multicultural-healthcare-providers
#4
Gerd Sylvi Sellevold, Veslemøy Egede-Nissen, Rita Jakobsen, Venke Sørlie
BACKGROUND: Many nursing homes appear as multicultural workplaces where the majority of healthcare providers have an ethnic minority background. This environment creates challenges linked to communication, interaction and cultural differences. Furthermore, the healthcare providers have varied experiences and understanding of what quality care of patients with dementia involves. PURPOSE: The aim of this study is to illuminate multi-ethnic healthcare providers' lived experiences of their own working relationship, and its importance to quality care for people with dementia...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28634469/alexander-disease-mutations-produce-cells-with-coexpression-of-glial-fibrillary-acidic-protein-and-ng2-in-neurosphere-cultures-and-inhibit-differentiation-into-mature-oligodendrocytes
#5
Ulises Gómez-Pinedo, Maria Salomé Sirerol-Piquer, María Durán-Moreno, José Manuel García-Verdugo, Jorge Matias-Guiu
BACKGROUND: Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. OBJECTIVES: Determine the effect of AxD-related mutations on adult neurogenesis. METHODS: We transfected different types of mutant GFAP into neurospheres using the nucleofection technique. RESULTS: We find that mutations may cause coexpression of GFAP and NG2 in neurosphere cultures, which would inhibit the differentiation of precursors into oligodendrocytes and thus explain the myelin loss occurring in the disease...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28634147/csahi-study-2-validation-of-multi-electrode-array-systems-mea60-2100-for-prediction-of-drug-induced-proarrhythmia-using-human-ips-cell-derived-cardiomyocytes-assessment-of-reference-compounds-and-comparison-with-non-clinical-studies-and-clinical-information
#6
Yumiko Nozaki, Yayoi Honda, Hitoshi Watanabe, Shota Saiki, Kiyotaka Koyabu, Tetsuji Itoh, Chiho Nagasawa, Chiaki Nakamori, Chiaki Nakayama, Hiroshi Iwasaki, Shinobu Suzuki, Kohji Tanaka, Etsushi Takahashi, Kaori Miyamoto, Kaoru Morimura, Atsuhiro Yamanishi, Hiroko Endo, Junko Shinozaki, Hisashi Nogawa, Tadahiro Shinozawa, Fumiyo Saito, Takeshi Kunimatsu
With the aim of reconsidering ICH S7B and E14 guidelines, a new in vitro assay system has been subjected to worldwide validation to establish a better prediction platform for potential drug-induced QT prolongation and the consequent TdP in clinical practice. In Japan, CSAHi HEART team has been working on hiPS-CMs in the MEA (hiPS-CMs/MEA) under a standardized protocol and found no inter-facility or lot-to-lot variability for proarrhythmic risk assessment of 7 reference compounds. In this study, we evaluated the responses of hiPS-CMs/MEA to another 31 reference compounds associated with cardiac toxicities, and gene expression to further clarify the electrophysiological characteristics over the course of culture period...
June 17, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28633992/eating-out-in-four-nordic-countries-national-patterns-and-social-stratification
#7
T B Lund, U Kjærnes, L Holm
Using a survey conducted in four Nordic countries (Denmark, Finland, Norway and Sweden) in 2012, we investigated whether eating out in cafés and restaurants in these countries is best characterized as a workday pattern activity or a leisure activity; and, whether frequent eating at cafés and restaurants is related to socio-demographic factors and factors relevant to the organization of daily life. We found that eating out is not a fundamental part of everyday eating. It is something which takes place occasionally...
June 17, 2017: Appetite
https://www.readbyqxmd.com/read/28633657/patient-safety-culture-in-norwegian-nursing-homes
#8
Gunnar Tschudi Bondevik, Dag Hofoss, Bettina Sandgathe Husebø, Ellen Catharina Tveter Deilkås
BACKGROUND: Patient safety culture concerns leader and staff interaction, attitudes, routines, awareness and practices that impinge on the risk of patient-adverse events. Due to their complex multiple diseases, nursing home patients are at particularly high risk of adverse events. Studies have found an association between patient safety culture and the risk of adverse events. This study aimed to investigate safety attitudes among healthcare providers in Norwegian nursing homes, using the Safety Attitudes Questionnaire - Ambulatory Version (SAQ-AV)...
June 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28633654/physical-activity-and-associated-factors-from-a-cross-sectional-survey-among-adults-in-northern-tanzania
#9
Beatrice John, Jim Todd, Innocent Mboya, Mary Mosha, Mark Urassa, Tara Mtuy
BACKGROUND: Insufficient physical activity (PA) is a major contributing factor in the growing problem of non-communicable diseases (NCDs) in urban and rural Sub-Saharan Africa. This study aimed to determine PA and associated factors among adults in Northern Tanzania. METHODS: We analyzed secondary data from a cross-sectional serological survey nested within the Magu health and demographic sentinel surveillance population in Magu District Northwestern Tanzania. All resident adults aged 15 years and older were invited to participate in the study, and physical activity data were analyzed for 5663 participants...
June 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28633372/farmer-suicides-a-qualitative-study-from-australia
#10
M Perceval, K Kõlves, P Reddy, D De Leo
Background: Farmers in Australia, in general, have poorer health outcomes, including higher rates of suicide. Aims: To investigate risk and protective factors and attitudes towards suicide and help-seeking among farmers living and working in New South Wales and Queensland in Australia. Methods: A qualitative study in which three farming sites were selected in each state to represent an area with a suicide rate equal to, below and above the state average...
June 14, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28632011/essential-public-health-competencies-for-medical-students-establishing-a-consensus-in-family-medicine
#11
Christopher P Morley, Scott R Rosas, Ranit Mishori, William Jordan, Yumi Shitama Jarris, Family Medicine/Public Health Competencies Work Group, Jacob Prunuske
Phenomenon: The integration of public health (PH) competency training into medical education, and further integration of PH and primary care, has been urged by the U.S. Institute of Medicine. However, PH competencies are numerous, and no consensus exists over which competencies are most important for adoption by current trainees. Our objective was to conduct a group concept mapping exercise with stakeholders identifying the most important and feasible PH skills to incorporate in medical and residency curricula...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28632004/behavioral-interventions-to-reduce-infections-in-pediatric-long-term-care-facilities-the-keep-it-clean-for-kids-trial
#12
Elaine L Larson, Meghan T Murray, Bevin Cohen, Edwin Simpser, Marianne Pavia, Olivia Jackson, Haomiao Jia, R Gordon Hutcheon, Linda Mosiello, Natalie Neu, Lisa Saiman
Children in pediatric long-term care facilities (pLTCF) represent a highly vulnerable population and infectious outbreaks occur frequently, resulting in significant morbidity, mortality, and resource use. The purpose of this quasi-experimental trial using time series analysis was to assess the impact of a 4-year theoretically based behavioral intervention on infection prevention practices and clinical outcomes in three pLTCF (288 beds) in New York metropolitan area including 720 residents, ages 1 day to 26 years with mean lengths of stay: 7...
March 3, 2017: Behavioral Medicine
https://www.readbyqxmd.com/read/28631537/sustainability-in-care-through-an-ethical-practice-model
#13
Linda Nyholm, Susanne Salmela, Lisbet Nyström, Camilla Koskinen
BACKGROUND: While sustainability is a key concept in many different domains today, it has not yet been sufficiently emphasized in the healthcare sector. Earlier research shows that ethical values and evidence-based care models create sustainability in care practice. OBJECTIVE: The aim of this study was to gain further understanding of the ethical values central to the realization of sustainability in care and to create an ethical practice model whereby these basic values can be made perceptible and active in care practice...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/28631221/effects-of-gas-condition-on-acetic-acid-fermentation-by-clostridium-thermocellum-and-moorella-thermoacetica-c-thermoaceticum
#14
Harifara Rabemanolontsoa, Dung Van Nguyen, Piradee Jusakulvjit, Shiro Saka
Fermentation with acetogens can be affected by cultivation gas phase, but to date, there is not enough evidence on that matter for Clostridium thermocellum and Moorella thermoacetica. In this work, the effects of sparged CO2 as well as sparged and non-sparged N2 on these microorganisms were studied using glucose and cellobiose as substrates. It was revealed that sparged CO2 and non-sparged N2 supported growth and acetic acid production by C. thermocellum and M. thermoacetica, while sparged N2 inhibited both of the microorganisms...
June 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28631154/soil-derived-organic-particles-and-their-effects-on-the-community-of-culturable-microorganisms
#15
Lukáš Bystrianský, Marcel Štofik, Milan Gryndler
Soil microbial community interacts with a range of particulate material in the soil, consisting of both inorganic and organic compounds with different levels of water solubility. Though sparingly water-soluble and insoluble organic compounds in the soil may affect living organisms, they are difficult to introduce into microbiological media. Their biological activity (i.e., their effect on soil microorganisms) thus has been almost neglected in most of the cultivation assays. To fill this gap, we propose the use of fine organic particles prepared from soil organic matter that are introduced into a laboratory medium where microbial community is cultivated...
June 19, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28630538/abortion-law-and-policy-around-the-world-in-search-of-decriminalization
#16
Marge Berer
The aim of this paper is to provide a panoramic view of laws and policies on abortion around the world, giving a range of country-based examples. It shows that the plethora of convoluted laws and restrictions surrounding abortion do not make any legal or public health sense. What makes abortion safe is simple and irrefutable-when it is available on the woman's request and is universally affordable and accessible. From this perspective, few existing laws are fit for purpose. However, the road to law reform is long and difficult...
June 2017: Health and Human Rights
https://www.readbyqxmd.com/read/28630406/emerging-fungal-pathogen-ophidiomyces-ophiodiicola-in-wild-european-snakes
#17
Lydia H V Franklinos, Jeffrey M Lorch, Elizabeth Bohuski, Julia Rodriguez-Ramos Fernandez, Owen N Wright, Liam Fitzpatrick, Silviu Petrovan, Chris Durrant, Chris Linton, Vojtech Baláž, Andrew A Cunningham, Becki Lawson
Snake fungal disease (SFD) is an emerging disease of conservation concern in eastern North America. Ophidiomyces ophiodiicola, the causative agent of SFD, has been isolated from over 30 species of wild snakes from six families in North America. Whilst O. ophiodiicola has been isolated from captive snakes outside North America, the pathogen has not been reported from wild snakes elsewhere. We screened 33 carcasses and 303 moulted skins from wild snakes collected from 2010-2016 in Great Britain and the Czech Republic for the presence of macroscopic skin lesions and O...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629892/engineered-myocardium-model-to-study-the-roles-of-hif-1%C3%AE-and-hif1a-as1-in-paracrine-only-signaling-under-pathological-level-oxidative-stress
#18
Aylin Acun, Pinar Zorlutuna
Studying heart tissue is critical for understanding and developing treatments for cardiovascular diseases. In this work, we fabricated precisely controlled and biomimetic engineered model tissues to study how cell-cell and cell-matrix interactions influence myocardial cell survival upon exposure to pathological level oxidative stress. Specifically, the interactions of endothelial cells (ECs) and cardiomyocytes (CMs), and the role of hypoxia inducible factor-1α (HIF-1α), with its novel alternative regulator, HIF-1α antisense RNA1 (HIF1A-AS1), in these interactions were investigated...
June 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28629882/quantification-of-fungal-growth-and-destruxin-a-during-infection-of-galleria-mellonella-larvae-by-metarhizium-brunneum
#19
A Ríos-Moreno, I Garrido-Jurado, M C Raya-Ortega, E Quesada-Moraga
Destruxin A is among the major secondary metabolites produced by the entomopathogenic ascomycete Metarhizium sp., and the lack of studies concerning production of destruxin A by the fungus is most likely the biggest obstacle for the registration of new fungal strains. Although several studies focus on the production of destruxin A in culture media, few studies examine destruxin A in vivo during host infection. In the current work, Galleria mellonella was used as an insect model to develop for the first time in vivo real-time PCR- and HPLC-MS-based quantification of fungal growth and metabolite production, respectively, during infection by two strains of M...
June 16, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28629867/culture-shapes-nursing-practice-findings-from-a-new-zealand-study
#20
Ruth Crawford, Jane Stein-Parbury, Denise Dignam
OBJECTIVES: This paper reports research undertaken to investigate nurses' and parents' experiences of communication about parental emotions in a hospital setting, with a focus on the environmental and cultural context within which the communication occurs. METHODS: A focused ethnography was employed as the aims were to understand the context within which nurse-parent interaction takes place, by exploring cultural factors, such as ways of living affecting nursing communication...
June 15, 2017: Patient Education and Counseling
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