Yunn-Yi Chen, Eun-Sil Shelley Hwang, Ritu Roy, Sandy DeVries, Joseph Anderson, Chrystal Wa, Patrick L Fitzgibbons, Timothy W Jacobs, Gaetan MacGrogan, Hans Peterse, Anne Vincent-Salomon, Taku Tokuyasu, Stuart J Schnitt, Frederic M Waldman
The clinical, pathologic, and molecular features of pleomorphic lobular carcinoma in situ (PLCIS) and the relationship of PLCIS to classic LCIS (CLCIS) are poorly defined. In this study, we analyzed 31 cases of PLCIS (13 apocrine and 18 nonapocrine subtypes) and compared the clinical, pathologic, immunophenotypic, and genetic characteristics of these cases with those of 24 cases of CLCIS. Biomarker expression was examined using immunostaining for E-cadherin, gross cystic disease fluid protein-15, estrogen, progesterone, androgen receptor, human epidermal growth factor receptor2, CK5/6, and Ki67...
November 2009: American Journal of Surgical Pathology