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Motor intentional disorders

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https://www.readbyqxmd.com/read/28258351/predicting-intentional-communication-in-preverbal-preschoolers-with-autism-spectrum-disorder
#1
Micheal Sandbank, Tiffany Woynaroski, Linda R Watson, Elizabeth Gardner, Bahar Keçeli Kaysili, Paul Yoder
Intentional communication has previously been identified as a value-added predictor of expressive language in preverbal preschoolers with autism spectrum disorder. In the present study, we sought to identify value-added predictors of intentional communication. Of five theoretically-motivated putative predictors of intentional communication measured early in the study (at study entry and 4 months after), three had significant zero-order correlations with later intentional communication (12 months after study entry) and were thus added to a linear model that predicted later intentional communication scores controlling for initial intentional communication scores at study entry...
March 4, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28194135/inaccurate-saccades-and-enhanced-vestibulo-ocular-reflex-suppression-during-combined-eye-head-movements-in-patients-with-chronic-neck-pain-possible-implications-for-cervical-vertigo
#2
Janine L Johnston, Pierre M Daye, Glen T D Thomson
BACKGROUND: The primate ocular motor system is designed to acquire peripheral targets of interest by coordinating visual, vestibular, and neck muscle activation signals. The vestibulo-ocular reflex (VOR) is greatly reduced at the onset of large eye-head (gaze) saccades and resumes before the end of the saccades to stabilize eye-in-orbit and ensure accurate target acquisition. Previous studies have relied on manipulating head movements in normal individuals to study VOR suppression and gaze kinematics...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28183377/impaired-awareness-of-motor-intention-in-functional-neurological-disorder-implications-for-voluntary-and-functional-movement
#3
K Baek, N Doñamayor, L S Morris, D Strelchuk, S Mitchell, Y Mikheenko, S Y Yeoh, W Phillips, M Zandi, A Jenaway, C Walsh, V Voon
BACKGROUND: Functional neurological disorders (FNDs), also known as conversion disorder, are unexplained neurological symptoms unrelated to a neurological cause. The disorder is common, yet poorly understood. The symptoms are experienced as involuntary but have similarities to voluntary processes. Here we studied intention awareness in FND. METHOD: A total of 26 FND patients and 25 healthy volunteers participated in this functional magnetic resonance study using Libet's clock...
February 10, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28176975/familial-aggregation-of-the-cerebellar-signs-in-familial-essential-tremor
#4
Elan D Louis, Nora Hernandez, Karen P Chen, Kelly V Naranjo, Jemin Park, Lorraine N Clark, Ruth Ottman
BACKGROUND: Although the hallmark feature of essential tremor (ET) is kinetic tremor, patients may exhibit additional motor features (e.g., intention tremor and mild gait ataxia) that are markers of an underlying abnormality of cerebellar function. ET is also a highly familial disorder, but we do not know whether the presence and expression of cerebellar signs are similar across family members. There are simply no published data. The alternative possibility is that these features are not heritable...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28132975/a-case-of-neuromyelitis-optica-spectrum-disorder-nmosd-with-sj%C3%A3-gren-s-syndrome-manifested-only-brain-involvement-by-preceding-parotitis
#5
Takahiro Furukawa, Naoko Matsui, Keiko Tanaka, Yuishin Izumi, Ryuji Kaji
A 33 year-old woman presented with intentional incontinence, motor aphasia, supranuclear gaze palsy, and spasticity after parotitis. Brain magnetic resonance images (MRI) showed abnormal signaling in long corticospinal tract involving internal capsules and cerebral peduncles, middle cerebellar peduncle, and frontal subcortical white matter lesions. She had a long history of dry eye and mouth. Immunoserological study showed that she was positive for anti-SS-A, aquaporin 4 (AQP4), and AQP5 antibodies. She clinically showed not only Sjögren's syndrome but also neuromyelitis optica spectrum disorder (NMOSD) without optic neuritis or myelitis...
February 25, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28000209/evaluation-of-non-natural-deaths-among-veterans-new-mexico-medical-examiner-investigated-deaths-2002-2011
#6
Melissa R LeBlanc, Camille P Clifford, Sarah L Lathrop
While it is recognized that veterans have increased rates of depression, post-traumatic stress disorder (PTSD), suicide, and substance use disorders, rates of homicide and unintentional injury deaths in veterans have been minimally investigated. We evaluated all non-natural deaths in New Mexico veterans between 2002 and 2011 in comparison with non-natural deaths among non-veterans. We reviewed all decedents in New Mexico with a history of military service and investigated by the medical examiner, excluding natural deaths and deaths due to fall from standing height...
December 21, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27928778/previously-unreported-biallelic-mutation-in-dnajc19-are-sensorineural-hearing-loss-and-basal-ganglia-lesions-additional-features-of-dilated-cardiomyopathy-and-ataxia-dcma-syndrome
#7
Sema Kalkan Ucar, Johannes A Mayr, René G Feichtinger, Ebru Canda, Mahmut Çoker, Saskia B Wortmann
BACKGROUND: Dilated cardiomyopathy (DCM), non-progressive cerebellar ataxia (A), testicular dysgenesis, growth failure, and 3-methylglutaconic aciduria are the hallmarks of DNAJC19 defect (or DCMA syndrome) due to biallelic mutations in DNAJC19. To date DCMA syndrome has been reported in 19 patients from Canada and in two Finnish siblings. The underlying pathomechanism is unknown; however, DNAJC19 is presumed to be involved in mitochondrial membrane related processes (e.g., protein import and cardiolipin remodeling)...
December 8, 2016: JIMD Reports
https://www.readbyqxmd.com/read/27920978/network-interactions-underlying-mirror-feedback-in-stroke-a-dynamic-causal-modeling-study
#8
Soha Saleh, Mathew Yarossi, Thushini Manuweera, Sergei Adamovich, Eugene Tunik
Mirror visual feedback (MVF) is potentially a powerful tool to facilitate recovery of disordered movement and stimulate activation of under-active brain areas due to stroke. The neural mechanisms underlying MVF have therefore been a focus of recent inquiry. Although it is known that sensorimotor areas can be activated via mirror feedback, the network interactions driving this effect remain unknown. The aim of the current study was to fill this gap by using dynamic causal modeling to test the interactions between regions in the frontal and parietal lobes that may be important for modulating the activation of the ipsilesional motor cortex during mirror visual feedback of unaffected hand movement in stroke patients...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27721995/environmental-enrichment-therapy-for-autism-outcomes-with-increased-access
#9
Eyal Aronoff, Robert Hillyer, Michael Leon
We have previously shown in two randomized clinical trials that environmental enrichment is capable of ameliorating symptoms of autism spectrum disorder (ASD), and in the present study, we determined whether this therapy could be effective under real-world circumstances. 1,002 children were given daily Sensory Enrichment Therapy, by their parents, using personalized therapy instructions given over the Internet. Parents were asked to assess the symptoms of their child every 2 weeks for up to 7 months. An intention-to-treat analysis showed significant overall gains for a wide range of symptoms in these children, including learning, memory, anxiety, attention span, motor skills, eating, sleeping, sensory processing, self-awareness, communication, social skills, and mood/autism behaviors...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27719868/factitious-disorders-and-malingering-in-relation-to-functional-neurologic-disorders
#10
REVIEW
C Bass, P Halligan
Interest in malingering has grown in recent years, and is reflected in the exponential increase in academic publications since 1990. Although malingering is more commonly detected in medicolegal practice, it is not an all-or-nothing presentation and moreover can vary in the extent of presentation. As a nonmedical disorder, the challenge for clinical practice remains that malingering by definition is intentional and deliberate. As such, clinical skills alone are often insufficient to detect it and we describe psychometric tests such as symptom validity tests and relevant nonmedical investigations...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27693821/post-traumatic-tremor-and-thalamic-deep-brain-stimulation-evidence-for-use-of-diffusion-tensor-imaging
#11
Sandra G J Boccard, Pedro Rebelo, Binith Cheeran, Alexander Green, James J FitzGerald, Tipu Z Aziz
BACKGROUND: Deep brain stimulation (DBS) is a well-established treatment to reduce tremor, notably in Parkinson disease. DBS may also be effective in post-traumatic tremor, one of the most common movement disorders caused by head injury. However, the cohorts of patients often have multiple lesions that may impact the outcome depending on which fiber tracts are affected. CASE DESCRIPTION: A 20-year-old man presented after road traffic accident with severe closed head injury and polytrauma...
September 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27692049/randomized-prospective-study-of-the-impact-of-a-sleep-health-program-on-firefighter-injury-and-disability
#12
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
STUDY OBJECTIVES: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. DESIGN: Prospective station-level randomized, field-based intervention...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27667783/comparison-of-feline-brain-anatomy-in-0-25-and-3%C3%A2-tesla-magnetic-resonance-images
#13
P Przyborowska, Z Adamiak, P Holak, Y Zhalniarovich
The intention of the comparison of both low and high field was to examine which anatomical brain structures of cats were visible on low field images, as in clinical veterinary practice, 3 Tesla (T) magnets were of limited availability. The research was performed on 20 European short-haired male and female cats, aged 1-3 years, with body weight of 2-4 kg. 0.25 T magnetic resonance images of neurocranium were acquired in all using T2-weighted fast spin echo sequences with repetition time (TR) of 4010 ms and echo time (TE) of 90 ms in dorsal and transverse plane, and T2-weighted fast spine echo sequences with TR of 4290 ms and TE of 120 ms in sagittal plane...
September 25, 2016: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/27630599/impairments-of-social-motor-synchrony-evident-in-autism-spectrum-disorder
#14
Paula Fitzpatrick, Jean A Frazier, David M Cochran, Teresa Mitchell, Caitlin Coleman, R C Schmidt
Social interactions typically involve movements of the body that become synchronized over time and both intentional and spontaneous interactional synchrony have been found to be an essential part of successful human interaction. However, our understanding of the importance of temporal dimensions of social motor synchrony in social dysfunction is limited. Here, we used a pendulum coordination paradigm to assess dynamic, process-oriented measures of social motor synchrony in adolescents with and without autism spectrum disorder (ASD)...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27560971/a-randomized-double-blind-placebo-controlled-trial-of-low-dose-sertraline-in-young-children-with-fragile-x-syndrome
#15
Laura Greiss Hess, Sarah E Fitzpatrick, Danh V Nguyen, Yanjun Chen, Kimberly N Gaul, Andrea Schneider, Kerrie Lemons Chitwood, Marwa Abd Al Azaim Eldeeb, Jonathan Polussa, David Hessl, Susan Rivera, Randi J Hagerman
OBJECTIVE: Observational studies and anecdotal reports suggest that sertraline, a selective serotonin reuptake inhibitor, may improve language development in young children with fragile X syndrome (FXS). METHODS: The authors evaluated the efficacy of 6 months of treatment with low-dose sertraline in a randomized, double-blind, placebo-controlled trial in 52 children with FXS aged 2 to 6 years. RESULTS: Eighty-one subjects were screened for eligibility, and 57 were randomized to sertraline (27) or placebo (30)...
October 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27521184/relationship-between-impulsivity-traits-and-awareness-of-motor-intention
#16
F Giovannelli, B Mastrolorenzo, A Rossi, G Gavazzi, S Righi, G Zaccara, M P Viggiano, M Cincotta
Deficient voluntary control of behaviour and impulsivity are key aspects of impulse control disorders. The objective of the present study was to evaluate the relationship between behavioural measures of impulsivity and the awareness of voluntary action. Seventy-four healthy volunteers completed the Barratt Impulsiveness Scale (BIS), a questionnaire used to measure impulsive personality traits, and a go/no-go task. Moreover, all participants performed a behavioural task based on the Libet's clock paradigm in which they were requested to report the time of a self-initiated movement (M-judgement) or the time they first feel their intention to move (W-judgement)...
October 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27497717/towards-physics-of-neural-processes-and-behavior
#17
REVIEW
Mark L Latash
Behavior of biological systems is based on basic physical laws, common across inanimate and living systems, and currently unknown physical laws that are specific for living systems. Living systems are able to unite basic laws of physics into chains and clusters leading to new stable and pervasive relations among variables (new physical laws) involving new parameters and to modify these parameters in a purposeful way. Examples of such laws are presented starting from the tonic stretch reflex. Further, the idea of control with referent coordinates is formulated and merged with the idea of hierarchical control and the principle of abundance...
October 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27445967/opposite-interplay-between-ppar-gamma-and-canonical-wnt-beta-catenin-pathway-in-amyotrophic-lateral-sclerosis
#18
REVIEW
Yves Lecarpentier, Alexandre Vallée
The opposite interplay between peroxisome proliferator-activated receptor gamma (PPAR gamma) and Wnt/beta-catenin signaling has led to the categorization of neurodegenerative diseases (NDs) as either NDs in which PPAR gamma is downregulated while the canonical Wnt/beta-catenin pathway is upregulated [amyotrophic lateral sclerosis (ALS), Parkinson's disease, Huntington's disease, multiple sclerosis, Friedreich's ataxia] or NDs in which PPAR gamma is upregulated while the canonical Wnt/beta-catenin signaling is downregulated (bipolar disorder, schizophrenia, Alzheimer's disease)...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27414076/fragile-x-associated-tremor-ataxia-syndrome-phenotypic-comparisons-with-other-movement-disorders
#19
Erin E Robertson, Deborah A Hall, Andrew R McAsey, Joan A O'Keefe
OBJECTIVE: The purpose of this paper is to review the typical cognitive and motor impairments seen in fragile X-associated tremor/ataxia syndrome (FXTAS), essential tremor (ET), Parkinson disease (PD), spinocerebellar ataxias (SCAs), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP) in order to enhance diagnosis of FXTAS patients. METHODS: We compared the cognitive and motor phenotypes of FXTAS with each of these other movement disorders. Relevant neuropathological and neuroimaging findings are also reviewed...
August 2016: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/27226262/blue-blocking-glasses-as-additive-treatment-for-mania-a-randomized-placebo-controlled-trial
#20
Tone Eg Henriksen, Silje Skrede, Ole B Fasmer, Helle Schoeyen, Ieva Leskauskaite, Jeanette Bjørke-Bertheussen, Jörg Assmus, Børge Hamre, Janne Grønli, Anders Lund
OBJECTIVES: The discovery of the blue lightsensitive retinal photoreceptor responsible for signaling daytime to the brain suggested that light to the circadian system could be inhibited by using blue-blocking orange tinted glasses. Blue-blocking (BB) glasses are a potential treatment option for bipolar mania. We examined the effectiveness of BB glasses in hospitalized patients with bipolar disorder in a manic state. METHODS: In a single-blinded, randomized, placebo-controlled trial (RCT), eligible patients (with bipolar mania; age 18-70 years) were recruited from five clinics in Norway...
May 2016: Bipolar Disorders
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