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https://www.readbyqxmd.com/read/28324197/the-spectrum-of-magnetic-resonance-findings-in-cerebrotendinous-xanthomatosis-redefinition-and-evidence-of-new-markers-of-disease-progression
#1
Andrea Mignarri, Maria Teresa Dotti, Antonio Federico, Nicola De Stefano, Marco Battaglini, Irene Grazzini, Paolo Galluzzi, Lucia Monti
Cerebrotendinous xanthomatosis (CTX) is a metabolic disease characterized by systemic signs and neurological impairment, which can be prevented if chenodeoxycholic acid (CDCA) treatment is started early. Despite brain MRI represents an essential diagnostic tool, the spectrum of findings is worth to be reappraised, and follow-up data are needed. We performed clinical evaluation and brain MRI in 38 CTX patients. Sixteen of them who were untreated at baseline examination underwent clinical and MRI follow-up after long-term treatment with CDCA...
March 21, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28323684/shifting-spatial-neglect-with-repeated-line-bisections-possible-role-of-lateralized-attentional-fatigue
#2
Mary Woods, John B Williamson, Keith D White, Charles G Maitland, Kenneth M Heilman
BACKGROUND AND OBJECTIVE: Many patients who have signs of neglect immediately after a right hemisphere stroke remain disabled even when they improve on tests of neglect. Few patients are tested for attentional persistence and fatigue despite their importance in many instrumental activities. To investigate whether stimulus repetition might alter the allocation of attention, we repeatedly tested a patient 16 weeks after she developed hemispatial neglect from a right hemisphere stroke. METHODS: During each of three testing sessions given in 1 day, we asked the patient to bisect 90 lines of two lengths, presented in 30-trial blocks in three locations: left, center, and right of her midsagittal plane, partially counterbalanced across sessions...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28323565/surveillance-for-highly-pathogenic-avian-influenza-in-wild-turkeys-meleagris-gallopavo-of-minnesota-during-2015-outbreaks-in-domestic-poultry
#3
Christopher S Jennelle, Michelle Carstensen, Erik C Hildebrand, Paul C Wolf, Daniel A Grear, Hon S Ip, Louis Cornicelli
An outbreak of a novel reassortant of highly pathogenic avian influenza A (H5N2) virus (HPAIV) decimated domestic turkeys ( Meleagris gallopavo ) from March through mid-June, 2015 in the state of Minnesota, USA. In response, as part of broader surveillance efforts in wild birds, we designed a pilot effort to sample and test hunter-harvested Wild Turkeys ( Meleagris gallopavo ) for HPAIV in Minnesota counties with known infected poultry facilities. We also collected opportunistic samples from dead Wild Turkeys or live Wild Turkeys showing neurologic signs (morbidity and mortality samples) reported by the public or state agency personnel...
March 21, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28319467/effects-of-iv-acetaminophen-on-core-body-temperature-and-hemodynamic-responses-in-febrile-critically-ill-adults-a-randomized-controlled-trial
#4
Hildy M Schell-Chaple, Kathleen D Liu, Michael A Matthay, Daniel I Sessler, Kathleen A Puntillo
OBJECTIVE: To determine the effects of IV acetaminophen on core body temperature, blood pressure, and heart rate in febrile critically ill patients. DESIGN: Randomized, double-blind, placebo-controlled clinical trial. SETTING: Three adult ICUs at a large, urban, academic medical center. PATIENTS: Forty critically ill adults with fever (core temperature, ≥ 38.3°C). INTERVENTION: An infusion of acetaminophen 1 g or saline placebo over 15 minutes...
March 17, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28318693/the-influence-of-dual-substrate-layer-extensive-green-roofs-on-rainwater-runoff-quantity-and-quality
#5
Xiaoou Wang, Yimei Tian, Xinhua Zhao
This study investigates the ability of dual-substrate-layer extensive green roofs to retain rainwater and reduce pollutant leaching. The substrates in dual-substrate-layer green roofs consist of an upper organic nutrition layer for plant growth and a lower inorganic adsorption layer for water retention and pollutant reduction. One traditional single-substrate-layer extensive green roof was built for comparison with dual-substrate-layer green roofs. During the experimental period, dual-substrate-layer green roofs supported better natural vegetation growth, with coverage exceeding 90%, while the coverage in single-substrate-layer green roof was over 80%...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28315116/evaluating-the-prevalence-of-potentially-inappropriate-prescribing-in-older-adults-in-intermediate-care-facilities-a-cross-sectional-observational-study
#6
Anna Millar, Carmel Hughes, Cristín Ryan
Background Potentially inappropriate prescribing (PIP) [encompassing potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs)], is prevalent amongst older adults in primary and secondary care. However, PIP prevalence in intermediate care (IC) is unknown. Objective To determine the prevalence of PIMs/PPOs and associated patient factors. Setting Three IC facilities in Northern Ireland. Method The Screening Tool of Older People's Prescriptions and the Screening Tool to Alert doctors to Right Treatment were used to identify PIP over 8 weeks...
March 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28314702/short-term-outcomes-of-the-multi-institutional-bladder-exstrophy-consortium-successes-and-complications-in-the-first-two-years-of-collaboration
#7
J G Borer, E Vasquez, D A Canning, J V Kryger, A Bellows, D Weiss, T Groth, A Shukla, M P Kurtz, M E Mitchell
INTRODUCTION/BACKGROUND: Bladder exstrophy is a rare diagnosis that presents major reconstructive challenges. To increase experience and proficiency in the care of bladder exstrophy (BE), the Multi-Institutional BE Consortium (MIBEC) was formed, with a focus on refining technical aspects of complete primary repair of bladder exstrophy (CPRE) and subsequent care. OBJECTIVE: Outcome measures included successful CPRE (absence of dehiscence), complications, and integrated points of technique and care over the short-term...
February 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28306194/electrospun-biodegradable-microfibers-induce-new-collagen-formation-in-a-rat-abdominal-wall-defect-model-a-possible-treatment-for-pelvic-floor-repair
#8
Cecilie Glindtvad, Menglin Chen, Jens Vinge Nygaard, Lise Wogensen, Axel Forman, Carl Christian Danielsen, Mehmet Berat Taskin, Karl-Erik Andersson, Susanne Maigaard Axelsen
Half of the female population over age 50 years will experience pelvic organ prolapse. We suggest a new approach based on tissue engineering principles to functionally reconstruct the anatomical structures of the pelvic floor. The aim of this study is to investigate the mechanical performance and effect on collagen and elastin production of a degradable mesh releasing basic fibroblast growth factor (bFGF). Implantation of biodegradable mesh with or without bFGF in their core has been conducted in 40 rats in an abdominal wall defect model...
March 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28304107/the-percutaneous-toxicokinetics-of-sulphur-mustard-in-a-damaged-skin-porcine-model-and-the-evaluation-of-woundstat%C3%A2-as-a-topical-decontaminant
#9
Charlotte A Hall, Helen L Lydon, Christopher H Dalton, J Kevin Chipman, John S Graham, Robert P Chilcott
This study used a damaged skin, porcine model to evaluate the in vivo efficacy of WoundStat™ for decontamination of superficial (non-haemorrhaging), sulphur mustard-contaminated wounds. The dorsal skin of 12 female pigs was subjected to controlled physical damage and exposed to 10 μL (14) C-radiolabelled sulphur mustard ((14) C-SM). Animals were randomly assigned to either a control or a treatment group. In the latter, WoundStat™ was applied 30 s post exposure and left in situ for 1 h. Skin lesion progression and decontaminant efficacy were quantified over 6 h using a range of biophysical measurements...
March 17, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28302284/hospital-based-screening-tools-in-the-identification-of-non-accidental-trauma
#10
Dani O Gonzalez, Katherine J Deans
Over 700,000 children are victims of abuse and neglect each year in the United States. Effective screening programs that entail broad capture of suspected non-accidental trauma (NAT) may help to identify sentinel injuries. This can facilitate earlier detection and psychosocial interventions in hopes of decreasing recurrent NAT, which confers a higher mortality rate. The purpose of this article is to outline essential components of hospital-based NAT screening tools and highlight existing programs. In general, these tools should include several components: education sessions for healthcare providers on how to identify signs of NAT, automated notes or checklists within the electronic medical record to prompt specialty referrals, and a multidisciplinary team of experts that can address the needs of these children in the acute care setting...
February 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28302119/efficacy-of-an-inactivated-bivalent-vaccine-against-the-prevalent-strains-of-newcastle-disease-and-h9n2-avian-influenza
#11
Jing Zhao, Huiming Yang, Hongjun Xu, Zengbin Ma, Guozhong Zhang
BACKGROUND: Newcastle disease (ND) and avian influenza subtype H9N2 (H9N2 AI) are two of the most important diseases of poultry, causing severe economic losses in the global poultry industry. Vaccination is an effective way to prevent and control the spread of ND virus (NDV) and H9N2 AI virus (AIV), but the antigenic differences between the current circulating strains and the vaccine strains might account for recent ND and H9N2 AI outbreaks in vaccinated poultry flocks. METHODS: We developed an inactivated bivalent H9N2 and NDV vaccine based on the current prevalent strains of H9N2 AIV and NDV in China and evaluated its efficacy in chickens in this study...
March 16, 2017: Virology Journal
https://www.readbyqxmd.com/read/28302099/monthly-food-insecurity-assessment-in-rural-mkushi-district-zambia-a-longitudinal-analysis
#12
Muzi Na, Bess L Caswell, Sameera A Talegawkar, Amanda Palmer
BACKGROUND: Perception-based scales are widely used for household food insecurity (HFI) assessment but were only recently added in national surveys. The frequency of assessments needed to characterize dynamics in HFI over time is largely unknown. The study aims to examine longitudinal changes in monthly reported HFI at both population- and household-level. METHODS: A total of 157 households in rural Mkushi District whose children were enrolled in the non-intervened arm of an efficacy trial of biofortified maize were included in the analysis...
March 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28301779/detection-of-bone-marrow-edema-in-nondisplaced-hip-fractures-utility-of-a-virtual-unenhanced-dual-energy-ct-application
#13
Trenton T Kellock, Savvas Nicolaou, Sandra S Y Kim, Sultan Al-Busaidi, Luck J Louis, Tim W O'Connell, Hugue A Ouellette, Patrick D McLaughlin
Purpose To quantify the sensitivity and specificity of dual-energy computed tomographic (CT) virtual noncalcium images in the detection of nondisplaced hip fractures and to assess whether obtaining these images as a complement to bone reconstructions alters sensitivity, specificity, or diagnostic confidence. Materials and Methods The clinical research ethics board approved chart review, and the requirement to obtain informed consent was waived. The authors retrospectively identified 118 patients who presented to a level 1 trauma center emergency department and who underwent dual-energy CT for suspicion of a nondisplaced traumatic hip fracture...
March 16, 2017: Radiology
https://www.readbyqxmd.com/read/28301614/a-phase-2-multicenter-double-blind-randomized-vehicle-controlled-clinical-study-to-assess-the-safety-and-efficacy-of-a-halobetasol-tazarotene-fixed-combination-in-the-treatment-of-plaque-psoriasis
#14
Jeffrey L Sugarman, Linda Stein Gold, Mark G Lebwohl, David M Pariser, Binu J Alexander, Radhakrishnan Pillai
<p>BACKGROUND: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Treatment options focus on relieving symptoms, reducing inflammation, induration, and scaling, and controlling the extent of the disease. Topical corticosteroids are the mainstay of treatment, however long-term safety remains a concern, particularly with the more potent formulations. Combination therapy with a corticosteroid and tazarotene may improve psoriasis signs at a lower corticosteroid concentration providing a superior safety profile...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28301423/no-adverse-safety-or-virological-changes-two-years-following-vorinostat-in-hiv-infected-individuals-on-antiretroviral-therapy
#15
Talia M Mota, Thomas A Rasmussen, Ajantha Rhodes, Surekha Tennakoon, Ashanti Dantanarayana, Fiona Wightman, Michelle Hagenauer, Janine Roney, Tim Spelman, Damian F J Purcell, James McMahon, Jennifer F Hoy, H Miles Prince, Julian H Elliott, Sharon R Lewin
OBJECTIVE: To determine the long term effects of vorinostat on safety and virological parameters in HIV-infected individuals on suppressive antiretroviral therapy (ART). DESIGN: Prospective longitudinal observational extended follow up of 20 HIV-infected individuals on ART previously enrolled in a clinical trial of daily vorinostat 400 mg for 14 days. Extended follow up included visits at 6, 12, 18 and 24 months post enrolment in the initial clinical trial. METHODS: Cell-associated unspliced (CA-US) HIV RNA, total HIV DNA and plasma HIV RNA were quantified by PCR and, CD4+ and CD8+ T cells quantified by flow cytometry...
March 15, 2017: AIDS
https://www.readbyqxmd.com/read/28301092/pharmacokinetics-and-safety-of-dw1029m-a-botanical-drug-for-the-treatment-of-diabetic-nephropathy-following-single-doses-in-healthy-subjects
#16
Yunjeong Kim, Ji-Young Jeon, Eun-Young Kim, Cheol-Hee Lim, Hwan Bong Jang, Min-Gul Kim
DW1029M is a botanical extract of Morus albalinne root bark and Puerariae radix that is used for the treatment of diabetic nephropathy. This study evaluated the safety and pharmacokinetics of DW1029M following its administration in healthy Korean subjects. We conducted a randomized, open-label, single-dose, crossover phase 1 clinical study. During each period, subjects received 300, 600, or 1200 mg oral doses of DW1029M. Plasma concentrations of puerarin, daidzin, and daidzein were analyzed using a liquid chromatography-tandem mass spectrometry...
March 16, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28300549/periocular-necrotizing-fasciitis-in-an-infant
#17
Alan D Proia
A 12-month-old boy developed periocular necrotizing fasciitis with swelling of both eyes and redness and a discharge from the left eye approximately 36 hours after blunt trauma. Computed tomography revealed pre-septal and soft tissue edema on the left side, but no signs of orbital involvement, orbital fractures, or drainable abscess in the anterior left lower eyelid. The inflammatory signs worsened over the next day, and there was purulent discharge from the left lower eyelid and an abscess and necrosis of the lower eyelid skin...
March 11, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28299240/validation-of-the-total-visual-acuity-extraction-algorithm-tova-for-automated-extraction-of-visual-acuity-data-from-free-text-unstructured-clinical-records
#18
Douglas M Baughman, Grace L Su, Irena Tsui, Cecilia S Lee, Aaron Y Lee
PURPOSE: With increasing volumes of electronic health record data, algorithm-driven extraction may aid manual extraction. Visual acuity often is extracted manually in vision research. The total visual acuity extraction algorithm (TOVA) is presented and validated for automated extraction of visual acuity from free text, unstructured clinical notes. METHODS: Consecutive inpatient ophthalmology notes over an 8-year period from the University of Washington healthcare system in Seattle, WA were used for validation of TOVA...
March 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28299150/awareness-and-practice-of-self-breast-examination-among-female-nurses-at-the-federal-teaching-hospital-ido-ekiti-nigeria
#19
Olusegun Emmanuel Gabriel, Oluwaserimi Adewumi Ajetunmobi, Olabode Muftau Shabi, Olaide Toyin Elegbede, Raymond Akujuobi Okere, Olusegun Adesola Busari, Ayokunle Samuel Dada
Breast cancer is the most common female malignancy linked with high levels of morbidity and mortality in developing countries due to delayed diagnosis. This research assessed the knowledge of signs and risk factors of breast cancer and practice of self breast examination (SBE) among female nurses in a rural tertiary Hospital. Eighty-five nurses ages 20 to 60 years were sampled by simple randomization over a period of eight weeks through a self-administered semi-structured questionnaire. The analysis was done using statistical package for social science version 17...
August 17, 2016: Journal of Public Health in Africa
https://www.readbyqxmd.com/read/28298668/unexplained-obstruction-of-an-integrated-cardiotomy-filter-during-cardiopulmonary-bypass
#20
Cory M Alwardt, Donald S Wilson, Octavio E Pajaro
Cardiopulmonary bypass (CPB) is considered relatively safe in most cases, yet is not complication free. We present a case of an integrated cardiotomy filter obstruction during CPB, requiring circuit reconfiguration. Approximately an hour after uneventful initiation of CPB the integrated cardiotomy filter became obstructed over several minutes, requiring circuit reconfiguration using an external cardiotomy filter to maintain functionality. Following reconfiguration, CPB was maintained with a fully functional circuit allowing safe patient support throughout the remainder of CPB...
March 2017: Journal of Extra-corporeal Technology
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