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https://www.readbyqxmd.com/read/29028898/diffloop-a-computational-framework-for-identifying-and-analyzing-differential-dna-loops-from-sequencing-data
#1
Caleb A Lareau, Martin J Aryee
Summary: The three-dimensional architecture of DNA within the nucleus is a key determinant of interactions between genes, regulatory elements, and transcriptional machinery. As a result, differences in DNA looping structure are associated with variation in gene expression and cell state. To systematically assess changes in DNA looping architecture between samples, we introduce diffloop, an R/Bioconductor package that provides a suite of functions for the quality control, statistical testing, annotation, and visualization of DNA loops...
September 29, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29016178/jerome-s-bruner-1915-2016
#2
Helen Haste, Howard Gardner
Presents an obituary for Jerome S. Bruner, who died in 2016. His long, and productive, life spanned much of the first century of experimental psychology and coincided with the launching of cognitive psychology, a field in which he played an indispensable and pioneering role. His innovative and provocative work constantly challenged the current "mainstream." His impact on education has been equated with that of John Dewey. He was driven throughout his life to pursue the nature of the "human" in both his conceptual and empirical work...
October 2017: American Psychologist
https://www.readbyqxmd.com/read/28986774/the-history-evolution-and-basic-science-of-osteotomy-techniques
#3
REVIEW
John Dabis, Oliver Templeton-Ward, Alice E Lacey, Badri Narayan, Alex Trompeter
Osteotomy techniques date back to Hippocrates circa 415 BC (Jones Hippocrates collected works I, Harvard University Press, Cambridge, 2006; Brorson in Clin Orthop Relat Res 467(7):1907-1914, 2009). There is debate about the best way to divide the bone surgically and which technique yields the best bone regenerate in lengthening; ensuring predictable new bone formation and healing of the osteotomy are the primary goals. We review the history and techniques of the osteotomy and consider the evidence for optimum bone formation...
October 6, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28981506/regional-initiatives-for-malaria-elimination-building-and-maintaining-partnerships
#4
Andrew A Lover, Kelly E Harvard, Alistair E Lindawson, Cara Smith Gueye, Rima Shretta, Roly Gosling, Richard Feachem
Andrew Lover and colleagues discuss regional malaria initiatives, the strengths and challenges.
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28978676/diet-quality-is-linked-to-insulin-resistance-among-adults-in-china
#5
Zhihong Wang, Linda S Adair, Jianwen Cai, Penny Gordon-Larsen, Anna Maria Siega-Riz, Bing Zhang, Barry M Popkin
Background: Little is known about the impact of Chinese diet quality changes on diabetes-related markers.Objective: The present study examined the association of changes in overall diet quality with various biomarkers of diabetes among adults in China.Methods: The current analysis used longitudinal diet data from 1991 to 2006 and fasting blood samples from 2009 for 4734 adults aged 18-65 y from the China Health and Nutrition Survey. Dietary intake was assessed by using 3 consecutive 24-h recalls and household food weighing...
October 4, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28974636/an-interview-with-jayaraj-rajagopal
#6
Aidan Maartens
Jayaraj (Jay) Rajagopal is a Principal Investigator at the Center for Regenerative Medicine at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School. A Howard Hughes Medical Institute Faculty Scholar, his lab works on the development and regeneration of the lung. He uses stem cell and animal models to develop novel insights that hopefully will provide inspiration for therapies to help treat human lung disease. He was awarded the Dr Susan Lim Award for Outstanding Young Investigator at the 2017 International Society for Stem Cell Research (ISSCR) meeting in Boston (MA,USA), where we met him to talk about how a fish tank started a life-long fascination with the lung, the transition to running his own lab, and his optimism for the future of both basic stem cell research and its clinical translation...
October 1, 2017: Development
https://www.readbyqxmd.com/read/28973551/region-specific-association-of-subjective-cognitive-decline-with-tauopathy-independent-of-global-%C3%AE-amyloid-burden
#7
Rachel F Buckley, Bernard Hanseeuw, Aaron P Schultz, Patrizia Vannini, Sarah L Aghjayan, Michael J Properzi, Jonathan D Jackson, Elizabeth C Mormino, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio
Importance: The ability to explore associations between reports of subjective cognitive decline (SCD) and biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical β-amyloid [Aβ] and tau) provides an important opportunity to understand the basis of SCD and AD risk. Objective: To examine associations between SCD and global Aβ and tau burdens in regions of interest in clinically healthy older adults. Design, Setting, and Participants: This imaging substudy of the Harvard Aging Brain Study included 133 clinically healthy older participants (Clinical Dementia Rating Scale global scores of 0) participating in the Harvard Aging Brain Study who underwent cross-sectional flortaucipir F 18 (previously known as AV 1451, T807) positron emission tomography (FTP-PET) imaging for tau and Pittsburgh compound B carbon 11-labeled PET (PiB-PET) imaging for Aβ...
October 2, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28973512/big-data-research-in-neurosurgery-a-critical-look-at-this-popular-new-study-design
#8
Chesney S Oravec, Mustafa Motiwala, Kevin Reed, Douglas Kondziolka, Fred G Barker, L Madison Michael, Paul Klimo
The use of "big data" in neurosurgical research has become increasingly popular. However, using this type of data comes with limitations. This study aimed to shed light on this new approach to clinical research. We compiled a list of commonly used databases that were not specifically created to study neurosurgical procedures, conditions, or diseases. Three North American journals were manually searched for articles published since 2000 utilizing these and other non-neurosurgery-specific databases. A number of data points per article were collected, tallied, and analyzed...
July 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28942086/validation-of-a-52-gene-risk-profile-for-outcome-prediction-in-patients-with-idiopathic-pulmonary-fibrosis-an-international-multicentre-cohort-study
#9
Jose D Herazo-Maya, Jiehuan Sun, Philip L Molyneaux, Qin Li, Julian A Villalba, Argyrios Tzouvelekis, Heather Lynn, Brenda M Juan-Guardela, Cristobal Risquez, Juan C Osorio, Xiting Yan, George Michel, Nachelle Aurelien, Kathleen O Lindell, Melinda J Klesen, Miriam F Moffatt, William O Cookson, Yingze Zhang, Joe G N Garcia, Imre Noth, Antje Prasse, Ziv Bar-Joseph, Kevin F Gibson, Hongyu Zhao, Erica L Herzog, Ivan O Rosas, Toby M Maher, Naftali Kaminski
BACKGROUND: The clinical course of idiopathic pulmonary fibrosis (IPF) is unpredictable. Clinical prediction tools are not accurate enough to predict disease outcomes. METHODS: We enrolled patients with IPF diagnosis in a six-cohort study at Yale University (New Haven, CT, USA), Imperial College London (London, UK), University of Chicago (Chicago, IL, USA), University of Pittsburgh (Pittsburgh, PA, USA), University of Freiburg (Freiburg im Breisgau, Germany), and Brigham and Women's Hospital-Harvard Medical School (Boston, MA, USA)...
September 20, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28937517/effects-of-a-short-video-based-resident-as-teacher-training-toolkit-on-resident-teaching
#10
Hope A Ricciotti, Taylor S Freret, Ashley Aluko, Bri Anne McKeon, Miriam J Haviland, Lori R Newman
OBJECTIVE: To pilot a short video-based resident-as-teacher training toolkit and assess its effect on resident teaching skills in clinical settings. METHODS: A video-based resident-as-teacher training toolkit was previously developed by educational experts at Beth Israel Deaconess Medical Center, Harvard Medical School. Residents were recruited from two academic hospitals, watched two videos from the toolkit ("Clinical Teaching Skills" and "Effective Clinical Supervision"), and completed an accompanying self-study guide...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28928278/an-interview-with-george-daley
#11
Aidan Maartens
George Daley is Dean of the Faculty of Medicine, Professor of Biological Chemistry and Molecular Pharmacology, and Caroline Shields Walker Professor of Medicine at Harvard Medical School. A former Howard Hughes Medical Institute Investigator and President of the International Society for Stem Cell Research (ISSCR) from 2007-2008, his lab works on the biology and clinical application of stem cells, with a particular focus on hematopoiesis. He was awarded the Public Service Award at the ISSCR 2017 meeting in Boston, where we caught up with him to discuss his move from the lab to the clinic and back again, his quest to derive human hematopoietic stem cells in vitro, and his advocacy for science in uncertain political times...
September 15, 2017: Development
https://www.readbyqxmd.com/read/28916178/the-cerebellum-s-contribution-to-beat-interval-discrimination
#12
S Paquette, S Fujii, H C Li, G Schlaug
From expert percussionists to individuals who cannot dance, there are widespread differences in people's abilities to perceive and synchronize with a musical beat. The aim of our study was to identify candidate brain regions that might be associated with these abilities. For this purpose, we used Voxel-Based-Morphometry to correlate inter-individual differences in performance on the Harvard Beat Assessment Tests (H-BAT) with local inter-individual variations in gray matter volumes across the entire brain space in 60 individuals...
September 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28915825/effect-of-a-mobile-app-intervention-on-vegetable-consumption-in-overweight-adults-a-randomized-controlled-trial
#13
Sarah Mummah, Thomas N Robinson, Maya Mathur, Sarah Farzinkhou, Stephen Sutton, Christopher D Gardner
BACKGROUND: Mobile applications (apps) have been heralded as transformative tools to deliver behavioral health interventions at scale, but few have been tested in rigorous randomized controlled trials. We tested the effect of a mobile app to increase vegetable consumption among overweight adults attempting weight loss maintenance. METHODS: Overweight adults (n=135) aged 18-50 years with BMI=28-40 kg/m(2) near Stanford, CA were recruited from an ongoing 12-month weight loss trial (parent trial) and randomly assigned to either the stand-alone, theory-based Vegethon mobile app (enabling goal setting, self-monitoring, and feedback and using "process motivators" including fun, surprise, choice, control, social comparison, and competition) or a wait-listed control condition...
September 15, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28910436/integrating-data-collection-into-office-work-flow-and-electronic-health-records-for-clinical-outcomes-research
#14
C Alessandra Colaianni, Patricia A Levesque, Robin W Lindsay
Meticulous collection of clinical outcomes metrics in patients undergoing elective surgery is important to ensure quality care; it is also increasing in importance as the Centers for Medicare & Medicaid Services moves to tie reimbursement to outcomes and insurance approval. This study assesses a systematic method for gathering preoperative and postoperative data on patients with nasal obstruction who undergo functional septorhinoplasty that was developed at the Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts...
September 14, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28904528/access-criteria-for-anti-tnf-agents-in-spondyloarthritis-influence-on-comparative-1-year-cost-effectiveness-estimates
#15
Stephanie Harvard, Daphne Guh, Nick Bansback, Pascal Richette, Alain Saraux, Bruno Fautrel, Aslam Anis
BACKGROUND: Anti-tumor necrosis factor (anti-TNF) agents are an effective, but costly, treatment for spondyloarthritis (SpA). Worldwide, multiple sets of access criteria aim to restrict anti-TNF therapy to patients with specific clinical characteristics, yet the influence of access criteria on anti-TNF cost-effectiveness is unknown. Our objective was to use data from the DESIR cohort, a prospective study of early SpA patients in France, to determine whether the French anti-TNF access criteria are the most cost-effective in that setting relative to other potential restrictions...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/28902790/impact-of-treatments-on-diabetic-control-and-gastrointestinal-symptoms-after-total-pancreatectomy
#16
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman
OBJECTIVES: The aims of this study were to compare the safety, efficacy, and patients' quality of life with continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDIs) in type 3c diabetes mellitus (T3cDM) following total pancreatectomy (TP) and pancreatic enzyme usage. METHODS: Thirty-nine patients with T3cDM (18 CSII patients vs 21 MDI patients) who underwent TP between 2000 and 2016 at 3 Harvard-affiliated hospitals and the University of Minnesota returned prospectively obtained questionnaires examining quality of life and both endocrine and exocrine pancreatic functions...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28899189/book-review-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-insanity-and-sanctity-in-byzantium-the-ambiguity-of-religious-experience-by-rotman-youval-cambridge-harvard-university-press-2016-xii-256-pp-39-95-hardcover
#17
https://www.readbyqxmd.com/read/28895835/massachusetts-what-universal-coverage-could-look-like
#18
Joseph Burns
The lowest rate of uninsured, but costs are a concern. That's due, in part, to the clout of the state's large prestigious health care systems, especially Partners Healthcare in Boston, which includes Harvard-affiliated Massachusetts General Hospital, and Brigham and Women's hospitals.
July 2017: Managed Care
https://www.readbyqxmd.com/read/28895811/outcomes-based-pricing-program-puts-money-in-beneficiaries-pockets
#19
Ed Silverman
Harvard Pilgrim's program gives rebates to beneficiaries if Repatha doesn't help them avoid a heart attack or stroke. It's just the latest in a growing number of outcomes-based pricing agreements in which an insurer can get a discount from a drugmaker if a drug doesn't help patients as much as expected.
August 2017: Managed Care
https://www.readbyqxmd.com/read/28894852/top-100-cited-classic-articles-in-breast-cancer-research
#20
Erdal Uysal
OBJECTIVE: This study aimed to analyze 100 most cited articles in breast cancer research. MATERIALS AND METHODS: The data in this study were obtained by a search conducted on the Web of Science (WOS). In brief, the term "breast cancer" was typed in the search box of WOS basic research including all the years and the data. The analysis was carried out by compiling the top 100 cited articles in the shortlist as sorted by the journals, categories of the studies, the countries, the centers, the authors and the publication date...
July 2017: Eur J Breast Health
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