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https://www.readbyqxmd.com/read/28527078/our-headache-fellowship-a-10-year-history
#1
Paul Rizzoli
There has been a clear trend in American medical education after World War II toward training specialization and subspecialization. After some early specialization efforts by the American Board of Psychiatry and Neurology, further efforts were undertaken by the United Council for Neurologic Subspecialties (UCNS), leading to the introduction of the neurologic subspecialty of Headache Medicine in March, 2005. The training program at our center at the Brigham and Women's Hospital Department of Neurology, Harvard Medical School, in Boston, Massachusetts, was accredited in 2008 and has graduated 14 trainees since its inception...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28523951/launching-biosimilar-rituximab-an-industry-opinion-on-biosimilar-uptake-in-europe
#2
Richard Trollope, Sue Johnson, Henry Ireland
Richard Trollope and Sue Johnson talk with Henry Ireland, Senior Editor about the recent approval of biosimilar rituximab (Truxima(®)) & the current state of biosimilar uptake across Europe Richard Trollope, Head of Biosimilars, Mundipharma International Limited, qualified as a biochemist before joining Wyeth's commercial operations, prior to its acquisition by Pfizer. Richard later joined Yamanouchi Pharmaceuticals (now Astellas Pharma). His fascination with oncology led him to join Mundipharma in Europe and after joining the company's UK arm (Napp Pharmaceuticals Limited), Richard began his journey in biosimilars...
May 19, 2017: Immunotherapy
https://www.readbyqxmd.com/read/28523464/the-role-of-ontogeny-in-the-evolution-of-human-cooperation
#3
Michael Tomasello, Ivan Gonzalez-Cabrera
To explain the evolutionary emergence of uniquely human skills and motivations for cooperation, Tomasello et al. (2012, in Current Anthropology 53(6):673-92) proposed the interdependence hypothesis. The key adaptive context in this account was the obligate collaborative foraging of early human adults. Hawkes (2014, in Human Nature 25(1):28-48), following Hrdy (Mothers and Others, Harvard University Press, 2009), provided an alternative account for the emergence of uniquely human cooperative skills in which the key was early human infants' attempts to solicit care and attention from adults in a cooperative breeding context...
May 18, 2017: Human Nature: An Interdisciplinary Biosocial Perspective
https://www.readbyqxmd.com/read/28520900/accelerating-high-dimensional-clustering-with-lossless-data-reduction
#4
Bahjat F Qaqish, Jonathon J O'Brien, Jonathan C Hibbard, Katie J Clowers
Motivation: For cluster analysis, high dimensional data is associated with instability, decreased classification accuracy and high computational burden. The latter challenge can be eliminated as a serious concern. For applications where dimension reduction techniques are not implemented, we propose a temporary transformation which accelerates computations with no loss of information. The algorithm can be applied for any statistical procedure depending only on Euclidean distances and can be implemented sequentially to enable analyses of data that would otherwise exceed memory limitations...
May 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28507040/cell-scientist-to-watch-melike-lakadamyali
#5
(no author information available yet)
Melike received a bachelor's degree in physics from the University of Texas at Austin and joined the laboratory of Xiaowei Zhuang at Harvard University for her PhD, which was awarded in 2006. She worked as a postdoctoral fellow under Jeff Lichtman at the Center for Brain Science at Harvard University. In 2010, Melike joined the Institute of Photonic Sciences (ICFO) in Barcelona, Spain, as a junior group leader. She was the recipient of an EMBO Young Investigator Award in 2013 and became senior group leader at the ICFO in 2015...
May 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28505466/the-conceptualization-of-emotion-regulation-difficulties-and-its-association-with-posttraumatic-stress-symptoms-in-traumatized-refugees
#6
Emma L Doolan, Richard A Bryant, Belinda J Liddell, Angela Nickerson
This study investigated the conceptualization of emotion regulation difficulties in a sample of refugees with varying levels of posttraumatic stress (PTS), and examined whether specific emotion regulation difficulties were associated with PTS severity. Refugees were administered an abbreviated version of the Difficulties in Emotion Regulation Scale, the PTSD Symptom Scale - Interview Version, and the Harvard Trauma Questionnaire. Confirmatory Factor Analysis was used to examine model fit for the 6-factor model originally proposed by the developers of the DERS and the more recently proposed 5-factor model that excludes the awareness subscale...
April 26, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28499756/genetic-variants-in-wnt2b-and-btrc-predict-melanoma-survival
#7
Qiong Shi, Hongliang Liu, Peng Han, Chunying Li, Yanru Wang, Wenting Wu, Dakai Zhu, Christopher I Amos, Shenying Fang, Jeffrey E Lee, Jiali Han, Qingyi Wei
Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival (CMSS) and then validated significant SNPs in another GWAS from Harvard University...
May 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28485300/gait-studies-for-a-quadrupedal-microrobot-reveal-contrasting-running-templates-in-two-frequency-regimes
#8
Benjamin Goldberg, Neel Doshi, Kaushik Jayaram, Robert Wood
Performance metrics such as speed, cost of transport, and stability are the driving factors behind gait selection in legged locomotion. To help understand the effect of gait on the performance and dynamics of small-scale ambulation, we explore four quadrupedal gaits over a wide range of stride frequencies on a 1.43g, biologically-inspired microrobot, the Harvard Ambulatory MicroRobot (HAMR). Despite its small size, HAMR can precisely control leg frequency, phasing, and trajectory, making it an exceptional platform for gait studies at scales relevant to insect locomotion...
May 9, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28479858/study-of-acupuncture-for-low-back-pain-in-recent-20-years-a-bibliometric-analysis-via-citespace
#9
Yu-Dan Liang, Ying Li, Jian Zhao, Xiao-Yin Wang, Hui-Zheng Zhu, Xiu-Hua Chen
BACKGROUND: Acupuncture has been applied to relieve low back pain (LBP) in many countries. However, a bibliometric analysis of the global use of acupuncture for LBP is rare. OBJECTIVE: The aim of this study was to demonstrate the state of the art and trends concerning the global use of acupuncture for LBP in recent 20 years. METHODS: Literature relating to acupuncture for LBP from 1997 to 2016 was retrieved from Web of Science. CiteSpace was used to analyze country/institution, cited journals, authors/cited authors, cited references, and keywords...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28472627/neuroimaging-markers-associated-with-maintenance-of-optimal-memory-performance-in-late-life
#10
Maria Dekhtyar, Kathryn V Papp, Rachel Buckley, Heidi I L Jacobs, Aaron P Schultz, Keith A Johnson, Reisa A Sperling, Dorene M Rentz
BACKGROUND: Age-related memory decline has been well-documented; however, some individuals reach their 8th-10th decade while maintaining strong memory performance. OBJECTIVE: To determine which demographic and biomarker factors differentiated top memory performers (aged 75+, top 20% for memory) from their peers and whether top memory performance was maintained over 3 years. METHODS: Clinically normal adults (n=125, CDR=0; age: 79.5±3.57 years) from the Harvard Aging Brain Study underwent cognitive testing and neuroimaging (amyloid PET, MRI) at baseline and 3-year follow-up...
May 1, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28467412/the-co-production-of-what-knowledge-values-and-social-relations-in-health-care
#11
Angela Filipe, Alicia Renedo, Cicely Marston
"Co-production" is becoming an increasingly popular term in policymaking, governance, and research. While the shift from engagement and involvement to co-production in health care holds the promise of revolutionising health services and research, it is not always evident what counts as co-production: what is being produced, under what circumstances, and with what implications for participants. We discuss these questions and propose that co-production can be understood as an exploratory space and a generative process that leads to different, and sometimes unexpected, forms of knowledge, values, and social relations...
May 2017: PLoS Biology
https://www.readbyqxmd.com/read/28461637/dental-students-perceptions-of-digital-assessment-software-for-preclinical-tooth-preparation-exercises
#12
Carly F Park, Justin M Sheinbaum, Yasushi Tamada, Raina Chandiramani, Lisa Lian, Cliff Lee, John Da Silva, Shigemi Ishikawa-Nagai
Objective self-assessment is essential to learning and continued competence in dentistry. A computer-assisted design/computer-assisted manufacturing (CAD/CAM) learning software (prepCheck, Sirona) allows students to objectively assess their performance in preclinical prosthodontics. The aim of this study was to evaluate students' perceptions of CAD/CAM learning software for preclinical prosthodontics exercises. In 2014, all third-year dental students at Harvard School of Dental Medicine (n=36) were individually instructed by a trained faculty member in using prepCheck...
May 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28461555/cell-scientist-to-watch-mitchell-guttman
#13
(no author information available yet)
Mitchell received a bachelor's degree in molecular and computational biology and a master's degree in computational biology and bioinformatics from the University of Pennsylvania. He then joined the laboratory of Eric Lander at the Broad Institute of MIT and Harvard and was awarded his PhD in 2012. The same year he was named in the Forbes '30 under 30: science and healthcare' list of rising stars and received an NIH early independence award. Mitchell subsequently moved to the California Institute of Technology as an Assistant Professor to establish his own laboratory...
May 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28461047/influence-of-cement-type-and-ceramic-primer-on-retention-of-polymer-infiltrated-ceramic-crowns-to-a-one-piece-zirconia-implant
#14
Nadja Rohr, Stefan Brunner, Sabrina Märtin, Jens Fischer
STATEMENT OF PROBLEM: The best procedure for cementing a restoration to zirconia implants has not yet been established. PURPOSE: The purpose of this in vitro study was to measure the retention of polymer-infiltrated ceramic crowns to zirconia 1-piece implants using a wide range of cements. The effect of ceramic primer treatment on the retention force was also recorded. The retention results were correlated with the shear bond strength of the cement to zirconia and the indirect tensile strength of the cements to better understand the retention mechanism...
April 28, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28457320/surgical-and-trauma-care-in-low-and-middle-income-countries-a-review-of-capacity-assessments
#15
REVIEW
Kevin J Blair, Lorenzo Paladino, Pamela L Shaw, Michael B Shapiro, Benedict C Nwomeh, Mamta Swaroop
BACKGROUND: Surgical and trauma capacity assessments help guide resource allocation and plan interventions to improve care for the injured in low- and middle-income countries (LMICs). To forge expert consensus on conducting these assessments, we undertook a systematic review of studies using five tools: (1) World Health Organization's (WHO) Guidelines for Essential Trauma Care, (2) WHO's Tool for Situational Analysis to Assess Emergency and Essential Surgical Care, (3) Personnel, Infrastructure, Procedures, Equipment, and Supplies tool, (4) Harvard Humanitarian Initiative tool, and (5) Emergency and Critical Care tool...
April 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28455492/seasonal-variations-of-leaf-and-canopy-properties-tracked-by-ground-based-ndvi-imagery-in-a-temperate-forest
#16
Hualei Yang, Xi Yang, Mary Heskel, Shucun Sun, Jianwu Tang
Changes in plant phenology affect the carbon flux of terrestrial forest ecosystems due to the link between the growing season length and vegetation productivity. Digital camera imagery, which can be acquired frequently, has been used to monitor seasonal and annual changes in forest canopy phenology and track critical phenological events. However, quantitative assessment of the structural and biochemical controls of the phenological patterns in camera images has rarely been done. In this study, we used an NDVI (Normalized Difference Vegetation Index) camera to monitor daily variations of vegetation reflectance at visible and near-infrared (NIR) bands with high spatial and temporal resolutions, and found that the infrared camera based NDVI (camera-NDVI) agreed well with the leaf expansion process that was measured by independent manual observations at Harvard Forest, Massachusetts, USA...
April 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28451906/saul-hertz-md-and-the-birth-of-radionuclide-therapy
#17
EDITORIAL
Frederic H Fahey, Frederick D Grant, James H Thrall
The year, 2016, marked the 75th anniversary of Dr. Saul Hertz first using radioiodine to treat a patient with thyroid disease. In November of 1936, a luncheon was held of the faculty of Harvard Medical School where Karl Compton, PhD, president of the Massachusetts Institute of Technology was invited to give a presentation entitled "What Physics Can Do for Biology and Medicine." Saul Hertz who attended the luncheon spontaneously asked the very pertinent question that perhaps changed the course of treatment of thyroid disease, "Could iodine be made radioactive artificially?" We review the events leading up to the asking of this question, the preclinical investigations by Dr...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28448234/leveraging-clinical-imaging-archives-for-radiomics-reliability-of-automated-methods-for-brain-volume-measurement
#18
Viraj R Adduru, Andrew M Michael, Maria Helguera, Stefi A Baum, Gregory J Moore
Purpose To validate the use of thick-section clinically acquired magnetic resonance (MR) imaging data for estimating total brain volume (TBV), gray matter (GM) volume (GMV), and white matter (WM) volume (WMV) by using three widely used automated toolboxes: SPM ( www.fil.ion.ucl.ac.uk/spm/ ), FreeSurfer ( surfer.nmr.mgh.harvard.edu ), and FSL (FMRIB software library; Oxford Centre for Functional MR Imaging of the Brain, Oxford, England, https://fsl.fmrib.ox.ac.uk/fsl ). Materials and Methods MR images from a clinical archive were used and data were deidentified...
April 27, 2017: Radiology
https://www.readbyqxmd.com/read/28436919/a-machine-learning-method-for-fast-and-accurate-characterization-of-depth-of-interaction-gamma-cameras
#19
Stefano Pedemonte, Larry Pierce, Koen Van Leemput
Measuring the depth-of-interaction (DOI) of gamma photons enables increasing the resolution of emission imaging systems. Several design variants of DOI-sensitive detectors have been recently introduced to improve the performance of scanners for Positron Emission Tomography (PET). However, the accurate characterization of the response of DOI detectors, necessary to accurately measure the DOI, remains an unsolved problem. Numerical simulations are, at the state of the art, imprecise, while measuring directly the characteristics of DOI detectors experimentally is hindered by the impossibility to impose the depth-of-interaction in an experimental set-up...
April 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28436262/private-philanthropy-and-basic-research-in-mid-twentieth-century-america-the-hickrill-chemical-research-foundation
#20
Leon Gortler, Stephen J Weininger
The Hickrill Chemical Research Foundation, located north of New York City on the estate of its patrons, Sylvan and Ruth Alice Norman Weil, had a short (1948-59) but productive life. Ruth Alice Weil received a Ph.D. in organic chemistry in 1947, directed by William von Eggers Doering of Columbia University. She intended that Hickrill contribute to cancer chemotherapy while providing resources for Doering's more speculative research. Ultimately, Doering's commitment to theoretical organic chemistry set Hickrill's research agenda...
April 24, 2017: Ambix
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