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William R Saltzman
This article describes the core principles and components of the FOCUS Program, a brief intervention for families contending with single or multiple trauma or loss events. It has been administered nationally to thousands of military family members since 2008 and has been implemented in a wide range of civilian community, medical, clinical, and school settings. Developed by a team from the UCLA and Harvard Medical Schools, the FOCUS Program provides a structured approach for joining with traditional and nontraditional families, crafting shared goals, and then working with parents, children, and the entire family to build communication, make meaning out of traumatic experiences, and practice specific skills that support family resilience...
October 13, 2016: Family Process
Arnold L Demain, Evan Martens
We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among microbial biochemists. He began his professional career as an organic chemistry PhD student at Nottingham University, moved on to a postdoctoral fellowship at Columbia University, then became a lecturer at the University of Manchester, followed by a fellowship in microbial biochemistry at Harvard Medical School. In 1965, he studied genetics at the Pasteur Institute, and 2 years later joined the University of Wisconsin in the Department of Biochemistry...
October 12, 2016: Journal of Antibiotics
Sarah L Aghjayan, Rachel F Buckley, Patrizia Vannini, Dorene M Rentz, Jonathan D Jackson, Reisa A Sperling, Keith A Johnson, Rebecca E Amariglio
BACKGROUND: Converging evidence suggests that subjective cognitive concerns (SCC) are associated with biomarker evidence of Alzheimer's disease (AD) prior to objective clinical impairment. However, the sensitivity of SCC reports in early AD may be biased by demographic factors. Here, we sought to investigate whether age, education, and sex influence the relationship between SCC and amyloid (Aβ) burden. METHODS: In this cross-sectional study, we examined 252 clinically normal (CN) individuals (57...
October 11, 2016: International Psychogeriatrics
Jessica Schuster, Christopher Chipko, Michael Kasper, Sandra Sha, Douglas Ciuba, James Petrikas, Anand Kuruvilla, Ravichandra Sandrapaty, Coral Quiet, Cynthia Anderson, Rashmi Benda, David Wazer, Jaroslaw Hepel, Douglas Arthur
PURPOSE: To report updated feasibility and reproducibility results for high-dose-rate noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT) in the setting of expanded patient and treatment facility number. METHODS AND MATERIALS: Fifteen independent community-based and academic centers reported 518 early-stage breast cancer patients from July 2007 to February 2015 on a privacy-encrypted online data registry. All patients' treatment included lumpectomy followed by combination of WBRT and NIBB...
October 6, 2016: Brachytherapy
Hua Yuan, Hongliang Liu, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, Rayjean J Hung, John McLaughlin, Yonathan Brhane, Paul Brennan, Heike Bickeboeller, Albert Rosenberger, Richard S Houlston, Neil Caporaso, Maria Teresa Landi, Joachim Heinrich, Angela Risch, David C Christiani, Zeynep H Gümüş, Robert J Klein, Christopher I Amos, Qingyi Wei
Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10(-7)) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE...
October 7, 2016: Scientific Reports
Pradip Dashraath, Harvard Z Lin
A 38-year-old woman who had undergone three low-segment cesarean sections was admitted to the hospital in labor at 36 weeks of gestation. Antenatal ultrasonography suggested placenta accreta (Panel A), with the appearance of irregular vascular spaces (asterisk) and loss of retroplacental hypoechoic..
October 6, 2016: New England Journal of Medicine
Christine M Mitchell, Zachary D Epstein-Peterson, Julia Bandini, Ada Amobi, Jonathan Cahill, Andrea Enzinger, Sarah Noveroske, John Peteet, Tracy Balboni, Michael Balboni
CONTEXT: While many studies have addressed the integration of a religion/spirituality curriculum into medical school training, few describe the process of curriculum development based on qualitative data from students and faculty. OBJECTIVES: The aim of this study is to explore the perspectives of medical students and chaplaincy trainees regarding the development of a curriculum to facilitate reflection on moral and spiritual dimensions of caring for the critically-ill, and to train students in self-care practices that promote professionalism...
September 29, 2016: Journal of Pain and Symptom Management
Kathryn L Butler, David A Hirsh, Emil R Petrusa, D Dante Yeh, Dana Stearns, David E Sloane, Jeffrey A Linder, Gaurab Basu, Lisa A Thompson, Marc A de Moya
OBJECTIVE: Optimal methods for medical student assessment in surgery remain elusive. Faculty- and housestaff-written evaluations constitute the chief means of student assessment in medical education. However, numerous studies show that this approach has poor specificity and a high degree of subjectivity. We hypothesized that an objective structured clinical examination (OSCE) in the surgery clerkship would provide additional data on student performance that would confirm or augment other measures of assessment...
September 27, 2016: Journal of Surgical Education
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
STUDY OBJECTIVES: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. DESIGN: Prospective station-level randomized, field-based intervention...
September 26, 2016: Sleep
Steven A Lopez, Edward O Pyzer-Knapp, Gregor N Simm, Trevor Lutzow, Kewei Li, Laszlo R Seress, Johannes Hachmann, Alán Aspuru-Guzik
The Harvard Organic Photovoltaic Dataset (HOPV15) presented in this work is a collation of experimental photovoltaic data from the literature, and corresponding quantum-chemical calculations performed over a range of conformers, each with quantum chemical results using a variety of density functionals and basis sets. It is anticipated that this dataset will be of use in both relating electronic structure calculations to experimental observations through the generation of calibration schemes, as well as for the creation of new semi-empirical methods and the benchmarking of current and future model chemistries for organic electronic applications...
September 27, 2016: Scientific Data
Margaret E Kruk, Hannah H Leslie, Stéphane Verguet, Godfrey M Mbaruku, Richard M K Adanu, Ana Langer
BACKGROUND: Global efforts to increase births at health-care facilities might not reduce maternal or newborn mortality if quality of care is insufficient. However, little systematic evidence exists for the quality at health facilities caring for women and newborn babies in low-income countries. We analysed the quality of basic maternal care functions and its association with volume of deliveries and surgical capacity in health-care facilities in five sub-Saharan African countries. METHODS: In this analysis, we combined nationally representative health system surveys (Service Provision Assessments by the Demographic and Health Survery Programme) with data for volume of deliveries and quality of delivery care from Kenya, Namibia, Rwanda, Tanzania, and Uganda...
September 23, 2016: Lancet Global Health
Mel Burden
A surgical site infection (SSI) surveillance module completed in 2014 highlighted that infection rates for breast surgery inpatients and readmissions at an acute trust had increased to 2.2%, from 0.5% in 2012. The national benchmark for 2014 established by Public Health England (PHE) was 1.0%. This demonstrated a greater than fourfold absolute increase in SSI for breast surgery during these periods. The infection rate could have been due to chance, but warranted investigation. The results were presented to the breast team and used to drive practice transformation through audit and observation, identifying areas of change to improve patient safety...
September 22, 2016: British Journal of Nursing: BJN
Vincent Alvarez, Jong Woo Lee, M Brandon Westover, Frank W Drislane, Jan Novy, Mohamed Faouzi, Nicola A Marchi, Barbara A Dworetzky, Andrea O Rossetti
OBJECTIVE: Our aim was to analyze and compare the use of therapeutic coma (TC) for refractory status epilepticus (SE) across different centers and its effect on outcome. METHODS: Clinical data for all consecutive adults (>16 years) with SE of all etiologies (except postanoxic) admitted to 4 tertiary care centers belonging to Harvard Affiliated Hospitals (HAH) and the Centre Hospitalier Universitaire Vaudois (CHUV) were prospectively collected and analyzed for TC details, mortality, and duration of hospitalization...
September 24, 2016: Neurology
Alejandra Martínez-Melo, Francisco Alonso Solís-Marín, Blanca Estela Buitrón-Sánchez, Alfredo Laguarda-Figueras
BACKGROUND: Research on echinoderms in Mexico began in the late nineteenth century. We present a dataset that includes the taxonomic and geographic information of irregular echinoids from Mexico, housed in four collections: 1) Colección Nacional de Equinodermos "Ma. Elena Caso Muñoz" from the Instituto de Ciencias del Mar y Limnología (ICML), Universidad Nacional Autónoma de México (UNAM); 2) Invertebrate Zoology Collection, Smithsonian Museum of Natural History, Washington, D.C...
2016: Biodiversity Data Journal
Johnny Kung, Chao-Ting Wu
The impact of genetic technologies is being felt in many aspects of society, including medicine and the legal system, as well as the personal lives of individuals. How do we make sure that all segments of the population are equally aware of these technologies and have ample opportunity to voice opinions and shape the future? One ongoing effort, which began ten years ago and in which we are directly involved, is the Personal Genetics Education Project, a nonprofit initiative housed within and largely supported by the Department of Genetics at Harvard Medical School...
September 2016: Hastings Center Report
Silvia Storti, Ilaria Boscolo Galazzo, Sehresh Khan, Paolo Manganotti, Gloria Menegaz
The application of time-varying measures of causality between source time series can be very informative to elucidate the direction of communication among the regions of an epileptic brain. The aim of the study was to identify the dynamic patterns of epileptic networks in focal epilepsy by applying multivariate adaptive directed transfer function (ADTF) analysis and graph-theory to high-density electroencephalographic (hdEEG) recordings. The cortical network was modeled after source reconstruction and topology modulations were detected during interictal spikes...
September 9, 2016: IEEE Journal of Biomedical and Health Informatics
Yin Zongyi, Chen Dongying, Li Baifeng
We aimed to analyze the global scientific output of regulatory T-cell (Treg) research and built a model to qualitatively and quantitatively evaluate publications from 2000 to 2015. Data were obtained from the Web of Science Core Collection (WoSCC) of Thomson Reuters on January 1, 2016. The bibliometric method and Citespace III were used to analyze authors, journals, publication outputs, institutions, countries, research areas, research hotspots, and trends. In total, we identified 35,741 publications on Treg research from 2000 to 2015, and observed that the annual publication rate increased with time...
2016: PloS One
Takayuki Sakagami, Kennon A Lattal
We describe an early operant conditioning chamber fabricated by Harvard University instrument maker Ralph Gerbrands and shipped to Japan in 1952 in response to a request of Professor B. F. Skinner by Japanese psychologists. It is a rare example, perhaps the earliest still physically existing, of such a chamber for use with pigeons. Although the overall structure and many of the components are similar to contemporary pigeon chambers, several differences are noted and contrasted to evolutionary changes in this most important laboratory tool in the experimental analysis of behavior...
May 2016: Behavior Analyst
Erik Vindbjerg, Jessica Carlsson, Erik Lykke Mortensen, Ask Elklit, Guido Makransky
BACKGROUND: Refugees are known to have high rates of post-traumatic stress disorder (PTSD). Although recent years have seen an increase in the number of refugees from Arabic speaking countries in the Middle East, no study so far has validated the construct of PTSD in an Arabic speaking sample of refugees. METHODS: Responses to the Harvard Trauma Questionnaire (HTQ) were obtained from 409 Arabic-speaking refugees diagnosed with PTSD and undergoing treatment in Denmark...
2016: BMC Psychiatry
Mohammad Nouh Issa, Yaqoub Ashhab
Brucella melitensis Rev.1 is an avirulent strain that is widely used as a live vaccine to control brucellosis in small ruminants. Although an assembled draft version of Rev.1 genome has been available since 2009, this genome has not been investigated to characterize this important vaccine. In the present work, we used the draft genome of Rev.1 to perform a thorough genomic comparison and sequence analysis to identify and characterize the panel of its unique genetic markers. The draft genome of Rev.1 was compared with genome sequences of 36 different Brucella melitensis strains from the Brucella project of the Broad Institute of MIT and Harvard...
September 22, 2016: Vaccine
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