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https://www.readbyqxmd.com/read/28646485/findings-from-the-harvard-medical-school-cambridge-integrated-clerkship-a-year-long-longitudinal-psychiatry-experience
#1
Elisa Cheng, David Hirsh, Elizabeth Gaufberg, Todd Griswold, J Wesley Boyd
OBJECTIVE: The Harvard Medical School Cambridge Integrated Clerkship is a longitudinal integrated clerkship that has provided an alternative clinical model for medical education in psychiatry since its inception in 2004. This study was undertaken in an effort to better understand the student experience of the Cambridge Integrated Clerkship and how it may have impacted students' perceptions of and interest in psychiatry, as well as performance. METHODS: Qualitative surveys were sent via e-mail to the first 11 student cohorts who had completed the Cambridge Integrated Clerkship (from 2004 to 2014) and for whom we had e-mail addresses (N = 100), and the free-text responses were coded thematically...
June 23, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28645171/upsetr-an-r-package-for-the-visualization-of-intersecting-sets-and-their-properties
#2
Jake R Conway, Alexander Lex, Nils Gehlenborg
Motivation: Venn and Euler diagrams are a popular yet inadequate solution for quantitative visualization of set intersections. A scalable alternative to Venn and Euler diagrams for visualizing intersecting sets and their properties is needed. Results: We developed UpSetR, an open source R package that employs a scalable matrix-based visualization to show intersections of sets, their size, and other properties. Availability: UpSetR is available at https://github...
June 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28639775/-%C3%A2-living-facing-death-improving-lausanne-s-medical-students-%C3%A2-attitude-toward-end-of-life-issues
#3
Emmanuel Tamchès, Lazare Benaroyo, Marc Antoine Bornet, Jean-Pierre Hornung, Gian Domenico Borasio
The optional course « Living facing death » is the result of an innovative educational approach jointly developed by CHUV's Palliative Care Service, Lausanne's School of Medicine, Medical Ethics Unit and the students' association « Doctors & Death ». It is intended for 3rd and 4th grade medical students and was inspired by previous experiences conducted at Harvard Medical School. Its primary objective is to help students to « take some distances ». A mixed quantitative/qualitative satisfaction questionnaire was administered to all participating students at the completion of the course...
May 24, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28639299/understanding-suicide-across-the-lifespan-a-united-states-perspective-of-suicide-risk-factors-assessment-management
#4
Ian H Steele, Natasha Thrower, Paul Noroian, Fabian M Saleh
Suicide is a troubling, preventable phenomenon. Prior to attempts, individuals often seek help, prompting practitioners to perform risk assessments that ideally use evidence-based risk management strategies. A literature review was performed using Harvard Countway Library of Medicine, Google Scholar, PubMed. Key words used were "Forensic Science," "Suicide Risk Management," "Pediatric Suicide Risk Factors," "Adult Suicide Risk Factors," "Geriatric Suicide Risk Factors," "Suicide Risk Assessment." Parameters limited articles to studies/reviews completed in the past twenty years in the United States...
June 21, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28637731/the-impact-of-the-asylum-process-on-mental-health-a-longitudinal-study-of-unaccompanied-refugee-minors-in-norway
#5
Marianne Jakobsen, Melinda Ashley Meyer DeMott, Tore Wentzel-Larsen, Trond Heir
OBJECTIVES: To examine the mental health of unaccompanied refugee minors prospectively during the asylum-seeking process, with a focus on specific stages in the asylum process, such as age assessment, placement in a supportive or non-supportive facility and final decision on the asylum applications. DESIGN: This was a2½ year follow-up study of unaccompanied minors (UM) seeking asylum in Norway. Data were collected within three weeks (n=138) and at 4 months (n=101), 15 months (n=84) and 26 months (n=69) after arrival...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28624048/comparison-of-two-different-types-of-oxidized-regenerated-cellulose-for-partial-breast-defects
#6
Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Jung Dug Yang, Jeong Woo Lee, Junjie Li, Ho Yong Park
BACKGROUND: A defect after partial mastectomy, sometimes, is hard to be filled with patient's own breast tissue. Two different types of oxidized regenerated cellulose (ORC) for filling of partial defects in small-sized breasts were compared with respect to clinicopathologic factors and outcomes. METHODS: A total of 45 patients with breast cancer underwent conventional partial mastectomy with insertion of an ORC filling material. The two filling materials used were a hemostasis-purposed ORC and adhesion barrier-purposed ORC...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28588980/addressing-the-challenges-of-diagnostics-demand-and-supply-insights-from-an-online-global-health-discussion-platform
#7
Nora Engel, Keri Wachter, Madhukar Pai, Jim Gallarda, Catharina Boehme, Isabelle Celentano, Rebecca Weintraub
Several barriers challenge development, adoption and scale-up of diagnostics in low and middle income countries. An innovative global health discussion platform allows capturing insights from the global health community on factors driving demand and supply for diagnostics. We conducted a qualitative content analysis of the online discussion 'Advancing Care Delivery: Driving Demand and Supply of Diagnostics' organised by the Global Health Delivery Project (GHD) (http://www.ghdonline.org/) at Harvard University...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28581400/first-results-of-a-phase-2-trial-of-once-weekly-hypofractionated-breast-irradiation-whbi-for-early-stage-breast-cancer
#8
Anthony E Dragun, Nicholas J Ajkay, Elizabeth C Riley, Teresa L Roberts, Jianmin Pan, Shesh N Rai, Dharamvir Jain, Amy R Quillo, Charles R Scoggins, Kelly M McMasters, Shiao Y Woo
PURPOSE: To report early outcome analysis of a prospective institutional phase 2 trial of weekly hypofractionated breast irradiation (WHBI) for patients undergoing breast-conserving surgery (BCS). METHODS AND MATERIALS: Patients who underwent BCS for American Joint Committee on Cancer stage 0, I, or II breast cancer with negative surgical margins received whole-breast radiation therapy to 30 or 28.5 Gy in 5 weekly fractions with or without an additional boost. The eligibility criteria were the same as for NSABP (National Surgical Adjuvant Breast and Bowel Project) B39/RTOG (Radiation Therapy Oncology Group) 0413, and there were no restrictions on age, breast size, tumor grade, receptor status, or the use of cytotoxic chemotherapy for otherwise eligible patients...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28580557/-localization-establishment-of-an-interdisciplinary-intervention-model-to-prevent-post-operative-delirium-in-older-patients-based-on-hospital-elder-life-program
#9
Yan-Yan Wang, Yu-Lin Liao, Lang-Li Gao, Xiu-Ying Hu, Ji-Rong Yue
BACKGROUND: Postoperative delirium is a significant complication in elderly patients. The occurrence of delirium may increase the related physical and psychological risks, delay the length of hospital stays, and even lead to death. According to the current evidence-based model, the application of interdisciplinary intervention may effectively prevent delirium, shorten the length of hospital stays, and save costs. PURPOSE: To establish a culturally appropriate interdisciplinary intervention model for preventing postoperative delirium in older Chinese patients...
June 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28579871/innovative-curriculum-for-second-year-harvard-mit-medical-students-practicing-communication-skills-with-volunteer-patients-giving-immediate-feedback
#10
Nadaa B Ali, Stephen R Pelletier, Helen M Shields
PURPOSE: Medical students are expected to develop excellent communication skills. The purpose of our study was to create an innovative communication skills exercise using real volunteer patients and physician co-teachers for students to practice communication skills while receiving immediate feedback. METHOD: This is a mixed methods study where second-year medical students participated in the communication skills exercise with real patients and physician co-teachers giving immediate feedback...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28572423/cell-scientist-to-watch-lidia-vasilieva
#11
(no author information available yet)
Lidia received a bachelor's degree from Krasnoyarsk State University in Russia and a master's degree from the Institute of Protein Research in Moscow. She then moved to Finland to work with Leevi Kääriäinen on the replication of RNA viruses for her PhD. Her postdoctoral studies led her to Harvard Medical School with a fellowship from the Leukemia and Lymphoma Society. Under the supervision of Steve Buratowski, Lidia focused on transcriptional regulation in eukaryotes. In 2009, Lidia obtained a Wellcome Trust Career Development Fellowship and started her own research group at the Department of Biochemistry in Oxford...
June 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28558094/hierarchical-organization-of-tau-and-amyloid-deposits-in-the-cerebral-cortex
#12
Jorge Sepulcre, Michel J Grothe, Mert Sabuncu, Jasmeer Chhatwal, Aaron P Schultz, Bernard Hanseeuw, Georges El Fakhri, Reisa Sperling, Keith A Johnson
Importance: Abnormal accumulation of tau and amyloid-β (Aβ) proteins in the human brain are 2 pathologic hallmarks of Alzheimer disease (AD). Because pathologic processes begin decades before the onset of the clinical manifestations, the study of the cortical distribution of early-stage pathologic alterations is critical in understanding the underpinnings of the disease. Objectives: To identify the in vivo brain spatial distributions of tau and Aβ deposits in a sample of cognitively normal participants in the Harvard Aging Brain Study, determine spatial patterns of pathologic alterations, and provide means for improved individual in vivo staging...
May 30, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28550365/a-longitudinal-study-of-neurotrophic-oxidative-and-inflammatory-markers-in-first-onset-depression-in-midlife-women
#13
Matheus A Pasquali, Bernard L Harlow, Claudio N Soares, Michael W Otto, Lee S Cohen, Luciano Minuzzi, Daniel P Gelain, Jose Claudio F Moreira, Benicio N Frey
Prospective studies have shown during the years preceding and following menopause, also known as "menopause transition", that midlife women are at higher risk for developing first-onset major depressive disorder (MDD). The biological factors associated with risk and resilience in this population are, however, largely unknown. Considering the growing body of evidence suggesting that inflammation, oxidative stress, and brain-derived neurotrophic factor (BDNF) are associated with the pathophysiology of MDD, we investigated serum levels of protein carbonyl, lipid peroxidation (thiobarbituric acid reactive substances-TBARS), thiol group content, BDNF, 3-nitrotyrosine, and heat shock protein 70 (HSP70) in a longitudinal cohort of first-onset MDD...
May 26, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28545932/the-association-between-tau-pet-and-retrospective-cortical-thinning-in-clinically-normal-elderly
#14
Molly R LaPoint, Jasmeer P Chhatwal, Jorge Sepulcre, Keith A Johnson, Reisa A Sperling, Aaron P Schultz
Tau pathology has been associated with neuronal loss at autopsy, but the temporal evolution of tau pathology and atrophy remains unclear. Here, we investigate the association between cross-sectional AV-1451-PET as a marker of tau pathology and cortical thickness cross-sectionally. We also investigated retrospective rates of cortical thinning over the three years preceding the AV-1451 scan in a clinically normal cohort of 103 older adults from the Harvard Aging Brain Study. Tau measurements were Geometric Transfer Matrix partial volume corrected standardized uptake value ratios (SUVRs) with a cerebellar grey reference region...
May 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28539725/inhibition-of-cytochrome-p450-cyp3a4-activity-by-extracts-from-57-plants-used-in-traditional-chinese-medicine-tcm
#15
Mohamed L Ashour, Fadia S Youssef, Haidy A Gad, Michael Wink
BACKGROUND: Herbal medicine is widely used all over the world for treating various health disorders. It is employed either alone or in combination with synthetic drugs or plants to be more effective. OBJECTIVE: The assessment of the effect of both water and methanol extracts of 57 widely used plants from Traditional Chinese Medicine (TCM) against the main phase I metabolizing enzyme CYP3A4 in vitro for the first time. MATERIALS AND METHODS: The inhibition of cytochrome P450 activity was evaluated using a luminescence assay...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28537853/dermatology-discharge-continuity-clinic-enhances-resident-autonomy-and-insight-into-transitions-of-care-competencies-a-cross-sectional-survey-study
#16
Jasmine Rana, Arash Mostaghimi
Dermatology residents perform consults on hospitalized patients, but are often limited in their ability to follow-up with these patients after discharge, leading to inadequate follow-up and understanding of post-discharge transitions of care. In 2013, a discharge continuity clinic (DCC) staffed by the inpatient consult dermatology resident and attending dermatologist was established at one of the four adult hospital sites residents rotate through in the Harvard Combined Dermatology Residency Program. Resident perceptions about the DCC and their educational experience on inpatient consult rotations with a DCC and without a DCC were obtained using a cross-sectional survey instrument in June 2016...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28535286/invited-commentary-is-strenuous-activity-good-for-you-the-legacy-of-ralph-paffenbarger
#17
Lewis H Kuller
Ralph Paffenbarger, Jr, MD, DrPH (1922-2007), was initially trained as an infectious disease epidemiologist at the Johns Hopkins School of Hygiene and Public Health (now the Bloomberg School of Public Health). He was the first Epidemiology Intelligence Service officer in the first Epidemiology Intelligence Service class. He joined the National Heart Institute (now the National Heart, Lung, and Blood Institute) in its very early days and later became a faculty member at Stanford University and Harvard University...
June 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28534784/incorporation-of-solvent-effect-into-multi-objective-evolutionary-algorithm-for-improved-protein-structure-prediction
#18
Shangce Gao, Jiujun Cheng, Yuki Todo, Mengchu Zhou
The problem of predicting the three-dimensional structure of a protein from its one-dimensional sequence has been called the "holy grail of molecular biology", and it has become an important part of structural genomics projects. Despite the rapid developments in computer technology and computational intelligence, it remains challenging and fascinating. In this paper, to solve it we propose a multi-objective evolutionary algorithm. We decompose the protein energy function Chemistry at HARvard Macromolecular Mechanics force fields into bond and non-bond energies as the first and second objectives...
May 17, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28532449/the-factor-structures-and-correlates-of-ptsd-in-post-conflict-timor-leste-an-analysis-of-the-harvard-trauma-questionnaire
#19
Alvin Kuowei Tay, Mohammed Mohsin, Susan Rees, Zachary Steel, Natalino Tam, Zelia Soares, Jessica Baker, Derrick Silove
BACKGROUND: Post-traumatic stress disorder (PTSD) is the most widely assessed form of mental distress in cross-cultural studies conducted amongst populations exposed to mass conflict and displacement. Nevertheless, there have been longstanding concerns about the universality of PTSD as a diagnostic category when applied across cultures. One approach to examining this question is to assess whether the same factor structure can be identified in culturally diverse populations as has been described in populations of western societies...
May 22, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28527078/our-headache-fellowship-a-10-year-history
#20
Paul Rizzoli
There has been a clear trend in American medical education after World War II toward training specialization and subspecialization. After some early specialization efforts by the American Board of Psychiatry and Neurology, further efforts were undertaken by the United Council for Neurologic Subspecialties (UCNS), leading to the introduction of the neurologic subspecialty of Headache Medicine in March, 2005. The training program at our center at the Brigham and Women's Hospital Department of Neurology, Harvard Medical School, in Boston, Massachusetts, was accredited in 2008 and has graduated 14 trainees since its inception...
May 2017: Neurological Sciences
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