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https://www.readbyqxmd.com/read/28429036/a-review-of-zika-virus-infections-in-pregnancy-and-implications-for-antenatal-care-in-singapore
#1
Harvard Zhenjia Lin, Paul Anantharajah Tambyah, Eu Leong Yong, Arijit Biswas, Shiao-Yng Chan
Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28428676/behavioral-problems-and-emotional-difficulties-at-children-and-early-adolescents-of-the-veterans-of-war-with-post-traumatic-stress-disorder
#2
Zihnet Selimbasic, Osman Sinanovic, Esmina Avdibegovic, Maja Brkic, Jasmin Hamidovic
INTRODUCTION: Behavioral problems and emotional difficulties at children of the veterans of war with post-traumatic stress disorder (PTSD) have not been researched entirely. In our country, which has a lot of persons suffering from some psychological traumas, this trauma seems to continue. AIM: The aim of this study was to determine the exposure, manifestations of behavioral problems and emotional difficulties at children and early adolescents, whose fathers were the veterans of war demonstrating post-traumatic stress disorder symptoms...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28428187/zambian-peer-educators-for-hiv-self-testing-zest-study-rationale-and-design-of-a-cluster-randomised-trial-of-hiv-self-testing-among-female-sex-workers-in-zambia
#3
Catherine E Oldenburg, Katrina F Ortblad, Michael M Chanda, Kalasa Mwanda, Wendy Nicodemus, Rebecca Sikaundi, Andrew Fullem, Leah G Barresi, Guy Harling, Till Bärnighausen
BACKGROUND: HIV testing and knowledge of status are starting points for HIV treatment and prevention interventions. Among female sex workers (FSWs), HIV testing and status knowledge remain far from universal. HIV self-testing (HIVST) is an alternative to existing testing services for FSWs, but little evidence exists how it can be effectively and safely implemented. Here, we describe the rationale and design of a cluster randomised trial designed to inform implementation and scale-up of HIVST programmes for FSWs in Zambia...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28422814/the-effect-of-rubric-guided-focused-personalized-coaching-sessions-and-video-recorded-presentations-on-teaching-skills-among-fourth-year-medical-students-a-pilot-study
#4
Vatche Tchekmedyian, Helen M Shields, Stephen R Pelletier, Valeria C Pazo
PROBLEM: As medical students become residents, teaching becomes an expected and integral responsibility. Yet, training-for-teaching opportunities are lacking. In 2014, the authors designed a pilot study using rubric-guided, focused, personalized coaching sessions and video-recorded presentations to improve student teaching skills among fourth-year students at Harvard Medical School. APPROACH: In 2014-2015, the authors recruited students from an elective on how to tutor preclinical students for the pilot, which consisted of four phases: a precoaching teaching presentation, a 30- to 45-minute coaching session, a postcoaching teaching presentation, and blinded reviewer ratings...
April 18, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28417648/danish-translation-and-validation-of-kessler-s-10-item-psychological-distress-scale-k10
#5
Camilla Thelin, Benjamin Mikkelsen, Gunnar Laier, Louise Turgut, Bente Henriksen, Lis Raabaek Olsen, Jens Knud Larsen, Sidse Arnfred
BACKGROUND: Psychological distress is a trans-diagnostic feature of mental suffering closely associated with mental disorders. Kessler's 10-item Psychological Distress Scale (K10), a scale with sound psychometric properties, is widely used in epidemiological studies. AIM: To translate and investigate whether K10 is a reliable and valid rating scale for the measurement of psychological distress in a Danish population. METHODS: The translation was carried out according to official WHO translation guidelines...
April 18, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28407737/pain-in-amaxhosa-women-living-with-hiv-aids-a-cross-sectional-study-of-ambulant-outpatients
#6
Romy Parker, Jennifer Jelsma, Dan J Stein
BACKGROUND: Pain is one of the most commonly reported symptoms in people living with HIV/AIDS, whether or not they are receiving anti-retroviral therapy. A recent systematic review identified a paucity of studies exploring pain in women in low and middle income countries. The prevalence and characteristics of pain in women living with HIV/AIDS may differ from that of men as many chronic pain conditions are more prevalent in women. The aims of this study were to establish pain prevalence, characteristics and management in amaXhosa women living with HIV/AIDS...
April 13, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28405608/circadian-phase-resetting-by-a-single-short-duration-light-exposure
#7
Shadab A Rahman, Melissa A St Hilaire, Anne-Marie Chang, Nayantara Santhi, Jeanne F Duffy, Richard E Kronauer, Charles A Czeisler, Steven W Lockley, Elizabeth B Klerman
BACKGROUND. In humans, a single light exposure of 12 minutes and multiple-millisecond light exposures can shift the phase of the circadian pacemaker. We investigated the response of the human circadian pacemaker to a single 15-second or 2-minute light pulse administered during the biological night. METHODS. Twenty-six healthy individuals participated in a 9-day inpatient protocol that included assessment of dim light melatonin onset time (DLMO time) before and after exposure to a single 15-second (n = 8) or 2-minute (n = 12) pulse of bright light (9,500 lux; 4,100 K fluorescent) or control background dim light (<3 lux; n = 6)...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28400551/genetic-variants-of-ptpn2-are-associated-with-lung-cancer-risk-a-re-analysis-of-eight-gwass-in-the-tricl-ilcco-consortium
#8
Yun Feng, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Younghun Han, Rayjean J Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeboeller, Albert Rosenberger, Richard S Houlston, Neil E Caporaso, Maria Teresa Landi, Irene Brueske, Angela Risch, Yuanqing Ye, Xifeng Wu, David C Christiani, Christopher I Amos, Qingyi Wei
The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. In the present study, we first investigated associations of 5,162 single nucleotide polymorphisms (SNPs) in 43 genes of this TCPTP pathway with lung cancer risk by using summary data of six published genome-wide association studies (GWAS) of 12,160 cases and 16,838 controls. We identified 11 independent SNPs in eight genes after correction for multiple comparisons by a false discovery rate <0...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28395673/rural-community-disaster-preparedness-and-risk-perception-in-trujillo-peru
#9
Matthew Stewart, Bridget Grahmann, Ariel Fillmore, L Scott Benson
Introduction Disasters will continue to occur throughout the world and it is the responsibility of the government, health care systems, and communities to adequately prepare for potential catastrophic scenarios. Unfortunately, low-and-middle-income countries (LMICs) are especially vulnerable following a disaster. By understanding disaster preparedness and risk perception, interventions can be developed to improve community preparedness and avoid unnecessary mortality and morbidity following a natural disaster...
April 11, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28392808/consumer-preferences-for-food-allergen-labeling
#10
Carlo A Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott, Larry D Lynd
BACKGROUND: Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) and subsequent update (2012) suggesting that research is needed to guide further iterations of the regulation to improve food allergen labeling and reduce risk of exposure. OBJECTIVE: The primary objective of this study was to examine consumer preferences in food labeling for allergy avoidance and anaphylaxis prevention...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28384241/mental-ill-health-in-structural-pathways-to-women-s-experiences-of-intimate-partner-violence
#11
Mercilene T Machisa, Nicola Christofides, Rachel Jewkes
BACKGROUND: Depression, post-traumatic stress disorder (PTSD), and binge drinking are among mental health effects of child abuse and intimate partner violence (IPV) experiences among women. Emerging data show the potential mediating role of mental ill health in the relationship of child abuse and IPV. There is evidence that PTSD, depression and alcohol abuse are comorbid common mental disorders and that a bidirectional relationship exists between depression and IPV in some settings. Furthermore, the temporal direction in the relationship of alcohol abuse and women's IPV experiences from different studies is unclear...
2017: PloS One
https://www.readbyqxmd.com/read/28378036/engaging-with-dementia-moral-experiments-in-art-and-friendship
#12
Janelle S Taylor
The box-office as well as critical success of the 2014 major motion picture Still Alice, starring Julianne Moore in the title role and based on the bestselling novel of the same name by the Harvard-trained neuroscientist Lisa Genova (Still Alice. Simon & Schuster, New York, 2009), marked an important moment in public cultural representations of people with dementia. Still Alice tells the story of Alice Howland, an eminent scientist whose increasing memory lapses are eventually diagnosed as early-onset Alzheimer's, and chronicles the transformations in her family relationships as her husband and three children respond to her decline in different ways...
April 4, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28369256/entropy-based-consensus-clustering-for-patient-stratification
#13
Hongfu Liu, Rui Zhao, Hongsheng Fang, Feixiong Cheng, Yun Fu, Yang-Yu Liu
Motivation: Patient stratification or disease subtyping is crucial for precision medicine and personalized treatment of complex diseases. The increasing availability of high-throughput molecular data provides a great opportunity for patient stratification. Many clustering methods have been employed to tackle this problem in a purely data-driven manner. Yet, existing methods leveraging high-throughput molecular data often suffers from various limitations, e.g., noise, data heterogeneity, high dimensionality or poor interpretability...
March 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28366889/-the-latest-invasion-from-britain-young-rawls-and-his-community-of-american-ethical-theorists
#14
P MacKenzie Bok
This piece shows how other archives can complement the Rawls Papers at Harvard by reconstructing Rawls's community of ethical theorists in the 1950s and early 1960s. It casts new light on Rawls's early immersion in the nascent movement of American Wittgensteinianism at Cornell, and traces his involvement in a transatlantic group of philosophers doing "analytic ethics" with an emphasis on inductive logic in order to rebut the "emotive theory." It further illustrates how the willingness of Rawls and his contemporaries to question "the naturalistic fallacy" laid the groundwork for Rawls to build his own mature moral theory on natural foundations...
2017: Journal of the History of Ideas
https://www.readbyqxmd.com/read/28364446/randomized-prospective-study-of-the-impact-of-a-sleep-health-program-on-firefighter-injury-and-disability
#15
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
Study Objectives: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. Design: Prospective station-level randomized, field-based intervention...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28349405/quantitative-modeling-and-automated-analysis-of-meiotic-recombination
#16
Martin A White, Shunxin Wang, Liangran Zhang, Nancy Kleckner
Many morphological features, in both physical and biological systems, exhibit spatial patterns that are specifically characterized by a tendency to occur with even spacing (in one, two, or three dimensions). The positions of crossover (CO) recombination events along meiotic chromosomes provide an interesting biological example of such an effect. In general, mechanisms that explain such patterns may (a) be mechanically based, (b) occur by a reaction-diffusion mechanism in which macroscopic mechanical effects are irrelevant, or (c) involve a combination of both types of effects...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28349371/intraoral-salivary-duct-cyst-clinical-and-histopathologic-features-of-177-cases
#17
Ivan J Stojanov, Umer A Malik, Sook-Bin Woo
The salivary duct cyst (SDC) is a reactive ductal ectasia most frequently seen in major salivary glands, and likely caused by obstruction. The aim of this study is to define the clinical and histopathologic spectrum of intraoral SDCs. Cases were retrieved from the archives of Harvard School of Dental Medicine/StrataDx, Inc. from January 2012 to August 2014. There were 177 cases of which 103 (58.2%) occurred in females, with a median age of 56 (range 2-95). Approximately half of cases (45.8%) presented in the area of the buccal mucosa, lower lip mucosa, or mandibular vestibule, and 23...
March 27, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28343698/my-most-valuable-learning-experience-starting-a-business
#18
Alexander Jay Ryu
Alexander is a preliminary medicine resident at State University of New York Upstate Medical University and a recent graduate of Harvard Medical School. While in medical school, he cofounded Wizdy Games, a company developing mobile games that teach children to manage various health conditions, and PreMed Insiders, an advisory service for those considering or applying to medical school.
April 2017: Surgery
https://www.readbyqxmd.com/read/28343538/accelerated-hypofractionated-adjuvant-whole-breast-radiation-with-simultaneous-integrated-boost-using-volumetric-modulated-arc-therapy-for-early-breast-cancer-a-phase-i-ii-dosimetric-and-clinical-feasibility-study-from-a-tertiary-cancer-care-centre-of-india
#19
Dodul Mondal, Pramod Kumar Julka, Daya Nand Sharma, Manisha Jana, Macharla Anjaneyelu Laviraj, Suryanarayan Vs Deo, Soumyajit Roy, Randeep Guleria, Goura K Rath
BACKGROUND: Hypofractionation has become standard of care after Breast Conserving Therapy (BCT) in many European and few others western countries. Though still debatable, tumor cavity boost is routinely practised in our centre. Hypofractionation is not yet the current standard of practice in Asian countries. Employing hypofractionation and simultaneous integrated boost to lumpectomy cavity with conformal technique is not the current practice in this region. Hence the study was performed to see whether accelerated hypofractionation and simultaneous boost can be combined using volumetric modulated arc therapy (VMAT) in treating early breast cancer (EBC) patients...
March 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28334409/siapopr-a-computational-method-to-simulate-evolutionary-branching-trees-for-analysis-of-tumor-clonal-evolution
#20
Thomas O McDonald, Franziska Michor
Summary: SIApopr (Simulating Infinite-Allele populations) is an R package to simulate homogeneous and inhomogeneous stochastic branching processes under a very flexible set of assumptions using the speed of C ++. The software simulates clonal evolution with the emergence of driver and passenger mutations under the infinite-allele assumption. The software is an application of the Gillespie Stochastic Simulation Algorithm expanded to a large number of cell types and scenarios, with the intention of allowing users to easily modify existing models or create their own...
March 16, 2017: Bioinformatics
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