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Tumor embolization

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https://www.readbyqxmd.com/read/29789901/cell-differentiation-in-cardiac-myxomas-confocal-microscopy-and-gene-expression-analysis-after-laser-capture-microdissection
#1
Angela Pucci, Claudia Mattioli, Marco Matteucci, Daniele Lorenzini, Francesca Panvini, Simone Pacini, Chiara Ippolito, Michele Celiento, Andrea De Martino, Amelio Dolfi, Beatrice Belgio, Uberto Bortolotti, Fulvio Basolo, Giovanni Bartoloni
Cardiac myxomas are rare tumors with a heterogeneous cell population including properly neoplastic (lepidic), endothelial and smooth muscle cells. The assessment of neoplastic (lepidic) cell differentiation pattern is rather difficult using conventional light microscopy immunohistochemistry and/or whole tissue extracts for mRNA analyses. In a preliminary study, we investigated 20 formalin-fixed and paraffin-embedded cardiac myxomas by means of conventional immunohistochemistry; in 10/20 cases, cell differentiation was also analyzed by real-time RT-PCR after laser capture microdissection of the neoplastic cells, whereas calretinin and endothelial antigen CD31 immunoreactivity was localized in 4/10 cases by double immunofluorescence confocal microscopy...
May 22, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29785570/phase-1b-investigation-of-the-mek-inhibitor-binimetinib-in-patients-with-advanced-or-metastatic-biliary-tract-cancer
#2
R S Finn, D H Ahn, M M Javle, B R Tan, C D Weekes, J C Bendell, A Patnaik, G N Khan, D Laheru, R Chavira, J Christy-Bittel, E Barrett, M B Sawyer, Tanios S Bekaii-Saab
Background The MAPK pathway plays a central role in regulation of several cellular processes, and its dysregulation is a hallmark of biliary tract cancer (BTC). Binimetinib (MEK162), a potent, selective oral MEK1/2 inhibitor, was assessed in patients with advanced BTC. Patients and Methods An expansion cohort study in patients who received ≤1 line of therapy for advanced BTC was conducted after determination of the maximum tolerated dose in this Phase 1 trial. Patients received binimetinib 60 mg twice daily...
May 22, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29780907/calcified-amorphous-tumor-a-rare-cause-of-central-retinal-artery-occlusion
#3
Jeffrey H Ma, Manjot K Gill
Purpose: We report the case of a central retinal artery occlusion secondary to presumed embolus from a calcified amorphous tumor of the heart, a very rare non-neoplastic cardiac mass. Observations: A 60-year-old female presented with acute unilateral vision loss of the left eye. Examination revealed hand motion visual acuity of the left eye and a left relative afferent pupillary defect. Fundoscopy showed whitening of the macula with a cherry red spot, consistent with a central retinal artery occlusion...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29777888/primary-intracranial-rhabdomyosarcoma-in-the-cerebellopontine-angle-resected-after-preoperative-embolization
#4
Keisuke Yoshida, Tomoru Miwa, Takenori Akiyama, Masaaki Nishimoto, Dai Kamamoto, Kazunari Yoshida
BACKGROUND: Primary intracranial rhabdomyosarcoma is a very rare malignant tumor. Due to moderately vascular and firm characteristics of the tumor, complete removal without complications is often difficult. Moreover, in pediatric patients, the volume of total blood is less than adults and minimal intraoperative hemorrhage is desirable. CASE DESCRIPTION: A 6-year-old boy presented with ataxia and was found to have a large cerebellopontine angle tumor and hydrocephalus...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29774484/effect-of-post-filter-anticoagulation-on-mortality-in-patients-with-cancer-associated-pulmonary-embolism
#5
Jieun Kang, Seon Ok Kim, Yeon-Mok Oh, Sang-Do Lee, Jae Seung Lee
BACKGROUND: Malignancy is associated with an increased risk of venous thromboembolism. Inferior vena cava filters are a viable alternative when anticoagulation is infeasible because of the risk of bleeding. Although the current guidelines recommend that all patients with a vena cava filter be treated with anticoagulation treatment when the risk of bleeding is reduced, studies concerning the role of concomitant anticoagulation after vena cava filter insertion in high-risk patients are scarce...
May 17, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29765823/the-natural-growth-rate-of-residual-juvenile-angiofibroma
#6
Nicholas R Rowan, Amanda L Stapleton, Molly E Heft-Neal, Paul A Gardner, Carl H Snyderman
Objectives  Examine the postoperative growth rate of residual juvenile angiofibroma (JA) in a large series of patients relative to pediatric growth parameters and other prognostic factors. Establish an algorithm for postoperative surveillance of patients with JA. Design  Retrospective case series. Setting  Tertiary referral academic center. Participants  Pediatric patients undergoing surgical resection of JA between September 2005 and June 2015. Main Outcome Measures  Postoperative recurrence and tumor growth rates...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29761151/endoscopic-ultrasound-guided-choledochoduodenostomy-as-palliative-treatment-a-challenging-case-report
#7
Helena Ribeiro, Richard Azevedo, Ana Caldeira, Rui Sousa, Eduardo Pereira, António Banhudo
We report the case of an 88-year-old female with obstructive jaundice due to a periampullary tumor. The patient developed acute cholangitis and consequent clinical deterioration, so it was decided to perform palliative biliary drainage. Due to duodenal tumor invasion, it was not possible to perform endoscopic retrograde cholangiopancreatography. A different approach was attempted and it was decided to carry out an endoscopic ultrasound-guided choledochoduodenostomy. This procedure was performed with a linear echoendoscope, and using a duodenal bulbar approach, a fistula was created between the bulb and the common bile duct...
April 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29754849/combination-therapies-quantifying-the-effects-of-transarterial-embolization-on-microwave-ablation-zones
#8
Erica M Knavel, Chelsey M Green, Annette Gendron-Fitzpatrick, Christopher L Brace, Paul F Laeseke
PURPOSE: To quantify the effect of transarterial embolization on microwave (MW) ablations in an in vivo porcine liver model. MATERIALS AND METHODS: Hepatic arteriography and cone-beam computed tomography (CT) scans were performed in 6 female domestic swine. Two lobes were embolized to an endpoint of substasis with 100-300-μm microspheres. MW ablations (65 W, 5 min) were created in embolized (n = 15) and nonembolized (n = 12) liver by using a 2.45-GHz system and single antenna...
May 10, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29752139/intraprocedural-parenchymal-blood-volume-is-a-predictor-of-treatment-response-for-chemoembolization-in-hepatocellular-carcinoma-results-of-a-prospective-study
#9
Nevin de Korompay, Mohammed Alshammari, Darren Klass, Frank Y Chou, John Chung, Stephen Ho, David M Liu
PURPOSE: To evaluate cone-beam parenchymal blood volume (PBV) before and after embolization as a predictor of radiographic response to transarterial chemoembolization in unresectable hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A phase IIa prospective clinical trial was conducted in patients with HCCs > 1.5 cm undergoing chemoembolization; 52 tumors in 40 patients with Barcelona Clinic Liver Criteria stage B disease met inclusion criteria. Pre- and postembolization PBV analysis was performed with a semiquantitative best-fit methodology for index tumors, with a predefined primary endpoint of radiographic response at 3 months...
May 8, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29751190/preoperative-embolization-of-skull-base-meningiomas-outcomes-in-the-onyx-era
#10
Colin J Przybylowski, Jacob F Baranoski, Alfred P See, Bruno C Flores, Rami O Almefty, Dale Ding, Kristina M Chapple, Nader Sanai, Andrew F Ducruet, Felipe C Albuquerque
OBJECTIVE: Preoperative embolization may facilitate skull base meningioma resection, but its safety and efficacy in the Onyx era have not been investigated. In this retrospective cohort study, we evaluated the outcomes of preoperative embolization of skull base meningiomas using Onyx as the primary embolysate. METHODS: We queried an endovascular database for patients with skull base meningiomas who underwent preoperative embolization at our institution in 2007-2017...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29744090/stepwise-management-of-hepatocellular-carcinoma-associated-with-abernethy-syndrome
#11
Niki Christou, Nabil Dib, Etienne Chuffart, Abdelkader Taibi, Sylvaine Durand-Fontanier, Denis Valleix, Muriel Mathonnet
Patients with congenital agenesis of the portal vein may develop hepatocellular tumors due to enhanced arterial blood flow. These tumors may be benign (FNH, adenomas) or malignant (hepatoblastoma, HCC). Liver resection can be proposed, and preoperative arterial embolization may decrease blood loss during surgery. Liver transplantation with PV reconstruction is also an option.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29735260/analysis-of-preoperative-portal-vein-embolization-outcomes-in-patients-with-hepatocellular-carcinoma-a-single-center-experience
#12
Josep Marti, Massimo Giacca, Kutaiba Alshebeeb, Sumeet Bahl, Charles Hua, Jeremy C Horn, Jad BouAyache, Rahul Patel, Marcelo Facciuto, Myron Schwartz, Sander Florman, Edward Kim, Ganesh Gunasekaran
PURPOSE: To analyze outcomes of patients with hepatocellular carcinoma (HCC) undergoing preoperative portal vein embolization (PVE). MATERIALS AND METHODS: A retrospective analysis of survival, recurrence, and complications was performed in 82 patients with HCC undergoing preoperative PVE and surgical treatment with curative intention from June 2006 to December 2014. RESULTS: Rate of major adverse events after PVE was 11% with no mortality...
May 5, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29735258/outcomes-of-pulmonary-artery-embolization-and-stent-graft-placement-for-the-treatment-of-hemoptysis-caused-by-lung-tumors
#13
Clément Marcelin, Jérome Soussan, Florian Desmots, Jean-Yves Gaubert, Vincent Vidal, Jean Michel Bartoli, Jean Izaaryene
PURPOSE: To evaluate the safety and efficacy of endovascular management of pulmonary artery lesions caused by lung tumors. MATERIALS AND METHODS: Nineteen patients (15 men, 4 women; average age: 60.3 years, range, 51-86 years) treated for massive or recurrent hemoptysis with transarterial pulmonary artery embolization between 2010 and 2016 were included in this multicenter, retrospective study. Inclusion criteria were: patients with lung cancer and at least 1 episode of hemoptysis with a pulmonary artery lesion detected by computed tomography (CT) angiography or after failed bronchial artery embolization...
May 5, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29732093/diketopyrrolopyrrole-based-semiconducting-polymer-nanoparticles-for-in-vivo-second-near-infrared-window-imaging-and-image-guided-tumor-surgery
#14
Kangquan Shou, Yufu Tang, Hao Chen, Si Chen, Lei Zhang, Ao Zhang, Quli Fan, Aixi Yu, Zhen Cheng
A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000-1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution...
March 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29729821/a-pediatric-carotid-body-tumor
#15
Anthony R Hogan, Juan E Sola, Sarah C Jernigan, Eric C Peterson, Ramzi T Younis
Carotid body tumors are rare childhood extra-adrenal paragangliomas. We present an 8-year old female with a neck mass mistaken as reactive lymphadenopathy. Computed tomography and magnetic resonance angiography, as well as preoperative embolization and balloon test occlusion, were utilized for planning and management. Surgical excision of the tumor was successful and pathological examination revealed a benign paraganglioma. Surgical treatment is curative for these benign lesions, however rare cases have presented years later with metastatic disease...
April 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29727331/10th-anniversary-of-alpps-lessons-learned-and-quo-vadis
#16
Hauke Lang, Eduardo de Santibañes, Hans J Schlitt, Massimo Malagó, Thomas van Gulik, Marcel A Machado, Elio Jovine, Stefan Heinrich, Giuseppe Maria Ettorre, Albert Chan, Roberto Hernandez-Alejandro, Ricardo Robles Campos, Per Sandström, Michael Linecker, Pierre-Alain Clavien
OBJECTIVE: Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has been tested in various indications and clinical scenarios, leading to steady improvements in safety. This report presents the current status of ALPPS. SUMMARY BACKGROUND DATA: ALPPS offers improved resectability, but drawbacks are regularly pointed out regarding safety and oncologic benefits. METHODS: During the 12th biennial congress of the European African-Hepato-Pancreato-Biliary Association (Mainz, Germany, May 23-26, 2017) an expert meeting "10th anniversary of ALPP" was held to discuss indications, management, mechanisms of regeneration, as well as pitfalls of this novel technique...
May 1, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29725882/a-rare-case-of-a-spontaneously-ruptured-secondary-hepatic-malignant-lymphoma
#17
Ko Oshita, Toshiyuki Itamoto, Akihiko Oshita, Hideki Nakahara, Takashi Nishisaka
BACKGROUND: Although secondary liver involvement of the lymphoma is common and occurs in 50% of patients with non-Hodgkin's lymphoma, liver tumor rupture in malignant lymphoma is extremely rare. We report a case of a spontaneously ruptured secondary liver involvement of non-Hodgkin's lymphoma that was successfully treated with transcatheter arterial embolization (TAE) to obtain hemostasis, and subsequent hepatectomy and systemic chemotherapy. To the best of our knowledge, this is only the second reported case of a ruptured hepatic lymphoma...
May 3, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29724521/chemoembolization-of-hepatocellular-carcinoma-with-drug-eluting-polyethylene-glycol-embolic-agents-single-center-retrospective-analysis-in-302-patients
#18
Filipe Veloso Gomes, João A Oliveira, Mariana Tomé Correia, Nuno Vasco Costa, João Abrantes, Daniel Torres, Pedro Pereira, Ana Isabel Ferreira, José Hugo Luz, Erik Spaepen, Tiago Bilhim, Élia Coimbra
PURPOSE: To evaluate the efficacy and safety of transarterial chemoembolization with polyethylene glycol (PEG) drug-eluting embolic agents in the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A single-center retrospective study of 302 patients (258 men; 85.4%) with HCC treated during a 20-month period was conducted. The mean patient age was 66 years ± 10; 142 (47%) had Barcelona Clinic Liver Cancer stage A disease and 134 had (44.4%) stage B disease; 174 (57...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29724419/acr-appropriateness-criteria-%C3%A2-radiologic-management-of-uterine-leiomyomas
#19
M-Grace Knuttinen, Gregory Stark, Eric J Hohenwalter, Linda D Bradley, Aaron R Braun, Matthew G Gipson, Charles Y Kim, Jason W Pinchot, Matthew J Scheidt, David M Sella, Clifford R Weiss, Jonathan M Lorenz
Uterine fibroids, also known as leiomyomas, are the most common benign tumor in women of reproductive age. When symptomatic, these patients can present with bleeding and/or bulk-related symptoms. Treatment options for symptomatic uterine leiomyomas include medical management, minimally invasive treatment such as uterine artery embolization, and surgical options, such as myomectomy. It is important to understand the role of these treatment options in various clinical scenarios so that appropriate consultation is performed...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29724061/gastrodoudenal-embolization-indications-technical-pearls-and-outcomes
#20
REVIEW
Gokhan Kuyumcu, Igor Latich, Rulon L Hardman, Gabriel C Fine, Rahmi Oklu, Keith B Quencer
The gastroduodenal artery (GDA) is frequently embolized in cases of upper GI bleed that has failed endoscopic therapy. Additionally, it may be done for GDA pseudoaneurysms or as an adjunctive procedure prior to Yttrim-90 (Y90) treatment of hepatic tumors. This clinical review will summarize anatomy and embryology of the GDA, indications, outcomes and complications of GDA embolization.
May 2, 2018: Journal of Clinical Medicine
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