keyword
https://read.qxmd.com/read/37644177/-new-developments-in-the-fight-against-bacterial-infections-update-on-antiobiotic-research-development-and-treatment
#1
REVIEW
Miriam Stegemann, Ulrike Trost
Infections caused by pathogens with antimicrobial resistance (AMR) pose a threat to modern healthcare and have triggered the development of comprehensive national and global action plans against the spread of AMR. These include an increasing global network with the focus on rational antibiotic use, innovative strategies on antibiotic research and development, and new therapeutic approaches in antibacterial drug research. In Europe 671,689 infections associated with AMR pathogens and 33,110 deaths directly related to AMR were counted in just 1 year...
August 29, 2023: Inn Med (Heidelb)
https://read.qxmd.com/read/33381838/supervised-learning-on-phylogenetically-distributed-data
#2
JOURNAL ARTICLE
Elliot Layne, Erika N Dort, Richard Hamelin, Yue Li, Mathieu Blanchette
MOTIVATION: The ability to develop robust machine-learning (ML) models is considered imperative to the adoption of ML techniques in biology and medicine fields. This challenge is particularly acute when data available for training is not independent and identically distributed (iid), in which case trained models are vulnerable to out-of-distribution generalization problems. Of particular interest are problems where data correspond to observations made on phylogenetically related samples (e...
December 30, 2020: Bioinformatics
https://read.qxmd.com/read/28946850/bordetella-bronchiseptica-pneumonia-in-a-patient-with-lung-cancer-a-case-report-of-a-rare-infection
#3
JOURNAL ARTICLE
Manlio Monti, Danila Diano, Francesco Allegrini, Angelo Delmonte, Valentina Fausti, Paola Cravero, Giulia Marcantognini, Giovanni Luca Frassineti
BACKGROUND: Bordetella bronchiseptica (B.bronchiseptica) is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. We present a rare case of B. bronchiseptica pneumonia in a patient with lung cancer. CASE PRESENTATION: A 52-year-old white male with non small cell lung cancer developed fever during treatment with nivolumab. A persistent productive cough and a deterioration in his clinical condition led to his hospitalization for evaluation...
September 25, 2017: BMC Infectious Diseases
https://read.qxmd.com/read/28573366/-antibiotic-stewardship%C3%A2-2-0-individualization-of-therapy
#4
REVIEW
M W Pletz, E Tacconelli, T Welte
Antibiotic resistance is a part of bacterial evolution and therefore unavoidable. In the context of missing novel treatment options, the restrictive use of available antibiotics in order to decelerate the spread of resistance is of high importance. This is the aim of Antibiotic Stewardship (ABS). ABS consists of two sides: a structural one and an individual one. The former deals with the formation of ABS teams, the analysis of antibiotic usage and resistance development, and the implementation of certain measures to improve antibiotic use; the latter is reflected by concrete bedside decisions: How can (broad) spectrum antibiotics be spared without harming the patient? This can be achieved, for example, by de-escalation, limiting duration of treatment, and avoiding nonindicated use...
July 2017: Der Internist
https://read.qxmd.com/read/22905060/antiobiotic-resistance-pattern-of-biofilm-forming-uropathogens-isolated-from-catheterised-patients-in-pondicherry-india
#5
JOURNAL ARTICLE
Pramodhini Subramanian, Niveditha Shanmugam, Umadevi Sivaraman, Shailesh Kumar, Stephen Selvaraj
BACKGROUND: Microbial biofilms pose a public health problem for persons requiring indwelling medical devices, as micro-organisms in biofilms are difficult to treat with antimicrobial agents. Thus the present study includes biofilm formation and antibiotic resistance pattern of uropathogens in hospitalised patients with catheter associated urinary tract infections (UTI). METHOD: This prospective analysis included 100 urine samples from catheterised patients with symptoms of UTI over a period of six months...
2012: Australasian Medical Journal
https://read.qxmd.com/read/21451505/effect-of-abcc2-mrp2-transport-function-on-erythromycin-metabolism
#6
COMPARATIVE STUDY
R M Franke, C S Lancaster, C J Peer, A A Gibson, A M Kosloske, S J Orwick, R H Mathijssen, W D Figg, S D Baker, A Sparreboom
The macrolide antiobiotic erythromycin undergoes extensive hepatic metabolism and is commonly used as a probe for cytochrome P450 (CYP) 3A4 activity. By means of a transporter screen, erythromycin was identified as a substrate for the transporter ABCC2 (MRP2) and its murine ortholog, Abcc2. Because these proteins are highly expressed on the biliary surface of hepatocytes, we hypothesized that impaired Abcc2 function may influence the rate of hepatobiliary excretion and thereby enhance erythromycin metabolism...
May 2011: Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/16642899/study-children-may-get-antibiotics-too-often
#7
JOURNAL ARTICLE
(no author information available yet)
Unnecessary use of antibiotics can endanger patients, increase bacteria resistance, and result in added expenditures. There are only four appropriate medications that should be given to children in whom strep is suspected. You may wish to consider giving Group A beta-hemolytic streptococcus test to children before prescribing an antiobiotic. Staff also should take into consideration whether the patient has been exposed to friends or relatives with strep.
April 2006: ED Management: the Monthly Update on Emergency Department Management
https://read.qxmd.com/read/14270126/-treatment-of-experimental-dysentery-produced-by-antiobiotic-resistant-strains-of-flexner-s-bacillus-with-a-combination-of-an-antibiotic-and-a-preparation-increasing-immunogenesis
#8
JOURNAL ARTICLE
https://read.qxmd.com/read/11400196/determination-of-gatifloxacin-in-human-plasma-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#9
JOURNAL ARTICLE
K Vishwanathan, M G Bartlett, J T Stewart
Gatifloxacin is an advanced-generation, 8-methoxyfluoroquinolone that is active against a broad spectrum of pathogens, including antiobiotic resistant Streptococcus pneumoniae. Development of a rapid, sensitive and selective method for the determination of gatifloxacin in human plasma is essential for understanding the pharmacokinetics of the drug when administered orally or intravenously. Solid phase extraction (SPE) using Oasis HLB was used to extract gatifloxacin and the internal standard ciprofloxacin from plasma...
2001: Rapid Communications in Mass Spectrometry: RCM
https://read.qxmd.com/read/11131955/resistance-in-respiratory-tract-pathogens-an-international-study-1997-1998
#10
JOURNAL ARTICLE
C Thornsberry, D F Sahm
Multiple antibiotic resistance threatens current treatment for community-acquired pneumonia (CAP). This paper presents a summary of resistance data for Streptococcus pneumoniae (6,223 isolates), Haemophilus influenzae (4,016) and Moraxella catarrhalis (1,263) collected from 153 centers throughout Japan, China, UK, Germany, Spain, France, Italy, Brazil and USA. Antiobiotics tested were: beta-lactams (penicillin, ampicillin, co-amoxiclav, cefuroxime, and ceftriaxone), macrolides (azithromycin and clarithromycin), sulphonamide (trimethoprim-sulfamethoxazole), glycopeptide (vancomycin) and fluoroquinolone (levofloxacin)...
October 2000: Journal of Chemotherapy
https://read.qxmd.com/read/10456609/successful-interventions-for-gram-negative-resistance-to-extended-spectrum-beta-lactam-antiobiotics
#11
REVIEW
L B Rice
Antibiotic resistance among nosocomial pathogens in this country's hospitals adds significantly to patient morbidity and mortality, and the cost of health care. Optimism for identifying antimicrobial agents that would "solve the problem" of resistance has been replaced by a much more guarded and realistic view of the battle between humans and pathogenic microorganisms. Efforts now are more appropriately directed toward limiting, rather than completely eliminating, resistance, generally by either infection control or antibiotic control measures, and sometime combinations of the two...
August 1999: Pharmacotherapy
https://read.qxmd.com/read/8972139/characterisation-and-identification-of-broad-spectrum-antibiotic-producing-streptomyces-hygroscopicus-d-1-5
#12
JOURNAL ARTICLE
D Chakraborty, B Mondal, S C Pal, S K Sen
A streptomycete strain D1.5 capable of producing broad spectrum antiobiotic was isolated from soil. The morphological, cultural, physiological and biochemical characters were studied, compared to known species and identified as Streptmoyces hygroscopicus. Antibiotic activity of the strain was tested against both Gram positive and negative bacteria as well as fungi. It exhibited complete resistance to beta-lactum antibiotics.
February 1995: Hindustan Antibiotics Bulletin
https://read.qxmd.com/read/8067731/influence-of-antimicrobial-therapy-on-kinetics-of-tumor-necrosis-factor-levels-in-experimental-endocarditis-caused-by-klebsiella-pneumoniae
#13
JOURNAL ARTICLE
J Mohler, B Fantin, J L Mainardi, C Carbon
The kinetics of tumor necrosis factor (TNF) levels in serum during therapy with cell wall-active agents (ceftriaxone, imipenem) and gentamicin were investigated in rabbits with experimental endocarditis caused by an isogenic pair of Klebsiella pneumoniae strains: a TEM-3 beta-lactamase-producing strain (KpR) or its susceptible variant (KpS). In vitro, KpR was resistant to ceftriaxone and was susceptible to gentamicin and imipenem, while KpS was susceptible to all three antibiotics. Serum TNF levels were determined in control rabbits hourly after bacterial inoculation and then daily; they were determined in treated animals hourly after the first antibiotic injection and then daily during a 4-day therapy with either imipenem (60 mg/kg of body weight four times daily), ceftriaxone (75 mg/kg once daily), or gentamicin (4 mg/kg once daily) alone or in combination with ceftriaxone...
May 1994: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/7768640/effect-of-vesicle-size-and-lipid-composition-on-the-in-vivo-tumor-selectivity-and-toxicity-of-the-non-cross-resistant-anthracycline-annamycin-incorporated-in-liposomes
#14
JOURNAL ARTICLE
Y Zou, Y H Ling, S Reddy, W Priebe, R Perez-Soler
Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivity and toxicity of Ann. Entrapment of Ann in multilamellar vesicles (L-Ann) resulted in a 20% lower heart AUC and a 30-40% higher tumor and liver AUC. Reduction of the liposome size from 1.6 to 0...
May 29, 1995: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/7766020/a-close-correlation-between-improvement-of-organic-solvent-tolerance-levels-and-alteration-of-resistance-toward-low-levels-of-multiple-antibiotics-in-escherichia-coli
#15
JOURNAL ARTICLE
R Aono, M Kobayashi, H Nakajima, H Kobayashi
We have isolated cyclohexane-tolerant mutants from Escherichi coli strain JA300, which is cyclohexane-sensitive and n-hexane-tolerant. These mutants were resistant to low levels of ampicillin, chloramphenicol, nalidixic acid, and tetracycline, and were sensitive to a low level of kanamycin. Spontaneous clones resistant to low levels of the antibiotics, isolated from JA300, showed altered levels of organic solvent tolerance. The clones resistant to ampicillin and chloramphenicol had cyclohexane tolerance. Some of the resistant clones had cyclohexane and n-pentane tolerances...
February 1995: Bioscience, Biotechnology, and Biochemistry
https://read.qxmd.com/read/7031249/transferable-plasmid-mediated-antibiotic-resistance-in-bacteroides
#16
JOURNAL ARTICLE
V O Rotimi, B I Duerden, S Hafiz
Plasmid-mediated resistance to chloramphenicol (Chlr), erythromycin (Eryr), tetracycline (Tetr) and clindamycin (Clindr) was transferred from three clinical isolates of Bacteroides fragilis and one faecal isolate of B. thetaiotaomicron to strains of B. fragilis, B. distasonis and Escherichia coli, and subsequently to B. fragilis and E. coli second-and third-stage recipients in series. Successful transfer was achieved by membrane-filter and centrifugation techniques that provide stable cell-to-cell contact but not by simple mixed broth culture...
November 1981: Journal of Medical Microbiology
https://read.qxmd.com/read/4199293/-antiobiotic-sensitivity-of-tubercular-bacilli-recently-isolated-in-dakar
#17
JOURNAL ARTICLE
M Castets, D de Souza, Y Vézard
No abstract text is available yet for this article.
1972: Bulletin de la Société Médicale D'Afrique Noire de Langue Française
https://read.qxmd.com/read/1122127/-sensitivity-of-certain-strains-of-pathogenic-leptospira-to-streptomycin-the-nature-of-resistant-variants-and-the-frequency-of-their-occurrence
#18
JOURNAL ARTICLE
E M Petrov, I G Chernukha
Streptomycin sensitivity of 112 Leptospira strains isolated from domestic and wild animals was studied. Independent of the isolation period and nature the strains proved to be highly sensitive to the antiobiotic (MIC 0.1 to 0.5 gamma/ml). On the example of a clone strain of Leptospira it was shown with a fluctuation test that streptomycin resistance occurred spontaneously. Frequency of the streptomycin resistant mutations was determined for 5 clone strains of L. interrogans. It was 10-9 to 10-7 per a Leptospira...
January 1975: Antibiotiki
https://read.qxmd.com/read/1110938/-sensitivity-of-candida-strains-isolated-from-bile-to-some-antifungal-antiobiotics-from-the-polyene-group
#19
JOURNAL ARTICLE
D Lipnicki, J Zamiechowska-miazga
No abstract text is available yet for this article.
January 13, 1975: Polski Tygodnik Lekarski
https://read.qxmd.com/read/1105566/restriction-endonuclease-analysis-of-mitochondrial-dna-from-grande-and-genetically-characterized-cytoplasmic-petite-clones-of-saccharomyces-cerevisiae
#20
JOURNAL ARTICLE
R Morimoto, A Lewin, H J Hsu, M Rabinowitz, H Fukuhara
Digestion of grande mitochondrial DNA (mtDNA) BY EcoRI restriction endonuclease gives rise to nine fragments with a total molecular weight of 51.8 x 10(6). HindIII digestion yields six fragments with a similar total molecular weight. Specific restriction fragments can be detected despite the fact that yeast mtDNA consists of a heterogeneous distribution of randomly broken molecules. Digestion patterns of 10 genetically characterized petite clones containing various combinations of five antiobiotic resistance markers indicate that the petite mtDNA predominantly represents deletion of the grande genome...
October 1975: Proceedings of the National Academy of Sciences of the United States of America
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