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post-interferon syndrome

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https://www.readbyqxmd.com/read/28721309/retinal-pigment-epithelial-cells-are-a-potential-reservoir-for-ebola-virus-in-the-human-eye
#1
Justine R Smith, Shawn Todd, Liam M Ashander, Theodosia Charitou, Yuefang Ma, Steven Yeh, Ian Crozier, Michael Z Michael, Binoy Appukuttan, Keryn A Williams, David J Lynn, Glenn A Marsh
PURPOSE: Success of Ebola virus (EBOV) as a human pathogen relates at the molecular level primarily to blockade the host cell type I interferon (IFN) antiviral response. Most individuals who survive Ebola virus disease (EVD) develop a chronic disease syndrome: approximately one-quarter of survivors suffer from uveitis, which has been associated with presence of EBOV within the eye. Clinical observations of post-Ebola uveitis indicate involvement of retinal pigment epithelial cells. METHODS: We inoculated ARPE-19 human retinal pigment epithelial cells with EBOV, and followed course of infection by immunocytochemistry and measurement of titer in culture supernatant...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28689166/ocular-surface-cytokine-profile-in-chronic-stevens-johnson-syndrome-and-its-response-to-mucous-membrane-grafting-for-lid-margin-keratinisation
#2
Srividya Gurumurthy, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal, Narayanasamy Angayarkanni
BACKGROUND: To study the tear cytokine and the conjunctival and oral mucosal marker profile in chronic ocular Stevens-Johnson syndrome (SJS) and their alteration following mucous membrane grafting (MMG) for lid margin keratinisation (LMK). METHODS: In a 1-year prospective study, SJS cases (n=25) and age-matched/sex-matched healthy controls (n=25) were recruited. Tear specimen (Schirmer's strip), conjunctival and oral mucosal imprints were collected from controls and SJS cases pre-MMG and post-MMG (at first follow-up, n=17)...
July 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28681506/safety-and-pharmacodynamics-of-intranasal-gsk2245035-a-tlr7-agonist-for-allergic-rhinitis-a-randomized-trial
#3
Anne K Ellis, Daphne C Tsitoura, Diana Quint, William Powley, Laurie A Lee
BACKGROUND: Toll-like receptor 7 (TLR7) stimulation in the airways may reduce responses to aeroallergens by induction of type 1 interferons (IFNs). GSK2245035 is a novel selective TLR7 agonist in pharmaceutical development. OBJECTIVE: Assessment of safety, pharmacodynamics and nasal allergic reactivity following repeated weekly intranasal (i.n.) GSK2245035. METHODS: This randomized, double-blind, placebo-controlled study (TL7116958) was conducted over two pollen seasons (2013-2014) and follow-up study (204509) conducted one year later...
July 5, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28611852/cnv-analysis-of-host-responses-to-porcine-reproductive-and-respiratory-syndrome-virus-infection
#4
El Hamidi A Hay, Igseo Choi, Lingyang Xu, Yang Zhou, Robert R R Rowland, Joan K Lunney, George E Liu
Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease with a significant impact on the swine industry causing major economic losses. The objective of this study is to examine copy number variations (CNVs) associated with the group-specific host responses to PRRS virus infection. We performed a genome-wide CNV analysis using 660 animals genotyped with on the porcine SNP60 BeadChip and discovered 7097 CNVs and 271 CNV regions (CNVRs). For this study, we used two established traits related to host response to the virus, i...
2017: Journal of Genomics
https://www.readbyqxmd.com/read/28536674/anti-idiotypic-antibodies-specific-to-prm-monoantibody-prevent-antibody-dependent-enhancement-of-dengue-virus-infection
#5
Miao Wang, Fan Yang, Dana Huang, Yalan Huang, Xiaomin Zhang, Chao Wang, Shaohua Zhang, Renli Zhang
Dengue virus (DENV) co-circulates as four serotypes (DENV1-4). Primary infection only leads to self-limited dengue fever. But secondary infection with another serotype carries a higher risk of increased disease severity, causing life-threatening dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Serotype cross-reactive antibodies facilitate DENV infection in Fc-receptor-bearing cells by promoting virus entry via Fcγ receptors (FcγR), a process known as antibody dependent enhancement (ADE). Most studies suggested that enhancing antibodies were mainly specific to the structural premembrane protein (prM) of DENV...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28457368/eradication-of-hepatitis-c-after-liver-transplantion-consequences-for-the-organization-of-the-transplant-patient-s-follow-up
#6
G Piai, L Miglioresi, G Valente
The recurrence of the hepatitis C virus (HCV) in the liver graft has been so far the main cause of morbidity and mortality in post-transplantation patients. The treatment has significantly committed the resources of transplant hepatologists despite the poor results obtained with the past standard treatment with the use of interferon plus ribavirin. The new direct-acting antivirals (DAAs) are safe and effective even in the transplant setting, and our purpose was to check whether the eradication of HCV can make predominant other clinical problems that require different skills from those classic to hepatology...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28439892/cerebrospinal-fluid-cyto-chemokine-profile-during-acute-herpes-simplex-virus-induced-anti-n-methyl-d-aspartate-receptor-encephalitis-and-in-chronic-neurological-sequelae
#7
Kavitha Kothur, Deepak Gill, Melanie Wong, Shekeeb S Mohammad, Sushil Bandodkar, Susan Arbunckle, Louise Wienholt, Russell C Dale
AIM: To examine the cytokine/chemokine profile of cerebrospinal fluid (CSF) during acute herpes simplex virus-induced N-methyl-d-aspartate receptor (NMDAR) autoimmunity and in chronic/relapsing post-herpes simplex virus encephalitis (HSE) neurological syndromes. METHOD: We measured longitudinal serial CSF cyto-/chemokines (n=34) and a glial marker (calcium-binding astroglial protein, S100B) in one patient during acute HSE and subsequent anti-NMDAR encephalitis, and compared the results with those from two patients with anti-NMDAR encephalitis without preceding HSE...
August 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28438633/structural-insights-into-the-interaction-of-coronavirus-papain-like-proteases-and-interferon-stimulated-gene-product-15-from-different-species
#8
Courtney M Daczkowski, John V Dzimianski, Jozlyn R Clasman, Octavia Goodwin, Andrew D Mesecar, Scott D Pegan
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) encode multifunctional papain-like proteases (PLPs) that have the ability to process the viral polyprotein to facilitate RNA replication and antagonize the host innate immune response. The latter function involves reversing the post-translational modification of cellular proteins conjugated with either ubiquitin (Ub) or Ub-like interferon-stimulated gene product 15 (ISG15). Ub is known to be highly conserved among eukaryotes, but surprisingly, ISG15 is highly divergent among animals...
June 2, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28403874/intranasal-immunization-of-pigs-with-porcine-reproductive-and-respiratory-syndrome-virus-like-particles-plus-2-3-cgamp-vaccigrade%C3%A2-adjuvant-exacerbates-viremia-after-virus-challenge
#9
Alexandria Van Noort, April Nelsen, Angela E Pillatzki, Diego G Diel, Feng Li, Eric Nelson, Xiuqing Wang
BACKGROUND: Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failure in pregnant sows and acute respiratory disease in young pigs. It is a leading infectious agent of swine respiratory complex, which has significant negative economic impact on the swine industry. Commercial markets currently offer both live attenuated and killed vaccines; however, increasing controversy exists about their efficacy providing complete protection. Virus-like particles (VLPs) possess many desirable features of a potent vaccine candidate and have been proven to be highly immunogenic and protective against virus infections...
April 12, 2017: Virology Journal
https://www.readbyqxmd.com/read/28365538/co-infection-with-hiv-associated-with-reduced-vulnerability-to-symptoms-of-depression-during-antiviral-treatment-for-hepatitis-c
#10
Renata Fialho, Marco Pereira, Neil Harrison, Jennifer Rusted, Richard Whale
In this prospective study, we examined new-onset major depressive disorder (MDD) and the differential expression of depressive symptoms in a sample of 132 HCV mono-infected and 40 HIV/HCV co-infected patients initiating pegylated interferon-based treatment, including protease inhibitor therapy. The semi-structured clinical interview (SCID-I) was used to assess MDD. Severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Of the total sample, 60 patients (34.9%) developed SCID-I defined MDD during antiviral treatment...
March 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28292546/novel-insights-into-host-responses-and-reproductive-pathophysiology-of-porcine-reproductive-and-respiratory-syndrome-caused-by-prrsv-2
#11
REVIEW
John C S Harding, Andrea Ladinig, Predrag Novakovic, Susan E Detmer, Jamie M Wilkinson, Tianfu Yang, Joan K Lunney, Graham S Plastow
A large challenge experiment using North American porcine reproductive and respiratory virus (PRRSV-2) provided new insights into the pathophysiology of reproductive PRRS. Deep phenotyping of dams and fetuses identified maternal and fetal predictors of PRRS severity and resilience. PRRSV infection resulted in dramatic decreases in all leukocyte subsets by 2days post inoculation. Apoptosis in the interface region was positively related to endometrial vasculitis, viral load in endometrium and fetal thymus, and odds of meconium staining...
March 2, 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28087284/pharmacological-and-surgical-therapy-for-the-central-giant-cell-granuloma-a-long-term-retrospective-cohort-study
#12
Willem Hans Schreuder, Henk van den Berg, Anne Marie Westermann, Zachary Scott Peacock, Jan de Lange
PURPOSE: This is a retrospective cohort study of patients with a central giant cell granuloma (CGCG) treated at a single center to assess and compare the different surgical and non-surgical approaches. MATERIAL AND METHODS: A cohort with a single histologically proven non-syndrome-related CGCG was selected and reviewed. Patients were allocated to group I (surgery), group II (pharmacotherapy), and group III (pharmacotherapy and surgery). The primary outcome was long-term radiologic response using computed tomography...
December 9, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27876202/an-interferon-inducing-porcine-reproductive-and-respiratory-syndrome-virus-vaccine-candidate-elicits-protection-against-challenge-with-the-heterologous-virulent-type-2-strain-vr-2385-in-pigs
#13
Eve Fontanella, Zexu Ma, Yanjin Zhang, Alessandra M M G de Castro, Huigang Shen, Patrick G Halbur, Tanja Opriessnig
Achieving consistent protection by vaccinating pigs against porcine reproductive and respiratory syndrome virus (PRRSV) remains difficult. Recently, an interferon-inducing PRRSV vaccine candidate strain A2MC2 was demonstrated to be attenuated and induced neutralizing antibodies. The objective of this study was to determine the efficacy of passage 90 of A2MC2 (A2P90) to protect pigs against challenge with moderately virulent PRRSV strain VR-2385 (92.3% nucleic acid identity with A2MC2) and highly virulent atypical PRRSV MN184 (84...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/27843537/retrospective-study-of-the-associations-between-hepatitis-c-virus-infection-and-metabolic-factors
#14
Shira Yair-Sabag, Elchanan Nussinson, Ofir Ben-Assuli, Fahmi Shibli, Azmi Shahbari, Shira Zelber-Sagi
AIM: To evaluate the bidirectional association between metabolic syndrome (MS) components and antiviral treatment response for chronic hepatitis C virus (HCV) infection. METHODS: This retrospective cohort study included 119 HCV + patients treated with pegylated-interferon-α and ribavirin. Metabolic characteristics and laboratory data were collected from medical records. Differences in baseline clinical and demographic risk factors between responders and non-responders were assessed using independent samples t-tests or χ(2) tests...
October 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27765052/distinct-functional-enrichment-of-transcriptional-signatures-in-pigs-with-high-and-low-ifn-gamma-responses-after-vaccination-with-a-porcine-reproductive-and-respiratory-syndrome-virus-prrsv
#15
Tahar Ait-Ali, Ivan Díaz, Ferran Soldevila, Esmeralda Cano, Yanli Li, Alison D Wilson, Bruno Giotti, Alan L Archibald, Enric Mateu, Laila Darwich
Little is known about the host factor in the response to PRRSV vaccination. For this purpose, piglets were immunized with a commercial PRRSV-live vaccine and classified as high responders (HR) or low responders (LR) as regards to the frequencies of virus-specific IFN-γ-secreting cells. Six weeks post vaccination, PBMCs isolated from three individuals with the most extreme responses in each HR and LR groups and 3 unvaccinated controls, were either stimulated with phytohaemagglutinin, challenged with the vaccine or mock treated for 24 h, prior conducting transcriptional studies, gene ontology and pathway analyses...
October 20, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27640439/recombinant-beta-interferon-could-clear-the-low-dose-infected-porcine-reproductive-and-respiratory-syndrome-virus-prrsv-in-marc-145-cells
#16
X Shi, X Zhang, L Wang, W Li, B Jiang, R Deng, A Wang, G Zhang
Porcine reproductive and respiratory syndrome virus (PRRSV) causes one of the most economically devastating and pandemic porcine diseases. Previous study has shown that MARC-145 cells pretreated with recombinant IFN-β (rIFN-β) couldn't develop cytopathic effect (CPE) of PRRSV. However, up to date, it is not clear whether MARC-145 cells post-treated with rIFN-β could develop CPE of PRRSV. The present work showed that the MARC-145 cells didn't develop the CPE at 120 hr post-infection (p.i.) with low-dose of PRRSV when the cells were pre-treated with rIFN-β (Group 1), post-treated with rIFN-β at 4 hr p...
2016: Acta Virologica
https://www.readbyqxmd.com/read/27556483/evaluation-of-the-cross-protective-efficacy-of-a-chimeric-porcine-reproductive-and-respiratory-syndrome-virus-constructed-based-on-two-field-strains
#17
Nadeem Shabir, Amina Khatun, Salik Nazki, Bumseok Kim, Eun-Jin Choi, Dong Sun, Kyoung-Jin Yoon, Won-Il Kim
One of the major hurdles to porcine reproductive and respiratory syndrome (PRRS) vaccinology is the limited or no cross-protection conferred by current vaccines. To overcome this challenge, a PRRS chimeric virus (CV) was constructed using an FL12-based cDNA infectious clone in which open reading frames (ORFs) 3-4 and ORFs 5-6 were replaced with the two Korean field isolates K08-1054 and K07-2273,respectively. This virus was evaluated as a vaccine candidate to provide simultaneous protection against two genetically distinct PRRS virus (PRRSV) strains...
2016: Viruses
https://www.readbyqxmd.com/read/27528396/deciphering-transcriptome-profiles-of-peripheral-blood-mononuclear-cells-in-response-to-prrsv-vaccination-in-pigs
#18
Md Aminul Islam, Christine Große-Brinkhaus, Maren Julia Pröll, Muhammad Jasim Uddin, Sharmin Aqter Rony, Dawit Tesfaye, Ernst Tholen, Michael Hölker, Karl Schellander, Christiane Neuhoff
BACKGROUND: Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important viral diseases affecting swine industry worldwide. Despite routine farm vaccination, effective control strategies for PRRS remained elusive which underscores the need for in-depth studies to gain insight into the host immune response to vaccines. The current study aimed to investigate transcriptional responses to PRRS Virus (PRRSV) vaccine in the peripheral blood mononuclear cells (PBMCs) within 3 days following vaccination in German Landrace pigs...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27439510/distinct-immune-responses-of-juvenile-and-adult-oysters-crassostrea-gigas-to-viral-and-bacterial-infections
#19
Timothy J Green, Agnes Vergnes, Caroline Montagnani, Julien de Lorgeril
Since 2008, massive mortality events of Pacific oysters (Crassostrea gigas) have been reported worldwide and these disease events are often associated with Ostreid herpesvirus type 1 (OsHV-1). Epidemiological field studies have also reported oyster age and other pathogens of the Vibrio genus are contributing factors to this syndrome. We undertook a controlled laboratory experiment to simultaneously investigate survival and immunological response of juvenile and adult C. gigas at different time-points post-infection with OsHV-1, Vibrio tasmaniensis LGP32 and V...
2016: Veterinary Research
https://www.readbyqxmd.com/read/27395032/2-5-oligoadenylate-synthetase-1-oas1-inhibits-prrsv-replication-in-marc-145%C3%A2-cells
#20
Jinhua Zhao, Na Feng, Zhenhong Li, Peng Wang, Ziyu Qi, Wan Liang, Xiang Zhou, Xuewen Xu, Bang Liu
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically destructive disease for global pig industry. Although its invasion mechanism is clear, the knowledge of pathogen and host interaction is less known. Here, we found that PPRSV infection led to induction of 2', 5'-oligoadenylate synthetase gene 1(OAS1), an important interferon-stimulated gene. More importantly, ectopic overexpression of OAS1 significantly restricted the replication of PRRSV in 24 and 36 h post-infection in Marc-145 cells, and indirect immunofluorescence assay with antibody against PRRSV N protein displayed significantly lower frequency of fluorescence stained cells and reduced cytopathogenic effects of PRRSV on OAS1-transfected Marc-145 cells...
August 2016: Antiviral Research
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