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https://www.readbyqxmd.com/read/24130147/tailored-doxorubicin-hyaluronan-conjugate-as-a-potent-anticancer-glyco-drug-an-alternative-to-prodrug-approach
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Oommen P Oommen, Javad Garousi, Marije Sloff, Oommen P Varghese
Releasibility of doxorubicin from drug-conjugates is believed to be a prerequisite for its anti-cancer activity. Here, a new glyco-drug approach that circumvents the releasibility restriction is reported, opening a new possibility to design efficient, target specific drug delivery system. It is discovered that stable amide coupling of doxorubicin (DOX) tohyaluronan (HA) shows dose dependent cytotoxicity to CD44 positive human coloncancer cells (HCT116) as compared to human breast cancer cells(MCF-7) and mouse fibroblast cells (NIH-3T3), which express less CD44 receptor...
March 2014: Macromolecular Bioscience
https://www.readbyqxmd.com/read/4848954/-informing-experiments-with-a-reproducible-substrate-of-human-coloncancer-cultivated-in-syrianhamster-gw-77-strain-by-the-modified-abderhalden-reaction-specific-tumor-proteinase-reaction-author-s-transl
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