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https://www.readbyqxmd.com/read/29761701/semi-quantitative-nucleic-acid-test-with-simultaneous-isotachophoretic-extraction-and-amplification
#1
Andrew T Bender, Mark D Borysiak, Amanda M Levenson, Lorraine Lillis, David S Boyle, Jonathan D Posner
Nucleic acid amplification tests (NAATs) provide high diagnostic accuracy for infectious diseases and quantitative results for monitoring viral infections. The majority of NAATs require complex equipment, cold chain dependent reagents, and skilled technicians to perform tests. This largely confines NAATs to centralized laboratories and can significantly delay appropriate patient care. Low-cost, point-of-care (POC) NAATs are especially needed in low-resource settings to provide patients with diagnosis and treatment planning in a single visit to improve patient care...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29760702/emerging-concepts-in-immune-thrombocytopenia
#2
REVIEW
Maurice Swinkels, Maaike Rijkers, Jan Voorberg, Gestur Vidarsson, Frank W G Leebeek, A J Gerard Jansen
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts which presents with an increased bleeding risk. Several genetic risk factors (e.g., polymorphisms in immunity-related genes) predispose to ITP. Autoantibodies and cytotoxic CD8+ T cells (Tc) mediate the anti-platelet response leading to thrombocytopenia. Both effector arms enhance platelet clearance through phagocytosis by splenic macrophages or dendritic cells and by induction of apoptosis. Meanwhile, platelet production is inhibited by CD8+ Tc targeting megakaryocytes in the bone marrow...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29757439/risk-of-thrombosis-with-anti-phospholipid-syndrome-in-systemic-lupus-erythematosus-treated-with-thrombopoietin-receptor-agonists
#3
Zelie Guitton, Louis Terriou, Jean-Christophe Lega, Raphaele Nove-Josserand, Miguel Hie, Zahir Amoura, James B Bussel, Mohamed Hamidou, Eric Rosenthal, Bertrand Lioger, Dominique Chauveau, Axel Chaminade, Nadine Magy-Bertrand, Marc Michel, Sylvain Audia, Bertrand Godeau, Matthieu Mahevas
Objectives: The use of thrombopoietin-receptor agonists (TPO-RAs) has increased as a second-line therapy in ITP, but the efficacy and safety of such drugs has not been evaluated in SLE-associated ITP. Methods: This was a multicentre retrospective cohort study from 2009 to 2016. Participating centres (n = 11) were secondary- or tertiary-care hospitals belonging to the French national network for adult ITP. Results: We included 18 patients with SLE-ITP treated with TPO-RAs; 10 (55%) had aPL, 5 (27%) showing definite APS...
May 10, 2018: Rheumatology
https://www.readbyqxmd.com/read/29755993/the-role-of-hydroxychloroquine-as-a-steroid-sparing-agent-in-the-treatment-of-immune-thrombocytopenia-a-review-of-the-literature
#4
REVIEW
Fatemeh Mohammadpour, Mona Kargar, Molouk Hadjibabaie
Immune Thrombocytopenia (ITP) is an autoimmune disease in which platelet destruction causes thrombocytopenia. Due to the known steroid toxicities, alternative agents have been evaluated for the treatment of these patients. We aimed to review the literature and find evidences regarding the potential benefits of hydroxychloroquine (HCQ) as a steroid-sparing agent in the treatment of ITP. We searched English language articles within Web of Science, PubMed, and Scopus. Cohorts, clinical trials, case reports, conference papers, and letters were included...
January 2018: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29755528/hypogammaglobulinemia-observed-one-year-after-rituximab-treatment-for-idiopathic-thrombocytopenic-purpura
#5
Bilal Ahmad Shoukat, Osama Ali, Dileep Kumar, Muhammad Bilal Gilani, Adeela Zahid, Shaheer Aslam Joiya, Maqsood Anwar Malik
We present the case of a 19-year-old female with severe hypogammaglobulinemia after having had treatment with rituximab for idiopathic thrombocytopenic purpura requiring intravenous immunoglobulins. She was admitted with the diagnosis of left-sided pneumonia with parapneumonic effusion. The patient was treated with piperacillin/tazobactam after having a poor response to co-amoxiclav. The patient had been tested for immunoglobulin levels, and the levels were very low. She has a history of ITP for which she received steroids...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29739453/spontaneous-renal-hemorrhage-secondary-to-choriocarcinoma-in-a-man-with-congenital-hypospadias-and-cryptorchidism-a-case-report-and-literature-review
#6
Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-Yu Xiong, Zi-Yi Yang, Yun-Xiao Zhu, Nathan Jeffreys
BACKGROUND: Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcinoma has previously been only reported in females. We present what we believe to be the first case of a male patient with genital malformation (hypospadias and cryptorchidism) and SRH at presentation of choriocarcinoma. CASE PRESENTATION: A 25-year-old man presented to the department with intense pain in the right flank region and lower back...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29738335/treatment-characteristics-efficacy-and-safety-of-thrombopoietin-analogues-in-routine-management-of-primary-immune-thrombocytopenia
#7
María E Mingot-Castellano, Isabel S Caparrós, Fernando Fernández, María Del Mar Perera-Alvarez, Reyes Jimenez-Bárcenas, Alberto Casaus García, Manuel González-Silva, María Yera-Cobo, María M Nieto-Hernandez, María J Rodríguez-Fernandez, Dana Díaz-Canales
: Thrombopoietin receptor agonist (TPO-RAs) have demonstrated good efficacy and tolerance in clinical trials in refractory chronic primary immune thrombocytopenia (ITP) or chronic ITP with contraindication for splenectomy. No head-to-head study is available, and differences in trials design do not allow comparisons. Information on the use of TPO-RAs in nonchronic ITP is scant. We described our experience with TPO-RAs in ITP (chronic, persistent and newly diagnosed ITP) in routine clinical practice. Retrospective series of 100 adult ITP patients was analysed; 41 treated with eltrombopag, 37 with romiplostim and 22 with both...
June 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29736158/efficacy-and-safety-of-a-new-10-intravenous-immunoglobulin-product-in-patients-with-primary-immune-thrombocytopenia-itp
#8
Junshik Hong, Soo-Mee Bang, Yeung-Chul Mun, Ho-Young Yhim, Jaehoon Lee, Hyeong-Seok Lim, Doyeun Oh
Background: In the current study, we aimed to investigate the efficacy and safety of intravenous immunoglobulin (IVIg)-SN 10%, a new 10% IVIg formulation, in adult patients with severe primary immune thrombocytopenia (ITP; platelet count < 20 × 109 /L). Methods: Patients diagnosed as primary ITP, aged 19 years old or more, and had a platelet count of < 20 × 109 /L by screening complete blood cell count performed within 2 weeks of study commencement were eligible...
May 7, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29729102/autoimmune-thrombocytopenic-purpura-among-patients-with-cancer-and-its-response-to-treatment
#9
Mahmoud H Ayesh Haj Yousef, Khaldoon Alawneh, Deeb Zahran, Najla H Aldaoud, Yousef Khader
OBJECTIVES: The aim of this study was to determine the rate of autoimmune thrombocytopenic purpura (ITP) in adult Jordanian patients diagnosed with cancer, to correlate this rate with the type of cancer, and to assess the response of ITP in cancer patients to treatment. METHODS: All adult patients aged 16 years or older who had been diagnosed with cancer at King Abdullah University Hospital (KAUH) between September 2002 and October 2017 were included in this study...
May 5, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29724313/-analysis-of-differentially-expressed-genes-and-the-interaction-network-between-acute-and-chronic-idiopathic-thrombocytopenic-purpura-in-children
#10
Xiao Mei Ren, Qi Ling Liu, Bao Xin, Rong Qiang Zhang
Objective To analyze the differentially expressed genes and key proteins in T cells between acute and chronic idiopathic thrombocytopenic purpura (ITP) in children and provide the basis for the prevention and therapies of this disease. Methods Microarray gene chip data from T cells of children with acute or chronic ITP were downloaded from the GEO Database. The gene expression profiles,gene function,and protein interaction network were analyzed by R,QOE,Networkanalyst,GCBI,and GenClip. Results The gene expression profiles between these two groups were significantly different...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29713331/optimization-of-nitrogen-phosphorus-and-potassium-fertilization-rates-for-overseeded-perennial-ryegrass-turf-on-dormant-bermudagrass-in-a-transitional-climate
#11
Muhammad Ihtisham, Shah Fahad, Tao Luo, Robert M Larkin, Shaohua Yin, Longqing Chen
Bermudagrass [ Cynodon dactylon (L.) Pers.] turf loss due to severe cold in transitional climates is a major concern. To overcome this problem, warm-season grass is often overseeded with a cool-season turfgrass. In this study, modeling and efficient nutrient management were used to evaluate this problem. A three-factor and five-level central composite rotatable design (CCRD) with a simulation of a regression model was used to optimize fertilization rates. The study investigated the combined effects of fertilization with nitrogen (N), phosphorus (P), and potassium (K) on both the morphological and physiological attributes and on the integrated turf performance (ITP) of overseeded perennial ryegrass ( Lolium perenne )...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29704458/gm-csf-and-il-4-are-not-involved-in-ivig-mediated-amelioration-of-itp-in-mice-a-role-for-il-11-cannot-be-ruled-out
#12
Bonnie J B Lewis, Danila Leontyev, Anton Neschadim, Megan Blacquiere, Donald R Branch
Previously, we reported that interleukin 4 (IL-4), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin 11 (IL-11), but not interleukin 33 (IL-33), are up-regulated in two strains of mice with immune thrombocytopenia (ITP) that are responsive to intravenous immunoglobulin (IVIg) treatment. Previously, IL-4 was ruled out in the mechanism of IVIg; however, other publications have suggested this cytokine as a major player in the mechanism of IVIg action. Thus, we sought to further investigate a role for IL-4 and, in addition, GM-CSF and IL-11 in the mechanism of action of IVIg using a murine model of ITP...
April 28, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29696721/il-10-polymorphisms-and-t-cell-subsets-could-affect-the-clinical-presentation-and-outcome-of-childhood-immune-thrombocytopenia-in-egyptian-population
#13
Mohamed A Soliman, Mohamed A Helwa, Samar K Fath-Allah, Mahmoud A El-Hawy, Hassan S Badr, Naglaa Fathy Barseem
The aim is to study IL-10 polymorphisms and IL-10 level and assess their relation to T-cell subsets in childhood immune thrombocytopenia (ITP). In all, 40 (25 acute, 15 chronic) ITP child patients were investigated at time of presentation, compared to 15 healthy, age- and gender-matched controls and followed up for 1 year to determine chronic cases. Studying the effect of IL-10 promoter polymorphism was done by PCR-RFLP, IL-10 level was determined by ELISA, natural killer cells and T-cell subsets were evaluated by flow cytometry...
May 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29696684/fostamatinib-for-the-treatment-of-adult-persistent-and-chronic-immune-thrombocytopenia-results-of-two-phase-3-randomized-placebo-controlled-trials
#14
James Bussel, Donald M Arnold, Elliot Grossbard, Jiří Mayer, Jacek Treliński, Wojciech Homenda, Andrzej Hellmann, Jerzy Windyga, Liliya Sivcheva, Alhossain A Khalafallah, Francesco Zaja, Nichola Cooper, Vadim Markovtsov, Hany Zayed, Anne-Marie Duliege
Spleen tyrosine kinase (Syk) signaling is central to phagocytosis-based, antibody-mediated platelet destruction in adults with immune thrombocytopenia (ITP). Fostamatinib, an oral Syk inhibitor, produced sustained on-treatment responses in a phase 2 ITP study. In two parallel, phase 3, multicenter, randomized, double-blind, placebo-controlled trials (FIT1 and FIT2), patients with persistent/chronic ITP were randomized 2:1 to fostamatinib (n=101) or placebo (n=49) at 100mg BID for 24 weeks with a dose increase in non-responders to 150mg BID after 4 weeks...
April 26, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29696185/intention-to-prevent-analyses-for-estimating-human-papillomavirus-vaccine-efficacy-in-clinical-studies
#15
Alfred Saah, Oliver Bautista, Alain Luxembourg, Gonzalo Perez
HPV vaccine efficacy trials have been conducted in populations exposed to HPV infection (i.e., sexually active individuals); participants were not excluded from participating in the trials based on their HPV status at baseline. Thus, some participants could have been infected at baseline with 1 or more vaccine HPV types. Because HPV vaccines are prophylactic and do not affect existing HPV infections, prophylactic efficacy was assessed in a per-protocol population (those not infected at enrollment to the HPV type being analyzed who also completed the 3-dose regimen of vaccine and had no protocol violations)...
September 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29693797/mobile-health-intervention-for-youth-with-sickle-cell-disease-impact-on-adherence-disease-knowledge-and-quality-of-life
#16
Lindsay M Anderson, Sarah Leonard, Jude Jonassaint, Joseph Lunyera, Melanie Bonner, Nirmish Shah
BACKGROUND: Adherence to illness self-management among youth with sickle cell disease (SCD) positively impacts health outcomes and decreases overall healthcare costs. Despite this, children with SCD face several barriers to adherence, with adherence rates that remain moderate to low. The current feasibility study examined the Intensive Training Program (ITP), a mobile health (mHealth) intervention for youth with SCD designed to promote disease knowledge, adherence, and patient-provider communication...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29692344/red-pulp-macrophages-in-the-human-spleen-are-a-distinct-cell-population-with-a-unique-expression-of-fc-%C3%AE-receptors
#17
Sietse Q Nagelkerke, Christine W Bruggeman, Joke M M den Haan, Erik P J Mul, Timo K van den Berg, Robin van Bruggen, Taco W Kuijpers
Tissue-resident macrophages in the spleen play a major role in the clearance of immunoglobulin G (IgG)-opsonized blood cells, as occurs in immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). Blood cells are phagocytosed via the Fc-γ receptors (FcγRs), but little is known about the FcγR expression on splenic red pulp macrophages in humans, with only a few previous studies that showed conflicting results. We developed a novel method to specifically isolate red pulp macrophages from 82 human spleens...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29683946/romiplostim-for-immune-thrombocytopenia-in-neuroblastoma-patients-receiving-chemotherapy
#18
Hannah Fassel, James B Bussel, Stephen S Roberts, Shakeel Modak
Thrombocytopenia, a serious complication of myelosuppressive chemotherapy in cancer patients, is managed with platelet transfusions until recovery of platelet counts. However, children receiving chemotherapy can rarely develop immune thrombocytopenia (ITP) that is refractory to transfused platelets. This limits the ability to achieve adequate platelet counts and administer further myelosuppressive chemotherapy safely, especially if first-line ITP therapy is ineffective. We report 2 cases of intravenous immunoglobulin refractory ITP in children receiving chemotherapy for high-risk neuroblastoma...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29683873/eltrombopag-induced-acute-liver-failure-in-a-pediatric-patient-a-pharmacokinetic-and-pharmacogenetic-analysis
#19
M Marano, J Serafinelli, S Cairoli, D Martinelli, M Pisani, G Palumbo, M G Cefalo, C Cecchetti, M Di Nardo, F S Falvella, B M Goffredo
Eltrombopag is an oral thrombopoietin-receptor-agonist (TPO-RA) approved for the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP), who are more than one year old, and show poor response to first-line therapy. ITP is a hematological disorder characterized by isolated thrombocytopenia in the absence of secondary causes or disorders. Eltrombopag is generally well tolerated in the pediatric population, therefore therapeutic drug monitoring (TDM) is not usually performed in clinical practice...
April 20, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29681562/successful-treatment-of-primary-immune-thrombocytopenia-accompanied-by-diabetes-mellitus-treated-using-clarithromycin-followed-by-prednisolone
#20
Masashi Ohe, Haruki Shida, Tetsuya Horita, Ken Furuya, Satoshi Hashino
Macrolides have immunomodulatory effects including anti-inflammatory effects as well as antibacterial activity. In consideration of these immunomodulatory effects, we report a patient with primary immune thrombocytopenia (ITP) treated using clarithromycin (CAM), a macrolide, followed by prednisolone (PSL). A 78-year-old man with thrombocytopenia was admitted to our hospital for further examination. Initial laboratory data showed reduced platelet counts (1.7 × 104 /μL). Finally, we diagnosed the patient as having primary ITP...
April 23, 2018: Drug Discoveries & Therapeutics
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