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Plasma exchange in nephrology

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https://www.readbyqxmd.com/read/27633388/therapeutic-apheresis-in-hematologic-autoimmune-and-dermatologic-diseases-with-immunologic-origin
#1
Rolf Bambauer, Reinhard Latza, Daniel Burgard, Ralf Schiel
The process of curing a patient by removing his illness by extracting blood is a very old one. Many years ago, phlebotomy was practiced to cure illness. Now, this old process, placed on a rational basis with therapeutic apheresis (TA), is being followed in clinical practice. Therapeutic plasma exchange (TPE) with hollow fiber modules has been used in different severe diseases for more than 40 years. Based on many years of experience with the extracorporeal circulation in end-stage renal disease, the authors herein give an overview of TA in immunological diseases, especially in hematologic, autoimmune and dermatologic diseases...
October 2016: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/27526708/paraprotein-related-kidney-disease-evaluation-and-treatment-of-myeloma-cast-nephropathy
#2
Kevin W Finkel, Eric P Cohen, Anushree Shirali, Ala Abudayyeh
Nearly 50% of patients with multiple myeloma develop renal disease, most commonly from AKI caused by cast nephropathy. Development of AKI is associated with poor 1-year survival and reduces the therapeutic options available to patients. There is a great need for more effective therapies. Cast nephropathy is caused by the interaction and aggregation of filtered free light chains and Tamm-Horsfall protein causing intratubular obstruction and damage. The key to treating cast nephropathy is rapid lowering of free light chains, because this correlates with renal recovery...
August 15, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27472247/what-are-the-newer-applications-for-therapeutic-apheresis-in-nephrology-current-indications-for-therapeutic-plasma-exchange-in-nephrology
#3
Michael E Stevenson, Nelson Leung, Jeffrey L Winters
No abstract text is available yet for this article.
September 2016: Seminars in Dialysis
https://www.readbyqxmd.com/read/26950980/-rituximab-therapy-in-the-treatment-of-anti-neutrophil-cytoplasmic-antibody-anca-positive-interstitial-pneumonia-case-report
#4
Tokiko Miyaoka, Mitsuyo Itabashi, Saeko Kumon, Kenichi Akiyama, Yuko Iwabuchi, Hiroshi Kataoka, Takahito Moriyama, Takashi Takei, Kosaku Nitta
We report a patient treated with rituximab for interstitial pneumonia (IP) associated with microscopic polyangiitis (MPA) and who was undergoing hemodialysis. A 59-year-old woman who had been treated with tacrolimus for 1 year for rheumatic arthritis was referred to the Department of Nephrology for fatigue, fever, weight loss, and rapidly developing renal dysfunction. On the first admission, severe renal dysfunction, proteinuria, hematuria, and an elevated titer of MPO-ANCA were observed, and the woman was diagnosed with rapidly progressive glomerulonephritis because of MPA...
2016: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/26833144/-clinical-efficacy-of-eculizumab-as-treatment-of-gemcitabine-induced-thrombotic-microangiopathy-a-case-report
#5
T Rogier, M Gerfaud-Valentin, C Pouteil-Noble, A Taleb, M Guillet, A Noel, C Broussolle, P Sève
INTRODUCTION: Gemcitabine-induced thrombotic microangiopathy is a rare event whose management is not yet consensual. The use of eculizumab could be of interest. CASE REPORT: A 68-year-old woman was treated by gemcitabine as adjuvant chemotherapy of a pancreatic adenocarcinoma. Two months later, the patient presented with mechanical hemolytic anemia, thrombocytopenia and high blood pressure that led to the diagnosis of thrombotic microangiopathy. Gemcitabine was stopped...
January 28, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26813768/therapeutic-plasma-exchange-does-age-matter-a-single-center-study
#6
Bruna Brunetta Gavranić, Nikolina Bašić-Jukić, Petar Kes
Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique designed for the removal of substances with large molecular weight from the plasma. However, it is not commonly performed in children and the elderly because of concern of potential complications. The Department of Nephrology at Zagreb University Hospital Centre's database (8335 procedures, 981 patients) was retrospectively analyzed from 1982 to 2011 to record indications, applications, and safety of TPE use in children (≤18 years), adults (>18 and <65 years), and elderly patients (≥65 years)...
August 2016: Artificial Organs
https://www.readbyqxmd.com/read/26613028/plasma-exchange-for-paediatric-kidney-disease-indications-and-outcomes-a-single-centre-experience
#7
Sudheer Kumar Reddy, Afsana Jahan, Swasti Chaturvedi, Indira Agarwal
BACKGROUND: Outcome data in paediatrics regarding the use of plasmapheresis for immunological kidney disease are scarce. OBJECTIVES: We aimed to evaluate the role of plasmapheresis in children presenting with severe renal impairment secondary to immunological kidney diseases. METHODS: A retrospective chart review of children admitted between January 2009 and August 2013 to the Paediatric Nephrology Unit, Christian Medical College, Vellore, India, and requiring plasma exchange was undertaken...
December 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26181153/-plasmapheresis-in-haematology
#8
REVIEW
Krzysztof Woźniak, Elżbieta Urbanowska, Emilian Snarski
Plasmapheresis also known as a therapeutic plasma exchange (TPE) is a procedure of plasma removal with it's ineligible plasma's component. Usually it is a supportive measure used simultaneously with the treatment, but in a few diseases, e.g. in trombotictrombocytopenic purpura (TTP), it is a first-choice treatment. During the plasmapheresis plasma is mostly replaced by 20% solution of albumin or combination of 20% solution of albumin and 0.9% solution of NaCl, however in some diseases fresh frozen plasma (FFP) is used...
2015: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26076055/acute-interstitial-nephritis-following-multiple-asian-giant-hornet-stings
#9
Xiang-Dong Li, Zheng Liu, Ying Zhai, Ming Zhao, Hai-Yan Shen, Yi Li, Bo Zhang, Tao Liu
BACKGROUND: The Asian giant hornet is the largest wasp species in the world. Its stings can cause acute interstitial nephritis and acute renal failure. From July to October, 2013, Asian giant hornet attacks have killed 42 people and injured 1675 people with their powerful venomous stings in Hanzhong, Ankang, and Shangluo, three cities in the southern part of Shaanxi Province, China. CASE REPORT: We report here a case of a 42-year-old man with acute interstitial nephritis following multiple Asian giant hornet stings...
2015: American Journal of Case Reports
https://www.readbyqxmd.com/read/26069915/-three-shades-of-fluids-bergstr%C3%A3-m-2-0%C3%A2-%C3%A2-furosemide-stress-test%C3%A2-%C3%A2-replacement-fluid-for-therapeutic-plasma-exchange
#10
Julius J Schmidt, Jan T Kielstein
Fluids play an important role in clinical nephrology.1) Temperature of dialysate fluid has recently re-attracted a lot of attention. Individualized cooling of the dialysate (0.5 °C below predialysis ear temperature) has been shown to not only prevent intradialytic hypotension but also to improve myocardial contractility and to prevent white matter changes in CKD5D.2) Access fluid in AKI is associated with an increased mortality. While Furosemide has no place in treating AKI the Furosemide stress test can help to identify patients with AKI that will eventually need renal replacement therapy...
June 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25852872/membrane-and-centrifugal-therapeutic-plasma-exchange-practical-difficulties-in-anticoagulating-the-extracorporeal-circuit
#11
B Puppe, E J Kingdon
Therapeutic plasma exchange (TPE) is a well-established treatment modality for nephrology patients, using two conventional methods: membrane (mTPE) or centrifugal TPE (cTPE). Although the efficacy of both treatments has been described, there are few reports that compare these methodologies. Here we describe three nephrology patients who were treated with both mTPE and cTPE. The mTPE method, but not the cTPE method, was associated with persistent difficulty anticoagulating the extracorporeal circuit in all three patients...
April 2014: Clinical Kidney Journal
https://www.readbyqxmd.com/read/25815219/retracted-anti-gbm-of-pregnancy-acute-renal-failure-resolved-after-spontaneous-abortion-plasma-exchange-hemodialysis-and-steroids
#12
Case Reports In Nephrology
[This retracts the article DOI: 10.1155/2014/243746.].
2015: Case Reports in Nephrology
https://www.readbyqxmd.com/read/25135618/indications-technique-and-outcome-of-therapeutic-apheresis-in-european-pediatric-nephrology-units
#13
Fabio Paglialonga, Claus Peter Schmitt, Rukshana Shroff, Karel Vondrak, Christoph Aufricht, Alan Rees Watson, Gema Ariceta, Michael Fischbach, Gunter Klaus, Tuula Holtta, Sevcan A Bakkaloglu, Alexandra Zurowska, Augustina Jankauskiene, Johan Vande Walle, Betti Schaefer, Elizabeth Wright, Roy Connell, Alberto Edefonti
BACKGROUND: Few observations on apheresis in pediatric nephrology units have been published. METHODS: This retrospective study involved children ≤18 years undergoing plasma exchange (PE), immunoadsorption (IA), or double filtration plasmapheresis (DFPP) in 12 European pediatric nephrology units during 2012. RESULTS: Sixty-seven children underwent PE, ten IA, and three DFPP, for a total of 738 PE and 349 IA/DFPP sessions; 67.2 % of PE and 69...
January 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/24832211/benefits-and-challenges-of-starting-a-new-therapeutic-apheresis-service-in-a-resource-constrained-setting
#14
REVIEW
Fatiu A Arogundade, Abubakr A Sanusi, Stephen O Oguntola, Bolanle A Omotoso, Emaad M Abdel-Rahman, Adewale Akinsola, Rasheed A Balogun
Therapeutic apheresis (TA) refers to a group of extracorporeal blood treatment modalities with clinical indications for which the clinicians' knowledge, availability and applicability vary widely worldwide. Therapeutic plasma exchange (TPE), the most common TA technique, is neither readily available nor affordable in many parts of Africa. This article focuses on the challenges of starting a TPE program in a resource-constrained economy and the result of a survey of Nigerian nephrology professionals on TPE. A critical appraisal of published manuscripts from Nigeria on TA was undertaken to assess uses, methods, and challenges encountered followed by a survey of the perceptions of Nigerian nephrology professionals on TPE...
August 2014: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/24496355/acute-antibody-mediated-rejection-of-the-kidney-transplant-experience-of-a-single-center-in-croatia
#15
Lidija Orlić, Branka Sladoje-Martinović, Ivana Mikolašević, Martina Pavletić Peršić, Ivan Bubić, Ita Jelić, Sanjin Rački
AIM: To describe the experience of the Department of Nephrology and Dialysis, University Hospital Rijeka, Croatia, in the treatment of patients with acute humoral rejection (AHR) of kidney transplant by using high dose of intravenous immunoglobulin (IVIG) alone and as a first line treatment. METHODS: Eight kidney transplant recipients in whom the AHR appeared at different time after the transplantation were reported. At the time of transplantation cross-match in all patients was negative for both T and B cells...
February 2014: Medicinski Glasnik
https://www.readbyqxmd.com/read/24217069/hemolytic-uremic-syndrome-outbreak-in-turkey-in-2011
#16
MULTICENTER STUDY
Zelal Ekinci, Cengiz Candan, Harika Alpay, Nur Canpolat, Sare Gülfem Akyüz, Zübeyde Gündüz, Ismail Dursun, Kenan Bek, Hasan Dursun, Emel Işıyel, Faruk Öktem, Yılmaz Tabel, İpek Akil, Ali Delibaş, Kaan Gülleroğlu, Nurver Akıncı, Nida Dinçel, Ozan Özkaya, Oğuz Söylemezoğlu
The aim of this retrospective multicenter study was to define the epidemiological and clinical features and prognostic factors of the first diarrhea-related hemolytic uremic syndrome (D+HUS) outbreak in Turkey in 2011. All pediatric nephrology centers in Turkey were asked about D+HUS patients via e-mail. Seventy D+HUS patients (median age: 5.7 years) participated. The seasonal peak was around the 7th, 8th and 9th months with 44 cases, centered in the east Marmara region. No causative agent could be identified...
May 2013: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/24178973/principles-of-separation-indications-and-therapeutic-targets-for-plasma-exchange
#17
REVIEW
Mark E Williams, Rasheed A Balogun
Extracorporeal "blood purification," mainly in the form of hemodialysis has been a major portion of the clinical activity of many nephrologists for the past 5 decades. A possibly older procedure, therapeutic plasma exchange, separates and then removes plasma as a method of removing pathogenic material from the patient. In contrast to hemodialysis, therapeutic plasma exchange preferentially removes biologic substances of high molecular weight such as autoantibodies or alloantibodies, antigen-antibody complexes, and Ig paraproteins...
January 2014: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/24151018/the-biobank-of-nephrological-diseases-in-the-netherlands-cohort-the-string-of-pearls-initiative-collaboration-on-chronic-kidney-disease-in-the-university-medical-centers-in-the-netherlands
#18
REVIEW
Gerjan J Navis, Peter J Blankestijn, Jeroen Deegens, Johan W De Fijter, Jaap J Homan van der Heide, Ton Rabelink, Raymond T Krediet, Arjan J Kwakernaak, Gozewijn D Laverman, Karel M Leunissen, Pieter van Paassen, Marc G Vervloet, Pieter M Ter Wee, Jack F Wetzels, Robert Zietse, Frans J van Ittersum
Despite advances in preventive therapy, prognosis in chronic kidney disease (CKD) is still grim. Clinical cohorts of CKD patients provide a strategic resource to identify factors that drive progression in the context of clinical care and to provide a basis for improvement of outcome. The combination with biobanking, moreover, provides a resource for fundamental and translational studies. In 2007, the Dutch government initiated and funded the String of Pearls Initiative (PSI), a strategic effort to establish infrastructure for disease-based biobanking in the University Medical Centres (UMCs) in the Netherlands, in a 4-year start-up period...
June 2014: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/24021908/insights-from-the-use-in-clinical-practice-of-eculizumab-in-adult-patients-with-atypical-hemolytic-uremic-syndrome-affecting-the-native-kidneys-an-analysis-of-19-cases
#19
Fadi Fakhouri, Yahsou Delmas, François Provot, Christelle Barbet, Alexandre Karras, Raifah Makdassi, Cécile Courivaud, Khair Rifard, Aude Servais, Catherine Allard, Virginie Besson, Maud Cousin, Valérie Châtelet, Jean-Michel Goujon, Jean-Philippe Coindre, Guillaume Laurent, Chantal Loirat, Véronique Frémeaux-Bacchi
BACKGROUND: Atypical hemolytic uremic syndrome (aHUS) is a devastating form of renal thrombotic microangiopathy. Despite plasma exchange, the standard treatment of aHUS for decades, the renal prognosis for patients with aHUS has remained poor. We assessed the off-trial use of eculizumab in adult patients with aHUS affecting the native kidneys. STUDY DESIGN: A retrospective study was conducted. aHUS was defined as the presence of 3 or more of the following: acute kidney injury (serum creatinine >1...
January 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/23812351/therapeutic-plasma-exchange-for-the-treatment-of-pediatric-renal-diseases-in-2013
#20
Caitlin E Carter, Nadine M Benador
Therapeutic plasma exchange is an extracorporeal treatment modality that removes systemic circulating pathologic factors or replaces absent plasma components and plays a role in many nephrologic conditions. It presents a number of technical challenges in the pediatric population but has become an increasingly common practice in pediatric nephrology over the past several decades. While prospective evidence is often lacking, our increased understanding of the molecular pathogenesis underlying many pediatric renal diseases provides sound reasoning for the use of plasma exchange in treating these conditions...
January 2014: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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