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https://www.readbyqxmd.com/read/28215596/sex-specific-respiratory-effects-of-acute-and-chronic-caffeine-administration-in-newborn-rats
#1
REVIEW
Hayet Kouchi, NagaPraveena Uppari, Vincent Joseph, Aida Bairam
Caffeine is widely used for the treatment of apnea of prematurity (AoP) but whether this effect varies with sex is unknown. To shed some light on this question, we present a summary of data obtained on the effects of caffeine on the respiratory chemoreflexes and apnea frequency in 1- and 12-days old male and female rats. Caffeine was either administered as a single acute injection (10mg/kg, i.p.) or for 10 consecutive days (7.5mg/kg/day between 3-12days of life by gavage, simulating its clinical use). Acute caffeine had little effects on breathing in 1-day old male and female rats...
February 16, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28203027/-a-new-method-to-orthodontically-correct-dental-occlusal-plane-canting-wave-shaped-arch
#2
X Zheng, X X Hu, N Ma, X H Chen
OBJECTIVE: To introduce a technique of second order wave-shaped arch wire to orthodontically treat dental occlusal plane canting (DOPC) with left-right interactive anchorage, and to test its clinical efficacy. METHODS: Among the permanent dentition malocclusion patients who showed no obvious facial asymmetry, we screened for patients who showed anterior occlusal plane canting (AOPC) after routine orthodontic examination, treatment planning, MBT fixed appliance installation and serial arch wires alignment...
February 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28199944/removal-of-pharmaceuticals-from-water-by-homo-heterogonous-fenton-type-processes-a-review
#3
REVIEW
Amir Mirzaei, Zhi Chen, Fariborz Haghighat, Laleh Yerushalmi
The presence of emerging contaminants such as pharmaceuticals in natural waters has raised increasing concern due to their frequent appearance and persistence in the aquatic ecosystem and the threat to health and safety of aquatic life, even at trace concentrations. Conventional water treatment processes are known to be generally inadequate for the elimination of these persistent contaminants. Therefore, the use of advanced oxidation processes (AOPs) which are able to efficiently oxidize organic pollutants has attracted a great amount of attention...
February 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28198554/practical-approaches-to-adverse-outcome-pathway-aop-development-and-weight-of-evidence-evaluation-as-illustrated-by-ecotoxicological-case-studies
#4
REVIEW
Kellie A Fay, Daniel L Villeneuve, Carlie A LaLone, You Song, Knut Erik Tollefsen, Gerald T Ankley
Adverse Outcome Pathways (AOPs) describe toxicant effects as a sequential chain of causally linked events beginning with a molecular perturbation and culminating in an adverse outcome at an individual or population level. Strategies for developing AOPs are still evolving and depend largely on the intended use or motivation for development and data availability. Four ecotoxicological AOP case studies, developed for different purposes, are described herein. In each situation, creation of the AOP began in a manner determined by the initial motivation for its creation, and expanded either to include additional components of the pathway, or to address the domains of applicability in terms of chemical initiators, susceptible species, life stages, etc...
February 15, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28194231/skinsensdb-a-curated-database-for-skin-sensitization-assays
#5
Chia-Chi Wang, Ying-Chi Lin, Shan-Shan Wang, Chieh Shih, Yi-Hui Lin, Chun-Wei Tung
Skin sensitization is an important toxicological endpoint for chemical hazard determination and safety assessment. Prediction of chemical skin sensitizer had traditionally relied on data from rodent models. The development of the adverse outcome pathway (AOP) and associated alternative in vitro assays have reshaped the assessment of skin sensitizers. The integration of multiple assays as key events in the AOP has been shown to have improved prediction performance. Current computational models to predict skin sensitization mainly based on in vivo assays without incorporating alternative in vitro assays...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28193557/birds-and-flame-retardants-a-review-of-the-toxic-effects-on-birds-of-historical-and-novel-flame-retardants
#6
REVIEW
Mélanie F Guigueno, Kim J Fernie
Flame retardants (FRs) are a diverse group of chemicals, many of which persist in the environment and bioaccumulate in biota. Although some FRs have been withdrawn from manufacturing and commerce (e.g., legacy FRs), many continue to be detected in the environment; moreover, their replacements and/or other novel FRs are also detected in biota. Here, we review and summarize the literature on the toxic effects of various FRs on birds. Birds integrate chemical information (exposure, effects) across space and time, making them ideal sentinels of environmental contamination...
February 10, 2017: Environmental Research
https://www.readbyqxmd.com/read/28183015/synergistic-degradation-of-phenols-using-peroxymonosulfate-activated-by-cuo-co3o4-mno2-nanocatalyst
#7
Aimal Khan, Zhuwei Liao, Yong Liu, Ali Jawad, Jerosha Ifthikar, Zhuqi Chen
The development of transition metal based heterogeneous catalysts with efficient reactivity and intensive stability is of great demand in peroxymonosulfate based AOPs in water treatment. Herein, we present a novel approach of creating stable and effective nano-rod catalyst of CuCo@MnO2 with tetragonal structure. A remarkable synergetic effect was found between bi-metallic oxides of Cu and Co: 0.5%Cu-2%Co-MnO2 can efficiently degrade 100% of 30ppm phenol, while 0.5%Cu@MnO2 or 2%Co@MnO2 alone is apparently sluggish for the degradation of organic contaminants...
January 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28161647/mineralization-and-biodegradability-enhancement-of-methyl-orange-dye-by-an-effective-advanced-oxidation-process
#8
Jhimli Paul Guin, Y K Bhardwaj, Lalit Varshney
An effective process for the oxidation of Methyl Orange dye (MO) was determined by comparing the mineralization efficiency between two advanced oxidation processes (AOPs) viz., ozonolysis and gamma radiolysis in presence and absence of an added inorganic salt potassium persulfate (K2S2O8). The effects of various operating parameters such as ozone flow rate and reaction temperature were optimized to achieve the best possible mineralization extent of MO by ozonolysis. The mineralization efficiency of MO was significantly enhanced during gamma radiolysis in presence of K2S2O8 (γ+K2S2O8) compared to in absence of K2S2O8...
January 19, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28151652/kinetic-study-of-hydroxyl-and-sulfate-radical-mediated-oxidation-of-pharmaceuticals-in-wastewater-effluents
#9
Lushi Lian, Bo Yao, Shaodong Hou, Jingyun Fang, Shuwen Yan, Weihua Song
Advanced oxidation processes (AOPs), such as hydroxyl radical (HO(•))- and sulfate radical (SO4(•-))-mediated oxidation, are alternatives for the attenuation of pharmaceuticals and personal care products (PPCPs) in wastewater effluents. However, the kinetics of these reactions needs to be investigated. In this study, kinetic models for 15 PPCPs were built to predict the degradation of PPCPs in both HO(•)- and SO4(•-)-mediated oxidation. In the UV/H2O2 process, a simplified kinetic model involving only steady state concentrations of HO(•) and its biomolecular reaction rate constants is suitable for predicting the removal of PPCPs, indicating the dominant role of HO(•) in the removal of PPCPs...
February 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28129603/metabolomics-for-informing-adverse-outcome-pathways-androgen-receptor-activation-and-the-pharmaceutical-spironolactone
#10
J M Davis, D R Ekman, D M Skelton, C A LaLone, G T Ankley, J E Cavallin, D L Villeneuve, T W Collette
One objective in developing adverse outcome pathways (AOPs) is to connect biological changes that are relevant to risk assessors (i.e., fecundity) to molecular and cellular-level alterations that might be detectable at earlier stages of a chemical exposure. Here, we examined biochemical responses of fathead minnows (Pimephales promelas) to inform an AOP relevant to spironolactone's activation of the androgen receptor, as well as explore other biological impacts possibly unrelated to this receptor. Liquid chromatography with high resolution mass spectrometry (LC-MS) was used to measure changes in endogenous polar metabolites in livers of male and female fish that were exposed to five water concentrations of spironolactone (0, 0...
March 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28128552/rapid-selective-circumneutral-degradation-of-phenolic-pollutants-using-peroxymonosulfate-iodide-metal-free-oxidation-role-of-iodine-atoms
#11
Yong Feng, Po-Heng Lee, Deli Wu, Kaimin Shih
The development of environmentally friendly, oxidation-selective advanced oxidation processes (AOPs) for water decontamination is important for resource recovery, carbon dioxide abatement, and cost savings. In this study, we developed an innovative AOP using a combination of peroxymonosulfate (PMS) and iodide ions (I(-)) for the selective removal of phenolic pollutants from aqueous solutions. The results showed that nearly 100% degradation of phenol, bisphenol A, and hydroquinone was achieved after reaction for 4 min in the presence of 65 μM PMS and 50 μM I(-)...
February 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28126574/nanostructured-cop-an-efficient-catalyst-for-degradation-of-organic-pollutants-by-activating-peroxymonosulfate
#12
Rui Luo, Chao Liu, Jiansheng Li, Jing Wang, Xingru Hu, Xiuyun Sun, Jinyou Shen, Weiqing Han, Lianjun Wang
A new catalyst system of CoP/peroxymonosulfate (PMS) is presented, which achieved significant improvement in catalytic activity. Nanostructured CoP, obtained by a simple solid-state reaction, exhibited dramatic catalytic activity with 97.2% degradation of orange II of 100ppm within 4min. Moreover, the high efficiency could be reached for other phenolic pollutants, i.e., phenol and 4-chlorophenol. The reaction rate is much higher than the most reported catalysts. Effect of parameters on catalytic activity of the catalyst was studied in detail...
January 22, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28126277/weight-of-evidence-evaluation-of-a-network-of-adverse-outcome-pathways-linking-activation-of-the-nicotinic-acetylcholine-receptor-in-honey-bees-to-colony-death
#13
REVIEW
Carlie A LaLone, Daniel L Villeneuve, Judy Wu-Smart, Rebecca Y Milsk, Keith Sappington, Kristina V Garber, Justin Housenger, Gerald T Ankley
Ongoing honey bee (Apis mellifera) colony losses are of significant international concern because of the essential role these insects play in pollinating crops. Both chemical and non-chemical stressors have been implicated as possible contributors to colony failure; however, the potential role(s) of commonly-used neonicotinoid insecticides has emerged as particularly concerning. Neonicotinoids act on the nicotinic acetylcholine receptors (nAChRs) in the central nervous system to eliminate pest insects. However, mounting evidence indicates that neonicotinoids also may adversely affect beneficial pollinators, such as the honey bee, via impairments on learning and memory, and ultimately foraging success...
January 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28117980/in-situ-photochemical-activation-of-sulfate-for-enhanced-degradation-of-organic-pollutants-in-water
#14
Guoshuai Liu, Shijie You, Yang Tan, Nanqi Ren
The advanced oxidation process (AOP) based on SO4(•-) radicals has been receiving growing attention in water and wastewater treatment. Producing SO4(•-) radicals by activation of peroxymonosulfate or persulfate faces the challenges of high operational cost and potential secondary pollution. In this study, we report the in situ photochemical activation of sulfate (i-PCAS) to produce SO4(•-) radicals with bismuth phosphate (BPO) serving as photocatalyst. The prepared BPO rod-like material could achieve remarkably enhanced degradation of 2,4-dichlorophenol (2,4-DCP) in the presence of sulfate, indicated by the first-order kinetic constant (k = 0...
February 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28111421/combined-approaches-using-adverse-outcome-pathways-and-big-data-to-find-potential-diseases-associated-with-humidifier-disinfectant
#15
Jong-Han Leem, Kyu Hyuck Chung
According to previous survey, about two million of people were expected to suffer from toxic effects due to humidifier disinfectant (HD), regardless of healing or not. Extremely small group are recognized as HDs' victims. Up to now, previous research tried to focus on interstitial fibrosis on terminal bronchiole because it is specific finding, compared with other diseases. To figure out overall effects from HDs, we recommend adverse outcome pathways (AOPs) as new approach. Reactive oxygen species (ROS) generation, decreased T-cell and pro-inflammatory cytokine release from macrophage could be key events between the exposure to HDs and diseases...
2016: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28107400/when-contact-is-not-enough-affecting-first-year-medical-students-image-towards-older-persons
#16
Sasmita Kusumastuti, Esther van Fenema, Eugenie C F Polman-van Stratum, Wilco Achterberg, Jolanda Lindenberg, Rudi G J Westendorp
CONTEXT: Many medical schools have initiated care internships to familiarize their students with older persons and to instil a professional attitude. OBJECTIVE: To examine the impact of care internships on the image that first-year medical students have of older persons and to explore the underlying concepts that may play a role in shaping this image. DESIGN: Survey before and after a two-week compulsory care internship using the Aging Semantic Differential (ASD; 32 adjectives) and the Attitudes toward Old People (AOP; 34 positions) questionnaires...
2017: PloS One
https://www.readbyqxmd.com/read/28092944/reaction-chemistry-to-characterize-the-molecular-initiating-event-in-skin-sensitization-a-journey-to-be-continued
#17
Andreas Natsch, Roger Emter
The publication by the OECD of the adverse outcome pathway (AOP) for skin sensitization has accelerated the development and validation of mechanistic tests and testing strategies to assess the potential of new molecules to trigger skin allergies. The molecular initiating event (MIE) in the AOP is reaction with skin peptides/proteins. It is followed by a number of cellular events. Currently, only one in chemico test to characterize the MIE was proposed to and underwent adoption by the OECD, while two cell-based assays have completed the process...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28092755/coagulation-flocculation-sequential-with-fenton-or-photo-fenton-processes-as-an-alternative-for-the-industrial-textile-wastewater-treatment
#18
Edison GilPavas, Izabela Dobrosz-Gómez, Miguel Ángel Gómez-García
In this study, the industrial textile wastewater was treated using a chemical-based technique (coagulation-flocculation, C-F) sequential with an advanced oxidation process (AOP: Fenton or Photo-Fenton). During the C-F, Al2(SO4)3 was used as coagulant and its optimal dose was determined using the jar test. The following operational conditions of C-F, maximizing the organic matter removal, were determined: 700 mg/L of Al2(SO4)3 at pH = 9.96. Thus, the C-F allowed to remove 98% of turbidity, 48% of Chemical Oxygen Demand (COD), and let to increase in the BOD5/COD ratio from 0...
January 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28043183/automated-3d-ultrasound-measurement-of-the-angle-of-progression-in-labor
#19
Elisa Montaguti, Nicola Rizzo, Gianluigi Pilu, Aly Youssef
OBJECTIVES: To assess the feasibility and reliability of an automated technique for the assessment of the angle of progression (AoP) in labor using three-dimensional (3D) ultrasound. METHODS: AoP was assessed using 3D transperineal ultrasound by two operators in 52 women in active labor to evaluate intra- and interobserver reproducibility. Furthermore, intermethod agreement between automated and manual techniques on 3D images, and between automated technique on 3D vs 2D images were evaluated...
January 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28039821/selecting-the-best-aop-for-isoxazolyl-penicillins-degradation-as-a-function-of-water-characteristics-effects-of-ph-chemical-nature-of-additives-and-pollutant-concentration
#20
Paola Villegas-Guzman, Javier Silva-Agredo, Oscar Florez, Ana L Giraldo-Aguirre, Cesar Pulgarin, Ricardo A Torres-Palma
To provide new insights toward the selection of the most suitable AOP for isoxazolyl penicillins elimination, the degradation of dicloxacillin, a isoxazolyl penicillin model, was studied using different advanced oxidation processes (AOPs): ultrasound (US), photo-Fenton (UV/H2O2/Fe(2+)) and TiO2 photocatalysis (UV/TiO2). Although all processes achieved total removal of the antibiotic and antimicrobial activity, and increased the biodegradability level of the solutions, significant differences concerning the mineralization extend, the pH of the solution, the pollutant concentration and the chemical nature of additives were found...
April 1, 2017: Journal of Environmental Management
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