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https://www.readbyqxmd.com/read/29149350/a-data-fusion-pipeline-for-generating-and-enriching-adverse-outcome-pathway-descriptions
#1
Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen, Roland C Grafström
Increasing amounts of systems toxicology data, including omics results, are becoming publically available and accessible in databases. Data-driven and informatics-tool supported pipeline schemas for fitting such data into Adverse Outcome Pathway (AOP) descriptions could potentially aid the development of non-animal based hazard and risk assessment methods. We devised a six-step workflow that integrated diverse types of toxicology data into a novel AOP scheme for pulmonary fibrosis. Mining of literature references and diverse data sources covering previous pathway descriptions and molecular results were coupled in a stepwise manner with informatics tools applications that enabled gene linkage and pathway identification in molecular interaction maps...
November 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29144558/association-of-oxidative-stress-with-clinical-characteristics-in-patients-with-rheumatoid-arthritis
#2
Sinan Kardeş, Mine Karagülle, İlker Durak, Aslıhan Avcı, Müfit Zeki Karagülle
BACKGROUND: Few studies examining the association between oxidative stress and clinical parameters or disease activity in rheumatoid arthritis (RA) patients are available. Therefore, the objective of this study was to test whether oxidative stress has any association with clinical parameters and disease activity in patients with RA. MATERIALS AND METHODS: In this post hoc cross-sectional study, 45 RA patients treated with traditional disease-modifying antirheumatic drugs (DMARDs) ± low-dose glucocorticoids ± non-steroidal analgesics for at least 3 months were analyzed...
November 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29144295/a-comparative-treatment-of-bleaching-wastewater-by-physicochemical-processes
#3
Ninad Oke, Swati Singh, Anurag Garg
The bleaching effluent discharged from a pulp and paper mill contains chlorinated organic compounds which are toxic to living matter. Physicochemical treatments such as coagulation and different advanced oxidation processes (AOPs) were employed for combined bleaching effluent generated from the first two stages (i.e. chlorination and alkali extraction) (pH = 3.5, chemical oxygen demand (COD) = 1,920 mg/L, and total organic carbon (TOC) = 663 mg/L). At optimum conditions (pH = 7.5, polyaluminium chloride (PAC) dose = 3...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29137732/ultrasound-assisted-biosynthesis-of-cuo-nps-using-brown-alga-cystoseira-trinodis-characterization-photocatalytic-aop-dpph-scavenging-and-antibacterial-investigations
#4
Haidong Gu, Xiao Chen, Feng Chen, Xing Zhou, Zohreh Parsaee
This contribution reports the biosynthesis of CuO NPs via ultrasound method using the Cystoseira trinodis extracts as an eco friendly and time saving process. The characterization of cupric oxide NPs was performed using XRD, FE-SEM, EDX, TEM, AFM, photoluminescence, UV-Vis, Raman and FT-IR spectroscopy investigations. SEM images show the spherical structure with the average crystallite size 6nm to 7.8nm of CuO. XRD analysis approved the formation of pure monoclinic crystallite structures of CuO NPs. These observations were confirmed by TEM analysis...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136817/rapid-quantification-of-persulfate-in-aqueous-systems-using-a-modified-hplc-unit
#5
Abbas Baalbaki, Nagham Zein Eddine, Saly Jaber, Maya Amasha, Antoine Ghauch
Existing analytical techniques used for the quantification of persulfate (PS) in water mostly rely on polarography, reductometry or spectrophotometry. Although acceptable to a certain extent, these methods did not satisfy environmental chemists seeking rapid, reproducible and accurate quantification of PS upon the application of ISCO and AOPs technologies. Accordingly, a novel flow injection/spectroscopy analytical technique is developed via the use of an HPLC coupled to bypass capillary columns and a DAD detector...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29134523/effect-of-water-constituents-on-the-degradation-of-sulfaclozine-in-the-three-systems-uv-tio2-uv-k2s2o8-and-uv-tio2-k2s2o8
#6
Liliane Ismail, Corinne Ferronato, Ludovic Fine, Farouk Jaber, Jean-Marc Chovelon
Bicarbonate, phosphate, chloride ions, and humic substances are among the constituents most widely present in natural waters. These non-target constituents can greatly affect the efficiency of advanced oxidation processes used for water decontamination due to their capacity to interfere with the adsorption of the target compounds on the surface of TiO2, absorb photons, scavenge hydroxyl radicals (·OH), and generate photochemical reactive intermediates. In this work, the effect of these constituents on the degradation of sulfaclozine (SCL) was monitored in three different AOPs systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29124641/the-mineralization-of-oxalic-acid-and-bio-treated-coking-wastewater-by-catalytic-ozonation-using-nickel-oxide
#7
Kaiyi Wu, Fengzhen Zhang, Haizhen Wu, Chaohai Wei
Coking wastewater after biological treatment still possesses potential environmental risk and should be mineralized further. This work focused on the mineralization of bio-treated coking wastewater using catalytic ozonation by NiO. First, oxalic acid, the typical by-product of advanced oxidation process (AOPs), was used to test the catalytic performance of NiOs, prepared by modified hydrothermal methods upon addition of different surfactants. This demonstrated that NiO upon addition of hexadecyltrimethylammonium (CTAB) had the best catalytic activity, due to its high concentration surface hydroxyl density and strong stability...
November 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29121472/comparing-the-uv-monochloramine-and-uv-free-chlorine-advanced-oxidation-processes-aops-to-the-uv-hydrogen-peroxide-aop-under-scenarios-relevant-to-potable-reuse
#8
Yi-Hsueh Chuang, Serena Chen, Curtis Chinn, William A Mitch
Utilities incorporating the potable reuse of municipal wastewater are interested in converting from the UV/H2O2 to the UV/free chlorine advanced oxidation process (AOP). The AOP treatment of reverse osmosis (RO) permeate often includes the de facto UV/chloramine AOP because chloramines applied upstream permeate RO membranes. Models are needed that accurately predict oxidant photolysis and subsequent radical reactions. By combining radical scavengers and kinetic modeling, we have derived quantum yields for radical generation by the UV photolysis of HOCl, OCl-, and NH2Cl of 0...
November 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29112453/new-animal-free-concepts-and-test-methods-for-developmental-toxicity-and-peripheral-neurotoxicity
#9
Marcel Leist
The complex toxicological fields of repeat dose organ toxicity (RDT) and developmental and reproductive toxicity (DART) still require new concepts and approaches to achieve a fully animal-free safety assessment of chemicals. One novel approach is the generation of relevant human cell types from pluripotent stem cells, and the use of such cells for the establishment of phenotypic test methods. Due to their broad endpoints, such tests capture multiple types of toxicants, i.e. they are a readout for the activation of many adverse outcome pathways (AOPs)...
November 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/29081041/graphene-based-materials-supported-advanced-oxidation-processes-for-water-and-wastewater-treatment-a-review
#10
Puthiya Veetil Nidheesh
Advanced oxidation processes (AOPs) received much attention in the field of water and wastewater treatment due to its ability to mineralize persistent organic pollutants from water medium. The addition of graphene-based materials increased the efficiency of all AOPs significantly. The present review analyzes the performance of graphene-based materials that supported AOPs in detail. Recent developments in this field are highlighted. A special focus has been awarded for the performance enhancement mechanism of AOPs in the presence of graphene-based materials...
October 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29068498/use-of-prospective-and-retrospective-risk-assessment-methods-that-simplify-chemical-mixtures-associated-with-treated-domestic-wastewater-discharges
#11
Jerome Diamond, Rolf Altenburger, Anja Coors, Scott Dyer, Michael Focazio, Karen Kidd, Albert A Koelmans, Kenneth M Y Leung, Mark Servos, Jason Snape, Johannes Tolls, Xiaowei Zhang
A framework is presented that is intended to facilitate the evaluation of potential aquatic ecological risks resulting from discharges of down the drain chemicals. A scenario is presented using representatives of many of the types of chemicals that are treated domestically. Predicted treated effluent chemical concentrations (PECS) are based on reported loading rates and routine removal rates for three types of treatment: trickling filter (TF), activated sludge secondary treatment (AS), and AS plus advanced oxidation process (AOP)...
October 25, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29051992/adverse-outcome-pathways-opportunities-limitations-and-open-questions
#12
Marcel Leist, Ahmed Ghallab, Rabea Graepel, Rosemarie Marchan, Reham Hassan, Susanne Hougaard Bennekou, Alice Limonciel, Mathieu Vinken, Stefan Schildknecht, Tanja Waldmann, Erik Danen, Ben van Ravenzwaay, Hennicke Kamp, Iain Gardner, Patricio Godoy, Frederic Y Bois, Albert Braeuning, Raymond Reif, Franz Oesch, Dirk Drasdo, Stefan Höhme, Michael Schwarz, Thomas Hartung, Thomas Braunbeck, Joost Beltman, Harry Vrieling, Ferran Sanz, Anna Forsby, Domenico Gadaleta, Ciarán Fisher, Jens Kelm, David Fluri, Gerhard Ecker, Barbara Zdrazil, Andrea Terron, Paul Jennings, Bart van der Burg, Steven Dooley, Annemarie H Meijer, Egon Willighagen, Marvin Martens, Chris Evelo, Enrico Mombelli, Olivier Taboureau, Alberto Mantovani, Barry Hardy, Bjorn Koch, Sylvia Escher, Christoph van Thriel, Cristina Cadenas, D Kroese, Bob van de Water, Jan G Hengstler
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a formalized, transparent and quality-controlled way, mechanistic information to apical endpoints for regulatory purposes. AOP links a molecular initiating event (MIE) to the adverse outcome (AO) via key events (KE), in a way specified by key event relationships (KER). Although this approach to formalize mechanistic toxicological information only started in 2010, over 200 AOPs have already been established. At this stage, new requirements arise, such as the need for harmonization and re-assessment, for continuous updating, as well as for alerting about pitfalls, misuses and limits of applicability...
October 19, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29022954/agreement-on-diabetic-retinopathy-grading-in-fundus-photographs-by-allied-ophthalmic-personnel-as-compared-to-ophthalmologist-at-a-community-setting-in-nepal
#13
Raba Thapa, Sanyam Bajimaya, Eli Pradhan, Govinda Paudyal
INTRODUCTION: Diabetic retinopathy (DR) is the emerging cause of blindness in the developing world. Timely detection of DR could save vision from its avoidable blinding condition. OBJECTIVE: To assess the accuracy of DR grading in fundus photographs by the allied ophthalmic personnel (AOP) as compared to ophthalmologist at a community setting in Nepal. MATERIALS AND METHODS: Fundus photographs of known diabetes subjects attending for DR screening were graded by two groups of AOP and ophthalmologist...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29022481/intra-and-interobserver-variability-of-intrapartum-transperineal-ultrasound-measurements-with-contraction-and-pushing
#14
José A Sainz, Ana Fernández-Palacín, Carlota Borrero, Adriana Aquise, Zenaida Ramos, José A García-Mejido
The aim of this study was to evaluate the inter- and intraobserver correlation of the different intrapartum-transperineal-ultrasound-parameters(ITU) (angle of progression (AoP), progression-distance (PD), head-direction (HD), midline-angle (MLA) and head-perineum distance (HPD)) with contraction and pushing. We evaluated 28 nulliparous women at full dilatation under epidural analgesia. We performed a transperineal ultrasound evaluating AoP and PD in the longitudinal plane, and MLA and HPD in the transverse plane...
October 12, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29017677/artery-of-percheron-infarct-ararity-not-to-be-missed
#15
Farheen Niazi, Sameen Bin Naeem
Artery of Percheron (AOP) is a rare vascular variant of posterior cerebral circulation and it supplies blood to the bilateral paramedian thalami and the rostral midbrain. Artery of Percheron infarct requires a comprehensive clinical and radiological examination. It can be easily overlooked due to normal CTfindings and wide range of differential diagnosis. Classic triad of presentation is altered mental status, memory impairment and the vertical gaze palsy. We report a case of a 66-year female who had sudden onset of severe vertigo, diplopia and ataxia...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28993029/water-depollution-using-metal-organic-frameworks-catalyzed-advanced-oxidation-processes-a-review
#16
Virender K Sharma, Mingbao Feng
This paper presents a review on the environmental applications of metal-organic frameworks (MOFs), which are inorganic-organic hybrid highly porous crystalline materials, prepared from metal ion/clusters and multidentate organic ligands. The emphases are made on the enhancement of the performance of advanced oxidation processes (AOPs) (photocatalysis, Fenton reaction methods, and sulfate radical (SO4(-))-mediated oxidations) using MOFs materials. MOFs act as adsorption and light absorbers, leading to superior performance of photocatalytic processes...
September 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28992483/impacts-of-inorganic-anions-and-natural-organic-matter-on-thermally-activated-persulfate-oxidation-of-btex-in-water
#17
Jie Ma, Yongqi Yang, Xianchenghao Jiang, Zhuoting Xie, Xiaoxuan Li, Changzhao Chen, Hongkun Chen
The present study investigated the impacts of water matrix constituents (CO3(2-), HCO3(-), Cl(-), Br(-), PO4(3-), HPO4(2-), H2PO4(-), NO3(-), SO4(2-) and natural organic matters (NOM) on the oxidation of a mixture of benzene, toluene, ethylbenzene, and xylenes (BTEX) by thermally activated persulfate (PS). In the absence of matrix constituents, the BTEX oxidation rates decreased in the following order: xylenes > toluene ≈ ethylbenzene > benzene. HCO3(-)/CO3(2-) and NOM inhibited the BTEX oxidation and the inhibiting effects became more pronounced as the HCO3(-)/CO3(2-)/NOM concentration increased...
September 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28987407/electron-beam-irradiation-induced-degradation-of-antidepressant-drug-fluoxetine-in-water-matrices
#18
Hai-Yang Shao, Ming-Hong Wu, Fei Deng, Gang Xu, Ning Liu, Xu Li, Liang Tang
With the development of psychiatric disorder in the current society, abuse of antidepressant drug fluoxetine (FLX) has made such compound an emerging contaminant in natural waters, and causes endocrine systems disturbance on some aquatic species. Herein, an efficient advanced oxidation process (AOP), electron beam irradiation was carried out to investigate the decomposition characteristics of such novel environmental pollutant, including the effects of initial concentration, pH, radical scavengers and anions...
October 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28987053/characteristics-and-experience-of-the-patient-in-psychotherapy-and-the-psychotherapy-s-effectiveness-a-structural-approach
#19
Agnieszka Szymańska, Kamila Dobrenko, Lidia Grzesiuk
OBJECTIVES: The study concerns the relationship between three groups of variables presenting the patient's perspective: (1) "patient's characteristics" before psychotherapy, including "expectations of the therapy"; (2) "experience in the therapy", including the "psychotherapeutic relationship"; and (3) "assessment of the direct effectiveness of the psychotherapy". Data from the literature are the basis for predicting relationships between all of these variables. METHODS: Measurement of the variables was conducted using a follow-up survey...
August 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28985600/factors-affecting-the-roles-of-reactive-species-in-the-degradation-of-micropollutants-by-the-uv-chlorine-process
#20
Zihao Wu, Kaiheng Guo, Jingyun Fang, Xueqin Yang, Hong Xiao, Shaodong Hou, Xiujuan Kong, Chii Shang, Xin Yang, Fangang Meng, Liwei Chen
The UV/chlorine process is an emerging advanced oxidation process (AOP) that produces various reactive species, such as hydroxyl radicals (HO) and reactive chlorine species (RCS). The effects of the treatment conditions, such as chlorine dosage and pH, and the water matrix components of natural organic matter (NOM), alkalinity, ammonia and halides, on the kinetics and reactive species in the degradation of four micropollutants, metronidazole (MDZ), nalidixic acid (NDA), diethyltoluamide (DEET) and caffeine (CAF), by the UV/chlorine process were investigated...
December 1, 2017: Water Research
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