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https://www.readbyqxmd.com/read/29346141/caffeine-controversies
#1
Samuel J Gentle, Colm P Travers, Waldemar A Carlo
PURPOSE OF REVIEW: Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction. The purpose of the review is to analyze this dynamic trajectory and discuss controversies that still remain after decades of caffeine use. RECENT FINDINGS: Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29341849/factors-affecting-occlusion-pressure-and-ischemic-preconditioning
#2
Henry Brown, Martyn J Binnie, Brian Dawson, Nicola Bullock, Brendan R Scott, Peter Peeling
PURPOSE: To determine the effect of limb selection (upper/lower), cuff width (small (6 cm)/medium (13 cm) upper; medium/large (18 cm) lower) and anthropometry on arterial occlusion pressure (AOP) in ischemic preconditioning (IPC). METHODS: Twenty athletes (10 females and 10 males) had surface anthropometry and dual x-ray absorptiometry (DXA) assessments before using Doppler ultrasound to confirm AOP for each limb. Subsequently, 5 min of occlusion occurred, with near-infrared spectroscopy (NIRS) measuring muscle oxygenation changes...
January 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29337105/chitosan-sodium-tripolyphosphate-nanoparticles-as-efficient-vehicles-for-antioxidant-peptidic-fraction-from-common-kilka
#3
Seyed Fakhreddin Hosseini, Mohammad Reza Soleimani, Maryam Nikkhah
Fish-purified antioxidant peptide (AOP)-loaded chitosan nanoparticles (CSNPs) were synthesized based on the ionotropic gelation between CS and sodium tripolyphosphate (TPP). The ζ-potential showed an earlier rise and later decrease with increasing concentrations of AOP. Transmission electron microscopy (TEM) images also revealed roughly uniform spherical-shaped nanoparticles with diameter of <100 nm. Molecular interactions among the components of the NPs and peptides were confirmed by FT-IR spectroscopy...
January 11, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29335167/fate-and-hazard-of-the-electrochemical-oxidation-of-triclosan-evaluation-of-polychlorodibenzo%C3%A2-p%C3%A2-dioxins-and-polychlorodibenzofurans-pcdd-fs-formation
#4
Claudia Solá-Gutiérrez, M Fresnedo San Román, Inmaculada Ortiz
Triclosan (TCS) is widely used as antiseptic or preservative in many personal care products (PCPs), such as cosmetics, hand wash, toothpaste and deodorant soaps, among others. It is characterized by acute toxicity, resistance to biodegradation, environmental persistence and relatively high lipophilicity. In order to protect the environment and natural resources from the negative effects of the discharge of polluted wastewater with TCS, the application of efficient remediation technologies able to degrade the pollutant to harmless levels becomes crucial...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29332373/use-of-adverse-outcome-pathways-aop-in-chemical-management-potential-advantages-and-limitations
#5
Jaeseong Jeong, Jinhee Choi
Amid revolutionary changes in toxicity assessment brought about by increasing regulation of chemicals, adverse outcome pathways (AOPs) have emerged as a useful framework to assess adverse effect of chemicals using molecular level effect, which aid in setting environmental regulation policies. AOPs are biological maps that describe mechanisms linking molecular initiating event to adverse outcomes at an individual level. Each AOP consists of a Molecular Initiating Event (MIE), Key Events (KEs), and an Adverse Outcome (AO)...
December 30, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29331640/recent-advances-in-application-of-uv-light-emitting-diodes-for-degrading-organic-pollutants-in-water-through-advanced-oxidation-processes-a-review
#6
REVIEW
Galina Matafonova, Valeriy Batoev
Over the last decade, ultraviolet light-emitting diodes (UV LEDs) have attracted considerable attention as alternative mercury-free UV sources for water treatment purposes. This review is a comprehensive analysis of data reported in recent years (mostly, post 2014) on the application of UV LED-induced advanced oxidation processes (AOPs) to degrade organic pollutants, primarily dyes, phenols, pharmaceuticals, insecticides, estrogens and cyanotoxins, in aqueous media. Heterogeneous TiO2-based photocatalysis in lab grade water using UVA LEDs is the most frequently applied method for treating organic contaminants...
January 4, 2018: Water Research
https://www.readbyqxmd.com/read/29316278/integrated-approaches-to-testing-and-assessment-iata-oecd-activities-on-the-development-and-use-of-adverse-outcome-pathways-and-case-studies
#7
Yuki Sakuratani, Masashi Horie, Eeva Leinala
The Organisation for Economic Co-operation and Development (OECD) works with member countries and other stakeholders to improve and harmonise chemical assessment methods. In 2012, the OECD Adverse Outcome Pathways (AOPs) Development Programme started. The Programme has published six AOPs thus far and more than 60 AOPs are under various stages of development under the Programme. This paper reviews recent OECD activities on the use of AOPs in developing Integrated Approaches to Testing and Assessments (IATAs)...
January 9, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29289294/intrinsic-chemiluminescence-production-from-the-degradation-of-haloaromatic-pollutants-during-environmentally-friendly-advanced-oxidation-processes-mechanism-structure-activity-relationship-and-potential-applications
#8
REVIEW
Benzhan Zhu, Chen Shen, Huiying Gao, Liya Zhu, Jie Shao, Li Mao
The ubiquitous distribution of halogenated aromatic compounds (XAr) coupled with their carcinogenicity has raised public concerns on their potential risks to both human health and the ecosystem. Recently, advanced oxidation processes (AOPs) have been considered as an "environmentally-friendly" technology for the remediation and destruction of such recalcitrant and highly toxic XAr. During our study on the mechanism of metal-independent production of hydroxyl radicals (OH) by halogenated quinones and H2O2, we found, unexpectedly, that an unprecedented OH-dependent two-step intrinsic chemiluminescene (CL) can be produced by H2O2 and tetrachloro-p-benzoquinone, the major carcinogenic metabolite of the widely used wood preservative pentachlorophenol...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29286519/comparative-characteristics-of-hepatoprotectors-used-for-the-treatment-of-non-alcoholic-steatohepatitis-associated-with-herpesvirus-infection-in-sufferers-of-the-chornobyl-accident
#9
O V Gasanova, E O Sarkisova, A A Chumak, L M Ovsyannikova, O V Nosach, L M Alohina, V A Gasanov, V V Kryzhanivska
Objective of the study was to determine the effectiveness of various groups of hepatoprotectors in the treatment of patients with nonalcoholic steatohepatitis (NASH) sufferers of the accident at the Chornobyl NPP following the assessment of metabolic changes and control of persistent infections. MATERIALS AND METHODS: The study included 104 males with NASH, who were sufferers of the Chornobyl disaster and underwent examination and treatment in the conditions of the clinics of the National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29283696/the-neuromuscular-determinants-of-unilateral-jump-performance-in-soccer-players-are-direction-specific
#10
Conall Murtagh, Christopher Nulty, Jos Vanrenterghem, Andy O'Boyle, Ryland Morgans, Barry Drust, Robert Erskine
PURPOSE: To investigate differences in neuromuscular factors between elite and non-elite players, and to establish which factors underpin direction-specific unilateral jump performance. METHODS: Elite (n=23; age, 18.1 ± 1.0 yrs; BMI, 23.1 ± 1.8 kg/m2) and non-elite (n=20; age, 22.3 ± 2.7 yrs; BMI, 23.8 ± 1.8 kg/m2) soccer players performed three unilateral countermovement jumps (CMJs) on a force platform in the vertical, horizontal-forward and medial directions...
December 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29248788/advanced-oxidation-processes-for-the-removal-of-natural-organic-matter-from-drinking-water-sources-a-comprehensive-review
#11
REVIEW
Mika Sillanpää, Mohamed Chaker Ncibi, Anu Matilainen
Natural organic matter (NOM), a key component in aquatic environments, is a complex matrix of organic substances characterized by its fluctuating amounts in water and variable molecular and chemical properties, leading to various interaction schemes with the biogeosphere and hydrologic cycle. These factors, along with the increasing amounts of NOM in surface and ground waters, make the effort of removing naturally-occurring organics from drinking water supplies, and also from municipal wastewater effluents, a challenging task requiring the development of highly efficient and versatile water treatment technologies...
December 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29245158/-intrapartum-translabial-ultrasound-a-systematic-analysis-of-the-fetal-head-station-in-the-first-stage-of-labor
#12
Fabian Kohls, Lars Brodowski, Elna Kuehnle, Nadine Kniebusch, Karim Djaffar Kalache, Alexander Weichert
Introduction This prospective study aimed to define the angle of progression (AOP) in relation to the height position of the fetal head during the first stage of labour. It was investigated if it is possible to predict the mode of delivery or the duration of labour by AOP. Methods Influencing factors on delivery were head circumference, birth-weight, administration of oxytocin, epidural anaesthesia (EA) and parity, and their impact on AOP was analysed. AOP was calculated using three different formulas. Inclusion criteria were vaginal delivery of singletons in cephalic, occipito-anterior presentation...
December 15, 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/29236470/a-case-study-application-of-the-aggregate-exposure-pathway-aep-and-adverse-outcome-pathway-aop-frameworks-to-facilitate-the-integration-of-human-health-and-ecological-endpoints-for-cumulative-risk-assessment-cra
#13
David E Hines, Stephen Edwards, Rory B Conolly, Annie M Jarabek
Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating endpoints across taxa can be challenging due to data availability and physiological differences among organisms. Adverse Outcome Pathways (AOPs) describe biological mechanisms leading to adverse outcomes (AOs) by assembling causal pathways with measurable intermediate steps termed key events (KEs), thereby providing a framework for integrating data across species...
December 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29219761/the-fate-of-nitrite-and-nitrate-during-anaerobic-digestion
#14
K Ghyselbrecht, A Monballiu, M H Somers, I Sigurnjak, E Meers, L Appels, B Meesschaert
Anaerobic digestion is widely used to produce renewable energy. However, the main drawback is the limited conversion efficiency of organic matter. Applying an advanced oxidation process (AOP) as a digestate post-treatment is able to increase this conversion efficiency but will also lead to the oxidation of ammonium to nitrite or nitrate. In this lab scale study, the fate of the latter in the digester was investigated. Nitrite and nitrate were therefore added in concentrations that could arise from rate limiting ammonium concentrations (1...
December 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29214480/amicarbazone-degradation-promoted-by-zvi-activated-persulfate-study-of-relevant-variables-for-practical-application
#15
Cátia A L Graça, Lucas T N Fugita, Adriana Correia de Velosa, Antonio Carlos S C Teixeira
Alarming amounts of organic pollutants are being detected in waterbodies due to their ineffective removal by conventional treatment techniques, which warn of the urgent need of developing new technologies for their remediation. In this context, advanced oxidation processes (AOPs), especially those based on Fenton reactions, have proved to be suitable alternatives, due to their efficacy of removing persistent organic compounds. However, the use of ferrous iron in these processes has several operational constraints; to avoid this, an alternative iron source was here investigated: zero-valent-iron (ZVI)...
December 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29209747/an-adverse-outcome-pathway-for-parkinsonian-motor-deficits-associated-with-mitochondrial-complex-i-inhibition
#16
REVIEW
Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknecht
Epidemiological studies have observed an association between pesticide exposure and the development of Parkinson's disease, but have not established causality. The concept of an adverse outcome pathway (AOP) has been developed as a framework for the organization of available information linking the modulation of a molecular target [molecular initiating event (MIE)], via a sequence of essential biological key events (KEs), with an adverse outcome (AO). Here, we present an AOP covering the toxicological pathways that link the binding of an inhibitor to mitochondrial complex I (i...
December 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29201551/investigation-of-the-comt-val158met-variant-association-with-age-of-onset-of-psychosis-adjusting-for-cannabis-use
#17
Rohit J Lodhi, Yabing Wang, David Rossolatos, Georgina MacIntyre, Alexandra Bowker, Candice Crocker, Hongyan Ren, Aleksandra Dimitrijevic, Darren A Bugbee, Alexandra Loverock, Brett Majeau, Sudhakar Sivapalan, Virginia M Newton, Philip Tibbo, Scot E Purdon, Katherine J Aitchison
Objective: COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample. Methods: One hundred and sixty-nine subjects with psychosis were recruited. AoP, defined as age of DSM-IV diagnosis was established using the Structured Clinical Interview for DSM-IV. Cannabis use data were collected using a self-report computerized questionnaire...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29196847/body-position-influences-arterial-occlusion-pressure-implications-for-the-standardization-of-pressure-during-blood-flow-restricted-exercise
#18
Peter Sieljacks, Louise Knudsen, Mathias Wernbom, Kristian Vissing
PURPOSE: Arterial occlusion pressure (AOP) measured in a supine position is often used to set cuff pressures for blood flow restricted exercise (BFRE). However, supine AOP may not reflect seated or standing AOP, thus potentially influencing the degree of occlusion. The primary aim of the study was to investigate the effect of body position on AOP. A secondary aim was to investigate predictors of AOP using wide and narrow cuffs. METHODS: Twenty-four subjects underwent measurements of thigh circumference, skinfold and blood pressure, followed by assessments of thigh AOP in supine and seated positions with a wide and a narrow cuff, respectively, using Doppler ultrasound...
December 1, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29183839/the-role-of-ethyl-acrylate-induced-gsh-depletion-in-the-rodent-forestomach-and-its-impact-on-mtd-and-in-vivo-genotoxicity-in-developing-an-adverse-outcome-pathway-aop
#19
R Ellis-Hutchings, J Giuliani, M Hayashi, S Masumori, E L McClymont, S Murphy, K Wiench
Adverse outcome pathways (AOP) and mode of action (MOA) frameworks help evaluate the toxicity findings of animal studies and their relevance to humans. To effectively use these tools to improve hazard identification and risk assessments for ethyl acrylate (EA), knowledge gaps in metabolism and genotoxicity were identified and addressed. For EA, hypothesized early key events relate to its irritation potential: concentration dependent irritation and cytotoxicity, progressing to regenerative proliferation and forestomach carcinogenicity after repeated oral bolus application in rodents...
November 25, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29179575/acknowledgments-to-aop-peer-reviewers-november-1-2016-to-november-1-2017
#20
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Annals of Pharmacotherapy
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