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https://www.readbyqxmd.com/read/29050532/genotoxic-evaluation-of-newly-synthesized-iminothiazolidinones
#1
Fatma Tulay Tugcu, Kadir Turhan, Mehmet Karadayi, Medine Gulluce
The current study was designed to assess the potential toxicological effects of newly synthesized iminothiazolidinones by employing Ames Salmonella, Escherichia coli WP2, Zea mays seed germination, and random amplified polymorphic DNA (RAPD) assay systems. The bacterial tester strains S. typhimurium TA1535, TA1537, TA1538, TA98, TA100, and E. coli WP2 uvrA were chosen to test the direct gene mutation inducing capabilities of the test materials in prokaryotic systems and Z. mays seeds for determination of potential toxicological effects in eukaryotic systems...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29049313/study-on-association-of-working-hours-and-occupational-physical-activity-with-the-occurrence-of-coronary-heart-disease-in-a-chinese-population
#2
Yao Ma, Ying-Jun Wang, Bing-Rui Chen, Hao-Jie Shi, Hao Wang, Mohammad Reeaze Khurwolah, Ya-Fei Li, Zhi-Yong Xie, Yang Yang, Lian-Sheng Wang
OBJECTIVE: To explore the association of working hours and occupational physical activity (OPA) with the occurrence of coronary heart disease (CHD) in a Chinese population. METHODS: A total of 595 participants (354 and 241 patients with and without CHD, respectively) aged between 24 and 65 were enrolled in our study, which was conducted at the First Affiliated Hospital of Nanjing Medical University between December 2015 and October 2016. Participant characteristics were collected from face-to-face questionnaires, and logistic regression analysis was conducted to examine the association of working hours and OPA with the occurrence of CHD...
2017: PloS One
https://www.readbyqxmd.com/read/29048875/exploring-chemistry-in-micro-compartments-using-guided-droplet-collisions-in-a-branched-quadrupole-trap-coupled-to-a-single-droplet-paper-spray-mass-spectrometer
#3
Michael I Jacobs, James F Davies, Lance Lee, Ryan D Davis, Frances A Houle, Kevin R Wilson
Recent studies suggest that reactions in aqueous micro-compartments can occur at significantly different rates than those in the bulk. Most studies have used electrospray to generate a polydisperse source of highly charged microdroplets, leading to multiple confounding factors potentially influencing reaction rates (e.g., evaporation, charge, size). Thus, the underlying mechanism for the observed enhancement remains unclear. We present a new type of electrodynamic balance-the branched quadrupole trap (BQT)-which can be used to study reactions in microdroplets in a controlled environment...
October 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29044014/-anaphylaxis-and-allergic-reactions-during-surgery-and-medical-procedures
#4
Blas J Larrauri, María Gabriela Torre, Eloísa Malbrán, María Cecilia Juri, Diego S Fernández Romero, Alejandro Malbrán
Anaphylaxis during anesthesia is an unpredictable, severe, and rare reaction. It has an incidence of 1/10 000 to 1/20 000 surgeries. In most series, the responsible drugs include neuromuscular blocking agents, latex, or antibiotics. The frequency and etiology of systemic allergic reactions in other medical procedures are largely unknown. The identification of responsible drugs of anaphylaxis is a complex task, requiring testing of all medications and substances used during surgery. We describe our experience in a retrospective study of 15 patients...
2017: Medicina
https://www.readbyqxmd.com/read/29041081/140-w-peak-power-laser-system-tunable-in-the-lwir
#5
François Gutty, Arnaud Grisard, Christian Larat, Dominique Papillon, Muriel Schwarz, Bruno Gerard, Ralf Ostendorf, Marcel Rattunde, Joachim Wagner, Eric Lallier
We present a high peak power rapidly tunable laser system in the long-wave infrared comprising an external-cavity quantum cascade laser (EC-QCL) broadly tunable from 8 to 10 µm and an optical parametric amplifier (OPA) based on quasi phase-matching in orientation-patterned gallium arsenide (OP-GaAs) of fixed grating period. The nonlinear crystal is pumped by a pulsed fiber laser system to achieve efficient amplification in the OPA. Quasi phase-matching remains satisfied when the EC-QCL wavelength is swept from 8 to 10 µm with a crystal of fixed grating period through tuning the pump laser source around 2 µm...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29039228/evaluation-of-the-respiratory-tract-toxicity-of-ortho-phthalaldehyde-a-proposed-alternative-for-the-chemical-disinfectant-glutaraldehyde
#6
Natasha R Catlin, Cynthia J Willson, Matthew Stout, Grace E Kissling, Suramya Waidyanatha, Gregory L Baker, Barry K Hayden, Michael Wyde
ortho-Phthalaldehyde (OPA) is a high-level chemical disinfectant that is commonly used for chemical sterilization of dental and medical instruments as an alternative to glutaraldehyde, a known skin and respiratory sensitizer. Concern for safe levels of human exposure remains due to a lack of toxicity data as well as human case reports of skin and respiratory sensitization following OPA exposure. The present study evaluated the inhalational toxicity of OPA in Harlan Sprague-Dawley rats and B6C3F1/N mice. Groups of 10 male and female rats and mice were exposed to OPA by whole-body inhalation for 3 months at concentrations of 0 (control), 0...
October 17, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/29034772/opa-interacting-protein-5-modulates-docetaxel-induced-cell-death-via-regulation-of-mitophagy-in-gastric-cancer
#7
Tae Woo Kim, Seon-Jin Lee, Young-Jun Park, Sang Yoon Park, Byung Moo Oh, Yun Sun Park, Bo-Yeon Kim, Young-Ha Lee, Hee Jun Cho, Suk Ran Yoon, Yong-Kyung Choe, Hee Gu Lee
Damage to mitochondria induces mitophagy, a cellular process that is gaining interest for its therapeutic relevance to a variety of human diseases. However, the mechanism underlying mitochondrial depolarization and clearance in mitophagy remains poorly understood. We previously reported that mitochondria-induced cell death was caused by knockdown of Neisseria gonorrhoeae opacity-associated-interacting protein 5 in gastric cancer. In this study, we show that Neisseria gonorrhoeae opacity-associated-interacting protein 5 loss and gain of function modulates mitophagy induced by treatment with docetaxel, a chemotherapy drug for gastric cancer...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29032259/effect-of-evaporative-weathering-and-oil-sediment-interaction-on-the-fate-and-behavior-of-diluted-bitumen-in-marine-environments-part-2-the-water-accommodated-and-particle-laden-hydrocarbon-species-and-toxicity-of-the-aqueous-phase
#8
Zeyu Yang, Yujuan Hua, Fatemeh Mirnaghi, Bruce P Hollebone, Paula Jackman, Carl E Brown, Chun Yang, Keval Shah, Mike Landriault, Brian Chan
In this study, the water accommodated and particle-laden hydrocarbon species, and the toxicity of the aqueous phase after oil-sediment interactions by varying the weathering states of diluted bitumen (Cold Lake blend (CLB)), oil type from light to heavy, and sediment type. Compared to the original oils, the sediment-laden total petroleum hydrocarbons (TPH) contained fewer hydrocarbons in the carbon range <C10, comparable contents in C10-C16 range, higher contents in both the C16-C34 and >C34 range. Sediment-laden oil amounts generally decreased with an increased viscosity and asphaltene content of the test oils, as well as with increased sediment particle size...
October 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29031278/activity-coefficients-from-molecular-simulations-using-the-opas-method
#9
Maximilian Kohns, Martin Horsch, Hans Hasse
A method for determining activity coefficients by molecular dynamics simulations is presented. It is an extension of the OPAS (osmotic pressure for the activity of the solvent) method in previous work for studying the solvent activity in electrolyte solutions. That method is extended here to study activities of all components in mixtures of molecular species. As an example, activity coefficients in liquid mixtures of water and methanol are calculated for 298.15 K and 323.15 K at 1 bar using molecular models from the literature...
October 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29028802/pneumococcal-responses-are-similar-in-papua-new-guinean-children-aged-3-5-years-vaccinated-in-infancy-with-pneumococcal-polysaccharide-vaccine-with-or-without-prior-pneumococcal-conjugate-vaccine-or-without-pneumococcal-vaccination
#10
Anita H J van den Biggelaar, Peter C Richmond, Angela Fuery, Denise Anderson, Christine Opa, Gerard Saleu, Mildred Lai, Jacinta P Francis, Michael P Alpers, William S Pomat, Deborah Lehmann
TRIAL DESIGN: In an earlier trial, Papua New Guinean (PNG) children at high risk of pneumococcal disease were randomized to receive 0 or 3 doses of 7-valent pneumococcal conjugate vaccine (PCV7), followed by a single dose of 23-valent pneumococcal polysaccharide vaccine (PPV23) at 9 months of age. We here studied in a non-randomized follow-up trial the persistence of pneumococcal immunity in these children at 3-5 years of age (n = 132), and in 121 community controls of a similar age with no prior pneumococcal vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/29017280/immunogenicity-of-the-13-valent-pneumococcal-conjugate-vaccine-in-older-adults-with-and-without-comorbidities-in-the-community-acquired-pneumonia-immunization-trial-in-adults-capita
#11
Anna M M van Deursen, Marlies A van Houten, Chris Webber, Michael Patton, Daniel A Scott, Scott Patterson, Mohinder Sidhu, Wayne Drews, William C Gruber, Emilio A Emini, Diederick E Grobbee, Marc J M Bonten, Elisabeth A M Sanders
Background: In the randomized controlled Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA), the efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13) against first episodes of vaccine-type community-acquired pneumonia in adults aged ≥65 years was 46%. The long-term immunogenicity of PCV13 in pneumococcal vaccine-naive older adults was investigated as part of CAPiTA. Methods: We determined the immune responses to PCV13 before and at 1, 12, and 24 months after vaccination in 1006 PCV13 recipients and 1005 controls with 3 age-stratified study participant cohorts...
September 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28982095/predictors-of-persistence-of-risky-drinking-in-adults-an-11-year-follow-up-study
#12
Janne Härkönen, Mauri Aalto, Jaana Suvisaari, Tomi Lintonen, Tomi Mäki-Opas, Sebastian Peña, Pia Mäkelä
AIM: To examine the long-term predictors of persistence of risky drinking in a baseline group of risky drinkers in whom alcohol use disorder had not been diagnosed. METHODS: The data was derived from a representative sample of the Finnish adult population aged 30 years or more, surveyed at 2 time points in the years 2000 (n = 5,726) and 2011 (n = 3,848, 67.2% of the baseline sample). Risky drinking was defined using BSQF-measurement (for men, 21 standard UK drinks or more per week; for women 14+ drinks) and not having alcohol abuse or alcohol dependence...
October 6, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28971965/development-and-qualification-of-an-opsonophagocytic-killing-assay-to-assess-immunogenicity-of-a-bioconjugated-escherichia-coli-vaccine
#13
Darren Abbanat, Todd A Davies, Karen Amsler, Wenping He, Kellen Fae, Sarah Janssen, Jan T Poolman, Germie P J M van den Dobbelsteen
The global burden of disease caused by extra-intestinal pathogenic Escherichia coli (ExPEC) is increasing as the prevalence of multidrug-resistant strains rises. A multivalent ExPEC O-antigen bioconjugate vaccine could have a substantial impact in preventing bacteremia and urinary tract infections. Development of an ExPEC vaccine requires a readout to assess the functionality of antibodies. We developed an opsonophagocytic killing assay (OPA) for four ExPEC serotypes (O1A, O2, O6A and O25B) based on methods established for pneumococcal conjugate vaccines...
September 27, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28965937/pneumococcal-polysaccharide-vaccination-in-allogeneic-hematopoietic-stem-cell-transplantation-recipients-a-prospective-single-center-study
#14
Keiji Okinaka, Yukihiro Akeda, Saiko Kurosawa, Shigeo Fuji, Kinuko Tajima, Kazunori Oishi, Takahiro Fukuda
Few studies have evaluated the response of allogeneic hematopoietic stem cell transplantation [allo-HSCT] recipients to pneumococcal polysaccharide vaccine-23 [PPSV23] in the modern transplant era when more elderly patients undergo allo-HSCT. We administered a single dose of PPSV23 to 30 allo-HSCT recipients and evaluated serotype-specific antibody responses using IgG measured by enzyme-linked immunosorbent assay and opsonophagocytic assay [OPA] titers in a multiplexed opsonophagocytic killing assay. The median patient age was 54 years [range, 23-68], and the interval from allo-HSCT to vaccination was 756 days [range, 389-1903]...
September 28, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28957191/thulium-fiber-laser-pumped-high-peak-power-picosecond-mid-infrared-orientation-patterned-gaas-optical-parametric-generator-and-amplifier
#15
L Xu, Q Fu, S Liang, D P Shepherd, D J Richardson, S-U Alam
We report a high-peak-power, picosecond, mid-infrared optical parametric generator (OPG) and optical parametric amplifier (OPA) based on orientation-patterned gallium arsenide pumped by a thulium:fiber master-oscillator-power-amplifier employing direct diode-seeded amplification. An OPG tuning range of 2550-2940 nm (signal) and 5800-8300 nm (idler) is demonstrated with peak powers as high as 3 (signal) and 2 kW (idler), and with pulse energies of 0.26 and 0.16 μJ, respectively. When seeded with a 0.6  cm(-1) linewidth tunable Cr:ZnSe laser, the OPA idler linewidth is narrowed to 1...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28957130/5%C3%A2-%C3%A2-%C3%AE-m-few-cycle-pulses-with-multi-gigawatt-peak-power-at-a-1%C3%A2-%C3%A2-khz-repetition-rate
#16
Lorenz von Grafenstein, Martin Bock, Dennis Ueberschaer, Kevin Zawilski, Peter Schunemann, Uwe Griebner, Thomas Elsaesser
A mid-infrared (mid-IR) optical parametric chirped pulse amplification (OPCPA) system generating few-cycle pulses with multi-gigawatt peak power at a 1 kHz repetition rate is reported. The system is pumped by a highly stable 2 μm picosecond chirped pulse amplifier based on Ho:YLF gain media to exploit the high nonlinearity of ZnGeP2 (ZGP) crystals for parametric amplification. The ZGP optical parametric amplification (OPA) is characterized by a high conversion efficiency of >10 %, resulting in 1.3 mJ idler pulses at a center wavelength of 5...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28957106/ultrabroadband-tunable-opa-design-using-a-spectrally-broadened-pump-source
#17
Seyed Ali Rezvani, Zuofei Hong, Xiaoxiao Pang, Shun Wu, Qingbin Zhang, Peixiang Lu
A robust optical parametric amplifier (OPA) scheme is proposed in which we have experimentally achieved broadband bandwidth for a collinear OPA design that exhibits good beam quality and spatial distribution using a type-I β barium borate crystal. The applied pump pulses are simultaneously spectrally broadened and temporally stretched in a multi-plate system before being used to amplify the temporally stretched white light. In this case, the phase matching can be obtained for a broad range of wavelengths, and we have managed to achieve bandwidths three times broader than a conventional narrowband pumped collinear OPA...
September 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28946262/validation-of-a-reversed-phase-high-performance-liquid-chromatographic-method-for-the-determination-of-free-amino-acids-in-rice-using-l-theanine-as-the-internal-standard
#18
G V V Liyanaarachchi, K R R Mahanama, H P P S Somasiri, P A N Punyasiri
The study presents the validation results of the method carried out for analysis of free amino acids (FAAs) in rice using l-theanine as the internal standard (IS) with o-phthalaldehyde (OPA) reagent using high-performance liquid chromatography-fluorescence detection. The detection and quantification limits of the method were in the range 2-16μmol/kg and 3-19μmol/kg respectively. The method had a wide working range from 25 to 600μmol/kg for each individual amino acid, and good linearity with regression coefficients greater than 0...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28942175/evaluation-of-immunological-responses-to-recombinant-porin-a-protein-rpoa-from-native-strains-of-neisseria-meningitidis-serogroups-a-and-b-using-omv-as-an-adjuvant-in-balb-c-mice
#19
Parviz Afrough, Saeid Bouzari, Seyed Fazlollah Mousavi, Mohammad Reza Asadi Karam, Farzam Vaziri, Abolfazl Fateh, Ava Behrouzi, Mohammadali Malekan, Seyed Davar Siadat
Neisseria meningitidis is one of the main causes of sepsis and meningitis, which are two serious life-threatening diseases in both children and adolescents. Porin A (porA) from both serogroup A and B were cloned into the pET28a plasmid and expressed in E. coli BL21 (DE3). The protein was expressed in Escherichia coli BL21 (DE3) and confirmed by SDS-PAGE and Western blot analysis. BALB/c mice were subcutaneously injected three times with 25 μg of the recombinant PorA. Specific total IgG antibodies and isotypes were evaluated using ELISA assay...
September 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28940659/physical-activity-and-22-year-all-cause-and-coronary-heart-disease-mortality
#20
Niklas Krause, Onyebuchi A Arah, Jussi Kauhanen
BACKGROUND: This study explores the effects of occupational (OPA) and leisure time physical activity (LTPA) on mortality relative to cardiorespiratory fitness and pre-existing coronary heart disease (CHD). METHODS: Associations between OPA, measured as energy expenditure (kcal/day) and relative aerobic workload (%VO2 max), LTPA, and 22-year mortality among 1891 Finnish men were assessed by Cox regression models stratified by CHD and adjusted for 19 confounders. RESULTS: In fully adjusted models, each 10% of relative aerobic workload increased all-cause mortality by 13% and CHD mortality 28% (P < 0...
November 2017: American Journal of Industrial Medicine
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