keyword
MENU ▼
Read by QxMD icon Read
search

OPA

keyword
https://www.readbyqxmd.com/read/29678874/mitochondrial-morphological-and-functional-reprogramming-following-cd137-4-1bb-co-stimulation
#1
Alvaro Teijeira, Sara Labiano, Saray Garasa, Inaki Etxeberria, Eva Santamaria, Ana Rouzaut, Michel Enamorado, Arantza Azpilikueta, Susana Inoges, Elixabet Bolanos-Mateo, Maria Angela Aznar, Alfonso R Sanchez-Paulete, David Sancho, Ignacio Melero
T and NK lymphocytes express CD137 (4-1BB), a costimulatory receptor of the TNFR family whose function is exploitable for cancer immunotherapy. Mitochondria regulate the function and survival of T lymphocytes. Herein, we show that CD137 costimulation provided by agonist mAb and CD137L (4-1BBL) induced mitochondria enlargement that resulted in enhanced mitochondrial mass and transmembrane potential in human and mouse CD8+ T cells. Such mitochondrial changes increased T-cell respiratory capacities and were critically dependent on mitochondrial fusion protein OPA-1 expression...
April 20, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29655626/a-toddler-pcv-booster-dose-following-3-infancy-priming-doses-increases-circulating-serotype-specific-igg-levels-but-does-not-increase-protection-against-carriage
#2
Ron Dagan, Shalom Ben-Shimol, Birgit Simell, David Greenberg, Nurith Porat, Helena Käyhty, Noga Givon-Lavi
BACKGROUND: We compared PCV7 serological response and protection against carriage in infants receiving 3 doses (2, 4, 6 months; 3+0 schedule) to those receiving a booster (12 months; 3+1). METHODS: A prospective, randomized controlled study, conducted between 2005 and 2008, before PCVs were implemented in Israel. Healthy infants were randomized 1:1:1 to receive 3+1, 3+0 and 0+2 (control group; 12, 18 months doses). Nasopharyngeal/oropharyngeal swabs were obtained at all visits...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29609306/highly-efficient-cascaded-extraction-optical-parametric-amplifier
#3
Huabao Cao, Szabolcs Tóth, Mikhail Kalashnikov, Vladimir Chvykov, Károly Osvay
The scheme of cascaded extraction optical parametric amplifier (CE-OPA) has been proposed as a final amplifier for high peak power laser systems. 4D numerical simulations show that conversion efficiency of a CE-OPA system pumped with a temporal Gaussian pump pulse is as close to the theoretical limit of quantum efficiency as a conventional OPA pumped with temporal flat-top pump pulse. The CE-OPA system is also similar to the conventional scheme in output energy stability and alignment sensitivity of the phase-matching angles, too...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29580858/analytical-validation-of-an-ultra-low-cost-mobile-phone-microplate-reader-for-infectious-disease-testing
#4
Li-Ju Wang, Nicole Naudé, Misganaw Demissie, Anne Crivaro, Malek Kamoun, Ping Wang, Lei Li
Most mobile health (mHealth) diagnostic devices for laboratory tests only analyze one sample at a time, which is not suitable for large volume serology testing, especially in low-resource settings with shortage of health professionals. In this study, we developed an ultra-low-cost clinically-accurate mobile phone microplate reader (mReader), and clinically validated this optical device for 12 infectious disease tests. The mReader optically reads 96 samples on a microplate at one time. 771 de-identified patient samples were tested for 12 serology assays for bacterial/viral infections...
March 23, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29580133/time-interval-of-revaccination-with-23-valent-pneumococcal-polysaccharide-vaccine-more-than-5-years-does-not-affect-the-immunogenicity-and-safety-in-the-japanese-elderly
#5
Kenji Kawakami, Hiroyuki Kishino, Shinichi Kanazu, Kenichi Takahashi, Tomoharu Iino, Miyuki Sawata, Luwy Musey
In the previous study, revaccination with 23-valent pneumococcal polysaccharide vaccine (PPSV23) in a total of 161 elderly subjects (≥70 years of age) who had received the initial vaccination at least 5 years before (range: 5 to11 years) showed an acceptable safety profile and induction of immune responses to the serotypes in PPSV23. The optimal interval between the initial vaccination and revaccination with PPSV23 is of interest to protect elderly from pneumococcal disease over the long-term. In this post-hoc analysis, we analyzed that the immunogenicity and safety of revaccination with PPSV23 by time interval after the initial vaccination...
March 26, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29561241/signposts-in-the-fog-objects-facilitate-scene-representations-in-left-scene-selective-cortex
#6
Talia Brandman, Marius V Peelen
We internally represent the structure of our surroundings even when there is little layout information available in the visual image, such as when walking through fog or darkness. One way in which we disambiguate such scenes is through object cues; for example, seeing a boat supports the inference that the foggy scene is a lake. Recent studies have investigated the neural mechanisms by which object and scene processing interact to support object perception. The current study examines the reverse interaction by which objects facilitate the neural representation of scene layout...
March 21, 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29559167/safety-and-immunogenicity-of-15-valent-pneumococcal-conjugate-vaccine-in-pneumococcal-vaccine-na%C3%A3-ve-adults-%C3%A2-50-years-of-age
#7
Susan J Ermlich, Charles P Andrews, Steven Folkerth, Richard Rupp, David Greenberg, Richard D McFetridge, Jonathan Hartzel, Rocio D Marchese, Jon E Stek, Chitrananda Abeygunawardana, Luwy K Musey
BACKGROUND: Pneumococcal disease remains a public health priority in adults. Safety and immunogenicity of 15-valent pneumococcal conjugate vaccine (PCV15) containing 13 serotypes included in 13-valent pneumococcal conjugate vaccine (PCV13) plus 2 additional serotypes (22F and 33F) was evaluated in adults ≥50 years old (NCT01513551). METHODS: 691 adults received one dose of PCV15, PCV13, or 23-valent pneumococcal polysaccharide vaccine (PPV23) and were followed 14 days for safety...
March 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29547938/cancer-testis-specific-gene-oip5-a-downstream-gene-of-e2f1-that-promotes-tumorigenesis-and-metastasis-in-glioblastoma-by-stabilizing-e2f1-signalling
#8
Jiang He, Yuzu Zhao, Erhu Zhao, Xianxing Wang, Zhen Dong, Yibiao Chen, Liqun Yang, Hongjuan Cui
Background: The cancer-testis specific gene Opa interacting protein 5 (OIP5) is a testis-specific gene that is reactivated in many human cancers, but its functions in glioblastoma remain unclear. Here, we assessed the significance of OIP5 in the tumorigenesis and metastasis of glioblastoma for the first time. Methods: An immunohistochemistry assay was performed to detect OIP5 expression changes in glioblastoma patients. Overall survival analysis was performed to evaluate the prognostic significance of OIP5...
March 14, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29547646/bioinformatic-analysis-of-meningococcal-msf-and-opc-to-inform-vaccine-antigen-design
#9
Clio A Andreae, Richard B Sessions, Mumtaz Virji, Darryl J Hill
Neisseria meningitidis is an antigenically and genetically variable Gram-negative bacterium and a causative agent of meningococcal meningitis and septicaemia. Meningococci encode many outer membrane proteins, including Opa, Opc, Msf, fHbp and NadA, identified as being involved in colonisation of the host and evasion of the immune response. Although vaccines are available for the prevention of some types of meningococcal disease, none currently offer universal protection. We have used sequences within the Neisseria PubMLST database to determine the variability of msf and opc in 6,500 isolates...
2018: PloS One
https://www.readbyqxmd.com/read/29543236/single-stage-mhz-mid-ir-opa-using-ligas-2-and-a-fiber-laser-pump-source
#10
Samuel B Penwell, Lukas Whaley-Mayda, Andrei Tokmakoff
We present the design and characterization of a tunable mid-IR optical parametric amplifier (OPA) with a 1 MHz 1033 nm fiber laser pump source. The OPA generates >10  nJ/pulse tunable from 3-7.5 μm with 85-165  cm-1 bandwidth and 140-540 fs pulse durations. The design utilizes a single stage of collinear, Type I amplification in lithium gallium sulfide (LGS) seeded by the near-IR portion of a super-continuum (SC) generated in yttrium aluminum garnet (YAG). The resulting mid-IR idler beam is isolated as the output...
March 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29530742/reducing-the-risk-of-iatrogenic-cjd-by-improving-the-cleaning-of-neurosurgical-instruments
#11
Andrew Smith, Sandra Winter, David Lappin, Andrea Sherriff, Ian McIvor, Pamela Philp, Nigel Suttner, Sulisti Holmes, Alan Stewart
BACKGROUND: Currently UK vCJD cases total 178, with an estimated maximum 1:2,000 carriage rate based on archived appendix and tonsil tissue, implying infection maybe rare but carriage relatively common. Previous workers have identified that maintenance of surgical instruments in a humid atmosphere after use and prior to cleaning assists cleaning efficacy. Relatively recently the Department of Health/Advisory Committee on Dangerous Pathogens UK have recommended a surgical instrument cleanliness threshold post cleaning of <5μg protein per instrument side...
March 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29529799/decoupling-phase-matching-bandwidth-and-interaction-geometry-using-non-collinear-quasi-phase-matching-gratings
#12
N Bigler, J Pupeikis, S Hrisafov, L Gallmann, C R Phillips, U Keller
In optical parametric amplification (OPA) of broadband pulses, a non-collinear angle between the interacting waves is typically introduced in order to achieve broadband phase-matching. Consequently, bandwidth and beam geometry are closely linked. This coupling restricts the geometrical layout of an OPA system. Here, we demonstrate a quasi-phase-matching (QPM) geometry for broadband OPA in which a transverse component is introduced to the QPM grating to impose an additional momentum on the generated wave. This momentum shift detunes the wavelength where the signal and the idler are group-velocity matched, thereby allowing for broadband phase-matching without having to add a non-collinear angle between the interacting waves...
March 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29526211/molecular-phylogeny-and-characterization-of-secondary-metabolite-profile-of-plant-pathogenic-alternaria-species-isolated-from-basil
#13
Ilenia Siciliano, Sara Franco Ortega, Giovanna Gilardi, Pietro Bosio, Angelo Garibaldi, Maria Lodovica Gullino
Alternaria leaf-spot is a new disease recently reported on basil in Italy. The correct identification of Alternaria species has suffered from many reclassifications in function of morphological features and molecular data. In our study, we performed an overall approach to obtain a better characterization of basil Alternaria isolates. Morphological characteristics, seven-genome region phylogenic analysis, and secondary metabolite profile differentiated the majority of the isolates as A. alternata. OPA 1-3 and OPA 10-2 were the best molecular regions to discriminate among the isolates...
August 2018: Food Microbiology
https://www.readbyqxmd.com/read/29475295/broadband-and-efficient-adiabatic-three-wave-mixing-in-a-temperature-controlled-bulk-crystal
#14
Andrey Markov, Anna Mazhorova, Holger Breitenborn, Andrew Bruhacs, Matteo Clerici, Daniele Modotto, Ottavia Jedrkiewicz, Paolo di Trapani, Arkady Major, François Vidal, Roberto Morandotti
Nonlinear interactions are commonly used to access to wavelengths not covered by standard laser systems. In particular, optical parametric amplification (OPA) is a powerful technique to produce broadly tunable light. However, common implementations of OPA suffer from a well-known trade-off, either achieving high efficiency for narrow spectra or inefficient conversion over a broad bandwidth. This shortcoming can be addressed using adiabatic processes. Here, we demonstrate a novel technique towards this direction, based on a temperature-controlled phase mismatch between the interacting waves...
February 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29442316/odd-paired-the-drosophila-zic-gene
#15
Deborah A Hursh, Brian G Stultz
Zinc finger in the cerebellum (Zic) proteins are a family of transcription factors with multiple roles during development, particularly in neural tissues. The founding member of the Zic family is the Drosophila odd-paired (opa) gene. The Opa protein has a DNA binding domain containing five Cys2His2-type zinc fingers and has been shown to act as a sequence-specific DNA binding protein. Opa has significant homology to mammalian Zic1, Zic2, and Zic3 within the zinc finger domain and in two other conserved regions outside that domain...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29440185/differing-associations-for-sport-versus-occupational-physical-activity-and-cardiovascular-risk
#16
Marco Mario Ferrario, Mattia Roncaioli, Giovanni Veronesi, Andreas Holtermann, Els Clays, Rossana Borchini, Marco Cavicchiolo, Guido Grassi, Giancarlo Cesana
OBJECTIVES: We investigate the independent and interacting long-term associations of occupational physical activity (OPA) and sport physical activity (SpPA) with the incidence of coronary heart disease (CHD) and cardiovascular diseases (CVD; CHD plus ischaemic stroke) in North Italian male workers. METHODS: 3574 employed men aged 25-64 years, free of CVD at baseline, recruited in three population-based and one factory-based cohorts, were included in the analysis...
February 9, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29432051/immunogenicity-and-persistence-of-a-prime-boost-re-vaccination-strategy-for-pneumococcal-vaccines-in-patients-with-rheumatoid-arthritis
#17
Mathilde Bahuaud, Constance Beaudouin-Bazire, Marine Husson, Anna Molto, Odile Launay, Frédéric Batteux, Maxime Dougados
OBJECTIVES: Patients with rheumatoid arthritis (RA) are at an increased risk of Pneumococcal infections. Immunogenicity and persistence of a prime-boost revaccination strategy using 13-valent/23-valent anti-pneumococcal vaccines was evaluated in patients with RA treated by Methotrexate (MTX) and anti-TNF. METHOD: Twenty-four patients with RA received one dose of PCV13 (Prevenar13ࣨ; Pfizer) followed two months later by one dose of PPV23 (Pneumovax®, Merck). Concentrations of IgG specific for 7 serotypes common to both vaccines and 3 uncommon serotypes, included only in the PPV23 were measured by ELISA and Opsonophagocytic Assay (OPA) at baseline and after 4, 12 and 24 months post-vaccine...
February 12, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29425932/ablation-of-c-ebp-homologous-protein-attenuates-renal-fibrosis-after-ureteral-obstruction-by-reducing-autophagy-and-microtubule-disruption
#18
Mi Ra Noh, Chang-Hoon Woo, Mae-Ja Park, Jee In Kim, Kwon Moo Park
Fibrosis is an undesirable consequence of injury and a critical problem in many diseases. Recent studies have demonstrated an association of C/EBP homologous protein (CHOP) with fibrosis. We investigated the mechanism of CHOP in kidney fibrosis progression after unilateral ureteral obstruction (UUO) using Chop gene-deleted (Chop-/-) mice and their wild-type littermates (Chop+/+). UUO-induced kidney fibrosis was reduced in the Chop-/- than Chop+/+ mice. After UUO, CHOP expression was detected in the cytosol and nucleus of distal tubule cells and collecting duct cells of the kidney...
February 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29420059/airway-management-in-athletes-wearing-lacrosse-equipment
#19
Thomas G Bowman, Richard J Boergers, Monica R Lininger
CONTEXT: Patient ventilation volume and rate have been found to be compromised due to the inability to seal a pocket mask over the chinstrap of football helmets. The effects of supraglottic airway devices such as the King LT and of lacrosse helmets on these measures have not been studied. OBJECTIVE: To assess the effects of different airway management devices and helmet conditions on producing quality ventilations while performing cardiopulmonary resuscitation on simulation manikins...
February 8, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29419407/hyperoxia-causes-mitochondrial-fragmentation-in-pulmonary-endothelial-cells-by-increasing-expression-of-pro-fission-proteins
#20
Cui Ma, Andreas M Beyer, Matthew Durand, Anne V Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D Ebben, R Blake Hill, Said H Audi, Meetha Medhora, Elizabeth R Jacobs
OBJECTIVE: We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND RESULTS: Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
keyword
keyword
81685
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"