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Deborah A Hursh, Brian G Stultz
Zinc finger in the cerebellum (Zic) proteins are a family of transcription factors with multiple roles during development, particularly in neural tissues. The founding member of the Zic family is the Drosophila odd-paired (opa) gene. The Opa protein has a DNA binding domain containing five Cys2His2-type zinc fingers and has been shown to act as a sequence-specific DNA binding protein. Opa has significant homology to mammalian Zic1, Zic2, and Zic3 within the zinc finger domain and in two other conserved regions outside that domain...
2018: Advances in Experimental Medicine and Biology
Marco Mario Ferrario, Mattia Roncaioli, Giovanni Veronesi, Andreas Holtermann, Els Clays, Rossana Borchini, Marco Cavicchiolo, Guido Grassi, Giancarlo Cesana
OBJECTIVES: We investigate the independent and interacting long-term associations of occupational physical activity (OPA) and sport physical activity (SpPA) with the incidence of coronary heart disease (CHD) and cardiovascular diseases (CVD; CHD plus ischaemic stroke) in North Italian male workers. METHODS: 3574 employed men aged 25-64 years, free of CVD at baseline, recruited in three population-based and one factory-based cohorts, were included in the analysis...
February 9, 2018: Heart: Official Journal of the British Cardiac Society
Mathilde Bahuaud, Constance Beaudouin-Bazire, Marine Husson, Anna Molto, Odile Launay, Frédéric Batteux, Maxime Dougados
OBJECTIVES: Patients with rheumatoid arthritis (RA) are at an increased risk of Pneumococcal infections. Immunogenicity and persistence of a prime-boost revaccination strategy using 13-valent/23-valent anti-pneumococcal vaccines was evaluated in patients with RA treated by Methotrexate (MTX) and anti-TNF. METHOD: Twenty-four patients with RA received one dose of PCV13 (Prevenar13ࣨ; Pfizer) followed two months later by one dose of PPV23 (Pneumovax®, Merck). Concentrations of IgG specific for 7 serotypes common to both vaccines and 3 uncommon serotypes, included only in the PPV23 were measured by ELISA and Opsonophagocytic Assay (OPA) at baseline and after 4, 12 and 24 months post-vaccine...
February 12, 2018: Human Vaccines & Immunotherapeutics
Mi Ra Noh, Chang-Hoon Woo, Mae-Ja Park, Jee In Kim, Kwon Moo Park
Fibrosis is an undesirable consequence of injury and a critical problem in many diseases. Recent studies have demonstrated an association of C/EBP homologous protein (CHOP) with fibrosis. We investigated the mechanism of CHOP in kidney fibrosis progression after unilateral ureteral obstruction (UUO) using Chop gene-deleted (Chop-/-) mice and their wild-type littermates (Chop+/+). UUO-induced kidney fibrosis was reduced in the Chop-/- than Chop+/+ mice. After UUO, CHOP expression was detected in the cytosol and nucleus of distal tubule cells and collecting duct cells of the kidney...
February 6, 2018: Biochimica et Biophysica Acta
Thomas G Bowman, Richard J Boergers, Monica R Lininger
CONTEXT: Patient ventilation volume and rate have been found to be compromised due to the inability to seal a pocket mask over the chinstrap of football helmets. The effects of supraglottic airway devices such as the King LT and of lacrosse helmets on these measures have not been studied. OBJECTIVE: To assess the effects of different airway management devices and helmet conditions on producing quality ventilations while performing cardiopulmonary resuscitation on simulation manikins...
February 8, 2018: Journal of Athletic Training
Cui Ma, Andreas M Beyer, Matthew Durand, Anne V Clough, Daling Zhu, Laura Norwood Toro, Maia Terashvili, Johnathan D Ebben, R Blake Hill, Said H Audi, Meetha Medhora, Elizabeth R Jacobs
OBJECTIVE: We explored mechanisms that alter mitochondrial structure and function in pulmonary endothelial cells (PEC) function after hyperoxia. APPROACH AND RESULTS: Mitochondrial structures of PECs exposed to hyperoxia or normoxia were visualized and mitochondrial fragmentation quantified. Expression of pro-fission or fusion proteins or autophagy-related proteins were assessed by Western blot. Mitochondrial oxidative state was determined using mito-roGFP. Tetramethylrhodamine methyl ester estimated mitochondrial polarization in treatment groups...
February 1, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Mahmoud A Omar, Abdel-Maaboud I Mohamed, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed
A new, selective and sensitive spectrofluorimetric method was designed for the quantitation of doxazosin (DOX), terazosin (TER) and alfuzosin (ALF) in their dosage forms and human plasma. The method adopts efficient derivatization of the studied drugs with ortho-phthalaldehyde (OPA), in the presence of 2-mercaptoethanol in borate buffer (pH9.7) to generate a highly fluorescent isoindole derivatives, which can strongly enhance the fluorescence intensities of the studied drugs, allowing their sensitive determination at 430nm after excitation at 337nm...
February 1, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Jimena Hebe Martinez, Agustina Alaimo, Roxana Mayra Gorojod, Soledad Porte Alcon, Federico Fuentes, Federico Coluccio Leskow, Mónica Lidia Kotler
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the Lewy bodies. Additional common features of this disease are the mitochondrial dysfunction and the activation/inhibition of autophagy both events associated to the intracellular accumulation of α-synuclein. The mechanism by which these events contribute to neural degeneration remains unknown...
January 27, 2018: Molecular and Cellular Neurosciences
Tin Komljenovic, Paolo Pintus
Optical phased arrays (OPAs) are important as they allow beam steering and scanning with no moving parts. As their channel count increases, the complexity of control and calibration becomes challenging. We propose an architecture and algorithm that provide rapid on-chip calibration and are scalable to arbitrary channel counts with significantly reduced chip area and reduced overall complexity compared to previously proposed approaches. The optimized phase shifter tuning algorithm - Deterministic Stochastic Gradient Descent (DSGD) - rapidly converges to the optimal state speeding up the digital-to-analog converter based control of large channel count OPAs...
February 5, 2018: Optics Express
Linpeng Yu, Yi Xu, Yanqi Liu, Yanyan Li, Shuai Li, Zhengzheng Liu, Wenkai Li, Fenxiang Wu, Xiaojun Yang, Yanli Yang, Cheng Wang, Xiaoming Lu, Yuxin Leng, Ruxin Li, Zhizhan Xu
By combining cross-polarized wave generation and femtosecond optical parametric amplification, a high-contrast front end featuring ultrahigh contrast, a broadband spectrum, an excellent beam profile, and good stability is built for a 10-PW-level Ti:sapphire laser in the Shanghai Superintense Ultrafast Laser Facility (SULF-10PW laser). The front end can deliver a cleaned pulse with a 110 μJ energy at 1 kHz, and the bandwidth of the cleaned pulse exceeds 60 nm (FWHM), which can support a 17 fs compressed pulse duration...
February 5, 2018: Optics Express
J Mehlan, S Uschold, N O Hansen, T Gosau, D Eggert, M Spitzer, H Petersen, S J Linke, R J Dwayne Miller
INTRODUCTION: The aim of this study was an analysis of the feasibility of a picosecond infrared laser fiber-assisted sclerostomy (PIRL-FAST) using a novel sapphire fiber and different energy levels of the picosecond laser. METHOD: The laser-assisted sclerostomy was carried out with a newly generated sapphire fiber of the PIRL-HP2-1064 OPA-3000 (Attodyne, Canada). Immediately after the intervention, the eyes were fixed in phosphate-buffered 3.5% formaldehyde. For subsequent histological analysis the eyes were cut into 4 μm thick sections and stained with hematoxylin and eosin (H&E, Merck, Darmstadt, Germany)...
January 31, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
J Jiratham-Opas, R Kanjanavanit, W Wongcharoen, B Punyawudho, P Arunmanakul, A Amaritakomol, P Topaiboon, S Gunaparn, A Phrommintikul
WHAT IS KNOWN AND OBJECTIVE: Digoxin is commonly prescribed for heart failure patients with reduced ejection fraction (HFrEF) and patients with atrial fibrillation (AF). Due to digoxin's narrow therapeutic range, monitoring the serum digoxin concentration (SDC) is important. However, the SDC measurement is not widely available. Equations using clinical parameters can be employed to estimate the SDC but have never been studied in the Thai population. Therefore, we conducted this study to evaluate the correlation between the measured SDC and predicted digoxin level using 2 commonly used equations: the Konishi equation and the Koup and Jusko equation...
January 24, 2018: Journal of Clinical Pharmacy and Therapeutics
Ronit Calderon-Margalit, Michal Cohen-Dadi, Dana Opas, Dena H Jaffe, Jacob Levine, Arie Ben-Yehuda, Ora Paltiel, Orly Manor
BACKGROUND: Israel is one of the few countries that have a national program for quality assessment of community healthcare. We aimed to evaluate whether improved performance in diabetes care was associated with improved health of diabetic patients on a national level. METHODS: We conducted a nationwide ecological study estimating improvements in diabetes-related quality indicators and health outcomes. We estimated both correlations between composite measures of diabetes-related quality indicators and selected outcomes, and assessed through a joinpoint analysis whether trends in selected outcomes changed 4 years after the inception of the national program...
January 17, 2018: Israel Journal of Health Policy Research
Pieter Coenen, Mette Korshøj, David M Hallman, Maaike A Huysmans, Allard J van der Beek, Leon M Straker, Andreas Holtermann
Recent studies suggest that while leisure-time physical activity (LTPA) promotes general health, engaging in occupational physical activity (OPA) may have negative health consequences. It has been hypothesized that the different health effects from OPA and LTPA can be explained by differences in physical activity (PA) intensity in these two domains. To assess the intensity of OPA and LTPA, we aimed to study the percentage heart rate reserve (%HRR) during similar types of OPA and LTPA during workdays. Data from the NOMAD study on Danish blue-collar workers (n=124) with objective measurements of PA (using accelerometers) and heart rate (using heart rate monitors) for 4 workdays were analysed...
January 13, 2018: Physiology & Behavior
Giulio Maria Rossi, Lu Wang, Roland E Mainz, Hüseyin Çankaya, Franz X Kärtner, Giovanni Cirmi
We study the effect of pump-seed timing fluctuations on the carrier-envelope phase (CEP) of signal and idler pulses emerging from an OP(CP)A. A simple analytical model is derived in order to provide an intuitive explanation of the origin of CEP fluctuations, while split-step simulations are performed to cover a broad range of different seeding schemes. Finally, we compare the simulation results with real observations of the CEP of idler pulses generated by an OPA. The quantitative model presented provides a key tool for designing the next generation of low-noise CEP-stable OP(CP)A-based sources...
January 15, 2018: Optics Letters
Young Ahn Yoon, Bo-Hyun Kim, Su-Hak Heo, Hwi Jun Kim, Young-Jin Choi
Human papillomavirus (HPV) is a major cause of cervical neoplasia development. HPV screening is very important because early treatment can prevent cervical cancer. Omniplex-HPV is a polymerase chain reaction followed by Luminex xMAP bead microarray technology that is designed for detecting 40 HPV genotypes. The aim of this study is to evaluate the analytical and clinical performance of the Omniplex-HPV in comparison with that of the commercially available RFMP (restriction fragment mass polymorphism) HPV PapilloTyper...
January 11, 2018: Archives of Virology
Amanda N de Faria, Marcos A E Cruz, Gília C M Ruiz, Daniela C Zancanela, Pietro Ciancaglini, Ana P Ramos
Calcium phosphates (CaPs) are biomaterials widely used in tissue regeneration with outstanding biological performance. Although the tremendous improvements achieved in CaP's materials research over the years, their interaction with physiological environments still need to be fully understood. The aim of this study is to explore a biomimetic Langmuir-Blodgett (LB) membrane to template the growth of hydroxyapatite (HAp) coatings on Ti surfaces and the ability of these coatings in inducing biomineralization by osteoblasts cultured in vitro...
January 4, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Yeshu Tan, Yatao Zou, Linzhong Wu, Qi Huang, Di Yang, Min Chen, Muyang Ban, Chen Wu, Tian Wu, Sai Bai, Tao Song, Qiao Zhang, Baoquan Sun
All inorganic perovskite nanocrystals (NCs) of CsPbX3 (X=Cl, Br, I or their mixture) are regarded as promising candidates for high performance light emitting diode (LED) owing to their high photoluminescence (PL) quantum yield (QY) and easy synthetic process. However, CsPbX3 NCs synthesized by existed methods, where oleic acid (OA) and oleylamine (OLA) are generally used as surface chelating ligands, suffer from poor stability due to the ligand loss, which drastically deteriorates their PL QY as well as dispersibility in solvents...
January 4, 2018: ACS Applied Materials & Interfaces
John F Duval, Lawrence M Opas, Thomas J Nasca, Paul Foster Johnson, Kevin B Weiss
No abstract text is available yet for this article.
December 2017: Journal of Graduate Medical Education
Liuyang Yang, Heng Zhou, Ping Cheng, Yun Yang, Yanan Tong, Qianfei Zuo, Jiao Luo, Qiang Feng, Quanming Zou, Hao Zeng
With more and more drug-resistant Staphylococcus aureus strains emerging in hospitals, there is an urgent need to develop an effective vaccine to combat S. aureus infection. In this study, we constructed a novel bivalent fusion vaccine, SpA-DKKAA-FnBPA37-507 (SF), based on the D domain of staphylococcal protein A (SpA) and the A domain of fibronectin-binding protein A (FnBPA). Immunisation with SF induced a more ideal protective effect compared with the single components alone in a sepsis model. It also showed broad immunoprotection against seven FnBPA isotypes...
December 28, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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