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https://www.readbyqxmd.com/read/28720550/sex-linked-association-between-cortical-scene-selectivity-and-navigational-ability
#1
Xiang-Zhen Kong, Yi Huang, Xin Hao, Siyuan Hu, Jia Liu
Spatial navigation is a crucial ability for living. Previous studies have shown that males are better at navigation than females, but little is known about the neural basis underlying the sex differences. In this study, we investigated whether cortical scene processing in three well-established scene-selective regions was sexually different, by examining sex differences in scene selectivity and its behavioral relevance to navigation. To do this, we used functional magnetic resonance imaging (fMRI) to scan the parahippocampal place area (PPA), retrosplenial complex (RSC), and occipital place area (OPA) in a large cohort of healthy young adults viewing navigationally relevant scenes (N = 202), and correlated their neural selectivity to scenes with their self-reported navigational ability...
July 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28715791/new-approach-for-the-diagnosis-of-histamine-intolerance-based-on-the-determination-of-histamine-and-methylhistamine-in-urine
#2
Oriol Comas-Basté, M Luz Latorre-Moratalla, Roberta Bernacchia, M Teresa Veciana-Nogués, M Carmen Vidal-Carou
Histamine intolerance is a disorder in the homeostasis of histamine due to a reduced intestinal degradation of this amine, mainly caused by diamine oxidase (DAO) enzyme deficiency, which provokes its accumulation in plasma and the appearance of adverse health affects. A new approach for the diagnosis of this intolerance could be the determination of histamine and its metabolites in urine. The aim of this work was to develop and validate a rapid method to determine histamine and methylhistamine in human urine by Ultra High Performance Liquid Chromatography and Fluorimetric detection (UHPLC-FL)...
July 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28698178/occupational-and-leisure-time-physical-activity-and-risk-of-disability-pension-prospective-data-from-the-hunt-study-norway
#3
Marius Steiro Fimland, Gunnhild Vie, Andreas Holtermann, Steinar Krokstad, Tom Ivar Lund Nilsen
OBJECTIVES: To prospectively investigate the association between occupational physical activity (OPA) and disability pension due to musculoskeletal cause, mental cause or any cause. We also examined the combined association of OPA and leisure-time physical activity (LTPA) with disability pension. METHODS: A population-based cohort study in Norway on 32 362 persons aged 20-65 years with questionnaire data on OPA and LTPA that were followed up for incident disability pension through the National Insurance Database...
July 11, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28685175/a-hybrid-molecularly-imprinted-polymer-coated-quantum-dot-nanocomposite-optosensor-for-highly-sensitive-and-selective-determination-of-salbutamol-in-animal-feeds-and-meat-samples
#4
Phannika Raksawong, Kochaporn Chullasat, Piyaluk Nurerk, Proespichaya Kanatharana, Frank Davis, Opas Bunkoed
A hybrid molecularly imprinted polymer (MIP)-coated quantum dot (QD) nanocomposite was synthesized and applied as a fluorescence probe for the highly sensitive and selective determination of salbutamol. The hybrid MIP-coated QD nanocomposite was synthesized via a copolymerization process in the presence of thioglycolic acid capped CdTe QDs with salbutamol as a template, 3-aminopropyltriethoxysilane as the functional monomer, and tetraethyl orthosilicate as a cross-linker. The optimum molar ratio of template, monomer, and cross-linker was 1:6:20...
July 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28684113/sericin-improves-heart-and-liver-mitochondrial-architecture-in-hypercholesterolaemic-rats-and-maintains-pancreatic-and-adrenal-cell-biosynthesis
#5
Sumate Ampawong, Duangnate Isarangkul, Pornanong Aramwit
Hypercholesterolaemia is well known to be associated with mitochondrial dysfunction, subsequently leading to multiple organ failure. Similar to other natural products, sericin is a candidate for adjunctive therapy in hyperlipidaemic conditions. However, the cholesterol-lowering mechanisms of sericin are multifactorial and controversial. Here, a high-cholesterol-fed rat model with or without sericin treatment was established using a dosage of 1,000mg/kg/day for 30 days. Blood lipid profiles, oxidative stress markers (superoxide dismutase, SOD; malondialdehyde, MDA; nuclear factor erythroid 2-related factor, Nrf-2), dysmorphic mitochondria in relation to fission (dynamin-related protein-1; Drp-1) and fusion (guanosine triphosphatase mutated in dominant optic atrophy; OPA-1) markers and biosynthetic markers (aquaporin, AQP-1; tubulin-4β, Tb4B) in the pancreas and adrenal gland were evaluated...
July 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28680338/evaluation-of-selected-immunological-parameters-and-the-concentration-of-vitamin-d-in-children-with-asthma-case-control-study
#6
Agata Wawrzyniak, Agnieszka Lipińska-Opałka, Robert Zdanowski, Sławomir Lewicki, Piotr Murawski, Bolesław Kalicki
Due to the increased incidence of allergic diseases and emerging effects of unsatisfactory control of asthma, new mechanisms for supervising the immune system should be searched. The aim of the study was to analyze the percentage of CD3, CD4, CD8, CD19, CD16/56, NKT, CD3 anti-HLADR3 and Foxp3 regulatory lymphocytes in patients with asthma. Additionally the correlation between immune parameters, severity of asthma and serum concentration of vitamin D was performed. 25 children diagnosed with asthma were enrolled...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28655955/comparison-of-efficacy-and-cost-effectiveness-of-0-55-ortho-phthalaldehyde-and-2-glutaraldehyde-for-disinfection-of-laryngoscopes-a-prospective-pilot-study
#7
Priyanka Pradeep Karnik, Nandini Malay Dave, Gita Nataraj, Rajarshi Gupta, Madhu Garasia
BACKGROUND AND AIMS: The laryngoscope is a potential source of cross-infection as it involves contact with the mucous membrane, saliva and occasionally blood. This study compared efficacy and cost-effectiveness of two Centre for Disease Control approved agents for disinfection of laryngoscope blades. METHODS: One hundred and sixty patients requiring laryngoscopy and intubation for general anaesthesia were randomly allocated into two groups. After tracheal intubation, used laryngoscope blades were cleaned with tap water...
June 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28654711/addressing-the-immunopathogenesis-of-atopic-dermatitis-advances-in-topical-and-systemic-treatment
#8
Lawrence F Eichenfield, Linda F Stein Gold
Several immunologic mediators-phosphodiesterase (PDE), interleukin (IL), small molecules, and Janus kinase-have been implicated in the pathogenesis of atopic dermatitis, and evidence has shown that blocking these mediators can help modify the disease process. Several new topical medications have been developed that target the enzyme PDE; crisaborole was recently approved by the US Food and Drug Administration (FDA) for the treatment of atopic dermatitis, and phase II studies have been completed on OPA-15406...
March 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28651195/stereological-and-biophysical-characteristics-of-the-ovine-surfactant-system-and-its-changes-caused-by-ovine-pulmonary-adenocarcinoma
#9
Ariane Jörger, Christa Acevedo, Diana Busley, Martin Ganter, Andreas Schmiedl, Esther Humann-Ziehank
Surfactant covers the inner surface of lung alveoli and lowers the surface tension to prevent alveoli from collapsing. A lack of surfactant or its dysfunction causes dyspnea. The Jaagsiekte Sheep Retrovirus (JSRV) causes ovine pulmonary adenocarcinoma (OPA), whose typical clinical appearance is fluid running from nostrils. This fluid might contain surfactant as alveolar type II pneumocytes (AEII) are target cells for JSRV. Therefore, the progressive dyspnea during OPA might be caused partially by surfactant alterations...
June 15, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28647484/neural-representation-of-geometry-and-surface-properties-in-object-and-scene-perception
#10
Matthew X Lowe, Jason Rajsic, Jason P Gallivan, Susanne Ferber, Jonathan S Cant
Multiple cortical regions are crucial for perceiving the visual world, yet the processes shaping representations in these regions are unclear. To address this issue, we must elucidate how perceptual features shape representations of the environment. Here, we explore how the weighting of different visual features affects neural representations of objects and scenes, focusing on the scene-selective parahippocampal place area (PPA), but additionally including the retrosplenial complex (RSC), occipital place area (OPA), lateral occipital (LO) area, fusiform face area (FFA) and occipital face area (OFA)...
June 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28633617/simultaneous-determination-of-primary-and-secondary-d-and-l-amino-acids-by-reversed-phase-high-performance-liquid-chromatography-using-pre-column-derivatization-with-two-step-labelling-method
#11
Takehiko Yokoyama, Masaharu Tokuda, Masafumi Amano, Koji Mikami
This work describes a method for the simultaneous determination of primary d- and l-amino acids and secondary amino acids such as d- and l-proline. In order to remove interferences in the simultaneous determination of primary and secondary amines, the primary amines were derivatized with o-phthalaldehyde/N-acetyl-l-cysteine (OPA/NAC) and subsequently with 1-(9-fluorenyl)ethyl chloroformate (FLEC) for secondary amines, in a pre-column separation derivatization technique. These fluorescent diastereomers of the amino acids were obtained within 3 min at room temperature and determined simultaneously by changing wavelengths during analysis in a single eluting run in the high-performance liquid chromatography column...
June 21, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28633321/places-in-the-brain-bridging-layout-and-object-geometry-in-scene-selective-cortex
#12
Moira R Dillon, Andrew S Persichetti, Elizabeth S Spelke, Daniel D Dilks
Diverse animal species primarily rely on sense (left-right) and egocentric distance (proximal-distal) when navigating the environment. Recent neuroimaging studies with human adults show that this information is represented in 2 scene-selective cortical regions-the occipital place area (OPA) and retrosplenial complex (RSC)-but not in a third scene-selective region-the parahippocampal place area (PPA). What geometric properties, then, does the PPA represent, and what is its role in scene processing? Here we hypothesize that the PPA represents relative length and angle, the geometric properties classically associated with object recognition, but only in the context of large extended surfaces that compose the layout of a scene...
June 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28624247/production-of-l-alanyl-l-glutamine-by-recycling-e-coli-expressing-%C3%AE-amino-acid-ester-acyltransferase
#13
Yimin Li, Wenjie Yuan, Jiaoqi Gao, Chao Fan, Wenzhong Wu, Fengwu Bai
In this study, the optimum induction and reaction conditions, and fermentation process of producing Ala-Gln by E. coli Origami 2 overexpressing α-amino acid ester acyltransferase (OPA) were investigated. Besides, the Ala-Gln synthesis by OPA achieved the maximum molar yield of 94.7% and productivity of 1.89g/L/min due to the extremely high enzyme activity. On this basis, repeated-cycle batch fermentation to produce Ala-Gln indicated that OPA could maintain high Ala-Gln yields and enzyme stabilities after several cell recycling...
June 14, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28601365/antibody-mediated-protection-against-staphylococcus-aureus-dermonecrosis-and-sepsis-by-a-whole-cell-vaccine
#14
Fan Zhang, Maria Jun, Olivia Ledue, Muriel Herd, Richard Malley, Ying-Jie Lu
Staphylococcus aureus is a very important human pathogen that causes significant morbidity and mortality worldwide. Several vaccine clinical trials based on generating antibody against staphylococcal surface polysaccharides or proteins have been unsuccessful. A killed whole cell lysate preparation (SaWCA) was made by lysing a USA 300 strain with lysostaphin followed by sonication and harvest of the supernatant fraction. Immunization with SaWCA and cholera toxin (CT) generated robust IL-17A but relatively modest antibody responses, and provided protection in the skin abscess but not in the dermonecrosis or invasive infection model...
June 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28583349/design-and-implementation-of-ep-based-pid-controller-for-chaos-synchronization-of-rikitake-circuit-systems
#15
Yi-You Hou
This article addresses an evolutionary programming (EP) algorithm technique-based and proportional-integral-derivative (PID) control methods are established to guarantee synchronization of the master and slave Rikitake chaotic systems. For PID synchronous control, the evolutionary programming (EP) algorithm is used to find the optimal PID controller parameters kp, ki, kd by integrated absolute error (IAE) method for the convergence conditions. In order to verify the system performance, the basic electronic components containing operational amplifiers (OPAs), resistors, and capacitors are used to implement the proposed chaotic Rikitake systems...
June 2, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28582295/cephalometric-improvement-of-severe-microretrognathia-with-an-anterior-open-bite-using-curvilinear-mandibular-distraction-osteogenesis
#16
Jing Li, Patrick A Gerety, Wen Xu, Scott P Bartlett, Jesse A Taylor
Curvilinear mandibular distraction osteogenesis (MDO) provides for multidimensional augmentation and rotation in mandibles with complex, abnormal morphology. This study aims to demonstrate cephalometric changes after curvilinear MDO.A prospectively maintained craniofacial database was queried for patients undergoing curvilinear MDO from 2009 to 2015. Demographic and operative data were collected. Cephalometric measurements were obtained from preoperative and postdistraction imaging, including sella-nasion-B point angle (SNB), mandibular plane angle (MPA), occlusal plane angle (OPA), and gonial angle (GA)...
June 2, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28581522/blockade-of-deubiquitylating-enzyme-rpn11-triggers-apoptosis-in-multiple-myeloma-cells-and-overcomes-bortezomib-resistance
#17
Y Song, S Li, A Ray, D S Das, J Qi, M K Samur, Y-T Tai, N Munshi, R D Carrasco, D Chauhan, K C Anderson
Proteasome inhibition is an effective therapy for multiple myeloma (MM) patients; however, the emergence of drug resistance is common. Novel therapeutic strategies to overcome proteasome inhibitor resistance are needed. In this study, we examined whether targeting deubiquitylating (DUB) enzymes upstream of 20S proteasome overcomes proteasome inhibitor resistance. Gene expression analysis, immunohistochemical studies of MM patient bone marrow, reverse transcription-PCR and protein analysis show that Rpn11/POH1, a DUB enzyme upstream of 20S proteasome, is more highly expressed in patient MM cells than in normal plasma cells...
June 5, 2017: Oncogene
https://www.readbyqxmd.com/read/28573395/a-comparative-study-reveals-the-higher-resolution-of-rapd-over-ardra-for-analyzing-diversity-of-nostoc-strains
#18
Hillol Chakdar, Sunil Pabbi
Nostoc is a diverse genus of filamentous cyanobacteria with tremendous potential for agricultural and industrial applications. Morphometric methods and routine 16S rDNA-based identification undermines the genetic diversity and impedes strain-level differentiation. A comparative study to deduce the discriminatory power of random amplified polymorphic DNA (RAPD) and amplified ribosomal DNA restriction analysis (ARDRA) for analyzing the genetic diversity of 20 Nostoc strains of diverse geographical origin was carried out...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28573220/jieyuanshen-decoction-exerts-antidepressant-effects-on-depressive-rat-model-via-regulating-hpa-axis-and-the-level-of-amino-acids-neurotransmitter
#19
Zhang Qiuxia, Ma Xinlong, Yang Yilong, Zhao Hui, Wang Yali, Yao Xiaoquan, Wang Lei, Chang Jiahui, Zou Haiyan
BACKGROUND: Jieyuanshen decoction (JYAS-D) - a traditional Chinese medicine was invented by Professor Nie based on classic formulas, chaihu jia longgu muli decoction has been proved as having favorable curative effects on depression in clinical practices. The aim of this study was to investigate the antidepressant effects and its molecular mechanism of JYAS-D. MATERIALS AND METHODS: The model of depression was established by Chronic Unpredictable Stress. Different doses (8...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28569854/tunable-7-12%C3%A2-%C3%A2-%C3%AE-m-picosecond-optical-parametric-amplifier-based-on-a-liinse-sub-2-sub-mid-infrared-crystal
#20
Shanpeng Wang, Shibo Dai, Ning Jia, Nan Zong, Chunlong Li, Yu Shen, Tongtong Yu, Jie Qiao, Zeliang Gao, Qinjun Peng, Zuyan Xu, Xutang Tao
Mid-infrared (MIR) nonlinear optical crystals of LiInSe<sub>2</sub> (LISe) were grown by a modified Bridgman technique on a (001)-seed. A 7-12 μm widely tunable picosecond (ps) MIR optical parametric amplifier (OPA) based on a LISe crystal was demonstrated for the first time, to the best of our knowledge. The MIR OPA was pumped by a 30 ps 1064 nm Nd:YAG laser and injected by a KTiOPO<sub>4</sub> (KTP)-based widely tunable near-infrared seed. The idler operating at 7.5 μm with the highest pulse energy of 170 μJ was obtained under a pump energy of 14 mJ...
June 1, 2017: Optics Letters
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