keyword
MENU ▼
Read by QxMD icon Read
search

liver fat content

keyword
https://www.readbyqxmd.com/read/28339712/effect-of-chinese-herbal-medicine-treatment-on-plasma-lipid-profile-and-hepatic-lipid-metabolism-in-hetian-broiler
#1
Z Xie, J Zhang, S Ma, X Huang, Y Huang
The purpose of this study was to investigate whether adding a Chinese herbal hedicine (CHM, including astragalus membranaceus, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, fructus crataegi, folium epimedii, radix saposhnikoviae, and pericarpium citri reticulatae) diet has effects on lipid metabolism in the liver of the broiler. Six-hundred-thirty Hetian broilers were divided into 3 groups including base diet (control), 0.3%, or 1% CHM diets, for 130 days. The results showed that CHM treatment significantly increased the slaughter performance...
February 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339172/maternal-high-fat-diet-consumption-enhances-offspring-susceptibility-to-dss-induced-colitis-in-mice
#2
Shima Bibi, Yifei Kang, Min Du, Mei-Jun Zhu
OBJECTIVE: Maternal high-fat diet (HFD) may alter the offspring intestinal immune system, thereby enhancing susceptibility toward inflammatory bowel disease. The objective of the current study was to investigate the impact of maternal HFD on offspring intestinal health using a mouse model of dextran sulfate sodium (DSS)-induced colitis. METHODS: Dams were provided with either HFD (60%) or control diet. After weaning, female offspring from both groups were kept on 45% HFD...
March 24, 2017: Obesity
https://www.readbyqxmd.com/read/28332301/a-randomized-trial-comparing-gliclazide-liraglutide-and-metformin-effects-on-diabetes-with-nonalcoholic-fatty-liver-disease
#3
Wenhuan Feng, Caixia Gao, Yan Bi, Min Wu, Ping Li, Shanmei Shen, Wei Chen, Tingting Yin, Dalong Zhu
OBJECTIVE: To compare the effects of gliclazide, liraglutide, and metformin in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease (NAFLD). METHODS: Eighty-seven subjects were randomized to receive liraglutide, metformin, or gliclazide for 24 weeks. Primary outcomes included hemoglobin A1c (HbA1c) levels, intrahepatic fat (IHF) content, and liver function. RESULTS: HbA1c levels and IHF content reduced after treatment in the three groups...
March 23, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28316468/nutritional-quality-and-physicochemical-characteristics-of-defatted-bovine-liver-treated-by-supercritical-carbon-dioxide-and-organic-solvent
#4
Sung-Won Kang, Hye-Min Kim, M Shafiur Rahman, Ah-Na Kim, Han-Sul Yang, Sung-Gil Choi
Defatted bovine liver (DBL) is a potential source of protein and minerals. Supercritical carbon dioxide (SC-CO2) and a traditional organic solvent method were used to remove lipid from bovine liver, and the quality characteristics of a control bovine liver (CBL), bovine liver defatted by SC-CO2 (DBLSC-CO2) at different pressures, and bovine liver defatted by organic solvent (DBL-OS) were compared. The DBLSC-CO2 samples had significantly higher (p<0.05) protein, amino acid, carbohydrate, and fiber contents than CBL and DBL-OS...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28315932/body-and-liver-fat-content-and-adipokines-in-schizophrenia-a-magnetic-resonance-imaging-and-spectroscopy-study
#5
Jong-Hoon Kim, Jung-Hyun Kim, Pil-Whan Park, Jürgen Machann, Michael Roden, Sheen-Woo Lee, Jong-Hee Hwang
RATIONALE: Although antipsychotic treatment often causes weight gain and lipid abnormalities, quantitative analyses of tissue-specific body fat content and its distribution along with adipokines have not been reported for antipsychotic-treated patients. OBJECTIVES: The purposes of the present study were to quantitatively assess abdominal and liver fat in patients with schizophrenia on antipsychotic treatment and age- and body mass index (BMI)-matched healthy controls and to evaluate their associations with plasma leptin and adiponectin levels...
March 18, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28300557/high-fat-diet-aggravates-2-2-4-4-tetrabromodiphenyl-ether-inhibited-testosterone-production-via-dax-1-in-leydig-cells-in-rats
#6
Zhan Zhang, Yongquan Yu, Hengsen Xu, Chao Wang, Minghui Ji, Jun Gu, Lu Yang, Jiansheng Zhu, Huibin Dong, Shou-Lin Wang
Growing evidence has revealed that a high-fat diet (HFD) could lead to disorders of glycolipid metabolism and insulin-resistant states, and HFDs have been associated with the inhibition of testicular steroidogenesis. Our previous study demonstrated that 2,2',4,4'-tetrabromodiphenyl ether (BDE47) could increase the risk of diabetes in humans and reduce testosterone production in rats. However, whether the HFD affects BDE47-inhibited testosterone production by elevating insulin levels and inducing related pathways remains unknown...
March 12, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28300213/effect-of-modulation-of-ppar-%C3%AE-activity-on-kupffer-cells-m1-m2-polarization-in-the-development-of-non-alcoholic-fatty-liver-disease
#7
Wenjing Luo, Qinyu Xu, Qi Wang, Huimin Wu, Jing Hua
Abnormal lipid-mediated hepatic inflammatory-immune dysfunction and chronic low grade inflammation play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Macrophage polarization is an important mechanism for the regulation of inflammatory response. Since PPAR-γ has emerged as a master regulator of macrophage polarization, we aimed to investigate the lipid-induced macrophage/Kupffer cell polarization in vivo and in vitro, and explore the association between PPAR-γ activity and macrophages M1/M2 polarization shifting...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299304/effects-of-phlebotomy-on-liver-enzymes-and-histology-of-patients-with-nonalcoholic-fatty-liver-disease
#8
Mahsa Khodadoostan, Maryam Zamanidoost, Ahmad Shavakhi, Hosein Sanei, Masood Shahbazi, Mehdi Ahmadian
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), defined as excessive liver fat deposition and one of end-stage liver disease causes. Increased ferritin levels are associated with insulin resistance and a higher hepatic iron and fat content. Hyperferritinemia has been associated with severity of liver damage in NAFLD. The study aimed to evaluate the effects of phlebotomy on liver enzymes and histology in such patients. MATERIALS AND METHODS: Thirty-two eligible patients who had NAFLD and after 6 months of lifestyle modification still had NAFLD, and whose ferritin serum was above 250 mg/dl, were enrolled in this clinical trial study...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28296591/hypolipidemic-and-antioxidant-effects-of-malus-toringoides-rehd-hughes-leaves-in-high-fat-diet-induced-hyperlipidemic-rats
#9
Shan Huang, Haifeng Liu, Ning Meng, Bin Li, Jule Wang
Malus toringoides (Rehd.) Hughes (MT) leaves are traditionally used as a medicine for treating or preventing cardiovascular disease in Tibet. In addition to the effect of this medicinal plant on thrombosis, we tested its effect on dyslipidemia in a hypolipidemic rat model. A total of 60 healthy Sprague-Dawley rats were randomly divided into six groups, as follows: normal control, model control, simvastatin groups, and MT low-, medium-, and high-dose groups. The normal controls were fed with a normal diet, whereas all other groups were fed with a high-fat diet...
March 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28294174/docosahexaenoic-acid-enrichment-in-nafld-is-associated-with-improvements-in-hepatic-metabolism-and-hepatic-insulin-sensitivity-a-pilot-study
#10
L Hodson, L Bhatia, E Scorletti, D E Smith, N C Jackson, F Shojaee-Moradie, M Umpleby, P C Calder, C D Byrne
BACKGROUND/OBJECTIVE: Treatment of subjects with non-alcoholic fatty liver disease (NAFLD) with omega-3 polyunsaturated fatty acids (FAs) suggests high levels of docosahexaenoic acid (DHA) tissue enrichment decrease liver fat content. We assessed whether changes in erythrocyte DHA enrichment (as a surrogate marker of changes in tissue enrichment) were associated with alterations in hepatic de novo lipogenesis (DNL), postprandial FA partitioning and hepatic and peripheral insulin sensitivity in a sub-study of the WELCOME trial (Wessex Evaluation of fatty Liver and Cardiovascular markers in NAFLD (non-alcoholic fatty liver disease) with OMacor thErapy)...
March 15, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28286210/using-a-3-proton-density-fat-fraction-as-a-cut-off-value-increases-sensitivity-of-detection-of-hepatic-steatosis-based-on-results-from-histopathology-analysis
#11
Patrik Nasr, Mikael F Forsgren, Simone Ignatova, Nils Dahlström, Gunnar Cedersund, Olof Dahlqvist Leinhard, Bengt Norén, Mattias Ekstedt, Peter Lundberg, Stergios Kechagias
It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy ((1)H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by magnetic resonance was derived from studies that did not use histopathology as the reference standard. We performed a prospective study to determine the accuracy of (1)H-MRS PDFF in measurement of steatosis using histopathology analysis as the standard...
March 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28284571/dynamic-mechanical-analysis-to-assess-viscoelasticity-of-liver-tissue-in-a-rat-model-of-nonalcoholic-fatty-liver-disease
#12
Xinyu Zhang, Xuehua Gao, Pengpeng Zhang, Yanrong Guo, Haoming Lin, Xianfen Diao, Yingxia Liu, Changfeng Dong, Yaxin Hu, Siping Chen, Xin Chen
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in both developed and developing countries. A noninvasive method of detecting early stage NAFLD and distinguishing non-alcoholic steatohepatitis (NASH) from simple steatosis (SS) would be useful. The over-accumulation of fat in hepatocytes alters the physical microstructure and chemical contents of the liver tissue. This study included dynamic mechanical analysis (DMA) testing on liver samples from a rat model of NAFLD to determine whether the tissue shows any significant changes in viscoelasticity due to the histological changes...
March 8, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28282403/chemokine-binding-protein-m3-limits-atherosclerosis-in-apolipoprotein-e-mice
#13
Dhanya Ravindran, Anisyah Ridiandries, Laura Z Vanags, Rodney Henriquez, Siân Cartland, Joanne T M Tan, Christina A Bursill
Chemokines are important in macrophage recruitment and the progression of atherosclerosis. The 'M3' chemokine binding protein inactivates key chemokines involved in atherosclerosis (e.g. CCL2, CCL5 and CX3CL1). We aimed to determine the effect of M3 on plaque development and composition. In vitro chemotaxis studies confirmed that M3 protein inhibited the activity of chemokines CCL2, CCL5 and CX3CL1 as primary human monocyte migration as well as CCR2-, CCR5- and CX3CR1-directed migration was attenuated by M3...
2017: PloS One
https://www.readbyqxmd.com/read/28282095/dietary-fat-proportionately-enhances-oxidative-stress-and-glucose-intolerance-followed-by-impaired-expression-of-the-genes-associated-with-mitochondrial-biogenesis
#14
Nabanita Das, Ashok Mandala, Sudarshan Bhattacharjee, Debasri Mukherjee, Debasish Bandyopadhyay, Sib Sankar Roy
Consumption of food that surpasses the metabolic necessity of the body leads to an epidemic condition termed obesity, which causes several metabolic disorders including oxidative damage. Dietary intervention can enlighten the mechanisms and therapeutics associated with these metabolic disorders. The reported studies related to diet include fat of different kinds and from different sources, however they lack dose response aspects. Our study highlighted the importance of dietary fat modification in modulating oxidative stress-induced glucose intolerance...
March 10, 2017: Food & Function
https://www.readbyqxmd.com/read/28279889/polysaccharide-from-angelica-sinensis-ameliorates-high-fat-diet-and-stz-induced-hepatic-oxidative-stress-and-inflammation-in-diabetic-mice-by-activating-the-sirt1-ampk-pathway
#15
Kaiping Wang, Zhuohong Tang, Jinglin Wang, Peng Cao, Qiang Li, Weizhi Shui, Hongjing Wang, Ziming Zheng, Yu Zhang
Polysaccharide from Angelica sinensis (Oliv.) Diels (ASP) possesses many bioactivities, such as hematopoiesis, anti-inflammation, antioxidation and metabolism regulation. The aim of this study was to investigate the mechanisms underlying the protection of a combination of high-fat diet and streptozotocin-induced liver damage in diabetic Balb/c mice by ASP. Results showed that ASP had beneficial effects on ameliorating hyperglycemia, dyslipidemia and liver injury. Moreover, mechanistic study for the liver-protective role in vivo demonstrated that ASP enhanced the activities of superoxide dismutase and glutathione peroxidase and increased the glutathione content, which resulted in the reduction of hepatic reactive oxygen species (ROS) and malondialdehyde, and reduced the protein expression levels of liver IKKα/NF-κB/p-IκBα and the concentrations of serum tumor necrosis factor-α/interleukin-6...
February 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28271035/attenuated-secretion-of-glucose-dependent-insulinotropic-polypeptide-gip-does-not-alleviate-hyperphagic-obesity-and-insulin-resistance-in-ob-ob-mice
#16
Satoko Shimazu-Kuwahara, Norio Harada, Shunsuke Yamane, Erina Joo, Akiko Sankoda, Timothy J Kieffer, Nobuya Inagaki
OBJECTIVE: Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake and storage. GIP receptor knockout mice are protected from diet induced weight gain and thus GIP antagonists have been proposed as a treatment for obesity. In this study, we assessed the role of GIP in hyperphagia induced obesity and metabolic abnormalities in leptin deficient (Lep(ob/ob)) mice. METHODS: We crossbred GIP-GFP knock-in homozygous mice (GIP(gfp/gfp)) that have complete GIP knockout, and mice heterozygous for the ob mutation (Lep(ob/+)) mice to generate Lep(ob/+)/GIP(+/+), Lep(ob/ob)/GIP(+/+), and Lep(ob/ob)/GIP(gfp/gfp) mice...
March 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28271032/bezafibrate-ameliorates-diabetes-via-reduced-steatosis-and-improved-hepatic-insulin-sensitivity-in-diabetic-tallyho-mice
#17
Andras Franko, Susanne Neschen, Jan Rozman, Birgit Rathkolb, Michaela Aichler, Annette Feuchtinger, Laura Brachthäuser, Frauke Neff, Marketa Kovarova, Eckhard Wolf, Helmut Fuchs, Hans-Ulrich Häring, Andreas Peter, Martin Hrabě de Angelis
OBJECTIVE: Recently, we have shown that Bezafibrate (BEZ), the pan-PPAR (peroxisome proliferator-activated receptor) activator, ameliorated diabetes in insulin deficient streptozotocin treated diabetic mice. In order to study whether BEZ can also improve glucose metabolism in a mouse model for fatty liver and type 2 diabetes, the drug was applied to TallyHo mice. METHODS: TallyHo mice were divided into an early (ED) and late (LD) diabetes progression group and both groups were treated with 0...
March 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28265828/liver-regeneration-is-impaired-in-mice-with-acute-exposure-to-a-very-low-carbohydrate-diet
#18
Hao Chen, Yandie Lin, Wu Sun, Yun Cai, Hao Li
BACKGROUND: The metabolic response to hepatic insufficiency has been implicated in the regulators of normal liver regeneration. Modulation of nutritional factors has been demonstrated to affect liver regeneration. Diets containing very low carbohydrate and high fat levels cause a unique metabolic state, the effect of which on liver regeneration is unknown. METHODS: Mice were placed on standard mice chow (ND) or a very low carbohydrate diet (VLCD) after 70% partial hepatectomy (PH)...
March 6, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28265495/obesity-induced-diet-leads-to-weight-gain-systemic-metabolic-alterations-adipose-tissue-inflammation-hepatic-steatosis-and-oxidative-stress-in-gerbils-meriones-unguiculatus
#19
Luciana L A Ventura, Nathália C L Fortes, Helton C Santiago, Marcelo V Caliari, Maria A Gomes, Dirce R Oliveira
BACKGROUND: Nowadays, the number of obese people in the world has reached alarming proportions. During the expansion of adipose tissue, a number of functions such as activation and release of cytokines and hormones may be affected. This leads the body to a pro-inflammatory pattern, which may affect the proper functioning of many tissues. Thus, studying the mechanisms by which obesity induces physiological disorders is necessary, and may be facilitated by the use of animal models, in particular rodents...
2017: PeerJ
https://www.readbyqxmd.com/read/28261926/acute-caloric-restriction-counteracts-hepatic-bile-acid-and-cholesterol-deficiency-in-morbid-obesity
#20
S Straniero, F Rosqvist, D Edholm, H Ahlström, J Kullberg, M Sundbom, U Risérus, M Rudling
BACKGROUND: Bile acid (BA) synthesis is regulated by BA signalling in the liver and by fibroblast growth factor 19 (FGF19), synthesized and released from the intestine. In morbid obesity, faecal excretion and hepatic synthesis of BAs and cholesterol are strongly induced and caloric restriction reduces their faecal excretion considerably. We hypothesized that the high intestinal food mass in morbidly obese subjects promotes faecal excretion of BAs and cholesterol, thereby creating a shortage of both BAs and cholesterol in the liver...
March 6, 2017: Journal of Internal Medicine
keyword
keyword
81684
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"