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https://www.readbyqxmd.com/read/29325281/-value-of-hydrogen-proton-magnetic-resonance-spectroscopy-in-the-determination-of-liver-triglyceride-in-patients-with-fatty-liver-disease-and-its-influencing-factors
#1
H J Qu, L Wang, P H Jin, Q Gao, J X Zhou, Y Song, J Wang, Y M Jiang, L Gong, G Y Chen, J P Ding, J P Shi
Objective: To investigate the value of 1H-magnetic resonance spectroscopy ((1)H-MRS) in determining the content of liver triglyceride in patients with fatty liver disease (FLD), as well as its influencing factors. Methods: A total of 124 patients with nonalcoholic fatty liver disease (NAFLD), chronic hepatitis B (CHB), or hepatitis B complicated by FLD who underwent liver biopsy in the Affiliated Hospital of Hangzhou Normal University were enrolled, and the clinical data, serological markers, FibroScan results, and (1)H-MRS results were collected...
November 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29319730/effect-of-different-commercial-fat-sources-on-brain-liver-and-blood-lipid-profiles-of-rats-in-growth-phase
#2
Michel Cardoso de Angelis-Pereira, Maria de Fátima Píccolo Barcelos, Juciane de Abreu Ribeiro Pereira, Rafaela Corrêa Pereira, Raimundo Vicente de Souza
PURPOSE: To investigate the fatty acid content of different fat sources and evaluate the effect of them on plasma and hepatic lipids and on the fatty acid profile of the brain tissue of Wistar rats. METHODS: Thirty male albino Wistar rats received for 59 days, the following diets: diet added of margarine with low content of polyunsaturated fatty acids (PUFA); diet added of margarine with high content of PUFA; diet added of butter; diet added of hydrogenated vegetable fat; diet added of soybean oil...
December 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29299589/hypolipidemic-effect-and-protection-ability-of-liver-kidney-functions-of-melanin-from-lachnum-ym226-in-high-fat-diet-fed-mice
#3
Fang Shi, Jinglei Li, Liuqing Yang, Guohua Hou, Ming Ye
In the present study, we investigated the hypolipidemic properties of melanin from Lachnum YM226 (LM) in high-fat diet induced hyperlipidemic mice. After the hyperlipidemic model was established, mice were randomly divided into six groups, as follows: normal control group (NC), hyperlipidemic control group (HC), positive control group (7 mg kg-1 d-1 simvastatin) (PC) and LM groups (50, 100 and 200 mg kg-1 d-1 denoted as LM-50, LM-100 and LM-200, respectively). Subsequently, the body weight, organ indices, lipid metabolism, antioxidant properties and liver-kidney functions of the mice were examined...
January 4, 2018: Food & Function
https://www.readbyqxmd.com/read/29298969/-dietetary-recommendation-for-non-alcoholic-fatty-liver-disease
#4
REVIEW
Anna Jeznach-Steinhagen, Joanna Ostrowska, Aneta Czerwonogrodzka-Senczyna, Iwona Boniecka, Wioletta Gronostajska
Non-alcoholic Fatty Liver Disease (NAFLD) is currently the most common chronic liver disease in the developed world. Nowadays, in the adult population of Europe it is estimated at 14% to 21%. Its most important risk factors are obesity and metabolic syndrome. Introducing lifestyle changes such as: dietary intervention and increased physical activity are the first-line treatment and are intended to support not only NAFLD but also associated diseases such as obesity, insulin resistance, diabetes and dyslipidemia...
December 22, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29285805/atmospheric-ammonia-alters-lipid-metabolism-related-genes-in-the-livers-of-broilers-gallus-gallus
#5
R N Sa, H Xing, S J Luan, Y B Sun, C Y Sun, H F Zhang
Atmospheric ammonia in animal housing is reported to have adverse effects on livestock performance and animal health. Previous experiments have found that 75 ppm ammonia reduced the production performance and altered body fat distribution quality of broilers. In this study, we examined the body fat distribution, serum metabolites and lipid metabolism gene expression of broiler exposed to ammonia. A total of 400 chickens were randomly allocated to four groups with four replicates and received ammonia treatments at 0, 25, 50 and 75 ppm, respectively, for 3 weeks...
December 29, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29279183/increased-fibrosis-a-novel-means-by-which-gh-influences-white-adipose-tissue-function
#6
Lara A Householder, Ross Comisford, Silvana Duran-Ortiz, Kevin Lee, Katie Troike, Cody Wilson, Adam Jara, Mitchell Harberson, Edward O List, John J Kopchick, Darlene E Berryman
OBJECTIVE: White adipose tissue (WAT) fibrosis - the buildup of extracellular matrix (ECM) proteins, primarily collagen - is now a recognized hallmark of tissue dysfunction and is increased with obesity and lipodystrophy. While growth hormone (GH) is known to increase collagen in several tissues, no previous research has addressed its effect on ECM in WAT. Thus, the purpose of this study is to determine if GH influences WAT fibrosis. DESIGN: This study examined WAT from four distinct strains of GH-altered mice (bGH and GHA transgenic mice as well as two tissue specific GH receptor gene disrupted lines, fat growth hormone receptor knockout or FaGHRKO and liver growth hormone receptor knockout or LiGHRKO mice)...
December 20, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29278293/green-tea-polyphenol-egcg-alleviates-metabolic-abnormality-and-fatty-liver-by-decreasing-bile-acid-and-lipid-absorption-in-mice
#7
Jinbao Huang, Simin Feng, Anna Liu, Zhuqing Dai, Hong Wang, Kenneth Reuhl, Wenyun Lu, Chung S Yang
SCOPE: The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been shown to ameliorate metabolic abnormalities and fatty liver. The present study investigated the mechanisms of actions of EGCG on bile acid homeostasis and lipid metabolism. METHODS: Male C57BL/6J mice were fed a low-fat diet, a high-fat western-style diet or a high-fat western-style diet containing 0.32% EGCG. The effects of the treatments on biochemical parameters, gene expression and lipidomics were analyzed...
December 26, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29274591/extract-of-citrus-maxima-pummelo-leaves-improve-hepatoprotective-activity-in-wistar-rats-submitted-to-the-induction-of-non-alcoholic-hepatic-steatosis
#8
Denise Lima Feksa, Ritiéle Pinto Coelho, Angélica Aparecida da Costa Güllich, Emanuelle S Dal Ponte, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini
Non-alcoholic fatty liver disease is a spectrum of liver changes, ranging from hepatic steatosis to hepatocellular carcinoma. The Citrus maxima (CM) has been shown to be beneficial to the organism, and these activities are attributed to the presence of phytochemical compounds. The objective of this study was to evaluate the n vitro antioxidant potential of the CM leaves extract and on Wistar rats submitted to hepatic steatosis induction by fructose-associated hyperlipid diet (FHD). For the evaluation of in vivo effects, the animals were distributed in G1 (normal diet - ND), G2 (FHD), G3 (ND + extract 50mg/kg) and G4 (FHD + extract 50 mg/kg)...
December 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29273469/circulating-triacylglycerols-but-not-pancreatic-fat-associate-with-insulin-secretion-in-healthy-humans
#9
Bettina Nowotny, Sabine Kahl, Birgit Klüppelholz, Barbara Hoffmann, Guido Giani, Roshan Livingstone, Peter J Nowotny, Valerie Stamm, Christian Herder, Andrea Tura, Giovanni Pacini, Jong-Hee Hwang, Michael Roden
BACKGROUND: Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipocytokines or from ectopic lipid storage in the pancreas. This study aimed to address whether circulating lipids, adipocytokines or pancreatic fat primarily associate with lower insulin secretion. SUBJECTS/METHODS: Nondiabetic persons (n=73), recruited from the general population, underwent clinical examinations, fasting blood drawing to measure TG and adipocytokines and oral glucose tolerance testing (OGTT) to assess basal and dynamic insulin secretion and sensitivity indices...
December 19, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29262266/effect-of-a-short-term-physical-activity-intervention-on-liver-fat-content-in-obese-children
#10
Dong-Woo Kang, Ji-Hye Park, Mi Kyung Lee, YoonMyung Kim, In Deok Kong, Choon Hee Chung, Young Hee Lee, Justin Y Jeon
Nonalcoholic fatty liver disease is the most common chronic liver disease and can present with advanced fibrosis or nonalcoholic steatohepatitis. The purpose of this study is to investigate the effect of a 7-day intense physical activity intervention on liver fat content in children with obesity. Fifty-seven obese children (Mean BMI: 26.5±3.2 kg/m2; Mean age: 12.0±0.8 y) participated in a 7-day physical activity program. All participants were housed together and their food intake and energy expenditure were strictly controlled...
December 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29261513/high-content-hydrogen-water-induced-downregulation-of-mir-136-alleviates-non-alcoholic-fatty-liver-disease-by-regulating-nrf2-via-targeting-meg3
#11
Xiang Wang, Jiao Wang
This study was aimed to investigate the potential regulatory mechanism of high-content hydrogen water (HHW) in non-alcoholic fatty liver disease (NAFLD). A high-fat diet (HFD)-induced NAFLD mice model and cellular model were prepared. The serum levels of alanine transaminase (ALT), aspartate transaminase (AST), total cholesterol (TCH) and triglycerides (TG) were measured. The expression levels of representative 5 miRNAs (miR-103, miR-488, miR-136, miR-505 and miR-148a) in liver tissues were determined by quantitative real-time PCR (qRT-PCR)...
June 27, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/29249214/hitting-a-triple-in-the-non-alcoholic-fatty-liver-disease-field-sucrose-intake-in-adulthood-increases-fat-content-in-the-female-but-not-in-the-male-rat-offspring-of-dams-fed-a-gestational-low-protein-diet
#12
L Nicolás-Toledo, M Cervantes-Rodríguez, E Cuevas-Romero, D L Corona-Quintanilla, E Pérez-Sánchez, E Zambrano, F Castelán, J Rodríguez-Antolín
The excessive consumption of carbohydrates is related to non-alcoholic fatty liver disease (NAFLD) in infants and adults. The effect of combining maternal malnutrition and a high carbohydrate intake on the development of NAFLD in adulthood remains unknown. We therefore hypothesized that consumption of 5% sucrose by the offspring of dams fed a low-protein diet during pregnancy promotes liver fat accumulation and oxidative damage differently in females and males. To test this, 12-month-old female and male offspring of mothers fed a Control (C) or low-protein diet (Restricted, R) were provided with either tap water or 5% sucrose for a period of 10 weeks...
December 18, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29247558/european-association-for-the-study-of-the-liver-easl-european-association-for-the-study-of-diabetes-easd-and-european-association-for-the-study-of-obesity-easo-clinical-practice-recommendations-for-the-management-of-non-alcoholic-fatty-liver-disease-evaluation
#13
A L Sberna, B Bouillet, A Rouland, M C Brindisi, A Nguyen, T Mouillot, L Duvillard, D Denimal, R Loffroy, B Vergès, P Hillon, J M Petit
AIMS: To evaluate the application of the recently proposed recommendations by the European Association for the Study of the Liver, European Association for the Study of Diabetes and European Association for the Study of Obesity for the diagnosis, treatment and follow-up of non-alcoholic fatty liver disease in people with Type 2 diabetes. METHODS: A total of 179 people with Type 2 diabetes were included in this study. Liver fat content (assessed using proton magnetic resonance spectroscopy), fatty liver index score, non-alcoholic fatty liver disease fibrosis score, and SteatoTest and FibroTest scores were determined...
December 16, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29241148/obesity-exacerbates-the-acute-metabolic-side-effects-of-olanzapine
#14
Logan K Townsend, Willem T Peppler, Natasha D Bush, David C Wright
Olanzapine is a second-generation antipsychotic used in the management of schizophrenia and various off-label conditions. The acute metabolic responses of olanzapine recapitulate many of the side effects associated with obesity. Obesity rates are high in the schizophrenic population, but it is unknown whether pre-existing obesity-associated metabolic dysfunction augments the acute side effects of olanzapine. To address this question, we compared the responses to olanzapine in lean and high-fat diet-induced (HFD) obese mice...
December 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29238866/validation-of-goose-liver-fat-measurement-by-qct-and-cse-mri-with-biochemical-extraction-and-pathology-as-reference
#15
Li Xu, Yangyang Duanmu, Glen M Blake, Chenxin Zhang, Yong Zhang, Keenan Brown, Xiaoqi Wang, Peng Wang, Xingang Zhou, Manling Zhang, Chao Wang, Zhe Guo, Giuseppe Guglielmi, Xiaoguang Cheng
OBJECTIVES: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. METHODS: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical measurement and histology...
December 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29234288/lipocalin-2-in-fructose-induced-fatty-liver-disease
#16
Jessica Lambertz, Thorsten Berger, Tak W Mak, Josef van Helden, Ralf Weiskirchen
The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ. However, precisely how fructose is involved in NAFLD progression is still not fully understood, limiting therapy. Lipocalin-2 (LCN2) is a small secreted transport protein that binds to fatty acids, phospholipids, steroids, retinol, and pheromones. LCN2 regulates lipid and energy metabolism in obesity and is upregulated in response to insulin...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29232702/adipose-tissue-deficiency-of-hormone-sensitive-lipase-causes-fatty-liver-in-mice
#17
Bo Xia, Guo He Cai, Hao Yang, Shu Pei Wang, Grant A Mitchell, Jiang Wei Wu
Fatty liver is a major health problem worldwide. People with hereditary deficiency of hormone-sensitive lipase (HSL) are reported to develop fatty liver. In this study, systemic and tissue-specific HSL-deficient mice were used as models to explore the underlying mechanism of this association. We found that systemic HSL deficient mice developed fatty liver in an age-dependent fashion between 3 and 8 months of age. To further explore the mechanism of fatty liver in HSL deficiency, liver-specific HSL knockout mice were created...
December 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29228164/liver-fat-content-non-alcoholic-fatty-liver-disease-and-ischaemic-heart-disease-mendelian-randomization-and-meta-analysis-of-279%C3%A2-013-individuals
#18
Bo Kobberø Lauridsen, Stefan Stender, Thomas Skårup Kristensen, Klaus Fuglsang Kofoed, Lars Køber, Børge G Nordestgaard, Anne Tybjærg-Hansen
Aims: In observational studies, non-alcoholic fatty liver disease (NAFLD) is associated with high risk of ischaemic heart disease (IHD). We tested the hypothesis that a high liver fat content or a diagnosis of NAFLD is a causal risk factor for IHD. Methods and results: In a cohort study of the Danish general population (n = 94 708/IHD = 10 897), we first tested whether a high liver fat content or a diagnosis of NAFLD was associated observationally with IHD...
December 8, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29227215/dietary-phosphatidylcholine-impacts-on-growth-performance-and-lipid-metabolism-in-adult-genetically-improved-farmed-tilapia-gift-strain-of-nile-tilapia-oreochromis-niloticus
#19
Juan Tian, Hua Wen, Xing Lu, Wei Liu, Fan Wu, Chang-Geng Yang, Ming Jiang, Li-Juan Yu
This study aimed to determine the effects of supplementing the diet of adult Nile tilapia Oreochromis niloticus with phosphatidylcholine (PC) on growth performance, body composition, fatty acid composition and gene expression. Genetically Improved Farmed Tilapia fish with an initial body weight of 83·1 (sd 2·9) g were divided into six groups. Each group was hand-fed a semi-purified diet containing 1·7 (control diet), 4·0, 6·5, 11·5, 21·3 or 41·0 g PC/kg diet for 68 d. Supplemental PC improved the feed efficiency rate, which was highest in the 11·5 g PC/kg diet...
December 11, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29222767/platelet-counts-and-liver-enzymes-after-gastric-bypass-surgery
#20
Hans-Erik Johansson, Anna Wåhlén, Erica Aldenbäck, Arvo Haenni
BACKGROUND: Obesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP)...
December 8, 2017: Obesity Surgery
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