Yawen Sun, Wenjuan Liu, Mu Su, Tao Zhang, Xia Li, Wenbin Liu, Yuping Cai, Deli Zhao, Ming Yang, Zhengjiang Zhu, Jialin Wang, Jinming Yu
Esophageal squamous cell carcinoma (ESCC) remains an important health concern in developing countries. Patients with advanced ESCC have a poor prognosis and survival rate, and achieving early diagnosis remains a challenge. Metabolic biomarkers are gradually gaining attention as early diagnostic biomarkers. Hence, this multicenter study comprehensively evaluated metabolism dysregulation in ESCC through an integrated research strategy to identify key metabolite biomarkers of ESCC. First, the metabolic profiles were examined in tissue and serum samples from the discovery cohort (n = 162; ESCC patients, n = 81; healthy volunteers, n = 81), and ESCC tissue-induced metabolite alterations were observed in the serum...
March 14, 2024: Cell Death Discovery