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Meibomian glands

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https://www.readbyqxmd.com/read/29778280/influence-of-cataract-surgery-on-meibomian-gland-dysfunction
#1
A El Ameen, S Majzoub, G Vandermeer, P-J Pisella
PURPOSE: To evaluate the influence of cataract surgery on Meibomian gland dysfunction, in particular on postoperative functional symptoms. PATIENTS AND METHODS: Thirty patients who underwent cataract surgery were included in the study. A clinical examination (OSDI questionnaire, measurement of tear break-up time (TBUT), corneal staining, Meibomian gland expression test) and a paraclinical evaluation (Meibomian gland loss [MGL] measured using ImageJ on Meibography, conjunctival hyperemia and non-invasive keratograph break-up time [NIK-BUT]) were performed preoperatively and at 1month and 3months after phacoemulsification...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29763693/influence-of-lipopolysaccharide-on-proinflammatory-gene-expression-in-human-corneal-conjunctival-and-meibomian-gland-epithelial-cells
#2
Di Chen, Afsun Sahin, Wendy R Kam, Yang Liu, Raheleh Rahimi Darabad, David A Sullivan
PURPOSE: Lipopolysaccharide (LPS), a bacterial endotoxin, is known to stimulate leuokotriene B4 (LTB4) secretion by human corneal (HCECs), conjunctival (HConjECs) and meibomian gland (HMGECs) epithelial cells. We hypothesize that this LTB4 effect represents an overall induction of proinflammatory gene expression in these cells. Our objective was to test this hypothesis. METHODS: Immortalized HCECs, HConjECs and HMGECs were cultured in the presence or absence of LPS (15 μg/ml) and ligand binding protein (LBP; 150 ng/ml)...
May 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29757849/ocular-surface-findings-in-patients-with-lichen-planopilaris
#3
Mehdi Gheisari, Sahar Dadkhahfar, Kaveh Fadakar, Reza Mahmoud Robati, Hamideh Moravvej, Mohammad Soleimani, Reza Mirshahi
PURPOSE: Lichen planopilaris (LPP) is a chronic lymphocytic- mediated disorder that selectively involves hair follicles, leading to cicatricial alopecia. The eyelash follicle and meibomian gland (MG) might also be involved in the disease process leading to ocular surface problems. METHODS: In this Cross-sectional case -control study, twenty-three patients with histologically confirmed LPP and 23 healthy controls were recruited in this controlled study. To quantify the signs and symptoms of LPP, we used the Lichen Planopilaris Activity Index...
May 10, 2018: Cornea
https://www.readbyqxmd.com/read/29723887/-lidline-tattoo-associated-with-basal-cell-carcinoma-of-the-lid-margin-coincidence-or-association
#4
Elisabeth M Messmer, Caroline Möhring-Bengisu, Christina Miller
A cystic lesion of the lid margin was excised suspecting basal cell carcinoma. On histology, black-turquoise pigment was seen in the dermis adjacent to the basal cell carcinoma. It was pronounced perivascular, intracellular in macrophages and fibroblasts, but also extracellular as free pigment in the tissue, compatible with an eyelid line tattoo. Typical tissue reactions to tattoo ink, meibomian gland dysfunction after lid margin tattoo, as well as inflammatory reactions in the retina and choroid associated with tattoos distant from the eye are discussed...
May 3, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29708939/outcomes-of-thermal-pulsation-treatment-for-dry-eye-syndrome-in-patients-with-sjogren-disease
#5
Morgan R Godin, Sandra S Stinnett, Preeya K Gupta
PURPOSE: To evaluate the clinical outcomes of thermal pulsation treatment in patients with meibomian gland dysfunction (MGD) and dry eye secondary to Sjogren disease. METHODS: Twenty-four eyes from 13 patients with previously diagnosed Sjogren disease who presented to our institution with dry eye symptoms and had thermal pulsation treatment were prospectively followed up. Patients underwent comprehensive slit-lamp examination, including MGD grading, gland oil flow, corneal and conjunctival staining scores, and tear break-up time (TBUT)...
April 26, 2018: Cornea
https://www.readbyqxmd.com/read/29699948/immediate-effect-of-a-tear-enhancer-and-meibomian-gland-expression-on-the-corneal-surface-and-whole-eye-higher-order-aberrations
#6
Giancarlo Montani, Paul J Murphy, Sudi Patel
PURPOSE: To investigate changes in higher order ocular aberrations (HOA) induced by the administration of 0.15% sodium hyaluronate tear enhancer (TE) and meibomian gland expression (ME) on the tear film of normal subjects. METHODS: HOA values were obtained from the corneal surface (CS) and whole eye (WE), using a corneal topographer and Shack-Hartmann aberrometer, from both eyes of 50 subjects (25 females, mean age±sd 32.5±11.0 years, and 25 males, 33.88±11.2 years) for two pupil sizes (3 and 6mm) in a dark environment...
April 23, 2018: Journal of Optometry
https://www.readbyqxmd.com/read/29696467/ocular-sebaceous-gland-carcinoma-an-update-of-the-literature
#7
REVIEW
Maria Vittoria Cicinelli, Swathi Kaliki
PURPOSE: To review and summarize the newest update on ocular sebaceous gland carcinoma (SGC) focusing on diagnosis and treatment. METHODS: A PubMed search was carried out using the terms "Sebaceous Carcinoma", "Meibomian Gland Carcinoma", "Sebaceous Cell Carcinoma", and "Sebaceous Gland Carcinoma". All studies published in English up to October 2017 were included in this review. RESULTS: Globally, the overall incidence of SGC is increasing making it the third most common eyelid malignancy after basal cell carcinoma (BCC) and squamous cell carcinoma...
April 25, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29692600/a-novel-system-tearcare-%C3%A2-for-the-treatment-of-the-signs-and-symptoms-of-dry-eye-disease
#8
David Badawi
Purpose: The objective of this study was to evaluate the safety and effectiveness of the TearCare® System in adult patients with clinically significant dry eye disease (DED). Patients and methods: This was a prospective, single-center, randomized, parallel-group, clinical trial. Subjects with DED were randomized to either a single TearCare treatment conducted at the clinic or 4 weeks of daily warm compress (WC) therapy. The TearCare procedure consisted of 12 minutes of thermal eyelid treatment immediately followed by manual expression of the meibomian glands...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29688838/intense-pulsed-light-applied-directly-on-eyelids-combined-with-meibomian-gland-expression-to-treat-meibomian-gland-dysfunction
#9
Bei Rong, Yun Tang, Ping Tu, Ruixing Liu, Jing Qiao, Wenjing Song, Rolando Toyos, Xiaoming Yan
OBJECTIVE: To determine the efficacy and safety of intense pulsed light (IPL) applied directly on the eyelids and meibomian gland expression (MGX) in treating meibomian gland dysfunction (MGD). BACKGROUND: IPL application on the periocular skin effectively improves meibomian gland secretion and tear film break-up time (TBUT) in patients with MGD/dry eye. METHODS: This prospective, randomized, double-masked, controlled study involved 44 patients...
April 24, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29681840/intraoperative-adjunctive-mitomycin-c-and-cryotherapy-for-recurrent-conjunctival-papillary-sebaceous-carcinoma
#10
Natsuki Monai, Reiko Tanabu, Takayuki Gonome, Katsunori Yokoi, Satoshi Urushidate, Satoko Morohashi, Hideaki Hirai, Akira Kurose, Mitsuru Nakazawa
Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy. Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29675376/clinical-efficacy-of-combined-topical-0-05-cyclosporine-a-and-0-1-sodium-hyaluronate-in-the-dry-eyes-with-meibomian-gland-dysfunction
#11
Ho-Yun Kim, Ji-Eun Lee, Ha-Na Oh, Ju-Whan Song, Sang-Youp Han, Jong-Soo Lee
AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis® , Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD). METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675375/the-association-between-demodex-infestation-and-ocular-surface-manifestations-in-meibomian-gland-dysfunction
#12
Xiao-Bo Zhang, Ying-Hui Ding, Wei He
AIM: To investigate the association between ocular demodex folliculorum infestation and ocular surface manifestations in meibomian gland dysfunction (MGD). METHODS: Eight-six patients with MGD were enrolled. All enrolled subjects were tested in the following sequence: ocular surface disease index (OSDI), slit-lamp biomicroscope examination, corneal surface regularity index (SRI) and surface asymmetry index (SAI), tear fluid collection, fluorescein tear film break-up time (F-BUT), corneal fluorescein staining (CFS), Schirmer I test (SIT) and demodex folliculorum counting...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29656524/the-prevalence-of-meibomian-gland-dysfunction-tear-film-and-ocular-surface-parameters-in-an-austrian-dry-eye-clinic-population
#13
Dieter Franz Rabensteiner, Haleh Aminfar, Ingrid Boldin, Gerold Schwantzer, Jutta Horwath-Winter
PURPOSE: The purpose of this study was to assess the prevalence of meibomian gland dysfunction (MGD) and its association with tear film and ocular surface parameters in an Austrian clinical population of dry eye patients. METHODS: The records of 1372 consecutive patients from a dry eye unit were analysed retrospectively. Symptoms and objective tear film and ocular surface parameters were evaluated. Patients were classified into pure MGD, pure aqueous tear deficiency (ATD), MGD combined with ATD, pure anterior blepharitis (AB), Sjogren's syndrome (SS) without MGD and SS together with MGD...
April 15, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29649988/the-function-and-morphology-of-meibomian-glands-in-patients-with-thyroid-eye-disease-a-preliminary-study
#14
Chia-Yu Wang, Ren-Wen Ho, Po-Chiung Fang, Hun-Ju Yu, Chun-Chih Chien, Chang-Chun Hsiao, Ming-Tse Kuo
BACKGROUND: To investigate function and morphology of the meibomian gland (MG) in patients with thyroid eye disease (TED). METHODS: In this prospective case series study, patients with unilateral or bilateral TED were consecutively enrolled. The diagnosis of TED was based on the typical orbital findings and/or radiographic evidence. The disease activity of TED was classified according to the clinical activity score (CAS). Degrees of lagophthalmos and exophthalmos, blinking rates, and results of the Schirmer test 1 were also recorded...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29627826/meibomian-gland-dysfunction-in-primary-and-secondary-sj%C3%A3-gren-syndrome
#15
David A Sullivan, Reza Dana, Rose M Sullivan, Kathleen L Krenzer, Afsun Sahin, Beril Arica, Yang Liu, Wendy R Kam, Athena S Papas, Jennifer M Cermak
PURPOSE: We hypothesized that women with primary (pSS) and secondary Sjögren syndrome (sSS; with systemic lupus erythematosus [SLE] or rheumatoid arthritis [RA]) have meibomian gland dysfunction (MGD). We sought to test our hypothesis. METHODS: Subjects with pSS, sSS + SLE, sSS + RA, and non-SS-related MGD were recruited from the Sjögren's Syndrome Foundation or outpatient clinics at Tufts University School of Dental Medicine or Brigham and Women's Hospital. The control population was recruited from the Greater Boston area...
April 6, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29625457/differentiation-patterns-of-immortalized-human-meibomian-gland-epithelial-cells-in-three-dimensional-culture
#16
Nagayoshi Asano, Ulrike Hampel, Fabian Garreis, Antje Schröder, Martin Schicht, Christian M Hammer, Friedrich Paulsen
Purpose: To establish a simplified three-dimensional (3D) meibomian gland culture model using a meibomian gland epithelial cell (HMGEC) line that might be a useful tool to gain deeper insights into meibomian gland dysfunction. For this purpose, 3D differentiation patterns and growth characteristics of HMGECs were studied on various membranes/scaffolds as well as in hanging drops. Methods: Several types of inserts consisting of different materials (Millicell-HA, Millicell-PCF, ThinCert, and Alvetex) as well as hanging drop culture were analyzed...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29587971/prevalence-of-meibomian-gland-dysfunction-at-the-time-of-cataract-surgery
#17
Béatrice Cochener, Albane Cassan, Laura Omiel
PURPOSE: To determine the incidence of meibomian gland dysfunction and quantify subjective dry-eye symptoms in cataract surgery candidates. SETTING: Brest University Hospital, Brest, France. DESIGN: Prospective case series. METHODS: Patients having cataract surgery between November 2015 and June 2016 completed the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire. Lipid layer thickness and partial blink rate measurements as well as gland structure assessment were performed using the Lipiview Ocular Surface Interferometer...
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29574281/the-significance-of-meibomian-gland-changes-in-asymptomatic-children
#18
Yinying Zhao, Siping Chen, Shangrong Wang, Yan Chen, Junhua Li, Yana Fu, Qi Dai, Xiaolei Lin, Yue Wu, Yune Zhao
PURPOSE: To evaluate meibomian gland morphology and function in children without ocular discomfort or pathology. METHOD: A total of 266 eyes of 266 children without signs or symptoms of ocular surface dysfunction were enrolled. Morphology of meibomian glands (MG) and non-invasive break-up time (BUT) was assessed by noncontact meibography. Based on lipid layer thickness (LLT) of the tear film measurements, 66 children were chosen to be assessed by meibomian glands yielding liquid secretion (MGYLS)...
March 21, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29573862/-ocular-surface-aging-pathophysiology-and-consequences-for-management
#19
REVIEW
T Audelan, M Legrand, M M'Garrech, A-L Best, E Barreau, M Labetoulle, A Rousseau
All the components of the ocular surface and the lacrimal system are affected by aging. Aging induces lacrimal gland fibrosis, Meibomian gland dysfunction, loss of corneal sensitivity, decreased corneal cell density, impairment of immune defences, increased local inflammation associated with hormonal changes, conjunctivochalasis, lid abnormalities, etc. Furthermore, homeostasis of the ocular surface may be altered by various age-related systemic comorbidities and iatrogenic interventions. Altogether, aging is considered the most predominant risk factor for dry eye disease...
March 21, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29563688/the-use-of-tea-tree-oil-in-treating-blepharitis-and-meibomian-gland-dysfunction
#20
Thuraya Noaman Maher
INTRODUCTION: Blepharitis and meibomian gland dysfunction are chronic inflammatory conditions with overlapping pathophysiology and symptomatology. Both microbial infection and seborrhea contribute to the pathophysiology and both may benefit from treatment with tea tree oil (TTO). We evaluated the therapeutic effect of eyelids scrubbing with TTO in a group of patients with lid margin disease. MATERIALS AND METHODS: Forty patients were recruited. Half of them received lid scrubbing with a TTO formula (Naviblef™) and the other half was treated by massage and cleansing...
January 2018: Oman Journal of Ophthalmology
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