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https://www.readbyqxmd.com/read/29694704/self-reported-snoring-is-associated-with-chronic-kidney-disease-independent-of-metabolic-syndrome-in-middle-aged-and-elderly-chinese
#1
Jun Song, Chuan Wang, Aixia Ma, Huizhen Zheng, Wenjian Zheng, Xinguo Hou, Cheng Hu, Li Chen, Weiping Jia
AIMS: To investigate the correlation between snoring and chronic kidney disease (CKD) and explore whether metabolic syndrome (MetS) plays an important role in this relationship among middle-aged and elderly Chinese. METHODS: The subjects included in this study were categorized into 3 subgroups based on self-reported snoring frequency (regularly [≥ 3 times per week], occasionally [between "regularly" and "never"] or never [< 1 time per month])...
April 25, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29694626/association-of-different-biomarkers-of-renal-function-with-d-dimer-levels-in-patients-with-type-1-diabetes-mellitus-renal-biomarkers-and-d-dimer-in-diabetes
#2
Caroline Pereira Domingueti, Rodrigo Bastos Fóscolo, Luci Maria S Dusse, Janice Sepúlveda Reis, Maria das Graças Carvalho, Karina Braga Gomes, Ana Paula Fernandes
Objective This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods D-Dimer and cystatin C were measured by ELISA. Creatinine and urea were determined by enzymatic method. Estimated glomerular filtration rate (eGFR) was calculated using CKD-EPI equation...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29694512/quality-of-life-on-hemodialysis-and-inflammation-a-descriptive-analysis
#3
M R Bacci, F Adami, F W S Figueiredo, B C A Alves, G L da Veiga, F L A Fonseca
Chronic kidney disease (CKD) is highly prevalent worldwide. Patients with CKD on hemodialysis are more likely to present behavioral changes and worse quality of life as a result of their routine and complications. They also have higher levels of cytokines. The aim of this study is to assess the relationship between the inflammatory profile and quality of life measured by KDOQL-SF36 in hemodialysis outpatients. Patients older than 21 years of age and on routine hemodialysis for at least 6 months with treatment on a regular weekly basis were included and their anthropometric parameters and serum inflammatory markers were evaluated...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29694247/protein-half-life-determines-expression-of-proteostatic-networks-in-podocyte-differentiation
#4
Christina B Schroeter, Sybille Koehler, Martin Kann, Bernhard Schermer, Thomas Benzing, Paul T Brinkkoetter, Markus M Rinschen
Podocytes are highly specialized, epithelial, postmitotic cells, which maintain the renal filtration barrier. When adapting to considerable metabolic and mechanical stress, podocytes need to accurately maintain their proteome. Immortalized podocyte cell lines are a widely used model for studying podocyte biology in health and disease in vitro. In this study, we performed a comprehensive proteomic analysis of the cultured human podocyte proteome in both proliferative and differentiated conditions at a depth of >7000 proteins...
April 25, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29694149/particle-size-exclusion-clogging-regimes-in-porous-media
#5
G Gerber, S Rodts, P Aimedieu, P Faure, P Coussot
From observations of the progressive deposition of noncolloidal particles by geometrical exclusion effects inside a 3D model porous medium, we get a complete dynamic view of particle deposits over a full range of regimes from transport over a long distance to clogging and caking. We show that clogging essentially occurs in the form of an accumulation of elements in pore size clusters, which ultimately constitute regions avoided by the flow. The clusters are dispersed in the medium, and their concentration (number per volume) decreases with the distance from the entrance; caking is associated with the final stage of this effect (for a critical cluster concentration at the entrance)...
April 6, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29693800/pharmacokinetics-and-pharmacodynamics-of-luseogliflozin-a-selective-sglt2-inhibitor-in-japanese-patients-with-type-2-diabetes-with-mild-to-severe-renal-impairment
#6
Yoshishige Samukawa, Masakazu Haneda, Yutaka Seino, Takashi Sasaki, Atsushi Fukatsu, Yusuke Kubo, Yuri Sato, Soichi Sakai
This open-label, parallel-group, multicenter study aimed to assess the effects of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of luseogliflozin. A single 5-mg dose of luseogliflozin was administered to Japanese patients with type 2 diabetes mellitus in the following groups: G1, normal renal function; G2, mild renal impairment; G3a, mild to moderate impairment; G3b, moderate to severe impairment; G4, severe impairment, based on estimated glomerular filtration rate (eGFR; ≥90, 60-89, 45-59, 30-44, 15-29 mL/min/1...
April 25, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29693458/segmental-ureterectomy-is-acceptable-for-high-risk-ureteral-carcinoma-comparing-to-radical-nephroureterectomy
#7
Zixiong Huang, Xiaowei Zhang, Xiaopeng Zhang, Qing Li, Shijun Liu, Luping Yu, Tao Xu
PURPOSE: To determine if segmental ureterectomy (SU) could be chosen for wider oncological indications than low-risk ureteral carcinoma, given the difficulties in accurate preoperative risk stratification determination and kidney-sparing needs for successive therapy. METHODS: Data from ureteral carcinoma patients who underwent open SU or laparoscopic radical nephroureterectomy (RNU) between 2011 and 2016 were retrospectively reviewed. Kaplan-Meier survival analysis and Cox regression model with patients' baseline characteristics (age, bladder cancer history, hydronephrosis), procedure type, and tumor characteristics (site, size, pathological features) as covariates were used to evaluate oncological outcomes...
April 25, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29693449/a-translational-model-of-chronic-kidney-disease-in-swine
#8
Alejandro R Chade, Maxx L Williams, Jason E Engel, Erika Guise, Taylor W Harvey
Animal models of chronic kidney disease (CKD) are critical for understanding its pathophysiology and for therapeutic development. The cardiovascular and renal anatomy and physiology of the pig are virtually identical to humans. This study aimed to develop a novel translational model of CKD that mimics the pathological features of CKD in humans. CKD was induced in 7 domestic pigs by bilateral renal artery stenosis and diet-induced dyslipidemia. Animals were observed for a total of 14 weeks. Renal hemodynamics and function were quantified in vivo using multi-detector CT after 6, 10, and 14 weeks of CKD...
April 25, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29692976/aminopropyl-groups-of-the-functionalized-mobil-crystalline-material-41-as-a-carrier-for-controlled-diclofenac-sodium-and-piroxicam-delivery
#9
Elham Khodaverdi, Mina Ahmadi, Hossein Kamali, Farzin Hadizadeh
Objective: Synthetic Mobil Crystalline Material 41 (MCM-41) as a mesoporous material and functionalized MCM-41 using aminopropyl groups were studied in order to investigate their ability to encapsulate and to control the release of diclofenac sodium and piroxicam. Materials and Methods: MCM-41 was synthesized through sol-gel procedure and functionalized with aminopropyl groups. The physicochemical properties of MCM-41 were studied through particle size analysis, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and carbon-hydrogen-nitrogen analysis...
October 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29692933/murine-nephrotoxic-nephritis-as-a-model-of-chronic-kidney-disease
#10
M K E Ougaard, P H Kvist, H E Jensen, C Hess, I Rune, H Søndergaard
Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD parameters including albuminuria, glomerular filtration rate (GFR), mesangial expansion, and renal fibrosis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29692931/the-reliability-of-the-use-of-serum-neutrophil-gelatinase-associated-lipocalin-levels-in-the-assessment-of-renal-functions-after-coronary-artery-bypass-grafting
#11
Ozan Onur Balkanay, Deniz Göksedef, Suat Nail Ömeroğlu, Gökhan İpek
Objective: Evaluation of perioperative renal function is very important for early diagnosis and treatment of acute kidney injury after coronary artery bypass grafting. Serum creatinine levels, creatinine clearance, and estimated glomerular filtration rates used in determination of postoperative kidney injury can lead to late detection. Therefore, it is necessary to make a diagnosis earlier in clinical practice and to search for a reliable method. The reliability of the use of serum neutrophil gelatinase-associated lipocalin levels in close follow-up of renal function was evaluated in patients with coronary artery bypass grafting under cardiopulmonary bypass in our study...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29692807/absence-of-association-between-preoperative-estimated-glomerular-filtration-rates-and-postoperative-outcomes-following-elective-gastrointestinal-surgeries-a-prospective-cohort-study
#12
Sivesh K Kamarajah, Behrad Barmayehvar, Mustafa Sowida, Amirul Adlan, Christina Reihill, Parvez Ellahee
Background: Preoperative risk stratification and optimising care of patients undergoing elective surgery are important to reduce the risk of postoperative outcomes. Renal dysfunction is becoming increasingly prevalent, but its impact on patients undergoing elective gastrointestinal surgery is unknown although much evidence is available for cardiac surgery. This study aimed to investigate the impact of preoperative estimated glomerular filtration rate (eGFR) and postoperative outcomes in patients undergoing elective gastrointestinal surgeries...
2018: Anesthesiology Research and Practice
https://www.readbyqxmd.com/read/29692316/extended-screening-for-infectious-diseases-among-newly-arrived-asylum-seekers-from-africa-and-asia-verona-province-italy-april-2014-to-june-2015
#13
Dora Buonfrate, Federico Gobbi, Valentina Marchese, Chiara Postiglione, Geraldo Badona Monteiro, Giovanni Giorli, Giuseppina Napoletano, Zeno Bisoffi
Background and aimManagement of health issues presented by newly-arrived migrants is often limited to communicable diseases even though other health issues may be more prevalent. We report the results of infectious disease screening proposed to 462 recently-arrived asylum seekers over 14 years of age in Verona province between April 2014 and June 2015. Methods: Screening for latent tuberculosis (TB) was performed via tuberculin skin test (TST) and/or QuantiFERON-TB Gold in-tube assay and/or chest X-ray. An ELISA was used to screen for syphilis...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29692189/use-of-the-embedded-peritoneal-dialysis-catheter
#14
S Sinha, M Fok, A Davenport, N Banga, B Lindsey, B Fernando, C J Forman
Introduction The use of embedded peritoneal dialysis (PD) catheters is purported to offer numerous benefits over standard placement. However, the optimum period of embedment and the effect of prolonged embedment on subsequent catheter function remain unclear. Methods This retrospective observational study looked at adult patients undergoing embedded PD catheter insertion in a large tertiary referral centre in the UK. Possible predictors for catheter non-function at externalisation were investigated. These included patient factors (age, sex, diabetic status, body mass index, ethnicity, smoking status, previous surgery, estimated glomerular filtration rate), procedural factors (modality of surgery, concurrent surgical procedure), duration of catheter embedment and catheter damage at externalisation...
April 25, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29691991/predicting-acute-renal-injury-in-cancer-patients-receiving-cisplatin-using-urinary-neutrophil-gelatinase-associated-lipocalin-and-cystatin-c
#15
Michael J Jelinek, Sang Mee Lee, Alicia Wyche Okpareke, Claudia Wing, Jay L Koyner, Patrick T Murray, Walter M Stadler, Peter H O' Donnell
Acute kidney injury (AKI) limits cisplatin use. We tested whether urine cystatin C (uCyC) and neutrophil gelatinase-associated lipocalin (uNGAL) can preidentify patients at risk for AKI. Patients initiating cisplatin-based chemotherapy were prospectively enrolled. uNGAL/uCyC were measured pre/post-cisplatin administration and compared with serum creatinine (sCr). AKI was defined as sCr increase ≥50% or ≥0.3 mg/dL above baseline. In all, 102 patients were enrolled; 95 provided evaluable data. Twenty-five patients developed AKI...
April 24, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/29691903/relation-between-respiratory-activity-and-sperm-parameters-in-boar-spermatozoa-cryopreserved-with-alpha-tocopherol-and-selected-by-sephadex
#16
M M Satorre, E Breininger, P D Cetica, M Córdoba
Our aim was to evaluate the effect of Sephadex filtration on respiratory activity of porcine spermatozoa and its relation with quality and functional sperm parameters. Samples were evaluated regarding oxygen uptake and sperm parameters: motility, plasma and acrosome membrane integrity, capacitation and acrosome reaction induction in vitro, plasma membrane functionality, determined by the hypo-osmotic swelling test (HOST), and lipid peroxidation assessed by thiobarbituric acid assay. Sephadex filtration improved all routine quality parameters (motility, plasma and acrosome membrane integrity) and functional parameters (HOST, in vitro capacitation and true acrosome reaction levels) and produced a significant decrease in cryocapacitation and lipid peroxidation...
April 24, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29691537/design-and-synthesis-of-functionalized-coordination-polymers-as-recyclable-heterogeneous-photocatalysts
#17
Cai-Ping Ye, Gan Xu, Zheng Wang, Jie Han, Lian Xue, Fu-Yu Cao, Qi Zhang, Lin-Feng Yang, Li-Zhou Lin, Xu-Dong Chen
The functionalized ligand 9,10-anthraquinone-1,4-dicarboxylate acid (H2AQDC) was designed and synthesized in order to develop metal-organic coordination polymers as heterogeneous catalysts with a photosensitizing feature. Two major considerations of the ligand design are anthraquinone moieties for photosensitizing to harvest light and carboxylate groups for polymeric coordination toward less solubility. A series of transition metal complexes based on this ligand were synthesized subsequently, namely {Co(AQDC)(H2O)3·2H2O}n (Co-AQDC), {Ni(AQDC)(H2O)3·2H2O}n (Ni-AQDC), {[Cu(AQDC)(H2O)3][Cu(AQDC)(H2O)2(DMF)]·(H2O)4}n (Cu-AQDC), {Zn1...
April 25, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29691363/detection-of-circulating-mycobacterium-tuberculosis-specific-dna-by-droplet-digital-pcr-for-vaccine-evaluation-in-challenged-monkeys-and-tb-diagnosis
#18
Neng Song, Yang Tan, Lingyun Zhang, Wei Luo, Qing Guan, Ming-Zhe Yan, Ruiqi Zuo, Weixiang Liu, Feng-Ling Luo, Xiao-Lian Zhang
Mycobacterium tuberculosis (M. tb) is emerging as a more serious pathogen due to the increased multidrug-resistant TB and co-infection of human immunodeficiency virus (HIV). The development of an effective and sensitive detection method is urgently needed for bacterial load evaluation in vaccine development, early TB diagnosis, and TB treatment. Droplet digital polymerase chain reaction (ddPCR) is a newly developed sensitive PCR method for the absolute quantification of nucleic acid concentrations. Here, we used ddPCR to quantify the circulating virulent M...
April 24, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29691135/order-entry-protocols-are-an-amenable-target-for-workflow-automation
#19
James Tudor, Chad Klochko, Milind Patel, Daniel Siegal
PURPOSE: Order entry protocol selection of advanced imaging studies is labor-intensive, can disrupt workflow, and may displace staff from more valuable tasks. The aim of this study was to explore and compare the behaviors of radiologic technologists and radiologists when determining protocol to identify opportunities for workflow automation. METHODS: A data set of over 273,000 cross-sectional examination orders from four hospitals within our health system was created...
April 21, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29691065/clinical-assessment-and-treatment-of-diabetes-in-patients-with-chronic-kidney-disease
#20
J Carretero Gómez, J C Arévalo Lorido
Diabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24.7% of patients. The prevalence of microalbuminuria, proteinuria and a reduced glomerular filtration rate is 36%, 8% and 22%, respectively. The presence of albuminuria is a predictor of chronic kidney disease. Diabetic kidney disease, previously known as diabetic nephropathy, refers to kidney disease caused by diabetes...
April 21, 2018: Revista Clínica Española
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