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https://www.readbyqxmd.com/read/29458174/networks-that-link-cytoskeletal-regulators-and-diaphragm-proteins-underpin-filtration-function-in-drosophila-nephrocytes
#1
Simi Muraleedharan, Aksah Sam, Helen Skaer, Maneesha S Inamdar
Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They possess an exceptional macromolecular assembly, the nephrocyte diaphragm (ND), which serves as a filtration barrier and helps maintain tissue homeostasis by filtering out wastes and toxic products. However, the elements that maintain nephrocyte architecture and the ND are not understood. We show that Drosophila nephrocytes have a unique cytoplasmic cluster of F-actin, which is maintained by the microtubule cytoskeleton and Rho-GTPases...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29457901/c-sp3-h-bond-functionalization-of-benzo-c-oxepines-via-c-o-bond-cleavage-formal-3-3-synthesis-of-multi-substituted-chromans
#2
Miao Wang, Bo-Cheng Tang, Jia-Chen Xiang, Yan Cheng, Zi-Xuan Wang, Jin-Tian Ma, Yan-Dong Wu, An-Xin Wu
An efficient base-promoted C(sp3)-H bond functionalization strategy for the synthesis of multi-substituted chromans from the formal [3+3] cycloaddition of benzo[c]oxepines and electron-rich phenols has been developed. The corresponding 4H-chromenes can be easily obtained in excellent yields by simple filtration from chromans. Preliminary mechanistic studies indicate that the C-O bond cleavage is the key step for the C(sp3)-H bond functionalization and this reaction could have occurred through a tandem C-O bond cleavage/ Michael addition/ annulation reactions...
February 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29456767/biochemical-characterization-of-two-clinically-relevant-human-fumarase-variants-defective-for-oligomerization
#3
REVIEW
Artemisa Bulku, Todd M Weaver, Melanie B Berkmen
Background: Fumarase, a significant enzyme of energy metabolism, catalyzes the reversible hydration of fumarate to L-malate. Mutations in the FH gene, encoding human fumarase, are associated with fumarate hydratase deficiency (FHD) and hereditary leiomyomatosis and renal cell cancer (HLRCC). Fumarase assembles into a homotetramer, with four active sites. Interestingly, residues from three of the four subunits within the homotetramer comprise each active site. Hence, any mutation affecting oligomerization is predicted to disrupt enzyme activity...
2018: Open Biochemistry Journal
https://www.readbyqxmd.com/read/29456238/remote-ischemic-postconditioning-ripc-of-the-upper-arm-results-in-protection-from-cardiac-ischemia-reperfusion-injury-following-primary-percutaneous-coronary-intervention-pci-for-acute-st-segment-elevation-myocardial-infarction-stemi
#4
Bangming Cao, Haipeng Wang, Chi Zhang, Ming Xia, Xiangjun Yang
BACKGROUND The aim of this study was to evaluate the role of remote ischemic postconditioning (RIPC) of the upper arm on protection from cardiac ischemia-reperfusion injury following primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI). MATERIAL AND METHODS Eighty patients with STEMI were randomized into two groups: primary PCI (N=44) and primary PCI+RIPC (N=36). RIPC consisted of four cycles of 5 minutes of occlusion and five minutes of reperfusion by cuff inflation and deflation of the upper arm, commencing within one minute of the first PCI balloon dilatation...
February 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29456222/prevalence-and-risk-factors-of-chronic-kidney-disease-in-cote-d-ivoire-an-analytic-study-conducted-in-the-department-of-internal-medicine
#5
Hubert Kouame Yao, Serge Didier Konan, Sindou Sanogo, Sery Patrick Diopoh, Amadou Demba Diallo
Chronic kidney disease (CKD) has become a public health problem because of its increasing prevalence. The objective of this study was to describe the current profile of CKD in our working conditions. This is a descriptive retrospective study of patients admitted for CKD during the period from January 2010 to December 2014 in the Internal Medicine Department of the university hospital of Treichville in Abidjan. CKD was defined by a glomerular filtration rate below 60 mL/min lasting for at least three months...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456209/assessment-of-prevalence-and-clinical-outcome-of-frailty-in-an-elderly-predialysis-cohort-using-simple-tools
#6
Hatem Ali, Tarek Abdelaziz, Fatima Abdelaal, Jyoti Baharani
The relationship between frailty and chronic kidney disease in elderly population has been recognized; however, studies concentrating on frailty in predialysis patients are limited. For nephrologists, the recognition of frailty is important as it has impact on decisions on the choice of dialysis modality and sometimes on whether dialysis is indeed in the patients' best interests. Many of the tools for routine assessment of frailty are not easily applicable to those clinicians not practicing elderly care medicine...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29455976/near-infrared-emissive-lanthanide-hybridized-nanofibrillated-cellulose-nanopaper-as-ultraviolet-filter
#7
Bailiang Xue, Zhao Zhang, Yongchang Sun, Junjie Wang, Huie Jiang, Min Du, Congcong Chi, Xinping Li
The lanthanide complexes [Yb(fac)3 (H2 O)2 , Yb(tta)3 (H2 O)2 , Nd(tta)3 (H2 O)2 ] functionalized nanofibrillated cellulose (Ln-NFC) nanopapers with near-infrared (NIR) luminescence and high transparency are rapidly fabricated after solvent exchange using a simple suction filtration film-making method. The effects of NFC and lanthanide complexes content on their photophysical properties of Ln-NFC nanopapers and their mechanism of UV filters are fully investigated. With increasing lanthanide complexes content in the Ln-NFC nanopaper, their transmittances are gradually decreased while their NIR luminescences are obviously increased...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455546/effects-of-complete-water-fasting-and-regeneration-diet-on-kidney-function-oxidative-stress-and-antioxidants
#8
V Mojto, A Gvozdjakova, J Kucharska, Z Rausova, O Vancova, J Valuch
OBJECTIVE: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress. BACKGROUND: Therapeutic WF is considered a healing method. METHODS: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Data on body weight, blood pressure, kidney functions, antioxidants, lipid peroxidation, cholesterols, triacylglycerols and selected biochemical parameters were obtained...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455284/speciation-analysis-of-arsenic-in-seafood-and-seaweed-part-i-evaluation-and-optimization-of-methods
#9
Mesay Mulugeta Wolle, Sean D Conklin
Several extraction and chromatographic methods were evaluated to identify optimum conditions for arsenic speciation analysis in seafood and seaweed. The extraction systems, which include aqueous, aqueous-organic, acidic, basic, and enzymatic solutions, were examined for their efficiency in extracting arsenic from finfish, crustaceans, molluscs, and seaweed keeping the chemical forms of the native arsenicals intact. While dilute solutions of nitric acid, hydrochloric acid, and tetramethylammonium hydroxide (TMAH) extract high fractions of arsenic from most of the matrices, the extractants oxidized arsenite (As3+ ) to arsenate (As5+ ) and converted some arsenosugars and non-polar arsenicals to known and/or unknown forms...
February 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29454867/acellular-filtrate-of-a-microbial-based-cleaning-product-potentiates-house-dust-mite-allergic-lung-inflammation
#10
Azam F Tayabali, Yan Zhang, Jason H Fine, Don Caldwell, Martha Navarro
Microbial-based cleaning products (MBCPs) contain bacteria and chemical constituents. They are used in consumer applications such as odour reduction, unclogging drains, and surface cleaning. To determine the capacity of a model MBCP to contribute to acute allergic lung inflammation, a two-week repeated exposure regimen was used. Mice were exposed by endotracheal instillation to saline alone, MBCP alone, house dust mites (HDM) alone, or sequentially (i.e., MBCP followed by HDM, HDM followed by MBCP, or HDM + MBCP followed by HDM)...
February 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29454540/asymmetric-cellulose-triacetate-is-a-safe-and-effective-alternative-for-online-haemodiafiltration
#11
Marta Albalate Ramón, Patricia Martínez Miguel, Lourdes Bohorquez, Patricia de Sequera, Hanane Bouarich, Rafael Pérez-García, Diego Rodríguez Puyol, Guillermina Barril, Jose Antonio Sánchez Tomero, Martin Giorgi, Manuel Rafael Ramirez Chamond
BACKGROUND: In post-dilution haemodiafiltration only synthetic membranes have been used to date. Asymmetric cellulose triacetate (ATA™) is now available, whose characteristics are suitable for this technique. OBJECTIVES: To describe the in vivo performance and behaviour of this membrane, to identify its depurative effectiveness, use in clinical practice and its biocompatibility, both acute and after one month of treatment. METHODS: Observational prospective study of 23 patients who were dialysed for 4 weeks using an ATA™ membrane and who maintained their prior regimen...
February 14, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29454528/continuous-infusion-versus-intermittent-bolus-injection-of-furosemide-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#12
REVIEW
Ka Ting Ng, Aslinah Velayit, Delton Kah Yeang Khoo, Amirah Mohd Ismail, Marzida Mansor
OBJECTIVE: Fluid overload is a common phenomenon seen in intensive care units (ICUs). However, there is no general consensus on whether continuous or bolus furosemide is safer or more effective in these hemodynamically unstable ICU patients. The aim of this meta-analysis was to examine the clinical outcomes of continuous versus bolus furosemide in a critically ill population in ICUs. DATA SOURCES: MEDLINE, EMBASE, PubMed, and the Cochrane Database of Systematic reviews were searched from their inception until June 2017...
January 10, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29454330/comparison-of-visceral-body-fat-indices-and-anthropometric-measures-in-relation-to-chronic-kidney-disease-among-chinese-adults-from-a-large-scale-cross-sectional-study
#13
Ying Dong, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Jingyu Nie, Congyi Zheng, Jiali Wang, Lan Shao, Ye Tian, Runlin Gao
BACKGROUND: The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat index (VFI), percentage body fat (PBF), body mass index (BMI), waist circumference (WC) and waist-to-height ratio (WHtR). METHODS: A total of 29,516 participants aged 35 years or above were selected using a stratified multistage random sampling method across China during 2012-2015...
February 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29454246/screening-of-physicochemical-treatment-processes-for-reducing-toxicity-of-hair-care-products-wastewaters
#14
Elisa Dias de Melo, Ann Mounteer, Eduarda Reis, Ellen Costa, Alana Vilete
Toxicity reduction in wastewaters from small hair care products manufacturing companies using coagulation/flocculation/sedimentation or flotation, membrane separation and powdered activated charcoal adsorption was evaluated. Raw wastewater composition varied widely within and especially between companies, but all exhibited high acute toxicity to Daphnia similis (EC(I)50; 48 h < 0.02-0.33%). Coagulation with aluminum sulfate and polyaluminum chloride aided by cationic or anionic polymers, as well as filtration on ultra (UF) and nanofiltration (NF) membranes efficiently removed turbidity (>99%) and oil and grease (>99%) and all treated samples exhibited similar dissolved organic matter contents...
February 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29453992/serum-cystatin-c-level-is-associated-with-carotid-arterial-wall-elasticity-in-subjects-with-type-2-diabetes-mellitus-a-potential-marker-of-early-stage-atherosclerosis
#15
Rei Kaneko, Shojiro Sawada, Ai Tokita, Rieko Honkura, Noriko Tumura, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Kenji Uno, Junta Imai, Tetsuya Yamada, Yukiya Miyachi, Hideyuki Hasegawa, Hiroshi Kanai, Yasushi Ishgaki, Hideki Katagiri
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria...
February 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29453878/estimated-gfr-in-stable-older-kidney-transplant-recipients-are-present-algorithms-valid-a-national-cross-sectional-cohort-study
#16
Kristian Heldal, Karsten Midtvedt, Anders Hartmann, Anna Varberg Reisaeter, Torbjørn Fossum Heldal, Stein Bergan, Cathrin Lytomt Salvador, Anders Åsberg
Several equations have been developed for estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease (CKD), but none were developed based on data from elderly kidney transplant recipients (KTR). The primary aim of this study was to evaluate different creatinine based equations in stable elderly KTR. A national cross-sectional study was performed using data from 263 consecutive kidney transplant recipients 60 years or older who performed a routine GFR measurement one year after engraftment...
February 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29453652/significance-of-the-nonneoplastic-renal-parenchymal-findings-in-robotic-partial-nephrectomy-series
#17
Ercan Malkoç, Matthew J Maurice, Oktay Akça, Önder Kara, Homayoun Zargar, Hiury Andrade, Daniel Ramirez, Peter Caputo, Robert Stein, Demirjian Sevag, Jihad H Kaouk
AIM: To describe the pathological characteristics of the peritumoral non-neoplastic renal parenchyma (NNRP) and to investigate their impact on long-term renal function after partial nephrectomy. MATERIALS AND METHODS: In our institutional robotic partial nephrectomy database, we identified 394 cases with pathological assessment of the NNRP and long-term postoperative renal functional follow-up. The NNRP was classified as normal (healthy renal parenchyma) or abnormal, based on the presence of arteriosclerosis, glomerulosclerosis, interstitial fibrosis, interstitial inflammation, and/or tubulopapillary hyperplasia...
February 16, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29453375/self-supporting-co-3-o-4-graphene-hybrid-films-as-binder-free-anode-materials-for-lithium-ion-batteries
#18
Shouling Wang, Ronghua Wang, Jie Chang, Ning Hu, Chaohe Xu
A self-supporting Co 3 O 4 /graphene hybrid film has been constructed via vacuum filtration of Co(OH) 2 nanosheet and graphene, followed by a two-step thermal treatment. Within the hybrid film, Co 3 O 4 nanoparticles with size of 40~60 nm uniformly in-situ grew on the surface of graphene, forming a novel porous and interleaved structure with strong interactions between Co 3 O 4 nanoparticles and graphene. Such fascinating microstructures can greatly facilitate interfacial electron transportation and accommodate the volume changes upon Li ions insertion and extraction...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453260/a-new-cell-extraction-method-reveals-hemolymph-microbiome-of-three-aquatic-invertebrates
#19
Xinxu Zhang, Zaiqiao Sun, Xusheng Zhang, Ming Zhang, Shengkang Li
Symbiotic microorganisms have been found in the hemolymph (blood) of many aquatic invertebrates, such as crabs, shrimps and oysters. Hemolymph is a critical site in host immune response. Currently, studies on hemolymph microorganisms are mostly performed with culture-dependent strategies using selective media (e.g., TCBS, 2216E, and LB) for enumerating and isolating microbial cells. However, doubts remain about the "true" representation of the microbial abundance and diversity of symbiotic microorganisms in hemolymph, particularly for uncultivable microorganisms which are believed to be more abundant than the cultured...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29453129/efficient-visible-light-induced-synthesis-of-silver-nanoparticles-by-penicillium-polonicum-ara-10-isolated-from-chetomorpha-antennina-and-its-antibacterial-efficacy-against-salmonella-enterica-serovar-typhimurium
#20
Sahadevan Neethu, Sebastian Jose Midhun, M A Sunil, Soman Soumya, E K Radhakrishnan, Mathew Jyothis
The green synthesis of silver nanoparticles (AgNPs) using biological systems such as fungi has evolved to become an important area of nanobiotechnology. Herein, we report for the first time the light-induced extracellular synthesis of silver nanoparticles using algicolous endophytic fungus Penicillium polonicum ARA 10, isolated from the marine green alga Chetomorpha antennina. Parametric optimization, including the concentration of AgNO 3 , fungal biomass, ratio of cell filtrate and AgNO 3 , pH, reaction time and presence of light, was done for rapid AgNPs production...
February 7, 2018: Journal of Photochemistry and Photobiology. B, Biology
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