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anti-MAG neuropathy

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https://www.readbyqxmd.com/read/27868289/determinants-of-health-related-quality-of-life-in-anti-mag-neuropathy-a-cross-sectional-multicentre-european-study
#1
Emilien Delmont, Fu Liong Hiew, Julien Cassereau, Anne-Catherine Aubé-Nathier, Aude-Marie Grapperon, Shahram Attarian, Yusuf A Rajabally
Our objective was to assess determinants of quality of life (QoL) in anti-myelin associated glycoprotein antibody (MAG) neuropathy. The SF-36 questionnaire was assessed in 55 patients, from Marseille, Angers (France) and Birmingham (United Kingdom). Routine clinical evaluations included MRC sum score, INCAT sensory score, Inflammatory Rasch-built Overall Disability Score (I-RODS), ataxia score, Jamar grip dynamometry, timed 10 m-walk, Neuropathic Pain Symptom Inventory (NPSI) score, and Fatigue Severity Score (FSS)...
November 21, 2016: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/27866733/review-of-the-literature-articles-published-in-the-last-five-years-that-have-changed-my-daily-practice
#2
REVIEW
E Delmont
Over the last five years, the management of peripheral neuropathies has become structured by the publication of recognized diagnostic criteria for inflammatory neuropathies and the elaboration of a function score, the R-ODS, used to evaluate the progression of these neuropathies. The concept of nodo-paranodopathy has enriched the concept of peripheral neuropathies, over-riding the classical mechanisms of axonal and demyelinating mechanisms. The structures of the nodes of Ranvier, gangliosides, contractin and neurofascin are preferential targets for auto-antibodies responsible for dysimmune neuropathies...
November 17, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27701752/immunotherapy-for-igm-anti-myelin-associated-glycoprotein-paraprotein-associated-peripheral-neuropathies
#3
REVIEW
Michael Pt Lunn, Eduardo Nobile-Orazio
BACKGROUND: Serum monoclonal anti-myelin-associated glycoprotein (anti-MAG) antibodies may be pathogenic in some people with immunoglobulin M (IgM) paraprotein and demyelinating neuropathy. Immunotherapies aimed at reducing the level of these antibodies might be expected to be beneficial. This is an update of a review first published in 2003 and previously updated in 2006 and 2012. OBJECTIVES: To assess the effects of immunotherapy for IgM anti-MAG paraprotein-associated demyelinating peripheral neuropathy...
October 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27463052/anti-mag-negative-distal-acquired-demyelinating-symmetric-neuropathy-in-association-with-a-neuroendocrine-tumor
#4
Taimour Alam, James J P Alix, D Ganesh Rao, Marios Hadjivassiliou
No abstract text is available yet for this article.
July 27, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27314957/is-distal-motor-and-or-sensory-demyelination-a-distinctive-feature-of-anti-mag-neuropathy
#5
Pierre Lozeron, Vincent Ribrag, David Adams, Marion Brisset, Marguerite Vignon, Marine Baron, Marion Malphettes, Marie Theaudin, Bertrand Arnulf, Nathalie Kubis
To report the frequency of the different patterns of sensory and motor electrophysiological demyelination distribution in patients with anti-MAG neuropathy in comparison with patients with IgM neuropathy without MAG reactivity (IgM-NP). Thirty-five anti-MAG patients at early disease stage (20.1 months) were compared to 23 patients with IgM-NP; 21 CIDP patients and 13 patients with CMT1a neuropathy were used as gold standard neuropathies with multifocal and homogeneous demyelination, respectively. In all groups, standard motor and sensory electrophysiological parameters, terminal latency index and modified F ratio were investigated...
September 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27267749/therapeutic-options-and-management-of-polyneuropathy-associated-with-anti-mag-antibodies
#6
Jean-Michel Vallat, Laurent Magy, Jonathan Ciron, Philippe Corcia, Gwendal Le Masson, Stéphane Mathis
INTRODUCTION: IgM monoclonal gammopathy with anti-MAG (myelin associated glycoprotein) antibodies is associated with demyelinating polyneuropathy. MAG mediates adhesion between the Schwann cell membrane (non-compact myelin) and axons. Various drugs have been tried in this form of neuropathy, with varying responses, but to date there is no consensus on the treatment of this disease. AREAS COVERED: Based on the medical literature and the experience of our group of clinicians, we offer some proposals for the management of anti-MAG neuropathy...
September 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27188752/long-term-disability-and-prognostic-factors-in-polyneuropathy-associated-with-anti-myelin-associated-glycoprotein-mag-antibodies
#7
Giuliana Galassi, Manuela Tondelli, Alessandra Ariatti, Francesca Benuzzi, Paolo Nichelli, Franco Valzania
Aim of the study Neuropathy associated with IgM monoclonal gammopathy (MGUS) represents distinctive clinical syndrome,characterized by male predominance,late age of onset,slow progression, predominantly sensory symptoms, deep sensory loss, ataxia, minor motor impairment. More than 50% of patients with neuropathy-associated MGUS possess antibodies against myelin-associated glycoprotein (MAG).Purpose of our study was to assess effects on disease progression of demographic, clinical, and neurophysiological variables in our large cohort of patients...
May 17, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26944145/ultrasound-of-the-nerves-an-appropriate-addition-to-nerve-conduction-studies-to-differentiate-paraproteinemic-neuropathies
#8
Ioanna M Athanasopoulou, Maria Rasenack, Christine Grimm, Hubertus Axer, Michael Sinnreich, Bernhard F Décard, Alexander Grimm
OBJECTIVE: To investigate the use of peripheral nerve ultrasound (PNUS) in addition to nerve conduction studies (NCS) in the diagnosis of paraproteinemic neuropathies (PN). METHODS: PNUS/NCS of predefined peripheral nerves and the 5th/6th cervical roots were performed in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) (+/-paraprotein), patients with anti-MAG neuropathy, and patients with neuropathy and multiple myeloma or monoclonal gammopathy of uncertain significance (MGUS) - summarized as M-protein associated neuropathies (MPAN) and compared to controls (+/-paraprotein)...
March 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26437251/the-importance-of-rare-subtypes-in-diagnosis-and-treatment-of-peripheral-neuropathy-a-review
#9
REVIEW
Brian C Callaghan, Raymond S Price, Kevin S Chen, Eva L Feldman
IMPORTANCE: Peripheral neuropathy is a prevalent condition that usually warrants a thorough history and examination but has limited diagnostic evaluation. However, rare localizations of peripheral neuropathy often require more extensive diagnostic testing and different treatments. OBJECTIVE: To describe rare localizations of peripheral neuropathy, including the appropriate diagnostic evaluation and available treatments. EVIDENCE REVIEW: References were identified from PubMed searches conducted on May 29, 2015, with an emphasis on systematic reviews and randomized clinical trials...
December 2015: JAMA Neurology
https://www.readbyqxmd.com/read/26301376/correlation-of-changes-in-gait-parameters-with-phenotype-outcome-measures-and-electrodiagnostic-abnormalities-in-a-patient-with-anti-mag-neuropathy-after-exacerbation-and-improvement
#10
Mary L Vo, Peter Martin, Norman Latov
Gait impairment is a common presentation in patients with IgM anti-myelin-associated glycoprotein (anti-MAG) antibody demyelinating neuropathy. However, current methods used to assess gait are limited. We report spatiotemporal gait parameters captured by GAITRite, a computerized walkway with embedded pressure sensors. The patient worsened after treatment with rituximab and subsequently improved with intravenous immunoglobulin. Serial gait assessments were performed at baseline and after treatment. Spatiotemporal gait parameters correlated with Medical Research Council sum score, Inflammatory Neuropathy Cause and Treatment disability score, and grip strength...
September 2015: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/26263475/recent-advances-in-outcome-measures-in-igm-anti-mag-neuropathies
#11
REVIEW
Mariëlle H J Pruppers, Ingemar S J Merkies, Nicolette C Notermans
PURPOSE OF REVIEW: This review aims to provide an overview of all randomized trials performed in IgM Anti-Myelin Associated Glycoprotein related peripheral neuropathy (MGUSP) with emphasis on the applied outcome measures including the rationale for their choice and possible limitations, emphasizing new advances in modern clinimetrics. RECENT FINDINGS: All clinical trials performed in patients with MGUSP have been negative, which raises many unanswered questions: were the sample sizes too small, the duration of the trials too short, the chosen medical interventions not aggressive enough, the definition of being a responder inadequate, and, last but not least, the outcome measures used improper? Only recently has attention been directed towards the possibility of using suboptimal outcome measures as a potential factor that may have contributed to the negative results in MGUSP...
October 2015: Current Opinion in Neurology
https://www.readbyqxmd.com/read/26065001/heterogeneity-of-polyneuropathy-associated-with-anti-mag-antibodies
#12
Laurent Magy, Raphaël Kaboré, Stéphane Mathis, Prisca Lebeau, Karima Ghorab, Christiane Caudie, Jean-Michel Vallat
Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin associated glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition is likely to involve anti-MAG antibody deposition on myelin sheaths of the peripheral nerves and it is supposed to be distinct from chronic inflammatory demyelinating neuropathy (CIDP), another immune-mediated demyelinating peripheral neuropathy. In this series, we have retrospectively reviewed clinical and laboratory findings from 60 patients with polyneuropathy, IgM gammopathy, and anti-MAG antibodies...
2015: Journal of Immunology Research
https://www.readbyqxmd.com/read/25867460/polyneuropathy-with-anti-sulfatide-and-anti-mag-antibodies-clinical-neurophysiological-pathological-features-and-response-to-treatment
#13
Marta Campagnolo, Sergio Ferrari, Chiara Dalla Torre, Ilaria Cabrini, Mario Cacciavillani, Marta Lucchetta, Susanna Ruggero, Elisabetta Toffanin, Tiziana Cavallaro, Chiara Briani
IgM paraproteins often present reactivity to myelin-associated glycoprotein (MAG) and sulfatide. We describe the clinical and neurophysiological findings, and therapy response in 21 patients with IgM paraproteinemic neuropathy (15 with anti-MAG antibodies, 1 with anti-sulfatide antibodies, and 5 with both reactivity), and in 2 with anti-sulfatide positivity and no hematological disease. All patients complained of sensory symptoms, the majority had demyelinating neuropathy. Indirect immunofluorescence on human normal sural nerves disclosed different staining patterns...
April 15, 2015: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/25748038/autoimmune-peripheral-neuropathies
#14
REVIEW
Pierre R Bourque, Jodi Warman Chardon, Rami Massie
Peripheral nervous system axons and myelin have unique potential protein, proteolipid, and ganglioside antigenic determinants. Despite the existence of a blood-nerve barrier, both humoral and cellular immunity can be directed against peripheral axons and myelin. Molecular mimicry may be triggered at the systemic level, as was best demonstrated in the case of bacterial oligosaccharides. The classification of immune neuropathy has been expanded to take into account specific syndromes that share unique clinical, electrophysiological, prognostic and serological features...
September 20, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/25672708/-fisher-syndrome-and-bickerstaff-brainstem-encephalitis
#15
REVIEW
Satoshi Kuwabara
This review described current status and perspectives of treatment for immune-mediated neuropathies, such as Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropathy, and demyelinating neuropathy with anti-MAG neuropathy. corticosteroids, immunoglobulin therapy, and plasmapheresis are conventional treatments for these neuropathies, but the responsiveness to the treatments significantly differ among the disorders. Promising new treatment options include anti-complement monoclonal antibody (Eculizumab, anti-C5) for Guillain-Barre syndrome, and rituximab (anti-CD20) for anti-MAG neuropathy...
2014: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/25597226/anti-sulfatide-igm-antibodies-in-peripheral-neuropathy-to-test-or-not-to-test
#16
C Giannotta, D Di Pietro, F Gallia, E Nobile-Orazio
BACKGROUND AND PURPOSE: Anti-sulfatide immunoglobulin M (IgM) antibodies have been associated with different forms of neuropathies but their diagnostic role in neuropathy remains unclear. METHODS: The clinical association of increased titers of anti-sulfatide IgM antibodies in 570 patients with neuropathy and related disorders examined in our laboratory since 2004 was reviewed. Sera were tested by enzyme-linked immunosorbent assay at the initial serum dilution of 1:32,000 and titrated by serial two-fold dilution...
May 2015: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/25582978/immunostaining-of-skin-biopsy-adds-no-diagnostic-value-in-mgus-associated-peripheral-neuropathy
#17
Ali Al-Zuhairy, Henrik Daa Schrøder, Torben Plesner, Niels Abildgaard, Søren H Sindrup
BACKGROUND AND PURPOSE: For several decades an association between MGUS, IgM-MGUS in particular, and peripheral neuropathy has been suspected. Several histopathology studies have shown binding of IgM to myelin and a secondary widening of myelin lamellae in cutaneous nerves and in the sural nerve of patients with IgM-MGUS, or Waldenström's Macroglobulinaemia (WM), and peripheral neuropathy. In this retrospective study we investigated the value of skin biopsy examination in the diagnosis of MGUS- and WM-associated peripheral neuropathy...
February 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/25572169/igm-mgus-associated-with-anti-mag-neuropathy-a-single-institution-experience
#18
Giampaolo Talamo, Muhammad A Mir, Manoj K Pandey, Jeffrey K Sivik, Divisha Raheja
Anti-MAG neuropathy is a very rare form of acquired polyneuropathy associated with IgM monoclonal gammopathy of undetermined significance (MGUS). We conducted a retrospective review of 194 consecutive MGUS patients seen at the Penn State Hershey Cancer Institute. We identified six patients among 37 (16 %) with IgM MGUS with anti-MAG neuropathy. Interestingly, an additional patient had anti-MAG neuropathy without MGUS. Common clinical manifestations were numbness and paresthesias of the extremities and gait imbalance...
June 2015: Annals of Hematology
https://www.readbyqxmd.com/read/25467141/axonal-loss-influences-the-response-to-rituximab-treatment-in-neuropathy-associated-with-igm-monoclonal-gammopathy-with-anti-myelin-associated-glycoprotein-antibody
#19
Yuichi Kawagashira, Haruki Koike, Ken Ohyama, Rina Hashimoto, Masahiro Iijima, Hiroaki Adachi, Masahisa Katsuno, Miles Chapman, Michael Lunn, Gen Sobue
Polyneuropathy associated with anti-Myelin-Associated Glycoprotein (MAG) antibody is a well-defined immune-mediated disease that develops in individuals with IgM monoclonal gammopathy. Factors related to response to rituximab treatment in anti-MAG neuropathy have not been clarified so far. We prospectively evaluated the clinical status, immunological changes, and electrophysiological parameters before and 12 months after rituximab treatment in 7 patients with anti-MAG neuropathy. Pathological indices of sural nerve biopsy specimens before rituximab treatment were investigated...
January 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/25467139/health-related-quality-of-life-in-chronic-inflammatory-neuropathies-a-systematic-review
#20
REVIEW
Yusuf A Rajabally, Andrea E Cavanna
Chronic inflammatory neuropathies represent a heterogeneous group of disorders which affect patients' functional status and quality of life. We conducted a systematic review of the scientific literature on the effects of both disease and treatment interventions on health-related quality of life (HRQoL) in this patient population. The available data are limited, as few studies have systematically considered HRQoL in patients with inflammatory neuropathies. Moreover, in treatment trials, HRQoL measures have exclusively been used as secondary outcome measures...
January 15, 2015: Journal of the Neurological Sciences
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