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https://www.readbyqxmd.com/read/28821071/on-the-use-of-ion-crosslinked-nanocellulose-hydrogels-for-wound-healing-solutions-physicochemical-properties-and-application-oriented-biocompatibility-studies
#1
Alex Basu, Jonas Lindh, Eva Ålander, Maria Strømme, Natalia Ferraz
Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented biocompatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material´s potential to maintain a suitable moist environment for different type of wounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821032/using-oxidized-amylose-as-carrier-of-linalool-for-the-development-of-antibacterial-wound-dressing
#2
Yongbo Lyu, He Ren, Mengchao Yu, Xinying Li, Defu Li, Changdao Mu
This study aimed to prepare antibacterial wound dressings based on collagen and linalool/oxidized amylose inclusion complex. Encapsulation with oxidized amylose was used as an effective way to introduce linalool into collagen matrix. Our results showed that the content of linalool in the composite dressings was efficiently increased thanks to the solubilization effect of oxidized amyloses. The developed composite dressings possessed porous structure. They had abilities to keep the wound in moist environment and meanwhile prevent the excess exudates accumulation...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820907/positive-regulatory-interactions-between-yap-and-hedgehog-signalling-in-skin-homeostasis-and-bcc-development-in-mouse-skin-in-vivo
#3
Bassem Akladios, Veronica Mendoza Reinoso, Jason E Cain, Taopeng Wang, Duncan L Lambie, D Neil Watkins, Annemiek Beverdam
Skin is a highly plastic tissue that undergoes tissue turnover throughout life, but also in response to injury. YAP and Hedgehog signalling play a central role in the control of epidermal stem/progenitor cells in the skin during embryonic development, in postnatal tissue homeostasis and in skin carcinogenesis. However, the genetic contexts in which they act to control tissue homeostasis remain mostly unresolved. We provide compelling evidence that epidermal YAP and Hedgehog/GLI2 signalling undergo positive regulatory interactions in the control of normal epidermal homeostasis and in basal cell carcinoma (BCC) development, which in the large majority of cases is caused by aberrant Hedgehog signalling activity...
2017: PloS One
https://www.readbyqxmd.com/read/28819460/a-tumor-ph-responsive-supramolecular-photosensitizer-for-activatable-photodynamic-therapy-with-minimal-in-vivo-skin-phototoxicity
#4
Xingshu Li, Bi-Yuan Zheng, Mei-Rong Ke, Yongfan Zhang, Jian-Dong Huang, Juyoung Yoon
A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is not photoactive under neutral conditions but is precisely and efficiently activated in a slightly acidic environment (pH 6.5). LDH-ZnPcS8 is prepared by using a simple coprecipitation method based on the electrostatic interaction between negatively charged octasulfonate-modified zinc(II) phthalocyanine (ZnPcS8) and cationic hydroxide layers of layered double hydroxide (LDH)...
2017: Theranostics
https://www.readbyqxmd.com/read/28819175/in-vivo-therapeutic-efficacy-of-frog-skin-derived-peptides-against-pseudomonas-aeruginosa-induced-pulmonary-infection
#5
Chen Chen, Maria Luisa Mangoni, Y Peter Di
Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to possess potent in vitro antipseudomonal activity. Here, they were first shown to preserve the barrier integrity of airway epithelial cells better than the human AMP LL-37. Furthermore, Esc(1-21)-1c was more efficacious than Esc(1-21) and LL-37 in protecting host from pulmonary bacterial infection after a single intra-tracheal instillation at a very low dosage of 0...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818334/the-use-of-acupuncture-in-first-aid-of-burns-clinical-report
#6
A Loskotova, J Loskotova
Burns are a very painful skin injury, or injury of soft tissues. The development of post-traumatic stress disorder can develop, even in those with minor injuries (Ia-IIb degree). Development of problems is very rapid and intense since, according to developmental embryology, the skin and central nervous system (CNS) descend from the same germ layer-ectoderm. This clinical report presents the results acquired from the data of 1008 patients suffering from burns treated by the acupuncture (ACU)-from 1983-2015 in the surgery ward of the hospital in Vysoke Myto in the Czech Republic...
August 14, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28818249/health-literacy-cancer-prevention-strategies-for-early-adults
#7
Robert A Simmons, Susan C Cosgrove, Martha C Romney, James D Plumb, Rickie O Brawer, Evelyn T Gonzalez, Linda G Fleisher, Bradley S Moore
Health literacy, the degree to which individuals have the capacity to obtain, process, and understand health information and services needed to make health decisions, is an essential element for early adults (aged 18-44 years) to make informed decisions about cancer. Low health literacy is one of the social determinants of health associated with cancer-related disparities. Over the past several years, a nonprofit organization, a university, and a cancer center in a major urban environment have developed and implemented health literacy programs within healthcare systems and in the community...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818243/mental-health-problems-and-cancer-risk-factors-among-young-adults
#8
Greta M Massetti, Cheryll C Thomas, Jessica King, Kathleen Ragan, Natasha Buchanan Lunsford
INTRODUCTION: Chronic mental health problems often emerge in young adulthood, when adults begin to develop lifelong health behaviors and access preventive health services. The associations between mental health problems and modifiable cancer risk factors in young adulthood are not well understood. METHODS: In 2016, the authors analyzed 2014 Behavioral Risk Factor Surveillance System data on demographic characteristics, health service access and use, health status, and cancer risk factors (tobacco use, alcohol use, overweight or obesity, physical activity, and sleep) for 90,821 young adults aged 18-39 years with mental health problems (depressive disorder or frequent mental distress) compared to other young adults...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28817649/point-of-care-wound-visioning-technology-reproducibility-and-accuracy-of-a-wound-measurement-app
#9
Sheila C Wang, John A E Anderson, Robyn Evans, Kevin Woo, Benjamin Beland, Denis Sasseville, Linda Moreau
BACKGROUND: Current wound assessment practices are lacking on several measures. For example, the most common method for measuring wound size is using a ruler, which has been demonstrated to be crude and inaccurate. An increase in periwound temperature is a classic sign of infection but skin temperature is not always measured during wound assessments. To address this, we have developed a smartphone application that enables non-contact wound surface area and temperature measurements. Here we evaluate the inter-rater reliability and accuracy of this novel point-of-care wound assessment tool...
2017: PloS One
https://www.readbyqxmd.com/read/28817637/genetic-diversity-of-the-o-antigens-of-proteus-species-and-the-development-of-a-suspension-array-for-molecular-serotyping
#10
Xiang Yu, Agnieszka Torzewska, Xinjie Zhang, Zhiqiu Yin, Dominika Drzewiecka, Hengchun Cao, Bin Liu, Yuriy A Knirel, Antoni Rozalski, Lei Wang
Proteus species are well-known opportunistic pathogens frequently associated with skin wound and urinary tract infections in humans and animals. O antigen diversity is important for bacteria to adapt to different hosts and environments, and has been used to identify serotypes of Proteus isolates. At present, 80 Proteus O-serotypes have been reported. Although the O antigen structures of most Proteus serotypes have been identified, the genetic features of these O antigens have not been well characterized. The O antigen gene clusters of Proteus species are located between the cpxA and secB genes...
2017: PloS One
https://www.readbyqxmd.com/read/28817534/radius-regeneration-after-open-fracture-and-extrusion-a-case-report
#11
Kristopher B McCall, David Y Chong
A pediatric patient presenting with an open forearm fracture with segmental defect is rare, and the pediatric orthopedic literature to guide treatment is sparse. There are several described methods to treat the defect, including bone grafting and bone transport techniques. In addition, there are reports of fibular regeneration after resection if the periosteum is left intact. We present a case report of complete regeneration of over half of a pediatric radial shaft with an intact periosteum, after traumatic extrusion from an open fracture...
August 16, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28817088/the-role-of-neurogenic-inflammation-in-blood-brain-barrier-disruption-and-development-of-cerebral-oedema-following-acute-central-nervous-system-cns-injury
#12
REVIEW
Annabel J Sorby-Adams, Amanda M Marcoionni, Eden R Dempsey, Joshua A Woenig, Renée J Turner
Acute central nervous system (CNS) injury, encompassing traumatic brain injury (TBI) and stroke, accounts for a significant burden of morbidity and mortality worldwide, largely attributable to the development of cerebral oedema and elevated intracranial pressure (ICP). Despite this, clinical treatments are limited and new therapies are urgently required to improve patient outcomes and survival. Originally characterised in peripheral tissues, such as the skin and lungs as a neurally-elicited inflammatory process that contributes to increased microvascular permeability and tissue swelling, neurogenic inflammation has now been described in acute injury to the brain where it may play a key role in the secondary injury cascades that evolve following both TBI and stroke...
August 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28817072/efficient-transdermal-delivery-of-alendronate-a-nitrogen-containing-bisphosphonate-using-tip-loaded-self-dissolving-microneedle-arrays-for-the-treatment-of-osteoporosis
#13
Hidemasa Katsumi, Yutaro Tanaka, Kaori Hitomi, Shu Liu, Ying-Shu Quan, Fumio Kamiyama, Toshiyasu Sakane, Akira Yamamoto
To improve the transdermal bioavailability and safety of alendronate (ALN), a nitrogen-containing bisphosphonate, we developed self-dissolving microneedle arrays (MNs), in which ALN is loaded only at the tip portion of micron-scale needles by a dip-coating method (ALN(TIP)-MN). We observed micron-scale pores in rat skin just after application of ALN(TIP)-MN, indicating that transdermal pathways for ALN were created by MN. ALN was rapidly released from the tip of MNs as observed in an in vitro release study...
August 17, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28816970/skin-metastases-in-epithelial-ovarian-and-fallopian-tube-carcinoma
#14
Isao Otsuka, Takuto Matsuura
This study aimed to investigate the clinical features and outcomes of skin metastasis in ovarian and fallopian tube carcinomas.We studied patients with epithelial ovarian or fallopian tube carcinoma who developed skin metastasis from 2001 through 2012, and were also treated with chemotherapy and/or surgery.Skin metastases were classified as umbilical metastasis (Sister Joseph nodule [SJN]) and nonumbilical metastasis. Patients who developed skin metastases at paracentesis sites were excluded.Of the 206 patients treated, 12 (5...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816739/nicolau-syndrome-embolia-cutis-medicamentosa-a-rare-and-poorly-recognized-iatrogenic-cause-of-cutaneous-thrombotic-vasculopathy
#15
Dominic Tabor, Chandra G Bertram, Andrew J K Williams, Marie E Mathers, Asok Biswas
Nicolau syndrome is a rare form of iatrogenic cutaneous necrosis which affects injection sites. Although classically associated with intramuscular injections, it may develop after subcutaneous or other routes of parenteral drug administration. Clinically, it manifests as necrotic ulcers that often develop in a background of erythematous and livedoid reticular patches. The histopathologic characteristics of Nicolau syndrome are poorly documented in the dermatopathology literature and features only rarely as one of the obscure causes of cutaneous thrombotic vasculopathy...
August 8, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28816043/electronic-muscles-and-skins-a-review-of-soft-sensors-and-actuators
#16
Dustin Chen, Qibing Pei
This article reviews several classes of compliant materials that can be utilized to fabricate electronic muscles and skins. Different classes of materials range from compliant conductors, semiconductors, to dielectrics, all of which play a vital and cohesive role in the development of next generation electronics. This paper covers recent advances in the development of new materials, as well as the engineering of well-characterized materials for the repurposing in applications of flexible and stretchable electronics...
August 17, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28815821/infant-feeding-patterns-and-eczema-in-children-in-the-first-6-years-of-life
#17
Nelís Soto-Ramírez, Suryatapa Kar, Hongmei Zhang, Wilfried Karmaus
BACKGROUND: Modes of infant feeding such as direct and indirect breastfeeding, and formula feeding, and their combinations may play a role in child health. OBJECTIVE: The aim was to investigate which feeding patterns in the first six months pose risks for eczema/skin allergy in children up to 6 years compared to direct breastfeeding for at least 3 months. METHODS: The Infant Feeding Practices Study II in the United States and its 6-year follow-up provided data on feeding modes in infancy and doctor's diagnosed eczema/skin allergy in the first 6 years of life (1,387 infants), based on parental reports...
August 16, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28815697/case-control-study-of-chronic-low-level-exposure-of-inorganic-arsenic-species-and-non-melanoma-skin-cancer
#18
Tae-Hoon Kim, Jeong-Wook Seo, Young-Seoub Hong, Ki-Hoon Song
A significant relationship between arsenic exposure and non-melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. However, there are few studies on quantitative exposure assessment of arsenic species in NMSC patients. To validate the contribution of each arsenic species to NMSC, we compared the creatinine-adjusted urinary concentration of arsenic species in NMSC patients and community controls...
August 16, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28815599/the-reduction-of-intraepidermal-p2x3-nerve-fiber-density-correlates-with-behavioral-hyperalgesia-in-a-rat-model-of-nerve-injury-induced-pain
#19
Malik Bechakra, Barthold N Schüttenhelm, Tiziana Pederzani, Pieter A van Doorn, Chris I de Zeeuw, Joost L M Jongen
Skin biopsies from patients with neuropathic pain often show changes in epidermal innervation, although it remains to be elucidated to what extent such changes can be linked to a particular subgroup of nerve fibers and how these changes are correlated with pain intensity. Here, we investigated to what extent behavioral signs of hyperalgesia are correlated with immunohistochemical changes of peptidergic and non-peptidergic epidermal nerve fibers in a rat model of nerve injury-induced pain. Rats subjected to unilateral partial ligation of the sciatic nerve developed significant mechanical and thermal hyperalgesia as tested by the withdrawal responses of the ipsilateral footpad to von Frey hairs and hotplate stimulation...
August 17, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28815554/severe-disruption-and-disorganization-of-dermal-collagen-fibrils-in-early-striae-gravidarum
#20
F Wang, K Calderone, T T Do, N R Smith, Y R Helfrich, T R B Johnson, S Kang, J J Voorhees, G J Fisher
BACKGROUND: Striae gravidarum (SG), or stretch marks of pregnancy, begin as erythematous streaks, and mature into hypopigmented atrophic bands. OBJECTIVES: To investigate molecular alterations that may promote atrophy of SG, we investigated dermal type I collagen fibrils, which provide human skin with support. METHODS: We obtained skin samples of recently developed, erythematous abdominal SG from pregnant women. To examine the organization of collagen fibrils, second-harmonic generation imaging was performed using multiphoton microscopy...
August 17, 2017: British Journal of Dermatology
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