Yanfang Peipei Zhu, Mary Speir, ZheHao Tan, Jamie Casey Lee, Cameron J Nowell, Alyce A Chen, Hajera Amatullah, Ari J Salinger, Carolyn J Huang, Gio Wu, Weiqi Peng, Kasra Askari, Eric Griffis, Majid Ghassemian, Jennifer Santini, Motti Gerlic, William B Kiosses, Sergio D Catz, Hal M Hoffman, Kimberly F Greco, Edie Weller, Paul R Thompson, Lai Ping Wong, Ruslan Sadreyev, Kate L Jeffrey, Ben A Croker
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase 4 (PAD4), is synonymous with NETosis and is considered independent of apoptosis. Mitochondrial- and death receptor-mediated apoptosis promote gasdermin E (GSDME)-dependent calcium mobilization and membrane permeabilization leading to histone H3 citrullination (H3Cit), nuclear DNA extrusion, and cytoplast formation...
December 22, 2023: Science Advances