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RANDOMIZED CONTROLLED TRIAL
Aswin Abraham, Karan Paul Sanghera, Farshid Gheisari, Stella Koumna, Terence Riauka, Sunita Ghosh, Heather Warkentin, Zsolt Gabos, Susan Chafe, Keith Tankel, Fleur Huang, Siham Sabri, David Ian Paterson, Bassam Abdulkarim, Kurian Joseph
PURPOSE: Myocardial perfusion defects after breast radiation therapy (RT) correlate with volume of irradiated left ventricle (LV). We aimed to determine the relationship between myocardial perfusion, LV dosimetry, and grade ≥2 late cardiac events in patients with breast cancer undergoing adjuvant RT. METHODS AND MATERIALS: A randomized study evaluated the benefit of inverse-planned intensity modulated radiation therapy over forward-planned intensity modulated radiation therapy for radiation toxicity in breast cancer...
May 1, 2022: International Journal of Radiation Oncology, Biology, Physics
#22
JOURNAL ARTICLE
Judith C Hugh, Lacey S J Haddon, John Maringa Githaka, Gilbert Bigras, Xiuying Hu, Brittney Madden, John Hanson, Zsolt Gabos, Nadia V Giannakopoulos, Fleur Huang, Mary M Hitt, Kirk J McManus, David Olson, Kelly Dabbs, John R Mackey
Estrogen is thought to cause proliferation of all estrogen receptor positive (ER+) breast cancers. Paradoxically, in the Women's Health Initiative Trial, estrogen-only hormone replacement therapy reduced the incidence and mortality of low grade, ER+, HER2- breast cancer. We gave estradiol to 19 post-menopausal women with newly diagnosed low-grade, ER+, HER2- breast cancer in a prospective window of opportunity clinical trial and examined the changes in proliferation and gene expression before and after estradiol treatment...
January 2022: Heliyon
#23
JOURNAL ARTICLE
Mark Wright, Bryson Dietz, Eugene Yip, Jihyun Yun, Zsolt Gabos, B G Fallone, Keith Wachowicz
PURPOSE: A rapid real-time 2D accelerated method was developed for MRI using principal component analysis (PCA) in the temporal domain. This method employs a moving window of previous dynamic frames to reconstruct the current, real-time frame within this window. This technique could be particularly useful in real-time tracking applications such as in MR-guided radiotherapy, where low latency real-time reconstructions are essential. METHODS: The method was tested retrospectively on 15 fully-sampled data sets of lung patient data acquired on a 3T Philips Achieva system...
September 15, 2021: Medical Physics
#24
REVIEW
Ndéye F Guissé, Joseph D Stone, Lukas G Keil, Tracey P Bastrom, Mark A Erickson, Burt Yaszay, Patrick J Cahill, Stefan Parent, Peter G Gabos, Peter O Newton, Michael P Glotzbecker, Michael P Kelly, Joshua M Pahys, Nicholas D Fletcher
PURPOSE: The Clavien-Dindosink (CDS) classification system provides more treatment-focused granularity than subjective methods of describing surgical complications; however, it has not been validated in posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). The purpose of this study was to modify the CDS system for application in patients with AIS undergoing PSF to assess its inter- and intra-rater reliability for describing complications faced by this population. METHODS: A review of all complications specific to patients with AIS captured in a large multicenter international database was performed...
January 2022: Spine Deformity
#25
RANDOMIZED CONTROLLED TRIAL
Arjun Sahgal, Sten D Myrehaug, Shankar Siva, Giuseppina L Masucci, Pejman J Maralani, Michael Brundage, James Butler, Edward Chow, Michael G Fehlings, Mathew Foote, Zsolt Gabos, Jeffrey Greenspoon, Marc Kerba, Young Lee, Mitchell Liu, Stanley K Liu, Isabelle Thibault, Rebecca K Wong, Maaike Hum, Keyue Ding, Wendy R Parulekar
BACKGROUND: Conventional external beam radiotherapy is the standard palliative treatment for spinal metastases; however, complete response rates for pain are as low as 10-20%. Stereotactic body radiotherapy delivers high-dose, ablative radiotherapy. We aimed to compare complete response rates for pain after stereotactic body radiotherapy or conventional external beam radiotherapy in patients with painful spinal metastasis. METHODS: This open-label, multicentre, randomised, controlled, phase 2/3 trial was done at 13 hospitals in Canada and five hospitals in Australia...
July 2021: Lancet Oncology
#26
JOURNAL ARTICLE
Daniela Muresan, Andreea Salcudean, Daniela Claudia Sabau, Cristina Raluca Bodo, Iosif Gabos Grecu
The aim of the study was to evaluate if bioresonance therapy can offer quantifiable results in patients with recurrent major depressive disorder and with mild, moderate, or severe depressive episodes by decreasing the level of depression due to the application of bioresonance therapy as independently or complementary treatment. The study included 140 patients suffering from depression, divided into three groups. The first group (40 patients) received solely bioresonance therapy, the second group (40 patients) received pharmacological treatment with antidepressants combined with bioresonance therapy, and the third group (60 patients) received solely pharmacological treatment with antidepressants...
2021: Journal of Medicine and Life
#27
JOURNAL ARTICLE
Áine O'Toole, Verity Hill, Oliver G Pybus, Alexander Watts, Issac I Bogoch, Kamran Khan, Jane P Messina, Houriiyah Tegally, Richard R Lessells, Jennifer Giandhari, Sureshnee Pillay, Kefentse Arnold Tumedi, Gape Nyepetsi, Malebogo Kebabonye, Maitshwarelo Matsheka, Madisa Mine, Sima Tokajian, Hamad Hassan, Tamara Salloum, Georgi Merhi, Jad Koweyes, Jemma L Geoghegan, Joep de Ligt, Xiaoyun Ren, Matthew Storey, Nikki E Freed, Chitra Pattabiraman, Pramada Prasad, Anita S Desai, Ravi Vasanthapuram, Thomas F Schulz, Lars Steinbrück, Tanja Stadler, Antonio Parisi, Angelica Bianco, Darío García de Viedma, Sergio Buenestado-Serrano, Vítor Borges, Joana Isidro, Sílvia Duarte, João Paulo Gomes, Neta S Zuckerman, Michal Mandelboim, Orna Mor, Torsten Seemann, Alicia Arnott, Jenny Draper, Mailie Gall, William Rawlinson, Ira Deveson, Sanmarié Schlebusch, Jamie McMahon, Lex Leong, Chuan Kok Lim, Maria Chironna, Daniela Loconsole, Antonin Bal, Laurence Josset, Edward Holmes, Kirsten St George, Erica Lasek-Nesselquist, Reina S Sikkema, Bas Oude Munnink, Marion Koopmans, Mia Brytting, V Sudha Rani, S Pavani, Teemu Smura, Albert Heim, Satu Kurkela, Massab Umair, Muhammad Salman, Barbara Bartolini, Martina Rueca, Christian Drosten, Thorsten Wolff, Olin Silander, Dirk Eggink, Chantal Reusken, Harry Vennema, Aekyung Park, Christine Carrington, Nikita Sahadeo, Michael Carr, Gabo Gonzalez, Tulio de Oliveira, Nuno Faria, Andrew Rambaut, Moritz U G Kraemer
Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations of biological concern were reported, one in the United Kingdom and one in South Africa. Using a combination of data from routine surveillance, genomic sequencing and international travel we track the international dispersal of lineages B.1.1.7 and B.1.351 (variant 501Y-V2). We account for potential biases in genomic surveillance efforts by including passenger volumes from location of where the lineage was first reported, London and South Africa respectively...
2021: Wellcome Open Research
#28
JOURNAL ARTICLE
A Sahgal, S D Myrehaug, S Siva, L Masucci, M C Foote, M Brundage, J Butler, E Chow, M G Fehlings, Z Gabos, J Greenspoon, M Kerba, Y K Lee, M C Liu, P Maralani, I Thibault, R Wong, M Hum, K Ding, W Parulekar
No abstract text is available yet for this article.
December 1, 2020: International Journal of Radiation Oncology, Biology, Physics
#29
JOURNAL ARTICLE
Thanh-Tin P Nguyen, Peter G Jacobs, Jessica Castle, Leah M Wilson, Kerry Kuehl, Deborah Branigan, Virginia Gabo, Florian Guillot, Michael C Riddell, Ahmad Haidar, Joseph El Youssef
Aerobic exercise in type 1 diabetes (T1D) causes rapid increase in glucose utilization due to muscle work during exercise, followed by increased insulin resistance after exercise. Better understanding of these changes is necessary for models of exercise in T1D. Twenty-six individuals with T1D underwent three studies at three insulin rates (100%, 150%, 300% of basal). After 3-hours run-in, participants performed 45 minutes aerobic exercise (moderate or intense). We determined area-under-the-curve for endogenous glucose production (AUCEGP ) and rate of glucose disappearance (AUCRd ) over 45 minutes from exercise start...
December 28, 2020: American Journal of Physiology. Endocrinology and Metabolism
#30
JOURNAL ARTICLE
Simona Stolnicu, Csilip Tunde, Gabos Szilard, Cristian Podoleanu, Francisc Rozsnyai
Genital and pelvic endometriosis is a frequently encountered lesion and its importance rely on associated symptoms and its propensity for malignant transformation. In the present paper we comment on the importance of correctly diagnose the malignant transformation of an endometriotic lesion into a cystic low-grade endometrial stromal sarcoma, which is a very rare event. Moreover, we discuss the ability of a low-grade endometrial stromal sarcoma to locally recurr and the differential diagnosis with stromal endometriosis, a lesion that is very rare, almost always microscopic and solid...
2020: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
#31
JOURNAL ARTICLE
Florian H Guillot, Peter G Jacobs, Leah M Wilson, Joseph El Youssef, Virginia B Gabo, Deborah L Branigan, Nichole S Tyler, Katrina Ramsey, Michael C Riddell, Jessica R Castle
The accuracy of continuous glucose monitoring (CGM) sensors may be significantly impacted by exercise. We evaluated the impact of three different types of exercise on the accuracy of the Dexcom G6 sensor. Twenty-four adults with type 1 diabetes on multiple daily injections wore a G6 sensor. Participants were randomized to aerobic, resistance, or high intensity interval training (HIIT) exercise. Each participant completed two in-clinic 30-min exercise sessions. The sensors were applied on average 5.3 days prior to the in-clinic visits (range 0...
September 29, 2020: Biosensors
#32
JOURNAL ARTICLE
Kurian Joseph, Sarah Zebak, Veronica Alba, Kayla Mah, Cara Au, Larissa Vos, Sunita Ghosh, Aswin Abraham, Susan Chafe, Ericka Wiebe, Hong-Wei Liu, Carole Chambers, Zsolt Gabos, Keith Tankel, Sasha Lupichuk, Karen King
BACKGROUND AND PURPOSE: The relative benefit of adjuvant radiotherapy (RT) alone in older women with low-risk early breast cancer (EBC) remains unclear. It is hypothesized that adjuvant RT-alone can improve outcomes of older patients with low-risk EBC, similar to endocrine therapy (ET) alone or combination of RT + ET. METHODS: In this population based study, we identified all women aged ≥70 with T1-2, N0, ER+ve, Her-2/neu-ve EBC treated with breast conserving surgery (BCS), followed by adjuvant treatments (RT-alone, ET-alone, or RT + ET combination) from 2005 to 2015...
September 14, 2020: Radiotherapy and Oncology
#33
JOURNAL ARTICLE
Leah M Wilson, Peter G Jacobs, Katrina L Ramsey, Navid Resalat, Ravi Reddy, Deborah Branigan, Joseph Leitschuh, Virginia Gabo, Florian Guillot, Brian Senf, Joseph El Youssef, Isabelle Isa Kristin Steineck, Nichole S Tyler, Jessica R Castle
OBJECTIVE: To assess the efficacy and feasibility of a dual-hormone (DH) closed-loop system with insulin and a novel liquid stable glucagon formulation compared with an insulin-only closed-loop system and a predictive low glucose suspend (PLGS) system. RESEARCH DESIGN AND METHODS: In a 76-h, randomized, crossover, outpatient study, 23 participants with type 1 diabetes used three modes of the Oregon Artificial Pancreas system: 1 ) dual-hormone (DH) closed-loop control, 2 ) insulin-only single-hormone (SH) closed-loop control, and 3 ) PLGS system...
September 9, 2020: Diabetes Care
#34
JOURNAL ARTICLE
K Joseph, L J Vos, Z Gabos, N Pervez, S Chafe, K Tankel, H Warkentin, S Ghosh, J Amanie, K Powell, L-A Polkosnik, S Horsman, M MacKenzie, S Sabri, M B Parliament, J Mackey, B Abdulkarim
AIMS: Skin toxicity is a common adverse effect of breast radiotherapy. We investigated whether inverse-planned intensity-modulated radiotherapy (IMRT) would reduce the incidence of skin toxicity compared with forward field-in-field breast IMRT (FiF-IMRT) in early stage breast cancer. MATERIALS AND METHODS: This phase III randomised controlled trial compared whole-breast irradiation with either FiF-IMRT or helical tomotherapy IMRT (HT-IMRT), with skin toxicity as the primary end point...
July 22, 2020: Clinical Oncology: a Journal of the Royal College of Radiologists
#35
JOURNAL ARTICLE
Michael Davidson, Cristian Gabos-Grecu
Development and regulatory approval of psychotropic drugs targets individuals with syndromes described in the current Diagnostic and Statistical Manual of Mental Disorders (DSM). This helps drug developers and regulators to communicate with prescribers, and prescribers to match a specific psychotropic with the individual patient(s) most likely to benefit from it. However, this practice has been criticized on the grounds that DSM syndromes are too heterogenous biologically, and the effects of psychotropics are too nonspecific to allow for an effective match...
March 2020: Dialogues in Clinical Neuroscience
#36
JOURNAL ARTICLE
Nichole S Tyler, Clara M Mosquera-Lopez, Leah M Wilson, Robert H Dodier, Deborah L Branigan, Virginia B Gabo, Florian H Guillot, Wade W Hilts, Joseph El Youssef, Jessica R Castle, Peter G Jacobs
Type 1 diabetes (T1D) is characterized by pancreatic beta cell dysfunction and insulin depletion. Over 40% of people with T1D manage their glucose through multiple injections of long-acting basal and short-acting bolus insulin, so-called multiple daily injections (MDI)1,2 . Errors in dosing can lead to life-threatening hypoglycaemia events (<70 mg dl-1 ) and hyperglycaemia (>180 mg dl-1 ), increasing the risk of retinopathy, neuropathy, and nephropathy. Machine learning (artificial intelligence) approaches are being harnessed to incorporate decision support into many medical specialties...
July 2020: Nature metabolism
#37
JOURNAL ARTICLE
Bryson Dietz, Jihyun Yun, Eugene Yip, Zsolt Gabos, B Gino Fallone, Keith Wachowicz
Accelerated MRI involves undersampling k-space, creating unwanted artifacts when reconstructing the data. While the strategy of incoherent k-space acquisition is proven for techniques such as compressed sensing, it may not be optimal for all techniques. This study compares the use of coherent low-resolution (coherent-LR) and incoherent undersampling phase-encoding for real-time 3D CNN image reconstruction. Data were acquired with our 3T Philips Achieva system. A retrospective analysis was performed on six non-small cell lung cancer patients who received dynamic acquisitions consisting of 650 free breathing images using a bSSFP sequence...
March 5, 2020: Physics in Medicine and Biology
#38
REVIEW
Alysa Fairchild, Neil Guest, Ariel Letcher, Brooklyn Mazure, Sunita Ghosh, Zsolt Gabos, Karen P Chu, Brock Debenham, Tirath Nijjar, Diane Severin, Rufus Scrimger, Wilson Roa, Don Yee
BACKGROUND: Prophylactic cranial irradiation (PCI) improves survival and prevents intracranial recurrence (IR) in limited stage (LS) and extensive stage (ES) small cell lung cancer (SCLC). However, despite PCI, IR affects 12%-45%, and limited data exist regarding salvage brain reirradiation (ReRT). We performed a population-based review of IR in SCLC. METHODS: Demographic, treatment, and outcome data of consecutive patients (N = 371) with SCLC assessed at a tertiary cancer centre (01/2013-12/2015) were abstracted, and summary statistics calculated...
March 2020: Journal of Medical Imaging and Radiation Sciences
#39
JOURNAL ARTICLE
Bryson Dietz, Jihyun Yun, Eugene Yip, Zsolt Gabos, B Gino Fallone, Keith Wachowicz
Investigate 3D (spatial and temporal) convolutional neural networks (CNNs) for real-time on-the-fly magnetic resonance imaging (MRI) reconstruction. In particular, we investigated the applicability of training CNNs on a patient-by-patient basis for the purpose of lung tumor segmentation. &#13; &#13; Methods: Data were acquired with our 3T Philips Achieva system. A retrospective analysis was performed on six non-small cell lung cancer patients who received fully sampled dynamic acquisitions consisting of 650 free breathing images using a bSSFP sequence...
September 2, 2019: Physics in Medicine and Biology
#40
JOURNAL ARTICLE
Leah M Wilson, Nichole Tyler, Peter G Jacobs, Virginia Gabo, Brian Senf, Ravi Reddy, Jessica R Castle
BACKGROUND: Decision support smartphone applications integrated with continuous glucose monitors may improve glycemic control in type 1 diabetes (T1D). We conducted a survey to understand trends and needs of potential users to inform the design of decision support technology. METHODS: A 70-question survey was distributed October 2017 through May 2018 to adults aged 18-80 with T1D from a specialty clinic and T1D Exchange online health community ( myglu.org ). The survey responses were used to evaluate potential features of a diabetes decision support tool by Likert scale and open responses...
August 23, 2019: Journal of Diabetes Science and Technology
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