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https://www.readbyqxmd.com/read/28102958/sliding-window-prior-data-assisted-compressed-sensing-for-mri-tracking-of-lung-tumors
#1
Eugene Yip, Jihyun Yun, Keith Wachowicz, Zsolt Gabos, Satyapal Rathee, B G Fallone
PURPOSE: Hybrid magnetic resonance imaging and radiation therapy devices are capable of imaging in real-time to track intrafractional lung tumor motion during radiotherapy. Highly accelerated magnetic resonance (MR) imaging methods can potentially reduce system delay time and/or improves imaging spatial resolution, and provide flexibility in imaging parameters. Prior Data Assisted Compressed Sensing (PDACS) has previously been proposed as an acceleration method that combines the advantages of 2D compressed sensing and the KEYHOLE view-sharing technique...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28092954/modeling-and-simulation-for-toxicity-assessment
#2
Cristina Anton, Jian Deng, Yau Shu Wong, Yile Zhang, Weiping Zhang, Stephan Gabos, Dorothy Yu Huang, Can Jin
The effect of various toxicants on growth/death and morphology of human cells is investigated using the xCELLigence Real-Time Cell Analysis High Troughput in vitro assay. The cell index is measured as a proxy for the number of cells, and for each test substance in each cell line, time-dependent concentration response curves (TCRCs) are generated. In this paper we propose a mathematical model to study the effect of toxicants with various initial concentrations on the cell index. This model is based on the logistic equation and linear kinetics...
June 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/28046734/su-g-jep1-15-sliding-window-prior-data-assisted-compressed-sensing-for-mri-lung-tumor-tracking
#3
E Yip, J Yun, K Wachowicz, Z Gabos, S Rathee, B Fallone
PURPOSE: Prior Data Assisted Compressed Sensing (PDACS) is a partial k-space acquisition and reconstruction method for mobile tumour (i.e. lung) tracking using on-line MRI in radiotherapy. PDACS partially relies on prior data acquired at the beginning of dynamic scans, and is therefore susceptible to artifacts in longer duration scan due to slow drifts in MR signal. A novel sliding window strategy is presented to mitigate this effect. METHODS: MRI acceleration is simulated by retrospective removal of data from the fully sampled sets...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28007166/comparative-cytotoxicity-of-fourteen-trivalent-and-pentavalent-arsenic-species-determined-using-real-time-cell-sensing
#4
Birget Moe, Hanyong Peng, Xiufen Lu, Baowei Chen, Lydia W L Chen, Stephan Gabos, Xing-Fang Li, X Chris Le
The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite (As(III)), monomethylarsonous acid (MMA(III)) originating from the oxide and iodide forms, dimethylarsinous acid (DMA(III)), dimethylarsinic glutathione (DMAG(III)), phenylarsine oxide (PAO(III)), arsenate (As(V)), monomethylarsonic acid (MMA(V)), dimethylarsinic acid (DMA(V)), monomethyltrithioarsonate (MMTTA(V)), dimethylmonothioarsinate (DMMTA(V)), dimethyldithioarsinate (DMDTA(V)), 3-nitro-4-hydroxyphenylarsonic acid (Roxarsone, Rox), and 4-aminobenzenearsenic acid (p-arsanilic acid, p-ASA)...
November 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/27994930/cortisol-and-hippocampal-volume-as-predictors-of-active-suicidal-behavior-in-major-depressive-disorder-case-report
#5
Theodor Moica, Iosif Gabos Grecu, Sorina Moica, Marieta Gabos Grecu, Gabriela Elena Buicu
BACKGROUND: Suicide is frequently encountered in patients suffering from major depressive disorder (MDD). Since only a third of treated depressed patients are able to achieve remission, in the last few years, new theories have been proposed to better understand the mechanism of this illness. Our paper analyzes the interrelation between cortisol as a marker of neuroendocrine theory as a response to stress, and hippocampal volume subfields in depression as a marker of neurogenesis and neuroplasticity theory...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27909639/factors-associated-with-the-use-of-radiation-therapy-in-patients-with-stage-iii-non-small-cell-lung-cancer-in-alberta-canada-a-population-based-study
#6
Hong-Wei Liu, Marc Kerba, Gerald Lim, Zsolt Gabos, Ivo A Olivotto, Anil Abraham Joy, Wilson Roa, Zoann Nugent, Harold Lau
BACKGROUND: Cancer care in Alberta, Canada is publicly funded and provides patients with access to health care facilities and providers. The distribution of patients and health services across Alberta presents challenges to the delivery of cancer care, especially radiation therapy. In this study, we examined the association between patient and health system factors, the use of radiation therapy and survival outcomes in patients with stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: The provincial cancer registry was used to identify all patients who presented with clinical stage III NSCLC, diagnosed from 2005 to 2007, in Alberta...
October 27, 2016: Curēus
https://www.readbyqxmd.com/read/27876603/canadian-phase-iii-randomized-trial-of-stereotactic-body-radiotherapy-versus-conventionally-hypofractionated-radiotherapy-for-stage-i-medically-inoperable-non-small-cell-lung-cancer-rationale-and-protocol-design-for-the-ontario-clinical-oncology-group-ocog
#7
Anand Swaminath, Marcin Wierzbicki, Sameer Parpia, James R Wright, Theodoros K Tsakiridis, Gordon S Okawara, Vijayananda Kundapur, Alexis Bujold, Naseer Ahmed, Khalid Hirmiz, Elizabeth Kurien, Edith Filion, Zsolt Gabos, Sergio Faria, Alexander V Louie, Timothy Owen, Elaine Wai, Kevin Ramchandar, Elisa K Chan, Jim Julian, Kathryn Cline, Timothy J Whelan
We describe a Canadian phase III randomized controlled trial of stereotactic body radiotherapy (SBRT) versus conventionally hypofractionated radiotherapy (CRT) for the treatment of stage I medically inoperable non-small-cell lung cancer (OCOG-LUSTRE Trial). Eligible patients are randomized in a 2:1 fashion to either SBRT (48 Gy in 4 fractions for peripherally located lesions; 60 Gy in 8 fractions for centrally located lesions) or CRT (60 Gy in 15 fractions). The primary outcome of the study is 3-year local control, which we hypothesize will improve from 75% with CRT to 87...
March 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27735141/dependent-personality-features-in-a-complex-case-of-borderline-personality-disorder
#8
Tudor Nirestean, Emese Lukacs, Aurel Nirestean, Iosif Gabos Grecu
Borderline personality disorder is a complex disease model as it encompasses a diversity of pathological personality traits and psychopathological symptoms. It is not surprising, therefore, that it is often manifested by personality disorders across all three clusters and accompanied by other mental (Axis I) disorders. This melange makes both psychological treatment and pharmacotherapy especially challenging, and this paper describes the case of a particularly complex case of a 33-year-old Romanian patient, who has a history of severe deprivation in childhood, mood and substance use disorder in association with borderline pathology...
October 13, 2016: Personality and Mental Health
https://www.readbyqxmd.com/read/27675969/a-phase-iii-randomized-control-trial-comparing-skin-sparing-helical-tomotherapy-versus-3d-conformal-radiation-therapy-in-early-stage-breast-cancer-acute-and-late-skin-toxicity-outcomes
#9
B S Abdulkarim, K Joseph, L Vos, H K Warkentin, Z Gabos, N Pervez, K Tankel, S Ghosh, S M J Chafe, M B Parliament
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27544524/genetic-mapping-of-resistance-to-the-ug99-race-group-of-puccinia-graminis-f-sp-tritici-in-a-spring-wheat-landrace-citr-4311
#10
E M Babiker, T C Gordon, S Chao, M N Rouse, R Wanyera, M Newcomb, G Brown-Guedira, Z A Pretorius, J M Bonman
A gene for Ug99 resistance from wheat landrace CItr 4311 was detected on the long arm of chromosome 2B. Wheat landrace CItr 4311 has seedling resistance to stem rust caused by Puccinia graminis f. sp. tritici race TTKSK and field resistance to the Ug99 race group. Parents, F1 seedlings, 121 doubled haploid (DH) lines, and 124 recombinant inbred lines (RILs) developed from a cross between CItr 4311 and the susceptible line LMPG-6 were evaluated for seedling resistance to race TTKSK. Goodness-of-fit tests indicated that a single dominant gene in CItr 4311 conditioned the TTKSK resistance...
November 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27359266/markers-linked-to-wheat-stem-rust-resistance-gene-sr11-effective-to-puccinia-graminis-f-sp-tritici-race-tkttf
#11
Jayaveeramuthu Nirmala, Shiaoman Chao, Pablo Olivera, Ebrahiem M Babiker, Bekele Abeyo, Zerihun Tadesse, Muhammad Imtiaz, Luther Talbert, Nancy K Blake, Eduard Akhunov, Michael O Pumphrey, Yue Jin, Matthew N Rouse
Wheat stem rust, caused by Puccinia graminis f. sp. tritici, can cause severe yield losses on susceptible wheat varieties and cultivars. Although stem rust can be controlled by the use of genetic resistance, population dynamics of P. graminis f. sp. tritici can frequently lead to defeat of wheat stem rust resistance genes. P. graminis f. sp. tritici race TKTTF caused a severe epidemic in Ethiopia on Ug99-resistant 'Digalu' in 2013 and 2014. The gene Sr11 confers resistance to race TKTTF and is present in 'Gabo 56'...
November 2016: Phytopathology
https://www.readbyqxmd.com/read/27330347/management-of-small-cell-lung-cancer-with-radiotherapy-a-pan-canadian-survey-of-radiation-oncologists
#12
J Shahi, J R Wright, Z Gabos, A Swaminath
BACKGROUND: The management of small-cell lung cancer (sclc) with radiotherapy (rt) varies, with many treatment regimens having been described in the literature. We created a survey to assess patterns of practice and clinical decision-making in the management of sclc by Canadian radiation oncologists (ros). METHODS: A 35-item survey was sent by e-mail to Canadian ros. The questions investigated the role of rt, the dose and timing of rt, target delineation, and use of prophylactic cranial irradiation (pci) in limited-stage (ls) and extensive-stage (es) sclc...
June 2016: Current Oncology
https://www.readbyqxmd.com/read/27182283/machine-learning-algorithms-for-mode-of-action-classification-in-toxicity-assessment
#13
Yile Zhang, Yau Shu Wong, Jian Deng, Cristina Anton, Stephan Gabos, Weiping Zhang, Dorothy Yu Huang, Can Jin
BACKGROUND: Real Time Cell Analysis (RTCA) technology is used to monitor cellular changes continuously over the entire exposure period. Combining with different testing concentrations, the profiles have potential in probing the mode of action (MOA) of the testing substances. RESULTS: In this paper, we present machine learning approaches for MOA assessment. Computational tools based on artificial neural network (ANN) and support vector machine (SVM) are developed to analyze the time-concentration response curves (TCRCs) of human cell lines responding to tested chemicals...
2016: BioData Mining
https://www.readbyqxmd.com/read/27124590/real-time-cell-electronic-sensing-of-coal-fly-ash-particulate-matter-for-toxicity-based-air-quality-monitoring
#14
Birget Moe, Chungang Yuan, Jinhua Li, Haiying Du, Stephan Gabos, X Chris Le, Xing-Fang Li
The development of a unique bioassay for cytotoxicity analysis of coal fly ash (CFA) particulate matter (PM) and its potential application for air quality monitoring is described. Using human cell lines, A549 and SK-MES-1, as live probes on microelectrode-embedded 96-well sensors, impedance changes over time are measured as cells are treated with varying concentrations (1 μg/mL-20 mg/mL) of CFA samples. A dose-dependent impedance change is determined for each CFA sample, from which an IC50 histogram is obtained...
June 20, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27120335/genetic-candidate-variants-in-two-multigenerational-families-with-childhood-apraxia-of-speech
#15
Beate Peter, Ellen M Wijsman, Alejandro Q Nato, Mark M Matsushita, Kathy L Chapman, Ian B Stanaway, John Wolff, Kaori Oda, Virginia B Gabo, Wendy H Raskind
Childhood apraxia of speech (CAS) is a severe and socially debilitating form of speech sound disorder with suspected genetic involvement, but the genetic etiology is not yet well understood. Very few known or putative causal genes have been identified to date, e.g., FOXP2 and BCL11A. Building a knowledge base of the genetic etiology of CAS will make it possible to identify infants at genetic risk and motivate the development of effective very early intervention programs. We investigated the genetic etiology of CAS in two large multigenerational families with familial CAS...
2016: PloS One
https://www.readbyqxmd.com/read/26708053/predicting-ghs-toxicity-using-rtca-and-discrete-time-fourier-transform
#16
Jiao Chen, Tianhong Pan, Tianqing Pu, Biao Huang, Dorothy Yu Huang, Weiping Zhang, Stephan Gabos, Can Jin
In order to promote the acceptance of cell-based toxicity testings, the accuracy of cytotoxicity test must be determined when compared to in vivo results. Traditional methods of cytotoxicity analysis, such as LC[Formula: see text] (concentration where 50% of the cells are killed) can be problematic since they have been found to vary with time. Technological advances in cytotoxicity testing make it easy to record the dynamic data on changes in cell proliferation, morphology, and damage. To effectively and reasonably analyze the dynamic data, we present a new in vitro toxicity assessed method using the discrete-time Fourier transform (DTFT) which maps the measured cell index from the time domain to the frequency domain...
February 2016: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/26516708/effects-of-variable-attachment-shapes-and-aligner-material-on-aligner-retention
#17
Hiltrud Dasy, Andreas Dasy, Greg Asatrian, Noémi Rózsa, Hao-Fu Lee, Jin Hee Kwak
OBJECTIVE: To evaluate the retention of four types of aligners on a dental arch with various attachments. MATERIALS AND METHODS: For this study, three casts were manufactured, two of which contained attachments (ellipsoid and beveled), and one without any attachments to serve as a control. Four types of aligners were thermoformed: Clear-Aligner (CA)-soft, CA-medium, and CA-hard, with various thicknesses, and Essix ACE. Measurements of vertical displacement force during aligner removal were performed with the Gabo Qualimeter Eplexor...
November 2015: Angle Orthodontist
https://www.readbyqxmd.com/read/26356067/prediction-of-curve-progression-in-idiopathic-scoliosis-validation-of-the-sanders-skeletal-maturity-staging-system
#18
Prakash Sitoula, Kushagra Verma, Laurens Holmes, Peter G Gabos, James O Sanders, Petya Yorgova, Geraldine Neiss, Kenneth Rogers, Suken A Shah
STUDY DESIGN: Retrospective case series. OBJECTIVE: This study aimed to validate the Sanders Skeletal Maturity Staging System and to assess its correlation to curve progression in idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: The Sanders Skeletal Maturity Staging System has been used to predict curve progression in idiopathic scoliosis. This study intended to validate that initial study with a larger sample size. METHODS: We retrospectively reviewed 1100 consecutive patients with idiopathic scoliosis between 2005 and 2011...
July 1, 2015: Spine
https://www.readbyqxmd.com/read/26349589/outcomes-in-stage-i-non-small-cell-lung-cancer-following-the-introduction-of-stereotactic-body-radiotherapy-in-alberta-a-population-based-study
#19
Hong-Wei Liu, Zsolt Gabos, Sunita Ghosh, Barbara Roberts, Harold Lau, Marc Kerba
PURPOSE: To review outcomes of patients with stage I non-small cell lung cancer (NSCLC) following the introduction of stereotactic body radiation therapy (SBRT). METHODS: SBRT cases were linked to the cancer registry database along with clinical, treatment and health service parameters for n=2146 cases of stage I NSCLC diagnosed between 2005 and 2011. The pre-diagnosis Aggregated Clinical Risk Grouping score (ACRG3) was used as a proxy for pre-treatment patient comorbidity...
October 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/26310101/electronic-monitoring-of-orthopedic-brace-compliance
#20
Tariq Rahman, Whitney Sample, Petya Yorgova, Geraldine Neiss, Kenneth Rogers, Suken Shah, Peter Gabos, Dan Kritzer, J Richard Bowen
PURPOSE: Brace compliance measurement in adolescent idiopathic scoliosis (AIS) has been the subject of a few recent studies. Various sensors have been developed to measure compliance. We have developed a temperature-based data logger-the Cricket-specifically for scoliosis braces, with associated custom software, that is embedded directly in the brace. The purpose of this study was to analyze patterns of brace wear and patient compliance among children with AIS using the Cricket. METHODS: Fifty-five AIS patients prescribed various brace-time regimens were monitored using the Cricket...
October 2015: Journal of Children's Orthopaedics
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