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Hong-Wei Liu, Marc Kerba, Gerald Lim, Zsolt Gabos, Ivo A Olivotto, Anil Abraham Joy, Wilson Roa, Zoann Nugent, Harold Lau
BACKGROUND: Cancer care in Alberta, Canada is publicly funded and provides patients with access to health care facilities and providers. The distribution of patients and health services across Alberta presents challenges to the delivery of cancer care, especially radiation therapy. In this study, we examined the association between patient and health system factors, the use of radiation therapy and survival outcomes in patients with stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: The provincial cancer registry was used to identify all patients who presented with clinical stage III NSCLC, diagnosed from 2005 to 2007, in Alberta...
October 27, 2016: Curēus
Anand Swaminath, Marcin Wierzbicki, Sameer Parpia, James R Wright, Theodoros K Tsakiridis, Gordon S Okawara, Vijayananda Kundapur, Alexis Bujold, Naseer Ahmed, Khalid Hirmiz, Elizabeth Kurien, Edith Filion, Zsolt Gabos, Sergio Faria, Alexander V Louie, Timothy Owen, Elaine Wai, Kevin Ramchandar, Elisa K Chan, Jim Julian, Kathryn Cline, Timothy J Whelan
We describe a Canadian phase III randomized controlled trial of stereotactic body radiotherapy (SBRT) versus conventionally hypofractionated radiotherapy (CRT) for the treatment of stage I medically inoperable non-small-cell lung cancer (OCOG-LUSTRE Trial). Eligible patients are randomized in a 2:1 fashion to either SBRT (48 Gy in 4 fractions for peripherally located lesions; 60 Gy in 8 fractions for centrally located lesions) or CRT (60 Gy in 15 fractions). The primary outcome of the study is 3-year local control, which we hypothesize will improve from 75% with CRT to 87...
October 3, 2016: Clinical Lung Cancer
Tudor Nirestean, Emese Lukacs, Aurel Nirestean, Iosif Gabos Grecu
Borderline personality disorder is a complex disease model as it encompasses a diversity of pathological personality traits and psychopathological symptoms. It is not surprising, therefore, that it is often manifested by personality disorders across all three clusters and accompanied by other mental (Axis I) disorders. This melange makes both psychological treatment and pharmacotherapy especially challenging, and this paper describes the case of a particularly complex case of a 33-year-old Romanian patient, who has a history of severe deprivation in childhood, mood and substance use disorder in association with borderline pathology...
October 13, 2016: Personality and Mental Health
B S Abdulkarim, K Joseph, L Vos, H K Warkentin, Z Gabos, N Pervez, K Tankel, S Ghosh, S M J Chafe, M B Parliament
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
E M Babiker, T C Gordon, S Chao, M N Rouse, R Wanyera, M Newcomb, G Brown-Guedira, Z A Pretorius, J M Bonman
A gene for Ug99 resistance from wheat landrace CItr 4311 was detected on the long arm of chromosome 2B. Wheat landrace CItr 4311 has seedling resistance to stem rust caused by Puccinia graminis f. sp. tritici race TTKSK and field resistance to the Ug99 race group. Parents, F1 seedlings, 121 doubled haploid (DH) lines, and 124 recombinant inbred lines (RILs) developed from a cross between CItr 4311 and the susceptible line LMPG-6 were evaluated for seedling resistance to race TTKSK. Goodness-of-fit tests indicated that a single dominant gene in CItr 4311 conditioned the TTKSK resistance...
August 20, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Jayaveeramuthu Nirmala, Shiaoman Chao, Pablo Olivera, Ebrahiem M Babiker, Bekele Abeyo, Zerihun Tadesse, Muhammad Imtiaz, Luther Talbert, Nancy K Blake, Eduard Akhunov, Michael O Pumphrey, Yue Jin, Matthew N Rouse
Wheat stem rust, caused by Puccinia graminis f. sp. tritici, can cause severe yield losses on susceptible wheat varieties and cultivars. Although stem rust can be controlled by the use of genetic resistance, population dynamics of P. graminis f. sp. tritici can frequently lead to defeat of wheat stem rust resistance genes. P. graminis f. sp. tritici race TKTTF caused a severe epidemic in Ethiopia on Ug99-resistant 'Digalu' in 2013 and 2014. The gene Sr11 confers resistance to race TKTTF and is present in 'Gabo 56'...
November 2016: Phytopathology
J Shahi, J R Wright, Z Gabos, A Swaminath
BACKGROUND: The management of small-cell lung cancer (sclc) with radiotherapy (rt) varies, with many treatment regimens having been described in the literature. We created a survey to assess patterns of practice and clinical decision-making in the management of sclc by Canadian radiation oncologists (ros). METHODS: A 35-item survey was sent by e-mail to Canadian ros. The questions investigated the role of rt, the dose and timing of rt, target delineation, and use of prophylactic cranial irradiation (pci) in limited-stage (ls) and extensive-stage (es) sclc...
June 2016: Current Oncology
Yile Zhang, Yau Shu Wong, Jian Deng, Cristina Anton, Stephan Gabos, Weiping Zhang, Dorothy Yu Huang, Can Jin
BACKGROUND: Real Time Cell Analysis (RTCA) technology is used to monitor cellular changes continuously over the entire exposure period. Combining with different testing concentrations, the profiles have potential in probing the mode of action (MOA) of the testing substances. RESULTS: In this paper, we present machine learning approaches for MOA assessment. Computational tools based on artificial neural network (ANN) and support vector machine (SVM) are developed to analyze the time-concentration response curves (TCRCs) of human cell lines responding to tested chemicals...
2016: BioData Mining
Birget Moe, Chungang Yuan, Jinhua Li, Haiying Du, Stephan Gabos, X Chris Le, Xing-Fang Li
The development of a unique bioassay for cytotoxicity analysis of coal fly ash (CFA) particulate matter (PM) and its potential application for air quality monitoring is described. Using human cell lines, A549 and SK-MES-1, as live probes on microelectrode-embedded 96-well sensors, impedance changes over time are measured as cells are treated with varying concentrations (1 μg/mL-20 mg/mL) of CFA samples. A dose-dependent impedance change is determined for each CFA sample, from which an IC50 histogram is obtained...
June 20, 2016: Chemical Research in Toxicology
Beate Peter, Ellen M Wijsman, Alejandro Q Nato, Mark M Matsushita, Kathy L Chapman, Ian B Stanaway, John Wolff, Kaori Oda, Virginia B Gabo, Wendy H Raskind
Childhood apraxia of speech (CAS) is a severe and socially debilitating form of speech sound disorder with suspected genetic involvement, but the genetic etiology is not yet well understood. Very few known or putative causal genes have been identified to date, e.g., FOXP2 and BCL11A. Building a knowledge base of the genetic etiology of CAS will make it possible to identify infants at genetic risk and motivate the development of effective very early intervention programs. We investigated the genetic etiology of CAS in two large multigenerational families with familial CAS...
2016: PloS One
Jiao Chen, Tianhong Pan, Tianqing Pu, Biao Huang, Dorothy Yu Huang, Weiping Zhang, Stephan Gabos, Can Jin
In order to promote the acceptance of cell-based toxicity testings, the accuracy of cytotoxicity test must be determined when compared to in vivo results. Traditional methods of cytotoxicity analysis, such as LC[Formula: see text] (concentration where 50% of the cells are killed) can be problematic since they have been found to vary with time. Technological advances in cytotoxicity testing make it easy to record the dynamic data on changes in cell proliferation, morphology, and damage. To effectively and reasonably analyze the dynamic data, we present a new in vitro toxicity assessed method using the discrete-time Fourier transform (DTFT) which maps the measured cell index from the time domain to the frequency domain...
February 2016: Journal of Bioinformatics and Computational Biology
Hiltrud Dasy, Andreas Dasy, Greg Asatrian, Noémi Rózsa, Hao-Fu Lee, Jin Hee Kwak
OBJECTIVE: To evaluate the retention of four types of aligners on a dental arch with various attachments. MATERIALS AND METHODS: For this study, three casts were manufactured, two of which contained attachments (ellipsoid and beveled), and one without any attachments to serve as a control. Four types of aligners were thermoformed: Clear-Aligner (CA)-soft, CA-medium, and CA-hard, with various thicknesses, and Essix ACE. Measurements of vertical displacement force during aligner removal were performed with the Gabo Qualimeter Eplexor...
November 2015: Angle Orthodontist
Prakash Sitoula, Kushagra Verma, Laurens Holmes, Peter G Gabos, James O Sanders, Petya Yorgova, Geraldine Neiss, Kenneth Rogers, Suken A Shah
STUDY DESIGN: Retrospective case series. OBJECTIVE: This study aimed to validate the Sanders Skeletal Maturity Staging System and to assess its correlation to curve progression in idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: The Sanders Skeletal Maturity Staging System has been used to predict curve progression in idiopathic scoliosis. This study intended to validate that initial study with a larger sample size. METHODS: We retrospectively reviewed 1100 consecutive patients with idiopathic scoliosis between 2005 and 2011...
July 1, 2015: Spine
Hong-Wei Liu, Zsolt Gabos, Sunita Ghosh, Barbara Roberts, Harold Lau, Marc Kerba
PURPOSE: To review outcomes of patients with stage I non-small cell lung cancer (NSCLC) following the introduction of stereotactic body radiation therapy (SBRT). METHODS: SBRT cases were linked to the cancer registry database along with clinical, treatment and health service parameters for n=2146 cases of stage I NSCLC diagnosed between 2005 and 2011. The pre-diagnosis Aggregated Clinical Risk Grouping score (ACRG3) was used as a proxy for pre-treatment patient comorbidity...
October 2015: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Tariq Rahman, Whitney Sample, Petya Yorgova, Geraldine Neiss, Kenneth Rogers, Suken Shah, Peter Gabos, Dan Kritzer, J Richard Bowen
PURPOSE: Brace compliance measurement in adolescent idiopathic scoliosis (AIS) has been the subject of a few recent studies. Various sensors have been developed to measure compliance. We have developed a temperature-based data logger-the Cricket-specifically for scoliosis braces, with associated custom software, that is embedded directly in the brace. The purpose of this study was to analyze patterns of brace wear and patient compliance among children with AIS using the Cricket. METHODS: Fifty-five AIS patients prescribed various brace-time regimens were monitored using the Cricket...
October 2015: Journal of Children's Orthopaedics
Ron El-Hawary, Peter Sturm, Patrick Cahill, Amer Samdani, Michael Vitale, Peter Gabos, Nathan Bodin, Charles d'Amato, Colin Harris, Ammar Al Khudairy, John T Smith
BACKGROUND: Rib-based and spine-based systems are commonly used distraction-based growth friendly treatments for early-onset scoliosis (EOS). Our primary purpose was to determine the risk of developing postoperative proximal junctional kyphosis (PJK) during distraction-based growth friendly surgery. METHODS: A multicenter, retrospective, radiographic comparison was performed for a group of 40 children with EOS who were treated with posterior distraction-based implants...
July 17, 2015: Journal of Pediatric Orthopedics
Mike Dickey, Wilson Roa, Suzanne Drodge, Sunita Ghosh, Brad Murray, Rufus Scrimger, Zsolt Gabos
The primary objective of this study was to compare dosimetric variables as well as treatment times of multiple static fields (MSFs), conformal arcs (CAs), and volumetric modulated arc therapy (VMAT) techniques for the treatment of early stage lung cancer using stereotactic body radiotherapy (SBRT). Treatments of 23 patients previously treated with MSF of 48Gy to 95% of the planning target volume (PTV) in 4 fractions were replanned using CA and VMAT techniques. Dosimetric parameters of the Radiation Therapy Oncology Group (RTOG) 0915 trial were evaluated, along with the van׳t Riet conformation number (CN), monitor units (MUs), and actual and calculated treatment times...
2015: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Jihyun Yun, Eugene Yip, Zsolt Gabos, Keith Wachowicz, Satyapal Rathee, B G Fallone
PURPOSE: To develop a neural-network based autocontouring algorithm for intrafractional lung-tumor tracking using Linac-MR and evaluate its performance with phantom and in-vivo MR images. METHODS: An autocontouring algorithm was developed to determine both the shape and position of a lung tumor from each intrafractional MR image. A pulse-coupled neural network was implemented in the algorithm for contrast improvement of the tumor region. Prior to treatment, to initiate the algorithm, an expert user needs to contour the tumor and its maximum anticipated range of motion in pretreatment MR images...
May 2015: Medical Physics
Sabina DiCindio, Lynda Arai, Michael McCulloch, Kesavan Sadacharam, Suken A Shah, Peter Gabos, Kirk Dabney, Mary C Theroux
BACKGROUND: Spinal deformity is one of the secondary musculoskeletal problems that occur with cerebral palsy (CP). Of the co morbidities associated with CP and spinal deformity, cardiac function is of theoretical concern. OBJECTIVE: The goal of our study was to determine the clinical relevance of routine preoperative cardiology evaluation via echocardiogram for patients with CP presenting for posterior spine fusion (PSF) surgery. METHODS: A retrospective chart review was performed of CP patients presenting for scoliosis surgery...
August 2015: Paediatric Anaesthesia
Hiltrud Dasy, Andreas Dasy, Greg Asatrian, Noémi Rózsa, Hao-Fu Lee, Jin Hee Kwak
Objective: To evaluate the retention of four types of aligners on a dental arch with various attachments. Materials and Methods: For this study, three casts were manufactured, two of which contained attachments (ellipsoid and beveled), and one without any attachments to serve as a control. Four types of aligners were thermoformed: Clear-Aligner (CA)-soft, CA-medium, and CA-hard, with various thicknesses, and Essix ACE. Measurements of vertical displacement force during aligner removal were performed with the Gabo Qualimeter Eplexor...
February 26, 2015: Angle Orthodontist
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