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Chondroblastoma

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https://www.readbyqxmd.com/read/28899740/histone-3-3-mutations-in-giant-cell-tumor-and-giant-cell-rich-sarcomas-of-bone
#1
Alberto Righi, Irene Mancini, Marco Gambarotti, Piero Picci, Gabriella Gamberi, Cristina Marraccini, Angelo Paolo Dei Tos, Lisa Simi, Pamela Pinzani, Alessandro Franchi
Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. While over 90% of GCTB presents histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study we examined a series of giant cell rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cell rich sarcomas...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882701/diagnostic-value-of-histone-3-mutations-in-osteoclast-rich-bone-tumors
#2
Erik Nohr, Lik Hang Lee, Justin M Cates, Marco Perizzolo, Doha Itani
Differentiating osteoclast-rich lesions of bone (giant cell tumor of bone [GCTB], chondroblastoma [CBA], and aneurysmal bone cyst [ABC]) can be challenging, especially in small biopsies or fine needle aspirations. Mutations affecting codons 34 and 36 of either H3 Histone Family Member 3A (H3F3A) and/or 3B (H3F3B) are characteristically seen in GCTB and CBAs. We devised a simple assay to identify these mutations and evaluated its applicability for routine clinical diagnosis. 124 tissue specimens from 108 patients (43 GCTBs, 38 CBAs and 27 ABCs) were collected from the archives of the Calgary Laboratory Services/University of Calgary and Vanderbilt University Medical Center...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28878541/an-unusual-localization-of-chondroblastoma-the-triradiate-cartilage-from-a-case-report-a-reconstructive-technique-proposal-with-imaging-evolution
#3
Carmine Zoccali, Francesco Arrigoni, Silvia Mariani, Federico Bruno, Antonio Barile, Carlo Masciocchi
INTRODUCTION: Chondroblastoma (also known as Codman tumor) is a rare intermediate grade cartilaginous neoplasm, representing less than 1% of all primary bone tumors; it characteristically arises in the epiphysis or apophysis of a long bone in young patients, predominantly males. The most frequent location of chondroblastoma is the humerus (70% incidence rate) and more rarely it is located in the pelvis. When it affects the hip, the triradiate cartilage is the most common site. MATERIALS AND METHODS: An unusual case of Chondroblastoma located in the triradiate cartilage is reported...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28862242/unusual-presentation-of-chondroblastoma-mimicking-trevor-s-disease
#4
A V Nair, S Anirudh
No abstract text is available yet for this article.
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28834661/intraoperative-crush-smear-cytology-of-vertebral-chondroblastoma-a-diagnostic-challenge
#5
Shilpa P Tathe, Sanjay N Parate, Kirti N Jaiswal, Archana A Randale
Chondroblastoma is a rare, cartilage producing primary neoplasm of the bone. Although generally benign, chondroblastoma is placed in the "intermediate, rarely metastasizing" category in the 2013 World Health Organization classification of bone tumors. It typically involves the epiphysis of long tubular bones and is exceptionally located in the vertebral column. To the best of our knowledge, less than 35 cases of vertebral chondroblastoma have been reported in the literature. We report a case of chondroblastoma involving D6 -D7 vertebrae in a 17-year-old male patient, diagnosed on intraoperative crush cytology and later confirmed on histopathology...
August 23, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28736834/temporal-bone-chondroblastoma-imaging-characteristics-with-pathologic-correlation
#6
Sun-Won Park, Ji-Hoon Kim, Ji Hoon Park, Kyung Chul Moon, Jin Chul Paeng, Byung Se Choi, Younghen Lee, Jae Hyoung Kim, Roh-Eul Yoo, Koung Mi Kang, Soo Chin Kim, Seung Hong Choi, Tae Jin Yun, Chul Ho Sohn
BACKGROUND: Chondroblastoma commonly involves the temporal bone in the craniofacial region, but its imaging features have not been elucidated. This study aimed to describe the imaging features of temporal bone chondroblastoma with their pathologic correlation. METHODS: Radiopathologic correlation was performed in 5 patients with temporal bone chondroblastoma from our database and in 11 patients identified through a PubMed search. RESULTS: The cases of temporal bone chondroblastoma commonly involve the squamous part, temporal and infratemporal fossae, temporomandibular joint, and tympanic cavity, with the following features: high attenuation with calcification; heterogeneity; low signal intensity on T2-weighted imaging with enhancement; a smooth interface to the brain; and strong hypermetabolism on fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28634924/chondroblastoma-in-adult-age
#7
Andrea Angelini, Mohammad Hassani, Andreas F Mavrogenis, Giulia Trovarelli, Carlo Romagnoli, Antonio Berizzi, Pietro Ruggieri
PURPOSE: Chondroblastoma (CB) is a rare benign tumor that occurs most commonly in the second decade of life. No studies on CB in adulthood have been reported. Our purposes were to report a single-institution experience on CB in adults and to discuss the clinical and imaging findings, type of treatment, oncologic and functional outcomes. PATIENTS AND METHODS: All patients diagnosed and treated for CB from 1981 to 2014 were reviewed. The main inclusion criterion was patients above their 30 years of age at diagnosis...
August 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28583274/benign-bone-conditions-that-may-be-fdg-avid-and-mimic-malignancy
#8
REVIEW
Thomas C Kwee, John M H de Klerk, Maarten Nix, Ben G F Heggelman, Stefan V Dubois, Hugo J A Adams
Positron emission tomography with the radiotracer (18)F-fluoro-2-deoxy-d-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy is important for correct patient management, including the avoidance of unnecessary additional invasive tests such as bone biopsy. This review summarizes and illustrates the spectrum of benign bone conditions that may be FDG-avid and mimic malignancy, including osteomyelitis, bone lesions due to benign systemic diseases (Brown tumor, Erdheim-Chester disease, Gaucher disease, gout and other types of arthritis, Langerhans cell histiocytosis, and sarcoidosis), benign primary bone lesions (bone cysts, chondroblastoma, chondromyxoid fibroma, desmoplastic fibroma, enchondroma, giant cell tumor and granuloma, hemangioma, nonossifying fibroma, and osteoid osteoma and osteoblastoma), and a group of miscellaneous benign bone conditions (post bone marrow biopsy or harvest status, bone marrow hyperplasia, fibrous dysplasia, fractures, osteonecrosis, Paget disease of bone, particle disease, and Schmorl nodes)...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28557595/chondroblastoma-an-update
#9
Wenqian Chen, Lisa M DiFrancesco
Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bones. Radiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Chondroblastoma, however, may also present with atypical features, such as prominent hemosiderin deposition, numerous giant cells, or the presence of a large aneurysmal bone cyst component...
June 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28521633/cd30-expression-in-pediatric-neoplasms-study-of-585-cases
#10
Jinjun Cheng, Haiqing Zhu, John Kim Choi
CD30 is a member of the tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), and its normal expression is restricted to activated T and B cells. In tumor cells, CD30 expression is most commonly associated with lymphoid malignancies (Hodgkin and non-Hodgkin lymphomas) and is a therapeutic target using anti-CD30 antibody. CD30 expression has been reported also in mostly adult non-lymphoid malignancies, raising the possibility of CD30-targeted therapy for additional tumors. In this study, we examined the incidence of CD30 expression in 251 hematopoietic and 334 non-hematopoietic cases of pediatric tumors...
June 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28502566/lateral-skull-base-chondroblastoma-resected-with-facial-nerve-posterior-transposition
#11
J Adnot, O Langlois, E Tollard, M Crahes, I Auquit-Auckbur, J-P Marie
INTRODUCTION: Chondroblastoma is a rare tumor that can involve the temporal bone. Because it is a benign tumor, functional surgery must be proposed. We report a case of a patient with a massive chondroblastoma operated on with preservation of the facial nerve, and description of the surgical technique. CASE PRESENTATION: A 37-year-old man presented with a 9-month history of a growing left pre-auricular mass and hearing loss. Neuroimaging showed an osteolytic mass invading the temporal bone and temporomandibular joint...
May 11, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28484590/histone-3-3-hotspot-mutations-in-conventional-osteosarcomas-a-comprehensive-clinical-and-molecular-characterization-of-six-h3f3a-mutated-cases
#12
Christian Koelsche, Daniel Schrimpf, Lars Tharun, Eva Roth, Dominik Sturm, David T W Jones, Eva-Kristin Renker, Martin Sill, Annika Baude, Felix Sahm, David Capper, Melanie Bewerunge-Hudler, Wolfgang Hartmann, Andreas E Kulozik, Iver Petersen, Uta Flucke, Hendrik W B Schreuder, Reinhard Büttner, Marc-André Weber, Peter Schirmacher, Christoph Plass, Stefan M Pfister, Andreas von Deimling, Gunhild Mechtersheimer
BACKGROUND: Histone 3.3 (H3.3) hotspot mutations in bone tumors occur in the vast majority of giant cell tumors of bone (GCTBs; 96%), chondroblastomas (95%) and in a few cases of osteosarcomas. However, clinical presentation, histopathological features, and additional molecular characteristics of H3.3 mutant osteosarcomas are largely unknown. METHODS: In this multicentre, retrospective study, a total of 106 conventional high-grade osteosarcomas, across all age groups were re-examined for hotspot mutations in the H3...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28484548/intra-axial-chondroblastoma-a-bony-tumor-in-the-cerebral-hemisphere-a-case-report-and-review-of-literature
#13
Mayur Sharma, Shadma W Khan, Vernon Velho, Rahul Mally
This case highlights a rare possibility of occurrence of chondroblastoma, a bony tumor, at an uncommon location. Extraosseous, soft tissue location of this bony tumor is rare and more so for intracranial intra-axial location. We report a case of an intra-axial frontal lobe lesion, histologically proven to be an extraosseous chondroblastoma. A 23-year-old male presented with a history of headache and vomiting of 1 month duration. Imaging was suggestive of left frontal lobe intra-axial calcified lesion suggestive of oligodendroglioma...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28454393/diagnosing-and-discriminating-between-primary-and-secondary-aneurysmal-bone-cysts
#14
Hiromi Sasaki, Satoshi Nagano, Hirofumi Shimada, Masahiro Yokouchi, Takao Setoguchi, Yasuhiro Ishidou, Osamu Kunigou, Kosuke Maehara, Setsuro Komiya
Aneurysmal bone cysts (ABCs) are benign bony lesions frequently accompanied by multiple cystic lesions and aggressive bone destruction. They are relatively rare lesions, representing only 1% of bone tumors. The pathogenesis of ABCs has yet to be elucidated. In the present study, a series of 22 cases of primary and secondary ABC from patients treated in Department of Orthopedic Surgery, Kagoshima University Hospital (Kagoshima, Japan) from 2001-2015 were retrospectively analyzed. The average age at the time of diagnosis of primary ABC was 17...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28396758/use-of-denosumab-in-recurrent-chondroblastoma-of-the-squamous-temporal-bone-a-case-report
#15
Nicholas Calvert, David Wood
Chondroblastoma is a rare, benign bone tumor that represents 1-2% of all primary bone tumors. Denosumab, a monoclonal antibody, has been demonstrated to inhibit the growth of giant cell tumors. We report a case of recurrent chondroblastoma of the squamous temporal bone that is currently suppressed with denosumab.
April 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28344536/capitate-chondroblastoma-a-case-report-and-review-of-the-literature
#16
Ali Izadpanah, Riyam T Zreik, Thomas Shives, Sanjeev Kakar
Background: Chondroblastomas are benign tumors that typically occur in the epiphysis of long bones. Carpal bone chondroblastomas are very rare and are known to have less aggressive behavior with no evidence of recurrence reported. Methods: We present a case of a recurrent chondroblastoma in the capitate that was treated with repeat curettage, application of phenol, and bone grafting. Results: At 3 years post surgery, the patient is disease free with excellent functional return. Conclusion: Chondroblastomas are rare within the carpus...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28300344/intramedullary-nailing-combined-with-bone-grafting-for-benign-lesions-of-the-proximal-femur
#17
Yan Zhang, Jia-Zhen Li, Xin-Chang Lu, Yi Zhang, Huai-Shuan Zhang, Hai-Long Shi, Zheng Lei, Guang Feng, Wei-Ping Fu
OBJECTIVE: To evaluate the effectiveness of intramedullary nailing for benign lesions of the proximal femur. METHOD: A retrospective analysis was carried out on 68 cases of benign lesions in the proximal femur at our hospital from April 2002 to April 2013 (38 men and 30 women). Mean age at surgery was 35.5 years (range, 22-56 years). The cases were divided into two groups: curettage of the lesion with bone grafting only as the grafting group (32 cases) and internal fixation after removal of the lesion as the fixation group (36 cases)...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28290305/a-rare-probable-chondroblastoma-of-the-calcaneus-in-a-pre-columbian-subadult-from-illinois
#18
Maria Ostendorf Smith, Christopher E Nicosia
Discrete cystic or tumorous intraosseous lesions can arise from a variety of benign and malignant conditions as well as trauma and infection. They are clinically rarely observed in the calcaneus. A fourteen-to-seventeen-year-old subadult recovered from a Late Woodland (∼AD 800-1100) period mortuary context in the Mississippi River Valley of central Illinois presents with a single lytic intraosseous lesion on the posterior right calcaneus that bilaterally perforates the cortex. The lesion, although primarily anterior to the epiphyseal plate, does breach it...
March 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28280610/investigation-of-the-human-h3-3b-h3f3b-gene-expression-as-a-novel-marker-in-patients-with-colorectal-cancer
#19
Habib Allah Ayoubi, Frouzandeh Mahjoubi, Rezvan Mirzaei
BACKGROUND: H3.3 histone is a replacement histone subtype that is express in entire cell cycle phases and overexpress in transcriptionally active regions, promoter regions, and intergenic or intragenic regulatory elements. This histone encoded by two genes termed H3.3A (H3F3A) and H3.3B (H3F3B). Mutations of these two genes lead to some human cancers such as chondroblastoma, osteosarcoma, and epithelial ovarian cancer. The aims of this study were to quantitatively examine the expression of H3...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28272066/unusual-presentation-of-chondroblastoma-mimicking-trevor-s-disease
#20
Y Karkhur, A Tiwari, T Verma, L Maini
Chondroblastoma is a benign bone tumor, represents 1%-2% of all primary bone tumors, typically seen in patients 10-25-year-old and more common in males. It occurs most frequently in the distal femur, proximal tibia, and proximal humerus. Soft tissue extension is extremely rare. Adjacent joints may develop effusions, but the tumor mass protruding into the joint has never been seen in case of chondroblastoma. We report a rare case of intra-articular chondroblastoma arising from proximal tibia in a 16-year-old boy and growing into the knee joint mimicking an intra-articular osteochondroma...
July 2017: Journal of Postgraduate Medicine
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