keyword
MENU ▼
Read by QxMD icon Read
search

Chondroblastoma

keyword
https://www.readbyqxmd.com/read/29307095/aggressive-curettage-of-a-chondroblastoma-like-osteosarcoma-of-the-proximal-end-of-the-tibia-a-case-report-with-seven-year-follow-up
#1
Luis Rafael Ramos Pascua, Paula Casas Ramos, Francisco Arias Martín, Francisco Miguel Izquierdo García
A chondroblastoma-like osteosarcoma (CLO) in the proximal epiphysis and metaphysis of the tibia in a 30-year-old male is presented. With a wrong diagnosis of chondroblastoma, an aggressive curettage was performed. Later, the patient refused en-bloc resection. Seven years after surgery, there has been no local recurrence, and the patient is living an ordinary and active life. CLO is a very uncommon and controversial histologic subtype of osteosarcoma that can be misdiagnosed as chondroblastoma and therefore incorrectly treated...
January 6, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29241742/diagnostic-utility-of-histone-h3-3g34-w-g34r-and-g34-v-mutant-specific-antibodies-for-giant-cell-tumors-of-bone
#2
Hidetaka Yamamoto, Takeshi Iwasaki, Yuichi Yamada, Yoshihiro Matsumoto, Hiroshi Otsuka, Masato Yoshimoto, Kenichi Kohashi, Kenichi Taguchi, Ryohei Yokoyama, Yasuharu Nakashima, Yoshinao Oda
Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% have H3F3A gene mutation. The RANKL inhibitor denosumab, when used for the treatment of GCTB, leads to histological changes such as new bone formation and giant cell depletion. Here we assessed the diagnostic utility of immunohistochemical staining with the antibodies against histone H3.3G34 W, G34R and G34 V mutant proteins for GCTB and other histologically similar bone and joint lesions...
December 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29215692/chondroid-tenosynovial-giant-cell-tumor-of-the-temporomandibular-joint-a-rare-case-report
#3
Ana Lia Anbinder, Barbara Maria Corrêa Geraldo, Rubens Guimarães, Débora Lima Pereira, Oslei Paes de Almeida, Yasmin Rodarte Carvalho
Tenosynovial giant cell tumor of diffuse type (TGCT-d) or pigmented villonodular synovitis (PVNS) is a locally aggressive lesion that mostly affects the joints of long bones. Chondroid tenosynovial giant cell tumor (CTGCT) or PVNS with chondroid metaplasia is a rare distinct subset of synovial tumors that has a predilection for the TMJ. We report a rare case of CTGCT in the TMJ, initially misdiagnosed as temporomandibular disorder (TMD). A 51-year-old woman was referred to the surgeon with the chief complaint of TMJ pain for 5 years and a past history of an unsuccessful TMD treatment...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29209799/-chondroblastoma
#4
REVIEW
G Jundt, D Baumhoer
Chondroblastomas are very rare benign primary bone tumors occurring preferentially in the epiphyses or apophyses of long bones in children and adolescents. In most cases the typical histological and imaging findings lead to a correct diagnosis that may be substantiated by demonstrating the highly specific point mutation in the H3F3B gene (p.K36M), either by sequencing or immunohistochemistry. Recurrences occur in 5-15% of cases, postsurgical metastatic deposits to the lungs are very rare (<1%). Histologically "malignant" chondroblastomas have been reported as single case reports...
December 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29142790/an-active-giant-cell-tumor-of-the-patella-a-case-report
#5
Svetoslav A Slavchev, Georgi P Georgiev, Kircho Patrikov
Primary neoplasms of the patella account for less than 1% of all primary bone tumors of the lower extremity, the most frequent of them being the giant cell tumor of bone, the chondroblastoma, and the aneurysmal bone cyst. Herein, we report the case of a 29-year-old woman with an active giant cell tumor of the patella (GCTP) with its clinical and radiological features and a brief review of the literature.
September 2, 2017: Curēus
https://www.readbyqxmd.com/read/29110035/-new-aspects-on-giant-cell-tumor-of-bone
#6
REVIEW
J Lüke, M Hasenfratz, P Möller, T F E Barth
A giant cell tumor of bone (GCTB) is one of the giant cell-rich lesions of bone and has to be differentiated from non-ossifying fibroma, aneurysmatic bone cyst, chondroblastoma, "brown tumor" and osteosarcoma containing giant cells. A hallmark of GCTB is the presence of the distinct histone 3 (H3F3A) mutation G34W and its detection either by sequencing methods or using immunohistochemistry with a novel antibody against this mutational site. Worrisome is the fact that under denosumab therapy a histological change of the lesions can be seen and there are first reports of sarcomas arising after therapy...
November 6, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29077506/a-rare-case-of-chondroblastoma-with-revision-after-graft-rejectiona-case-report
#7
Brandon Gumbiner, Elizabeth Jacobsen, Mary Stancukas, Ngan Nguyen
We present a rare case of calcaneal chondroblastoma with subsequent surgical revision after graft rejection in a 13-year-old boy. Complications were encountered after the injectable bone graft filler was placed in the calcaneus after curettage. With noted subsequent sinus tract formation, revision surgery was performed that involved dissection of the sinus tract, removal of bone void filler, and application of demineralized bone matrix sponge human allograft soaked in vancomycin-impregnated saline. Sixteen weeks after the revision surgical intervention, the patient resumed normal athletic activities without pain or restrictions...
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29068085/-chondroblastoma-like-epithelioid-fibrous-histiocytoma-a-previously-undescribed-and-potentially-confusing-variant
#8
Anthony P Martinez, Youran Zou, Steven D Billings, Andrew L Folpe
BACKGROUND: Epithelioid benign fibrous histiocytoma has been considered a variant of fibrous histiocytoma, but is now considered a distinct entity, typically showing ALK expression. Most show typical morphological features, including an epidermal collarette and large, bland, epithelioid cells. We have recently encountered 2 examples showing an unusual pattern of pericellular calcification, a previously unreported finding. METHODS: Available slides were reviewed and clinical follow-up was obtained...
October 25, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28971570/chondroblastoma-of-extra-craniofacial-bones-clinicopathological-analyses-of-103-cases
#9
Eiichi Konishi, Yasuaki Nakashima, Masayuki Mano, Yasuhiko Tomita, Toshikazu Kubo, Nobuhito Araki, Eiichi Morii, Hideki Yoshikawa, Hironori Haga, Junya Toguchida, Takafumi Ueda, Masahiko Osawa, Manabu Hoshi, Takeshi Inoue, Masanari Aono, Akio Yanagisawa
We elucidated clinicopathological characteristics of chondroblastoma (CB) in Japan, and reliable clinicopathologic parameters predicting local recurrence and/or metastasis. Clinicopathological profiles of 103 CB (80 male, 23 female) in extra-craniofacial bones were retrieved. Numerical scoring of nine pathological and five radiological features was statistically analyzed to determine prognostic significance. Age ranged 8-61 years (average 19.6 years). Frequently involved sites were femur, tibia, calcaneus, patella and humerus...
October 2017: Pathology International
https://www.readbyqxmd.com/read/28936339/utility-of-vs38c-in-the-diagnostic-and-prognostic-assessment-of-osteosarcoma-and-other-bone-tumours-tumour-like-lesions
#10
E S Hookway, Z Orosz, Y Uchihara, A Grigoriadis, A B Hassan, U Oppermann, N A Athanasou
BACKGROUND: VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is abundant in osteosarcoma cells. The aim of this study was to determine the diagnostic and prognostic utility of VS38c in the histological assessment of osteosarcoma and other bone tumours/tumour-like leisons. METHODS: Immunohistochemical staining with VS38c was carried out on formalin-fixed specimens of osteosarcoma (pre/post-chemotherapy) and a wide range of benign and malignant bone lesions...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28933651/characterization-of-h3-3k36m-as-a-tool-to-study-h3k36-methylation-in-cancer-cells
#11
Saumya M Sankaran, Or Gozani
Recurrent mutations at key lysine residues in the histone variant H3.3 are thought to play an etiologic role in the development of distinct subsets of pediatric gliomas and bone and cartilage cancers. H3.3K36M is one such mutation that was originally identified in chondroblastomas, and its expression in these tumors contributes to oncogenic reprogramming by triggering global depletion of dimethylation and trimethylation at H3K36 with a concomitant increase in the levels of H3K27 trimethylation. H3.3K36M expression can also cause epigenomic changes in cell types beyond chondrocytic cells...
September 21, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28899740/histone-3-3-mutations-in-giant-cell-tumor-and-giant-cell-rich-sarcomas-of-bone
#12
Alberto Righi, Irene Mancini, Marco Gambarotti, Piero Picci, Gabriella Gamberi, Cristina Marraccini, Angelo Paolo Dei Tos, Lisa Simi, Pamela Pinzani, Alessandro Franchi
Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. While over 90% of GCTB presents histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study we examined a series of giant cell rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cell rich sarcomas...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28882701/diagnostic-value-of-histone-3-mutations-in-osteoclast-rich-bone-tumors
#13
Erik Nohr, Lik Hang Lee, Justin M Cates, Marco Perizzolo, Doha Itani
Differentiating osteoclast-rich lesions of bone (giant cell tumor of bone [GCTB], chondroblastoma [CBA], and aneurysmal bone cyst [ABC]) can be challenging, especially in small biopsies or fine needle aspirations. Mutations affecting codons 34 and 36 of either H3 Histone Family Member 3A (H3F3A) and/or 3B (H3F3B) are characteristically seen in GCTB and CBAs. We devised a simple assay to identify these mutations and evaluated its applicability for routine clinical diagnosis. 124 tissue specimens from 108 patients (43 GCTBs, 38 CBAs and 27 ABCs) were collected from the archives of the Calgary Laboratory Services/University of Calgary and Vanderbilt University Medical Center...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28878541/an-unusual-localization-of-chondroblastoma-the-triradiate-cartilage-from-a-case-report-a-reconstructive-technique-proposal-with-imaging-evolution
#14
Carmine Zoccali, Francesco Arrigoni, Silvia Mariani, Federico Bruno, Antonio Barile, Carlo Masciocchi
INTRODUCTION: Chondroblastoma (also known as Codman tumor) is a rare intermediate grade cartilaginous neoplasm, representing less than 1% of all primary bone tumors; it characteristically arises in the epiphysis or apophysis of a long bone in young patients, predominantly males. The most frequent location of chondroblastoma is the humerus (70% incidence rate) and more rarely it is located in the pelvis. When it affects the hip, the triradiate cartilage is the most common site. MATERIALS AND METHODS: An unusual case of Chondroblastoma located in the triradiate cartilage is reported...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28862242/unusual-presentation-of-chondroblastoma-mimicking-trevor-s-disease
#15
A V Nair, S Anirudh
No abstract text is available yet for this article.
August 31, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28834661/intraoperative-crush-smear-cytology-of-vertebral-chondroblastoma-a-diagnostic-challenge
#16
Shilpa P Tathe, Sanjay N Parate, Kirti N Jaiswal, Archana A Randale
Chondroblastoma is a rare, cartilage producing primary neoplasm of the bone. Although generally benign, chondroblastoma is placed in the "intermediate, rarely metastasizing" category in the 2013 World Health Organization classification of bone tumors. It typically involves the epiphysis of long tubular bones and is exceptionally located in the vertebral column. To the best of our knowledge, less than 35 cases of vertebral chondroblastoma have been reported in the literature. We report a case of chondroblastoma involving D6 -D7 vertebrae in a 17-year-old male patient, diagnosed on intraoperative crush cytology and later confirmed on histopathology...
August 23, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28736834/temporal-bone-chondroblastoma-imaging-characteristics-with-pathologic-correlation
#17
Sun-Won Park, Ji-Hoon Kim, Ji Hoon Park, Kyung Chul Moon, Jin Chul Paeng, Byung Se Choi, Younghen Lee, Jae Hyoung Kim, Roh-Eul Yoo, Koung Mi Kang, Soo Chin Kim, Seung Hong Choi, Tae Jin Yun, Chul Ho Sohn
BACKGROUND: Chondroblastoma commonly involves the temporal bone in the craniofacial region, but its imaging features have not been elucidated. This study aimed to describe the imaging features of temporal bone chondroblastoma with their pathologic correlation. METHODS: Radiopathologic correlation was performed in 5 patients with temporal bone chondroblastoma from our database and in 11 patients identified through a PubMed search. RESULTS: The cases of temporal bone chondroblastoma commonly involve the squamous part, temporal and infratemporal fossae, temporomandibular joint, and tympanic cavity, with the following features: high attenuation with calcification; heterogeneity; low signal intensity on T2-weighted imaging with enhancement; a smooth interface to the brain; and strong hypermetabolism on fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28634924/chondroblastoma-in-adult-age
#18
Andrea Angelini, Mohammad Hassani, Andreas F Mavrogenis, Giulia Trovarelli, Carlo Romagnoli, Antonio Berizzi, Pietro Ruggieri
PURPOSE: Chondroblastoma (CB) is a rare benign tumor that occurs most commonly in the second decade of life. No studies on CB in adulthood have been reported. Our purposes were to report a single-institution experience on CB in adults and to discuss the clinical and imaging findings, type of treatment, oncologic and functional outcomes. PATIENTS AND METHODS: All patients diagnosed and treated for CB from 1981 to 2014 were reviewed. The main inclusion criterion was patients above their 30 years of age at diagnosis...
August 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28583274/benign-bone-conditions-that-may-be-fdg-avid-and-mimic-malignancy
#19
REVIEW
Thomas C Kwee, John M H de Klerk, Maarten Nix, Ben G F Heggelman, Stefan V Dubois, Hugo J A Adams
Positron emission tomography with the radiotracer 18F-fluoro-2-deoxy-d-glucose (FDG) plays an important role in the evaluation of bone pathology. However, FDG is not a cancer-specific agent, and knowledge of the differential diagnosis of benign FDG-avid bone alterations that may resemble malignancy is important for correct patient management, including the avoidance of unnecessary additional invasive tests such as bone biopsy. This review summarizes and illustrates the spectrum of benign bone conditions that may be FDG-avid and mimic malignancy, including osteomyelitis, bone lesions due to benign systemic diseases (Brown tumor, Erdheim-Chester disease, Gaucher disease, gout and other types of arthritis, Langerhans cell histiocytosis, and sarcoidosis), benign primary bone lesions (bone cysts, chondroblastoma, chondromyxoid fibroma, desmoplastic fibroma, enchondroma, giant cell tumor and granuloma, hemangioma, nonossifying fibroma, and osteoid osteoma and osteoblastoma), and a group of miscellaneous benign bone conditions (post bone marrow biopsy or harvest status, bone marrow hyperplasia, fibrous dysplasia, fractures, osteonecrosis, Paget disease of bone, particle disease, and Schmorl nodes)...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28557595/chondroblastoma-an-update
#20
REVIEW
Wenqian Chen, Lisa M DiFrancesco
Chondroblastoma is a rare primary bone tumor of young people that typically arises in the ends of the long bones. Radiologic investigations show a small, circumscribed, lytic lesion. The tumor is characterized histologically by the proliferation of chondroblasts along with areas of mature cartilage, giant cells, and occasionally, secondary aneurysmal bone cyst formation. Chondroblastoma, however, may also present with atypical features, such as prominent hemosiderin deposition, numerous giant cells, or the presence of a large aneurysmal bone cyst component...
June 2017: Archives of Pathology & Laboratory Medicine
keyword
keyword
81662
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"