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Clear cell sarcoma

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https://www.readbyqxmd.com/read/29661713/review-with-novel-markers-facilitates-precise-categorization-of-41-cases-of-diagnostically-challenging-undifferentiated-small-round-cell-tumors-a-clinicopathologic-immunophenotypic-and-molecular-analysis
#1
Isidro Machado, Akihiko Yoshida, María Gema Nieto Morales, Lucas Faria Abrahão-Machado, Samuel Navarro, Julia Cruz, Javier Lavernia, Antonina Parafioriti, Piero Picci, Antonio Llombart-Bosch
BACKGROUND: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable. DESIGN: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis...
November 29, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29626598/ewsr1-nfatc2-gene-fusion-in-a-soft-tissue-tumor-with-epithelioid-round-cell-morphology-and-abundant-stroma-a-case-report-and-review-of-the-literature
#2
Jarish N Cohen, Amit J Sabnis, Gregor Krings, Soo-Jin Cho, Andrew E Horvai, Jessica L Davis
Mesenchymal round cell tumors are a diverse group of neoplasms defined by primitive, often high-grade cytomorphology. The most common molecular alterations detected in these tumors are gene rearrangements involving EWSR1 to one of many fusion partners. Rare EWSR1-NFATC2 gene rearrangements, corresponding to a t(20;22) gene translocation, have been described in mesenchymal tumors with clear round cell morphology and a predilection for the skeleton. We present a case of a tumor harboring the EWSR1-NFATC2 gene fusion arising in the subcutaneous tissue of a young woman...
April 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29623567/clear-cell-sarcoma-like-tumor-of-the-gastrointestinal-tract
#3
Gokce Askan, Faruk Erdem Kombak, Ipek Erbarut Seven, Olca Basturk
No abstract text is available yet for this article.
April 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29607435/renal-clear-cell-sarcoma-presenting-as-a-spontaneous-renal-hematoma-a-rare-presentation
#4
Zeynep Canan Ozdemir, Burcu Ayvaci, Yeter Duzenli Kar, Mehmet Oguzman, Mehmet Surhan Arda, Mustafa Fuat Acikalin, Ozcan Bor
Clear cell sarcoma of the kidney (CCSK) is an uncommon renal neoplasm of childhood. It represents between 2% and 9% of all pediatric renal tumors, and generally arises before the age of 5 years. It often mimics other pediatric renal tumors. Presently described is the case of a 7-year-old girl who presented with complaints of vomiting and abdominal pain. Abdominal ultrasonography revealed a right renal mass, and the patient developed a renal hematoma a few hours after admission. The patient underwent a nephroureterectomy with a provisional diagnosis of Wilms tumor; however, histopathological examination of a specimen revealed CCSK...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29578183/four-case-reports-on-pelvic-tumors-with-deep-venous-thromboses-as-main-symptoms-and-literature-review
#5
Cheng Liu, Dingfeng Li, Jun Guo, Qiu Cui, Linlin Zhang, Yanjun Zeng
To probe into the reasons for misdiagnoses of pelvic tumor as deep venous thromboses as well as the diagnostic methods and effective treatments on pelvic tumor. Four case reports on misdiagnosing pelvic tumor as deep venous thromboses and further analysis on the causes of misdiagnosis, diagnosis, and treatment with the literature study. The four cases were misdiagnosed as pelvic tumor, which actually were fibroneuroma, myxo.fluidity liposarcoma, moderately differentiated squamous cell carcinoma, and synovial sarcoma, respectively...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29575451/corrigendum-zekri-w-alfaar-as-yehia-d-et-al-clear-cell-sarcoma-of-the-kidney-patients-characteristics-and-improved-outcome-in-developing-countries-pediatr-blood-cancer-2014-61-2185-2190-doi-10-1002-pbc-25192
#6
https://www.readbyqxmd.com/read/29540190/development-of-neoplasms-in-pediatric-patients-with-rheumatic-disease-exposed-to-anti-tumor-necrosis-factor-therapies-a-single-centre-retrospective-study
#7
Alexandra Okihiro, Rachana Hasija, Lillia Fung, Bonnie Cameron, Brian M Feldman, Ronald Laxer, Rayfel Schneider, Earl Silverman, Lynn Spiegel, Rae S M Yeung, Shirley M L Tse
BACKGROUND: Anti-TNF (Tumor necrosis factor) therapy is effective in treating pediatric patients with refractory rheumatic disease. There is however a concern that anti-TNF usage may increase the risk of malignancy. Reports on specific types of malignancy in this patient population have been emerging over the past decade, but there is a need for additional malignancy reports, as these events are rare. Therefore, a retrospective chart review was performed on the biologic database of pediatric rheumatology patients at The Hospital for Sick Children (SickKids) from 1997 to 2013 for neoplasms, patient demographic information and rheumatologic treatment course...
March 14, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29529647/synovial-sarcoma-is-not-associated-with-a-higher-risk-of-lymph-node-metastasis-compared-with-other-soft-tissue-sarcomas
#8
Andrew J Jacobs, Carol D Morris, Adam S Levin
BACKGROUND: Reported rates of the incidence of lymph node metastasis in soft tissue sarcoma vary considerably. Many are based on single-institution series and small patient populations. Certain sarcoma subtypes, including synovial sarcoma, have been associated with a higher risk of lymph node involvement. Most single centers have insufficient numbers of patients to assess lymph node metastasis accurately, but larger national databases may allow a more accurate estimation. QUESTIONS/PURPOSES: We queried a large national database and asked the following questions: (1) What proportion of patients with soft tissue sarcoma have lymph node metastasis and distant metastasis? (2) What histologic subtypes are associated with increased risk of nodal metastasis? (3) What is the impact of lymph node metastases and histologic subtype on survival? (4) Does lymph node excision improve survival of patients with soft tissue sarcoma? METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program is a national database that covers a geographic cross-section representing approximately 28% of the US population across demographic groups...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29528717/malignant-mesothelioma-in-individuals-with-nonmesothelial-neoplasms
#9
Kelly J Butnor, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli
CONTEXT: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed. OBJECTIVE: - To assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM. DESIGN: - Individuals with MM and second neoplasms were identified from a database of 3900 MM cases. The expected prevalence of each type of neoplasm was calculated and compared with the actual prevalence in the study population using available Surveillance, Epidemiology, and End Results data and other published data...
March 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29509095/delayed-metastasis-of-clear-cell-sarcoma-of-kidney-to-bladder-after-7-disease-free-years
#10
Adam Lang, Louis P Dehner
INTRODUCTION: Clear cell sarcoma of the kidney (CCSK) is childhood neoplasm with its own distinctive pattern of metastasis and may appear after a disease free interval of 5 years or more. MATERIALS AND METHODS: Histopathology and immunohistochemistry were available from the radical nephrectomy and the later partial cystectomy, which was performed after a seven disease-free interval. RESULTS: The pathologic features of the primary tumor were those of a classic CCSK with a monotypic pattern of uniform rounded to ovoid tumor cells with a background network of delicate blood vessels...
March 6, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29491075/clear-cell-sarcoma-like-tumor-of-the-gastrointestinal-tract-clinical-outcome-and-pathologic-features-of-a-molecularly-characterized-tertiary-center-case-series
#11
Michela Libertini, Khin Thway, Jonathan Noujaim, Florian Puls, Christina Messiou, Cyril Fisher, Robin L Jones
BACKGROUND/AIM: Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLTGT) is a very rare and relatively recently characterized mesenchymal neoplasm arising within the wall of the small bowel, stomach, or large bowel, predominantly in adolescents and young adults. Only few anecdotal reports or small series have been published and a consensus on treatment has not been formulated. Complete resection remains the only curative option for localized disease, but despite optimal surgery, CCSLTGT typically shows highly aggressive behavior with a high rate of local recurrence, metastases, and death from disease...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29490634/a-novel-canine-histiocytic-sarcoma-cell-line-initial-characterization-and-utilization-for-drug-screening-studies
#12
Marilia Takada, Maciej Parys, Emmalena Gregory-Bryson, Paulo Vilar Saavedra, Matti Kiupel, Vilma Yuzbasiyan-Gurkan
BACKGROUND: Histiocytic sarcoma is a rare disorder in humans, however it is seen with appreciable frequency in certain breeds of dogs, such as Bernese mountain dog. The purpose of this study was to fully characterize a novel canine histiocytic sarcoma cell line, and utilize it as a tool to screen for potential therapeutic drugs. METHODS: The histiocytic sarcoma cell line was characterized by expression of cellular markers as determined by immunohistochemistry and flow cytometry techniques...
March 1, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29485128/position-paper-rationale-for-the-treatment-of-children-with-ccsk-in-the-umbrella-siop-rtsg-2016-protocol
#13
REVIEW
Saskia L Gooskens, Norbert Graf, Rhoikos Furtwängler, Filippo Spreafico, Christophe Bergeron, Gema L Ramírez-Villar, Jan Godzinski, Christian Rübe, Geert O Janssens, Gordan M Vujanic, Ivo Leuschner, Aurore Coulomb-L'Hermine, Anne M Smets, Beatriz de Camargo, Sara Stoneham, Harm van Tinteren, Kathy Pritchard-Jones, Marry M van den Heuvel-Eibrink
The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) has developed a new protocol for the diagnosis, treatment, and follow-up monitoring of childhood renal tumours - the UMBRELLA SIOP-RTSG 2016 protocol (the UMBRELLA protocol). This protocol has been designed to continue international collaboration in the treatment of childhood renal tumours and will be implemented in over 50 different countries. Clear cell sarcoma of the kidney, which is a rare paediatric renal tumour that most commonly occurs in children between 2 and 4 years of age, is specifically addressed in the UMBRELLA protocol...
February 27, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29484066/percutaneous-radiofrequency-ablation-for-a-recurrent-metastasis-after-resection-of-liver-metastases-from-an-ileal-clear-cell-sarcoma-long-term-local-tumor-control
#14
Jung Wook Seo
Clear-cell sarcomas (CCSs) in the gastrointestinal tract are extremely rare and aggressive tumors. We present the first case of a CCS arising in the ileum and metastasizing to the liver; our patient was a 60-year-old man. After the resection of the CCS and the liver metastases, a new liver metastasis developed, which was treated via percutaneous radiofrequency ablation only. At the 5-year follow-up, the ablated region was stable without local tumor progression. Percutaneous radiofrequency ablation is a viable local treatment option for recurrent metastases from an ileal CCS if they are detected when small and at an early stage in follow-up studies...
December 2017: Radiology Case Reports
https://www.readbyqxmd.com/read/29483744/-segmental-vena-cava-resection-for-the-treatment-of-renal-tumor-with-invading-tumor-thrombus
#15
J F Ye, L L Ma, L Zhao, G L Wang
OBJECTIVE: To investigate the safety and perioperative experience of the segmental resection of the vena cava. METHODS: From May 2015 to July 2017, 92 renal tumor patients with venous tumor thrombus were treated in Peking University Third Hospital, of whom 17 underwent nephrectomy with resection of the invaded vena cava for renal tumor with tumor thrombus invading vena cava. The preoperative features included that 15 patients were male and 2 female, the mean age was (59...
February 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29401145/clear-cell-sarcoma-of-the-tongue-on-mri-and-pet-ct
#16
Mickael Tordjman, Matthieu Dubois, Maxime de Malherbe, Yves Denoux, Quentin Gillebert
F-FDG PET/CT and MRI were performed in a 44-year-old woman to characterize a mass of the anterior tongue. MR images showed a voluminous mass, well circumscribed and enhanced heterogeneously after gadolinium chelates injection. There was an intense uptake on PET/CT. Pathological examination and molecular analysis revealed the diagnosis of clear cell sarcoma of the tongue. We present a case of clear cell sarcoma of the tongue, which includes imaging features. It is an extremely rare tumor, with only 3 cases previously reported in the literature...
February 3, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29398970/alveolar-soft-part-sarcoma-presenting-as-hypervascular-adrenal-metastasis
#17
Manjunath Goroshi, Anurag R Lila, Tushar Bandgar, Nalini S Shah
Hypervascular adrenal masses include pheochromocytoma, metastases caused by clear renal cell carcinoma/hepatocellular carcinoma. Alveolar soft part sarcoma (ASPS) causing hypervascular metastases is not described in the literature. Here, we describe the first case of ASPS presenting as hypervascular metastasis. Our case was a 23-year-old male incidentally detected right adrenal mass during the evaluation of pain in the abdomen. On computed tomography (CT), adrenal mass showed bright enhancement in early arterial phase (unenhanced Hounsfield unit [HU]-45...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29397940/kshv-virf4-enhances-bcl6-transcription-via-downregulation-of-irf4-expression
#18
Hye Ryun Yu, Yeong Jun Kim, Hye-Ra Lee
Primary effusion lymphoma (PEL), strongly linked with latent infection of Kaposi's sarcoma-associated herpesvirus (KSHV), constitutively expresses cellular interferon regulatory factor 4 (IRF4) while suppressing the expression of B cell lymphoma 6 (BCL6). Recently, it was shown that IRF4, a key transcriptional repressor of BCL6, might be a pivotal regulator of KSHV for balancing between latency and its reactivation in PEL cells. However, the action of the BCL6-IRF4 transcription factor axis during KSHV's life cycle is not clear...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29397265/the-evaluation-of-circulating-endothelial-progenitor-cells-and-related-angiogenic-markers-as-prognostic-factors-in-soft-tissue-tumors
#19
Ioannis Karampinis, Elena Joas, Anna Dreyer, Ulrich Ronellenfitsch, Jens Jakob, Peter Hohenberger, Kai Nowak
INTRODUCTION: Neovascularisation is a critical step in the progression of malignant tumors. Circulating endothelial progenitor cells (cEPC) have been proposed as surrogate markers of vasculogenesis in malignancies. In this project, we studied the impact of tumor-specific therapy on cEPC and associated angiogenic factors in patients with soft tissue tumors. MATERIALS AND METHODS: Fifty-three patients with soft tissue tumors (25 soft tissue sarcomas, 19 GIST, 9 desmoids) and 15 healthy controls were included...
January 31, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29391414/design-and-synthesis-of-coumarin-based-organoselenium-as-a-new-hit-for-myeloprotection-and-synergistic-therapeutic-efficacy-in-adjuvant-therapy
#20
Arup Ranjan Patra, Somnath Singha Roy, Abhishek Basu, Avishek Bhuniya, Arin Bhattacharjee, Subhadip Hajra, Ugir Hossain Sk, Rathindranath Baral, Sudin Bhattacharya
A newly designed organoselenium compound, methyl substituted umbelliferone selenocyanate (MUS), was synthesized as a primary hit against the myelotoxic activity of carboplatin. MUS was administered at 6 mg/kg b.wt, p.o. in concomitant and pretreatment schedules with carboplatin (12 mg/kg b.wt, i.p. for 10 days) in female Swiss albino mouse. MUS treatment reduced (P < 0.001) the percentage of chromosomal aberrations, micronuclei formation, DNA damage and apoptosis in murine bone marrow cells and also enhanced (P < 0...
February 1, 2018: Scientific Reports
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